Science in China. Series C, Life Sciences / Chinese Academy of Sciences最新文献_第8页

Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells. 人胎盘Adamalysin 19 (ADAM19)的动态变化及其对滋养细胞侵袭和粘附的影响。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0102-8

MeiRong Zhao, Wei Qiu, YuXia Li, QingXiang Amy Sang, YanLing Wang

{"title":"Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.","authors":"MeiRong Zhao, Wei Qiu, YuXia Li, QingXiang Amy Sang, YanLing Wang","doi":"10.1007/s11427-009-0102-8","DOIUrl":"https://doi.org/10.1007/s11427-009-0102-8","url":null,"abstract":"Human ADAM19 is a recently identified member of the ADAM family. It is highly expressed in human placentas, but its dynamic change and function at the human feto-maternal interface during placentation remain to be elucidated. In this present study, the spatial and temporal expression and cellular localization of ADAM19 in normal human placentas were first demonstrated, and the effects of ADAM19 on trophoblast cell adhesion and invasion were further investigated by using a human choriocarcinoma cell line (JEG-3) as an in vitro model. The data demonstrated that ADAM19 was widely distributed in villous cytotrophoblast cells, syncytiotrophoblast cells, column trophoblasts, and villous capillary endothelial cells during early pregnancy. The mRNA and protein level of ADAM19 in placentas was high at gestational weeks 8-9, but diminished significantly at mid- and term pregnancy. In JEG-3 cells, the overexpression of ADAM19 led to diminished cell invasion, as well as increases in cell adhesiveness and the expression of E-cadherin, with no changes in beta-catenin expression observed. These data indicate that ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"710-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0102-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28456012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The role of the DLPFC in inductive reasoning of MCI patients and normal agings: an fMRI study. DLPFC在MCI患者和正常衰老的归纳推理中的作用:一项fMRI研究。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0089-1

YanHui Yang, PeiPeng Liang, ShengFu Lu, KunCheng Li, Ning Zhong

{"title":"The role of the DLPFC in inductive reasoning of MCI patients and normal agings: an fMRI study.","authors":"YanHui Yang, PeiPeng Liang, ShengFu Lu, KunCheng Li, Ning Zhong","doi":"10.1007/s11427-009-0089-1","DOIUrl":"https://doi.org/10.1007/s11427-009-0089-1","url":null,"abstract":"Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal aging, and whether the activation pattern of this region was different between MCI patients and normal aging. The fMRI results indicated that MCI patients had no difference from normal aging in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal aging, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal aging. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of aging, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"789-95"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0089-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28378231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Strigolactones are a new-defined class of plant hormones which inhibit shoot branching and mediate the interaction of plant-AM fungi and plant-parasitic weeds. 独脚金内酯是一类新发现的植物激素，其作用是抑制植物枝条分枝，介导植物am真菌与植物寄生杂草的相互作用。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0104-6

Caiyan Chen, Junhuang Zou, Shuying Zhang, David Zaitlin, Lihuang Zhu

{"title":"Strigolactones are a new-defined class of plant hormones which inhibit shoot branching and mediate the interaction of plant-AM fungi and plant-parasitic weeds.","authors":"Caiyan Chen, Junhuang Zou, Shuying Zhang, David Zaitlin, Lihuang Zhu","doi":"10.1007/s11427-009-0104-6","DOIUrl":"https://doi.org/10.1007/s11427-009-0104-6","url":null,"abstract":"Because plants are sessile organisms, the ability to adapt to a wide range of environmental conditions is critical for their survival. As a consequence, plants use hormones to regulate growth, mitigate biotic and abiotic stresses, and to communicate with other organisms. Many plant hormones function pleiotropically in vivo, and often work in tandem with other hormones that are chemically distinct. A newly-defined class of plant hormones, the strigolactones, cooperate with auxins and cytokinins to control shoot branching and the outgrowth of lateral buds. Strigolactones were originally identified as compounds that stimulated the germination of parasitic plant seeds, and were also demonstrated to induce hyphal branching in arbuscular mycorrhizal (AM) fungi. AM fungi form symbioses with higher plant roots and mainly facilitate the absorption of phosphate from the soil. Conforming to the classical definition of a plant hormone, strigolactones are produced in the roots and translocated to the shoots where they inhibit shoot outgrowth and branching. The biosynthesis of this class of compounds is regulated by soil nutrient availability, i.e. the plant will increase its production of strigolactones when the soil phosphate concentration is limited, and decrease production when phosphates are in ample supply. Strigolactones that affect plant shoot branching, AM fungal hyphal branching, and seed germination in parasitic plants facilitate chemical synthesis of similar compounds to control these and other biological processes by exogenous application.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"693-700"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0104-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28456010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Establishment of bovine prion peptide-based monoclonal antibodies for identifying bovine prion. 牛朊病毒肽基单克隆抗体的建立。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0100-z

Li Zhao, XinSheng Hou, Rong Ji, ChunHui Han, XiuPing Yu, Tao Hong

引用次数: 2

Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus. 乙型肝炎病毒基因型与C型感染所致慢性乙型肝炎患者特异性与非特异性细胞免疫的比较及意义

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0098-0

XiBing Gu, XiaoJuan Yang, Dong Wang, Zhong Hua, HangYuan Wu, HaoKun Chen, YueQin Xu, ZhongHua Lu

{"title":"Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus.","authors":"XiBing Gu, XiaoJuan Yang, Dong Wang, Zhong Hua, HangYuan Wu, HaoKun Chen, YueQin Xu, ZhongHua Lu","doi":"10.1007/s11427-009-0098-0","DOIUrl":"https://doi.org/10.1007/s11427-009-0098-0","url":null,"abstract":"The present study was designed to investigate possible relationships between the genotypes of hepatitis B virus (HBV) and the HBV-specific cytotoxic T lymphocyte (CTL) responses. HBV genotypes, HBV specific CTL HBV DNA and other markers of HBV infection were determined in 138 patients with chronic hepatitis B. The results showed that the patients infected with genotype C (n=62) had a significantly lower HBV-specific CTL response than those who were infected with HBV genotype B (P<0.01). HBV DNA titer was higher in patients infected with HBV genotype C than in those infected with HBV genotype B (P<0.01). Both alanine aminotransferase (ALT) and total bilirubin (TBIL) were higher in HBV genotype C infected patients than in those infected with genotype B (P<0.01 and <0.05, respectively). These results suggest that compared with CHB patients infected with HBV genotype B, the higher HBV DNA level and more severe liver damages in the patients infected with genotype C of HBV may be associated with genotype C of the virus.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"719-23"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0098-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28456013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Growth phase-dependent expression of proteins with decreased plant-specific N-glycans and immunogenicity in tobacco BY2 cells. 烟草 BY2 细胞中植物特异性 N-聚糖和免疫原性减少的蛋白质的表达与生长期有关。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0093-5

BoJiao Yin, NuoYan Zheng, Yin Li, SanYuan Tang, LiMing Liang, Qi Xie

{"title":"Growth phase-dependent expression of proteins with decreased plant-specific N-glycans and immunogenicity in tobacco BY2 cells.","authors":"BoJiao Yin, NuoYan Zheng, Yin Li, SanYuan Tang, LiMing Liang, Qi Xie","doi":"10.1007/s11427-009-0093-5","DOIUrl":"10.1007/s11427-009-0093-5","url":null,"abstract":"Plants possess some desirable characteristics to synthesize recombinant glycoproteins for pharmaceutical application. However, the mammalian glycoproteins produced in plants are somewhat different from their natural counterparts in terms of N-glycoforms. The immunogenicity of plant-specific glyco-epitopes is the major concern in human therapy. Here, the distribution of N-glycans in different growth phases of tobacco BY2 cells and their immunogenicity in mice were determined. It was observed that the percentage of beta1,2-xylose and alpha1,3-fucose in proteins of growing cells increased and the corresponding protein extracts caused accelerated immune response in mice. Based on this observation, the recombinant erythropoietin in BY2 cells was expressed and characterized, and Western blot analysis showed that the recombinant erythropoietin contained a relatively small amount of plant-specific glyco-epitopes in the early phase of culture growth. This study may provide a simple but effective strategy for the production of therapeutic glycoproteins with human-like N-glycan structures in plant hosts to avoid a great allergenic risk.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"739-46"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0093-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28378225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Spectral response of rice (Oryza sativa L.) leaves to Fe(2+) stress. 水稻叶片对铁(2+)胁迫的光谱响应

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0103-7

GuangYu Chi, Xin Chen, Yi Shi, XinHui Liu

{"title":"Spectral response of rice (Oryza sativa L.) leaves to Fe(2+) stress.","authors":"GuangYu Chi, Xin Chen, Yi Shi, XinHui Liu","doi":"10.1007/s11427-009-0103-7","DOIUrl":"https://doi.org/10.1007/s11427-009-0103-7","url":null,"abstract":"In the management of lake eutrophication, the regulation effect of Fe is considered, in addition to the controlling nitrogen- and phosphorus input. Based on the \"Fe hypothesis\", this paper tentatively applied plant spectral response to the remote sensing early-warning mechanism of lake eutrophication. A laboratory water culture experiment with rice (Oryza sativa L.) was conducted to study Fe uptake by plants and the chlorophyll concentration and visible-near infrared spectrum of vegetable leaves as well as their interrelations under Fe(2+) stress. Three spectral indices, i.e., A (1) (integral value of the changes of spectral reflectivity in the range 460-670 nm under Fe(2+) stress), A (2) (integral value of the changes of spectral reflectivity in the range of 760-1000 nm under Fe(2+) stress) and S (blue-shift range of red edge curve under Fe(2+) stress), were used to establish quantitative models about the relationships between the rice leaf spectrum and Fe(2+) stress. With the increase of Fe(2+) in a culture solution, the Fe content in rice plants increased, while the chlorophyll concentration in vegetative leaves decreased. The spectral reflectivity of vegetable leaves increased in the visible light band but decreased in the near infrared band, and the blue-shift range of the red edge curve increased. The indices A (1), A (2) and S all had significant correlations with the Fe content in rice leaves, the correlation coefficient being respectively 0.951 (P < 0.01), -0.988 (P < 0.01) and 0.851 (P < 0.01), and simulated (multiple correlation coefficients R (2) > 0.96) and predict the Fe level in rice leaves.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"747-53"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0103-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28378226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Functional analysis of the Autographa californica nucleopolyhedrovirus IAP1 and IAP2. 加州签名蝇核多角体病毒IAP1和IAP2的功能分析。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0105-5

XianDong Zeng, Fang Nan, ChangYong Liang, JianHua Song, Qian Wang, Just M Vlak, XinWen Chen

{"title":"Functional analysis of the Autographa californica nucleopolyhedrovirus IAP1 and IAP2.","authors":"XianDong Zeng, Fang Nan, ChangYong Liang, JianHua Song, Qian Wang, Just M Vlak, XinWen Chen","doi":"10.1007/s11427-009-0105-5","DOIUrl":"https://doi.org/10.1007/s11427-009-0105-5","url":null,"abstract":"The Autographa californica nucleopolyhedrovirus (AcMNPV) contains three apoptosis suppressor genes: p35, iap1 and iap2. AcMNPV P35 functions as a pancaspase inhibitor, but the function of IAP1 and IAP2 has not been entirely resolved. In this paper, we analyze the function of IAP1 and IAP2 in detail. AcMNPV with p35-deletion inhibited the apoptosis of BTI-Tn-5B1-4 (Tn-Hi5) cells induced by a Helicoverpa armigera single nucleocapsid NPV (HearNPV) infection and rescued the replication of HearNPV and BV production in these cells. Transient-expression experiments indicated that both IAP1 and IAP2 suppress apoptosis of Tn-Hi5 cells during HearNPV infection. Recombinant HearNPVs expressing AcMNPV iap1, iap2 and p35, respectively, not only prevented apoptosis but also allowed HearNPV to replicate in Tn-Hi5 cells. However, the iap1, iap2 and p35 genes when expressed in HearNPV were unable to rescue BV production. These results indicate that both AcMNPV iap1 and iap2 function independently as apoptosis inhibitors of and are potential host range factors.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"761-70"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0105-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28378228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0106-4

Bo Yang, SuYong Yang, Lun Zhao, LiuHua Yin, Xu Liu, ShaSha An

{"title":"Event-related potentials in a Go/Nogo task of abnormal response inhibition in heroin addicts.","authors":"Bo Yang, SuYong Yang, Lun Zhao, LiuHua Yin, Xu Liu, ShaSha An","doi":"10.1007/s11427-009-0106-4","DOIUrl":"https://doi.org/10.1007/s11427-009-0106-4","url":null,"abstract":"Inhibitory control dysfunction is regarded as a core feature in addicts. The major objective of this study was to explore the time course of response inhibition in chronic heroin addicts and provide the neurophysiological evidence of their inhibitory control dysfunction. The amplitudes and latencies of ERP components were studied in fourteen heroin addicts (mean duration of heroin use being (13.54+/-5.71) years (Mean+/-SD), average abstinence being ((4.67+/-6.44) months)) and fourteen matched healthy controls with a visual Go/Nogo task. Our results showed that heroin addicts demonstrated significantly larger Go-N2 amplitudes which results in a decreased N2 Go/Nogo effect, but no statistically significant differences were found between heroin addicts and controls in P3. The ERP data suggest that fronto-central areas of heroin addicts were impaired during the inhibition process (200-300 ms) and over-activated to targets. The impaired early process might reflect an abnormal conflict monitoring process in heroin addicts. These results consolidate the inhibitory control dysfunction hypothesis in chronic heroin users.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"780-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0106-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28378230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

The effects of centrally administered fluorocitrate via inhibiting glial cells on working memory in rats. 中央给药氟柠檬酸盐抑制神经胶质细胞对大鼠工作记忆的影响。

Science in China. Series C, Life Sciences / Chinese Academy of Sciences Pub Date : 2009-08-01 Epub Date: 2009-08-29 DOI: 10.1007/s11427-009-0101-9

Lei Wang, Chao-Cui Li, Gong-Wu Wang, Jing-Xia Cai

{"title":"The effects of centrally administered fluorocitrate via inhibiting glial cells on working memory in rats.","authors":"Lei Wang, Chao-Cui Li, Gong-Wu Wang, Jing-Xia Cai","doi":"10.1007/s11427-009-0101-9","DOIUrl":"https://doi.org/10.1007/s11427-009-0101-9","url":null,"abstract":"Although prefrontal and hippocampal neurons are critical for spatial working memory, the function of glial cells in spatial working memory remains uncertain. In this study we investigated the function of glial cells in rats' working memory. The glial cells of rat brain were inhibited by intracerebroventricular (icv) injection of fluorocitrate (FC). The effects of FC on the glial cells were examined by using electroencephalogram (EEG) recordings and delayed spatial alternation tasks. After icv injection of 10 microL of 0.5 nmol/L or 5 nmol/L FC, the EEG power spectrum recorded from the hippocampus increased, but the power spectrum for the prefrontal cortex did not change, and working memory was unaffected. Following an icv injection of 10 microL of 20 nmol/L FC, the EEG power spectra in both the prefrontal cortex and the hippocampus increased, and working memory improved. The icv injection of 10 microL of 50 nmol/L FC, the EEG power spectra in both the prefrontal cortex and in the hippocampus decreased, and working memory was impaired. These results suggest that spatial working memory is affected by centrally administered FC, but only if there are changes in the EEG power spectrum in the prefrontal cortex. Presumably, the prefrontal glial cells relate to the working memory.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"52 8","pages":"701-9"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11427-009-0101-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28456011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10