Sideritis species in challenging against cancer: Cytotoxic, antiproliferative and apoptotic roles on different cancer cells

Abstract

Sideritis species belonging to the Lamiaceae family are represented by many species around the world. They exhibit many bioactivities due to their important phytochemicals. They have remarkable bioactivities such as antioxidant, anticancer, antimicrobial, anti-inflammatory, etc. for important sectors such as pharmaceuticals and food. They are thought to be important resources in the fight against cancer, especially due to their cytotoxic effects on cancer cells. Many studies on various cancer cells have reported cytotoxic, antiproliferative and apoptotic properties of sideritis species. In this study, the phytochemical contents of sideritis species growing in different geographies and their cytotoxic, antiproliferative and apoptotic effects in the fight against cancer were discussed in detail molecularly.