Head and Neck Optical Diagnostics Society最新文献_第3页

A patient with ulcerated calcifying epithelioma of Malherbe in the pinna: case report. 耳廓Malherbe钙化上皮瘤溃疡1例。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-21 DOI: 10.1186/1758-3284-4-25

Tahwinder Upile, Waseem Jerjes, Fabian Sipaul, Ann Sandison, Panagiotis Kafas, Mohammed Al-Khawalde, Hani Radhi

{"title":"A patient with ulcerated calcifying epithelioma of Malherbe in the pinna: case report.","authors":"Tahwinder Upile, Waseem Jerjes, Fabian Sipaul, Ann Sandison, Panagiotis Kafas, Mohammed Al-Khawalde, Hani Radhi","doi":"10.1186/1758-3284-4-25","DOIUrl":"https://doi.org/10.1186/1758-3284-4-25","url":null,"abstract":"Introduction: Although pilomatrixomas are frequently encountered by dermatologists and pathologists in the differential diagnosis of head and neck lesions, this is not usually the case among head and neck surgeons. A pilomatrixoma (calcifying epithelioma of Malherbe) is a benign tumour of the hair matrix cells. Histologically it is characterised by the presence of ghost cells, basophilic cells and foreign body cells. It may sometimes be difficult to histologically distinguish it from its malignant counterpart, the pilomatrix carcinoma. We report an interesting case of an ulcerated pilomatrixoma of the pinna in a middle-aged Caucasian female.Case presentation: A 46-year-old Caucasian female presented with a one-month history of tender brownish lump on the pinna. Initially it was thought to represent a pyogenic granuloma. The lesion was treated by wide circular excision. Histopathological evaluation reported a benign calcifying epithelioma of Malherbe.Conclusion: A search of the world's literature has led us to believe that this is a rare case of a calcifying epithelioma of Malherbe of the pinna. The rapid growth and ulcerative nature of this tumour makes this case even more unique.","PeriodicalId":49195,"journal":{"name":"Head and Neck Optical Diagnostics Society","volume":"4 ","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2012-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1758-3284-4-25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30633366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Branchial cysts within the parotid salivary gland. 腮腺涎腺内的鳃裂囊肿。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-18 DOI: 10.1186/1758-3284-4-24

Tahwinder Upile, Waseem Jerjes, Mohammed Al-Khawalde, Panagiotis Kafas, Steve Frampton, Angela Gray, Bruce Addis, Ann Sandison, Nimesh Patel, Holger Sudhoff, Hani Radhi

引用次数: 14

Definitive radiotherapy for early stage glottic cancer by 6 MV photons. 6mv光子放射治疗早期声门癌。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-18 DOI: 10.1186/1758-3284-4-23

Chi-Chung Tong, Kwok-Hung Au, Roger Kai-Cheong Ngan, Foon-Yiu Cheung, Sin-Ming Chow, Yiu-Tung Fu, Joseph Siu-Kei Au, Stephen Chun-Key Law

{"title":"Definitive radiotherapy for early stage glottic cancer by 6 MV photons.","authors":"Chi-Chung Tong, Kwok-Hung Au, Roger Kai-Cheong Ngan, Foon-Yiu Cheung, Sin-Ming Chow, Yiu-Tung Fu, Joseph Siu-Kei Au, Stephen Chun-Key Law","doi":"10.1186/1758-3284-4-23","DOIUrl":"https://doi.org/10.1186/1758-3284-4-23","url":null,"abstract":"Purpose: To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.Methods and materials: We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.Results: The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.Poorly differentiated histology and tumor biologically effective dose<65 Gy15 were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.Conclusion: Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.","PeriodicalId":49195,"journal":{"name":"Head and Neck Optical Diagnostics Society","volume":"4 ","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2012-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1758-3284-4-23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30628099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The use of specific anti-growth factor antibodies to abrogate the oncological consequences of transfusion in head & neck squamous cell carcinoma: an in vitro study. 使用特异性抗生长因子抗体消除头颈部鳞状细胞癌输血的肿瘤学后果:一项体外研究。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-16 DOI: 10.1186/1758-3284-4-22

Tahwinder Upile, Waseem Jerjes, Sandeep Singh, Mohammed Al-Khawalde, Zaid Hamdoon, Hani Radhi, Colin Hopper

{"title":"The use of specific anti-growth factor antibodies to abrogate the oncological consequences of transfusion in head & neck squamous cell carcinoma: an in vitro study.","authors":"Tahwinder Upile, Waseem Jerjes, Sandeep Singh, Mohammed Al-Khawalde, Zaid Hamdoon, Hani Radhi, Colin Hopper","doi":"10.1186/1758-3284-4-22","DOIUrl":"https://doi.org/10.1186/1758-3284-4-22","url":null,"abstract":"Introduction: Perioperative blood transfusion is associated with reduced prognosis in a number of solid malignancies. We investigate its role in a head & neck squamous cell cancer (HNSCC) cell lines. Growth of these cell lines was analogous to endothelial growth. Direct exposure to transfusion products exaggerated this effect. It was logical therefore to assess the effects of anti-endothelial antibodies on this interaction.Materials and methods: Control (HUVEC) and tumour cell lines were exposed to transfusion products. The pre-incubation of the transfusion product with anti-endothelial growth factors was assessed by a growth assay. Where appropriate cells were pre-incubated for 1 hour with 10 μl of a mixture of 100 μl of each and anti-ligand antibodies, the corresponding blood product supplement was incubated with 10 μl of a mixture of 100 μl each of anti-ligand antibodies 1 hour before supplementation to the appropriate cell line. All results are representative of at least two independent experiments carried out in triplicate.Results: The antibody did not directly reduce growth in the tumour cell line, however there was a significant reduction (p<0.001) in tumour cell line vascular mimicry caused by transfusion products pre-incubation with anti-endothelial growth factor antibody. This was found in several other tumours.Conclusion: Perioperative blood transfusion is associated with reduced prognosis in a number of solid malignancies including HNSCC. However this phenomenon is abrogated by the use of anti-endothelial growth factor antibodies. This suggests that the original effect was mediated by the endothelial growth factor family.","PeriodicalId":49195,"journal":{"name":"Head and Neck Optical Diagnostics Society","volume":"4 ","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2012-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1758-3284-4-22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30623126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tongue cancer in young patients: case report of a 26-year-old patient. 年轻患者舌癌:一26岁患者的病例报告。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-14 DOI: 10.1186/1758-3284-4-20

Aleksandra Credé, Michael Locher, Marius Bredell

引用次数: 6

Reconstruction of scalp defects with the radial forearm free flap. 前臂桡侧游离皮瓣修复头皮缺损。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-14 DOI: 10.1186/1758-3284-4-21

Larissa Sweeny, Brendan Eby, J Scott Magnuson, William R Carroll, Eben L Rosenthal

{"title":"Reconstruction of scalp defects with the radial forearm free flap.","authors":"Larissa Sweeny, Brendan Eby, J Scott Magnuson, William R Carroll, Eben L Rosenthal","doi":"10.1186/1758-3284-4-21","DOIUrl":"https://doi.org/10.1186/1758-3284-4-21","url":null,"abstract":"Background: Advanced and recurrent cutaneous squamous cell carcinoma of the scalp and forehead require aggressive surgical excision often resulting in complex defects requiring reconstruction. This study evaluates various microvascular free flap reconstructions in this patient population, including the rarely utilized radial forearm free flap.Patients and methods: A retrospective review of patients undergoing free flap surgeries (n = 47) of the scalp between 1997 and 2011 were included. Patients were divided primarily into two cohorts: a new primary lesion (n = 21) or recurrence (n = 26). Factors examined include patient demographics, indication for surgery, defect, type of flap used, complications (major and minor), and outcomes.Results: The patients were primarily male (n = 34), with a mean age of 67 years (25-91). A total of 58 microvascular free flap reconstructions were performed (radial forearm free flap: n = 28, latissimus dorsi: n = 20, rectus abdominis: n = 9, scapula: n = 1). Following reconstruction with a radial forearm free flap, duration of hospitalization was shorter (P = 0.04) and complications rates were similar (P = 0.46). Donor site selection correlated with defect area (P < 0.001), but not with the extent of skull defect (P = 0.70). Larger defect areas correlated with higher complications rates (P = 0.03) and longer hospitalization (P = 0.003). Patients were more likely to require multiple reconstructions if referred for a recurrent lesions (P = 0.01) or received prior radiation therapy (P = 0.02).Conclusion: Advanced and recurrent malignancies of the scalp are aggressive and challenging to treat. The radial forearm free flap is an underutilized free flap in the reconstruction of complex scalp defects.","PeriodicalId":49195,"journal":{"name":"Head and Neck Optical Diagnostics Society","volume":"4 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2012-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1758-3284-4-21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30615257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Systemic therapy in the management of metastatic or advanced salivary gland cancers. 转移性或晚期唾液腺癌的全身治疗。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-04 DOI: 10.1186/1758-3284-4-19

Aymen Lagha, Nesrine Chraiet, Mouna Ayadi, Sarra Krimi, Bassem Allani, Hela Rifi, Henda Raies, Amel Mezlini

引用次数: 79

Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma. 谷氨酸-1、HIF-1α、PI3K和p-Akt在耵聍腺瘤中的表达。

Head and Neck Optical Diagnostics Society Pub Date : 2012-05-02 DOI: 10.1186/1758-3284-4-18

Wan-Qin Shen, Ke-Jia Cheng, Yang-Yang Bao, Shui-Hong Zhou, Hong-Tian Yao

引用次数: 16

Photodynamic therapy in the management of potentially malignant and malignant oral disorders. 光动力疗法在治疗潜在恶性和恶性口腔疾病中的应用。

Head and Neck Optical Diagnostics Society Pub Date : 2012-04-30 DOI: 10.1186/1758-3284-4-16

Waseem Jerjes, Zaid Hamdoon, Colin Hopper

引用次数: 38

CO2 lasers in the management of potentially malignant and malignant oral disorders. CO2激光在潜在的恶性和恶性口腔疾病的管理。

Head and Neck Optical Diagnostics Society Pub Date : 2012-04-30 DOI: 10.1186/1758-3284-4-17

Waseem Jerjes, Zaid Hamdoon, Colin Hopper

{"title":"CO2 lasers in the management of potentially malignant and malignant oral disorders.","authors":"Waseem Jerjes, Zaid Hamdoon, Colin Hopper","doi":"10.1186/1758-3284-4-17","DOIUrl":"https://doi.org/10.1186/1758-3284-4-17","url":null,"abstract":"The CO2 laser was invented in 1963 by Kumar Patel. Since the early 1970s, CO2 laser has proved to be an effective method of treatment for patients with several types of oral lesions, including early squamous cell carcinoma.Laser surgery of oral premalignant disorders is an effective tool in a complete management strategy which includes careful clinical follow-up, patient education to eliminate risk factors, reporting and biopsying of suspicious lesions and any other significant lesions. However, in a number of patients, recurrence and progression to malignancy remains a risk. CO2 laser resection has become the preferred treatment for small oral and oropharyngeal carcinomas. Laser resection does not require reconstructive surgery. There is minimal scarring and thus, optimum functional results can be expected.New and improved applications of laser surgery in the treatment of oral and maxillofacial/head and neck disorders are being explored. As more surgeons become experienced in the use of lasers and as our knowledge of the capabilities and advantages of this tool expands, lasers may play a significant role in the management of different pathologies.","PeriodicalId":49195,"journal":{"name":"Head and Neck Optical Diagnostics Society","volume":" ","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2012-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1758-3284-4-17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40192985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30