Problems of Geroscience最新文献

Association between Telomere Length and Geriatric Status in Centenarians 百岁老人端粒长度与老年状态之间的关系

Problems of Geroscience Pub Date : 2023-12-18 DOI: 10.37586/2949-4745-2-2023-102-107

K. Eruslanova, S. O. Zhikrivetskaya, Yulia V. Kotovskaya, O. N. Tkacheva

{"title":"Association between Telomere Length and Geriatric Status in Centenarians","authors":"K. Eruslanova, S. O. Zhikrivetskaya, Yulia V. Kotovskaya, O. N. Tkacheva","doi":"10.37586/2949-4745-2-2023-102-107","DOIUrl":"https://doi.org/10.37586/2949-4745-2-2023-102-107","url":null,"abstract":" Aim. To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. Materials and methods. The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental Activities of Daily Living (IADL), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS-15). DNA was isolated from frozen blood and a study of telomere length was performed. The comparison of telomere length in groups of patients with frailty and individual geriatric syndromes was carried out. Results. The study involved 60 people (98±1.8 years, 86.7% women). The analysis found no differences in telomere length in study participants with and without frailty, as well as in the analysis of individual geriatric syndromes. No correlation was found between telomere length and the results of comprehensive geriatric assessment scales. There was no difference in telomere length in patients who died within 3 years of follow-up and no. Conclusion. No relationship was found between telomere length and frailty. Thus, telomere length cannot be considered as a reliable biomarker of functional aging.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138964354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senolytic drugs: implications for clinical practice 抗衰老药物:对临床实践的启示

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-7-14

A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko

引用次数: 0

The rate of aging and its association with risk factors of cardiovascular diseases 衰老速度及其与心血管疾病危险因素的关系

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-31-38

A. A. Akopyan, I. D. Strazhesko, A. A. Moskalev, I. A. Orlova

{"title":"The rate of aging and its association with risk factors of cardiovascular diseases","authors":"A. A. Akopyan, I. D. Strazhesko, A. A. Moskalev, I. A. Orlova","doi":"10.37586/2949-4745-1-2023-31-38","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-31-38","url":null,"abstract":"Background. Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging.Aim. The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases. Materials and methods. We calculated biological artery age and found associations of “old” arteries and rate of aging with risk factors of cardiovascular diseases in 143 adults without cardiovascular diseases. The data were analyzed by their categorization into 3 tertiles using regression methods.Results. “Old” arteries were associated with chronological age (p < 0,001; ОR = 0,55; 95% CI: 0,43 — 0,71) and hypertension (p = 0,002; ОR = 6,04; 95% CI: 1,98 — 18,42) in general group, age (p < 0,001; ОR = 0,45; 95% CI: 0,30 — 0,68), hypertension (p = 0,004; ОR = 12,79; 95% CI: 2,25 — 72,55) and family history of oncology (p = 0,036; ОR = 0,14; 95% CI: 0,02 — 0,88) in women subgroup and age (p = 0,001; ОR = 0,45; 95% CI: 0,28 — 0,76) and 3rd tertile of glycated hemoglobin (p = 0,041; ОR = 65,05; 95% CI: 1,19 — 3548,29) in men subgroup. Difference between biological and chronological age in a group of “old” arteries was associated with chronological age (p = 0,001; β = -1,24; 95% CI: -1,95 — -0,53) and with chronological age (p < 0,001; β = 1,71; 95% CI: 1,06 — 2,36) and 3rd tertile of glycated hemoglobin (p = 0,009; β = -4,78; 95% CI: -8,32 — -1,24) in group of “young” arteries.Conclusion. This study demonstrates that accelerated arterial aging is associated with hypertension and high levels of glycated haemoglobin.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Long COVID Symptoms and Clinical and Laboratory Characteristics 长冠状病毒症状与临床和实验室特征的关系

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-39-50

L. V. Maytesyan, I. R. Tsoy, O. N. Tkacheva, I. D. Strazhesko

引用次数: 0

Geroprotective effect of the mitochondrial-targeted antioxidant SkQBerb in a model of chronological aging of human MB135 myoblasts 线粒体靶向抗氧化剂SkQBerb在人MB135成肌细胞时间衰老模型中的衰老保护作用

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-25-30

M. A. Chelombitko, G. V. Morgunova, N. Y. Strochkova, K. G. Lyamzaev

{"title":"Geroprotective effect of the mitochondrial-targeted antioxidant SkQBerb in a model of chronological aging of human MB135 myoblasts","authors":"M. A. Chelombitko, G. V. Morgunova, N. Y. Strochkova, K. G. Lyamzaev","doi":"10.37586/2949-4745-1-2023-25-30","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-25-30","url":null,"abstract":"Background. The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity and activity of senescent cells in the body. Previous studies have demonstrated the geroprotective properties of mitochondrial- directed compounds based on plastoquinone and berberine in various in vitro and in vivo models. Thus, it is plausible that SkQBerb, a mitochondrialtargeted compound combining berberine and plastoquinone, may exhibit higher geroprotective potential compared to previously studied compounds.Objective. The aim of this study is to investigate the geroprotective activity of SkQBerb in a chronological aging model using MB135 myoblasts.Materials and Methods. The effect of SkQBerb on various aging characteristics of human MB135 myoblasts was assessed. Histochemical staining for β-galactosidase was performed using a commercially available kit. The levels of proinflammatory cytokines IL-6 and IL-8 were determined using pre-made immunoassay kits. Additionally, Western blotting was employed to evaluate the levels of p21, pRb (Ser807/811), and LC3B proteins.Results. Analysis of the results revealed that SkQBerb, at concentrations ranging from 20–100 nM, effectively suppressed the accumulation of senescent cells in MB135 cells subjected to chronological aging. Furthermore, it significantly reduced the levels of IL-6 and IL-8, key factors associated with the secretory phenotype.Conclusion. The findings of this study suggest a potential geroprotective and senomorphic effect of SkQBerb. These results open up possibilities for utilizing this mitochondrial-targeted compound as a geroprotector in future applications.","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic burden of some age-related diseases 一些与年龄有关的疾病的经济负担

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-51-57

M. S. Arbatskiy

{"title":"Economic burden of some age-related diseases","authors":"M. S. Arbatskiy","doi":"10.37586/2949-4745-1-2023-51-57","DOIUrl":"https://doi.org/10.37586/2949-4745-1-2023-51-57","url":null,"abstract":"Background. One of the main concerns posed by implementing new biomedical technologies is the lack of a pharmacoeconomic justification for the economic effect or the burden of certain nosologies on the state budget. To date, the medical literature on age-related diseases focuses on diagnosis, pathogenesis, new methods of treatment and the results of prescribed treatment. However, assessing the economic burden of these diseases is equally important. Only for selected diseases, regular publications on the calculation of the economic effect and economic burden of diseases can be found. For less common diseases, there are single publications, the information from which is no longer relevant and requires regular updating and maintenance.Aim. To conduct an indicative assessment of the economic burden for the most common age-related diseases.Materials and methods. When preparing the publication, foreign and domestic sources containing economic information about the most common age-associated diseases were used.Annual reports of biopharmaceutical companies producing drugs for the treatment of age-related diseases were used to obtain an understanding of current developments in the treatment of these diseases. Additionally, data from Rosreestr (Russian Federal Service for State Registration, Cadastre and Cartography) were used for certain diseases.Results. According to the analyzed information, it has been found that age-related diseases are a significant economic burden for the healthcare system of the state. However, not all specialized medical organizations assess the economic burden associated with such diseases.Conclusion. As a result of analyzing the economic burden of the most common age-related diseases, the conclusion can be drawn that regular assessment of the economic burden for Alzheimer's disease, diabetes, chronic obstructive pulmonary disease, depression, atherosclerosis and osteoporosis is necessary","PeriodicalId":489436,"journal":{"name":"Problems of Geroscience","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136026257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of kynurenine pathway metabolites in the development of frailty in older adults 犬尿氨酸途径代谢物在老年人虚弱发展中的作用

Problems of Geroscience Pub Date : 2023-09-11 DOI: 10.37586/2949-4745-1-2023-15-24

V. S. Pykhtina

引用次数: 0