Journal of the Korean Surgical Society最新文献_第3页

Measuring the stress of the surgeons in training and use of a novel interventional program to combat it. 测量外科医生在训练中的压力，并使用一种新的介入方案来对抗压力。

Journal of the Korean Surgical Society Pub Date : 2012-05-01 Epub Date: 2012-04-26 DOI: 10.4174/jkss.2012.82.5.312

Ioannis Christakis, Marios T Pagkratis, Lisa Varvogli, Christina Darviri, George Chroussos

{"title":"Measuring the stress of the surgeons in training and use of a novel interventional program to combat it.","authors":"Ioannis Christakis, Marios T Pagkratis, Lisa Varvogli, Christina Darviri, George Chroussos","doi":"10.4174/jkss.2012.82.5.312","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.5.312","url":null,"abstract":"Purpose: Stress poses a serious risk for training surgeons since their performance and well-being in reflected in patients' health. This study focuses on measuring the stress of training surgeons and at the same time evaluates prospectively the results of an innovative program that uses alternative techniques to combat the effects of stress.Methods: The study was a pilot randomized controlled trial, with a duration of 6 months. Participants were allocated to a control and an intervention group. Trainees then completed three questionnaires, quality of life, perceived stress scale (PSS) and job content questionnaire serving as a baseline measurement. Only the intervention group used diaphragmatic breathing and progressive muscular relaxation techniques, twice a day, for 20 minutes each, and for a total period of eight weeks. At the end of the study, the same questionnaires were completed again by both groups.Results: The sample of the study included 28 and 32 trainees in the control and the intervention group, respectively. The Cronbach's α value for the PSS stress-measuring questionnaire was 0.772. The intervention group presented statistically significant lower values of stress (30.50, P < 0.05) in comparison to the control group (27.54).Conclusion: The medical community, and especially surgeons, have been reluctant up to now to embrace interventional programs that go beyond the traditional use of medication in order to address stress related issues. The positive results and feedback from small studies, such as ours, can provide the driving force for further research that will give us solid, evidence-based, answers.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 5","pages":"312-6"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.5.312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30598859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Gene expression profiling of papillary thyroid carcinomas in Korean patients by oligonucleotide microarrays. 用寡核苷酸芯片分析韩国患者甲状腺乳头状癌的基因表达谱。

Journal of the Korean Surgical Society Pub Date : 2012-05-01 Epub Date: 2012-04-26 DOI: 10.4174/jkss.2012.82.5.271

Ki-Wook Chung, Seok Won Kim, Sun Wook Kim

{"title":"Gene expression profiling of papillary thyroid carcinomas in Korean patients by oligonucleotide microarrays.","authors":"Ki-Wook Chung, Seok Won Kim, Sun Wook Kim","doi":"10.4174/jkss.2012.82.5.271","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.5.271","url":null,"abstract":"Purpose: The incidence of papillary thyroid carcinomas (PTCs) is rapidly increasing in Korea. Analyzing the gene expression profiling (GEP) of PTCs will facilitate the advent of new methods in diagnosis, prognostication, and treatment. We performed this study to find the GEP of Korean PTCs.Methods: We performed oligonucleotide microarray analysis with 19 PTCs and 7 normal thyroid glands. Differentially expressed genes were selected using a t-test (|fold| >3) and adjusted Benjamini-Hochberg false discovery rate P-value < 0.01. Quantitative reverse transcription-polymerase chain reaction (QRT-PCR) was used to validate microarray data. A classification model was developed by support vector machine (SVM) algorithm to diagnose PTCs based on molecular signatures.Results: We identified 79 differentially expressed genes (70 up-regulated and 9 down-regulated) according to the criteria. QRT-PCR for five genes (CDH3, NGEF, PROS1, TGFA, MET) was confirmatory of the microarray data. Hierarchical cluster analysis and a classification model by the SVM algorithm accurately differentiated PTCs from normal thyroid gland based on GEP.Conclusion: A disease classification model showed excellent accuracy in diagnosing PTCs, thus showing the possibility of molecular diagnosis in the future. This GEP could serve as baseline data for further investigation in the management of PTCs based on molecular signatures.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 5","pages":"271-80"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.5.271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30598853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Splenectomy affects the balance between hepatic growth factor and transforming growth factor-β and its effect on liver regeneration is dependent on the amount of liver resection in rats. 脾切除术影响大鼠肝脏生长因子和转化生长因子-β之间的平衡，其对肝脏再生的影响与肝切除量有关。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.238

Joohyun Kim, Chang-Ju Kim, Il-Gyu Ko, Sun Hyung Joo, Hyung Joon Ahn

{"title":"Splenectomy affects the balance between hepatic growth factor and transforming growth factor-β and its effect on liver regeneration is dependent on the amount of liver resection in rats.","authors":"Joohyun Kim, Chang-Ju Kim, Il-Gyu Ko, Sun Hyung Joo, Hyung Joon Ahn","doi":"10.4174/jkss.2012.82.4.238","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.4.238","url":null,"abstract":"Purpose: Small-for-size syndrome (SFSS) is a major problem in liver surgery, and splenectomy has been used to prevent SFSS. However, it is unknown whether splenectomy has the same effect on liver regeneration in both standard and marginal hepatectomy. The aim of this study is to see a difference in effect of splenectomy on liver regeneration according to the amount of liver resection.Methods: Thirty male Sprague-Dawley rats (220 to 260 g) were divided into the following five groups: control (n = 6), 70% hepatectomy (n = 6), 70% hepatectomy with splenectomy (n = 6), 90% hepatectomy (n = 6), and 90% hepatectomy with splenectomy (n = 6). The animals were euthanized 24 hours after surgery and liver specimens were obtained. To assess liver regeneration, we performed immunohistochemistry of liver tissue using 5-bromo-2-deoxyuridine (BrdU) labeling and Western blot analysis of hepatic growth factor (HGF) and transforming growth factor-β (TGF-β) in the liver tissue.Results: The splenectomized subgroup had a higher BrdU-positive cell count in the 90% hepatectomy group, but not in the 70% hepatectomy group (P < 0.001). Splenectomy significantly decreased TGF-β expression (P = 0.005) and increased the HGF to TGF-β ratio (P = 0.002) in the 90% hepatectomy group, but not in the 70% hepatectomy group.Conclusion: The positive effect of splenectomy on liver regeneration was greater in the group with the larger liver resection. This phenomenon may be related to the relative balance between HGF and TGF-β in the liver.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 4","pages":"238-45"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.4.238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30566994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Oncologic manifestations of neurofibromatosis type 1 in Korea. 韩国1型神经纤维瘤病的肿瘤表现。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.205

Eui Tae Kim, Hwan Namgung, Hyun Deok Shin, Soon Il Lee, Jee Eun Kwon, Myung Chul Chang, Dong Guk Park

{"title":"Oncologic manifestations of neurofibromatosis type 1 in Korea.","authors":"Eui Tae Kim, Hwan Namgung, Hyun Deok Shin, Soon Il Lee, Jee Eun Kwon, Myung Chul Chang, Dong Guk Park","doi":"10.4174/jkss.2012.82.4.205","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.4.205","url":null,"abstract":"Purpose: The aim of this study was to investigate the incidence and spectrum of malignant tumors in Korean neurofibromatosis type 1 (NF1) patients.Methods: We retrospectively reviewed 125 patients who were diagnosed with NF1 at a single institution from 1995 to 2010. The incidence, location, histologic type, and radiologic findings of malignant tumors as well as development of multiple primary tumors were analyzed.Results: Eighteen malignant tumors occurred in 16 patients (12.8%) among 125 Korean NF1 patients; 9 carcinomas, 8 sarcomas and 1 central nervous system (CNS) tumor. Five tumors were of nervous system origin and 13 were non-nervous system tumors. The locations of the tumors were as follow: 1 CNS, 2 lung, 3 breast, 3 stomach, 3 small bowel, 1 colon, 1 liver, 1 uterus, 1 neck, and 2 in extremities. Three malignant peripheral nerve sheath tumors (MPNSTs) occurred at the neck and extremity, and one in the liver. All three gastrointestinal stromal tumors (GISTs) had multiple tumors in the jejunum, and one MPNST and one pheochromocytoma were accompanied in two GISTs. Multiple primary tumors, benign or malignant were reported in 4 patients (25.0%), synchronously or metachronously.Conclusion: Korean NF1 patients had a high risk of developing malignant tumors. The common malignant tumors in Koreans such as breast, lung and stomach cancers developed frequently in addition to the NF1-related tumors such as MPNST or GIST.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 4","pages":"205-10"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.4.205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30567576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

A case report of primary breast angiosarcoma with fatal pulmonary hemorrhage due to thrombocytopenia. 原发性乳腺血管肉瘤合并致死性肺出血1例报告。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.251

Yong-Seok Kim, Young-Joong Kim, Kwang-Il Yim, Woo-Chan Park

引用次数: 5

Adrenocortical tumors in children 18 years old and younger. 18岁及以下儿童的肾上腺皮质肿瘤。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.246

Min Jeng Cho, Dae Yeon Kim, Seong Chul Kim, Tae Hoon Kim, In Koo Kim

{"title":"Adrenocortical tumors in children 18 years old and younger.","authors":"Min Jeng Cho, Dae Yeon Kim, Seong Chul Kim, Tae Hoon Kim, In Koo Kim","doi":"10.4174/jkss.2012.82.4.246","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.4.246","url":null,"abstract":"Purpose: Pediatric adrenocortical tumors (ACTs) are rare. We reviewed findings in 8 children, 18 years of age or younger, diagnosed with ACT in our institution over the past 15 years.Methods: We retrospectively reviewed 8 children with ACTs treated between 1996 and 2010.Results: Three girls and 5 boys were treated for ACTs; their median age at presentation was 144 months (range, 28 months to 18 years). Seven patients showed signs of endocrine dysfunction, 4 with Cushing syndrome, 2 with virilization, and 1 with hyperaldosteronism. One patient, with symptoms of hematuria, underwent a computed tomography scan, which showed an adrenal mass. The median duration of symptoms prior to resection was 6 months (range, 1 to 24 months). Five patients had adenomas and 3 had carcinomas. All underwent complete resection of the tumor, with laparoscopic adrenalectomy performed on 3 patients with adenoma and 1 with carcinoma. The median tumor weight was 12.5 g (range, 1 to 130 g) and the median tumor volume was 18.3 cm(3) (range, 2.2 to 299.2 cm(3)). At a median follow-up of 5.1 years (range, 4 months to 15 years), all 8 patients remain alive with no recurrence of disease.Conclusion: The characteristics of pediatric ACTs vary considerably. Laboratory findings, clinical hormonal features, and tumor size could not distinguish adenomas from carcinomas before surgery. Complete tumor resection was successful, with no tumor recurrence. However, the small number of patients and short follow-up period limit assessments of prognosis.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 4","pages":"246-50"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.4.246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30566995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Primary tuberculosis appendicitis with mesenteric mass. 原发性结核性阑尾炎伴肠系膜肿块。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.266

So-Hyun Nam, Jin Soo Kim, Ki Hoon Kim, Sung Jin Park

引用次数: 7

Laparoscopic reversal of Hartmann's procedure. 哈特曼手术的腹腔镜逆转。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.256

Joong-Min Park, Kyong-Choun Chi

引用次数: 24

Clinical and radiologic preoperative predicting factors for GB cholesterol polyp. GB胆固醇息肉的临床及术前放射学预测因素。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.232

Hye-Lin Song, Jun-Ho Shin, Hungdai Kim, Yong-Lai Park, Chang-Hak Yoo, Byung-Ho Son, Ji-Sup Yoon, Hyung-Ok Kim

{"title":"Clinical and radiologic preoperative predicting factors for GB cholesterol polyp.","authors":"Hye-Lin Song, Jun-Ho Shin, Hungdai Kim, Yong-Lai Park, Chang-Hak Yoo, Byung-Ho Son, Ji-Sup Yoon, Hyung-Ok Kim","doi":"10.4174/jkss.2012.82.4.232","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.4.232","url":null,"abstract":"Purpose: To use the clinical and radiological data to differentiate non-cholesterol versus cholesterol gall bladder (GB) polyps, which can be useful in deciding the treatment of the patient.Methods: One hundred and eighty-seven patients underwent cholecystectomy for GB polyps of around 10 mm for 10 years, and were divided into two groups, cholesterol polyps (146 patients) and non-cholesterol polyps (41 patients) based on the postoperative pathological findings. Gender, age, body weight, height, body mass index (BMI), symptoms, laboratory findings, size, number of polyps, presence of GB stone and maximum diameter measured by preoperative ultrasonography (USG), computed tomography (CT), and pathological diameter were subjected to comparative analysis.Results: Patients diagnosed with cholesterol polyps were younger in age and had higher BMI, and the total cholesterol levels and white blood cell levels were higher, but were not statistically significant. It was notable to see that 28.6% of the cholesterol polyps were not found in the preoperative CT yet the percentage of the undetectable rate was significantly lower (8%) in the non-cholesterol polyp group. There was a discrepancy in maximum diameters between the two radiological methods in both groups but the discrepancy was significantly larger in the cholesterol polyp group.Conclusion: The clinical signs that can be helpful to diagnose whether it is a cholesterol polyp or not are younger patients who have high BMI, polyps which are detectable only on the USG and large maximum diameters between the USG and CT. And if the discrepancy of the maximum diameter is lesser than 1mm the polyp may be considered as a non-cholesterol polyp.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 4","pages":"232-7"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.4.232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30567579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Impact of chronologic age in the elderly with gastric cancer. 年龄对老年胃癌患者的影响。

Journal of the Korean Surgical Society Pub Date : 2012-04-01 Epub Date: 2012-03-27 DOI: 10.4174/jkss.2012.82.4.211

Sung Ryol Lee, Hyung Ook Kim, Chang Hak Yoo

{"title":"Impact of chronologic age in the elderly with gastric cancer.","authors":"Sung Ryol Lee, Hyung Ook Kim, Chang Hak Yoo","doi":"10.4174/jkss.2012.82.4.211","DOIUrl":"https://doi.org/10.4174/jkss.2012.82.4.211","url":null,"abstract":"Purpose: Although the incidence of gastric cancer has declined in the general population, it is the second most frequent cause of death due to malignancy in the world with its incidence in the elderly increasing as a result of increased life expectancy. This present study tried to find the optimal treatment for patients aged 75 years or older with gastric cancer through comparison of the clinicopathological characteristics, surgical outcomes, and identifying prognostic factors of survival.Methods: Elderly patients who underwent gastric resection for gastric cancer from January, 1999 to February, 2009 (n = 470) were divided into two groups: very elderly patients, 75 years or older (n = 95), and younger elderly patients, between 65 and 74 years old (n = 365).Results: Distinct characteristics of very elderly patients included more frequent underlying disease, deeper invasion, and more frequent lymph node metastasis. There were significant differences in overall survival between the two groups at stages III-B and IV. However, postoperative hospital stays, postoperative morbidity, mortality and early stage did not differ between curatively resected patients in the two groups.Conclusion: Due to improved postoperative care, gastrectomy of gastric cancer is the treatment of choice in very elderly patients. Therefore, early diagnosis through regular medical screening and curative gastrectomy with lymph node dissection should be performed in very elderly gastric cancer patients.","PeriodicalId":49157,"journal":{"name":"Journal of the Korean Surgical Society","volume":"82 4","pages":"211-8"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2012.82.4.211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30567577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19