Kidney International Supplements最新文献

{"title":"Clinical perspective-evolving evidence of mineralocorticoid receptor antagonists in patients with chronic kidney disease and type 2 diabetes.","authors":"P. Rossing","doi":"10.1016/j.kisu.2021.11.005","DOIUrl":"https://doi.org/10.1016/j.kisu.2021.11.005","url":null,"abstract":"","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"44 1","pages":"27-35"},"PeriodicalIF":5.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88637651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis","authors":"James M. Luther ,&nbsp;Agnes B. Fogo","doi":"10.1016/j.kisu.2021.11.006","DOIUrl":"https://doi.org/10.1016/j.kisu.2021.11.006","url":null,"abstract":"<div><p>Chronic kidney disease is characterized by progressive scarring that results in loss of normal tissue in the kidney and eventually end-stage kidney disease. Interstitial fibrosis and tubular atrophy have been most closely correlated with decline in renal function. Potential mechanisms include profibrotic changes in tubules, influx of profibrotic rather than healing reparative macrophages, and an increase in activated myofibroblasts. Aldosterone activates the mineralocorticoid receptor in the collecting duct to increase sodium reabsorption, resulting in increased blood pressure. Aldosterone also promotes inflammation and fibrosis in the kidney by activating the mineralocorticoid receptor in other cellular compartments, including podocytes, mesangial cells, epithelial cells, and myeloid cells. Aldosterone also may act indirectly by stimulating factors in epithelial tissues that contribute to inflammatory macrophage polarization, myofibroblast differentiation, and progressive fibrosis. This review discusses the potential mechanisms by which aldosterone and mineralocorticoid receptor activation promotes inflammation and fibrosis via nonclassical pathways in the kidney.</p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"12 1","pages":"Pages 63-68"},"PeriodicalIF":5.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2157171621000691/pdfft?md5=a7ec8f6991b7907b657001d663b2504a&pid=1-s2.0-S2157171621000691-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72098619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aldosterone and mineralocorticoid receptor signaling as determinants of cardiovascular and renal injury: an extraordinary paradigm shift","authors":"Murray Epstein","doi":"10.1016/j.kisu.2021.11.007","DOIUrl":"https://doi.org/10.1016/j.kisu.2021.11.007","url":null,"abstract":"","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"12 1","pages":"Pages 1-6"},"PeriodicalIF":5.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2157171621000708/pdfft?md5=6a3d9af2d8b38080e37d182a8dae2b61&pid=1-s2.0-S2157171621000708-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72089519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms.","authors":"J. Bauersachs, Achim Lother","doi":"10.1016/j.kisu.2021.11.001","DOIUrl":"https://doi.org/10.1016/j.kisu.2021.11.001","url":null,"abstract":"","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"44 1","pages":"19-26"},"PeriodicalIF":5.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84894272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts.","authors":"C. Ferrario, L. Groban, Hao Wang, Xuming Sun, Jessica L. Voncannon, Kendra N. Wright, Sarfaraz Ahmad","doi":"10.1016/j.kisu.2021.11.002","DOIUrl":"https://doi.org/10.1016/j.kisu.2021.11.002","url":null,"abstract":"","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"101 1","pages":"36-47"},"PeriodicalIF":5.5,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76070610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in North America and the Caribbean","authors":"Aminu K. Bello ,&nbsp;Mark McIsaac ,&nbsp;Ikechi G. Okpechi ,&nbsp;David W. Johnson ,&nbsp;Vivekanand Jha ,&nbsp;David C.H. Harris ,&nbsp;Syed Saad ,&nbsp;Deenaz Zaidi ,&nbsp;Mohamed A. Osman ,&nbsp;Feng Ye ,&nbsp;Meaghan Lunney ,&nbsp;Kailash Jindal ,&nbsp;Scott Klarenbach ,&nbsp;Kamyar Kalantar-Zadeh ,&nbsp;Csaba P. Kovesdy ,&nbsp;Rulan S. Parekh ,&nbsp;Bhanu Prasad ,&nbsp;Maryam Khan ,&nbsp;Parnian Riaz ,&nbsp;Marcello Tonelli ,&nbsp;Adeera Levin","doi":"10.1016/j.kisu.2021.01.001","DOIUrl":"10.1016/j.kisu.2021.01.001","url":null,"abstract":"<div><p><span><span>The International Society of Nephrology established the Global Kidney Health Atlas project to define the global capacity for </span>kidney replacement therapy<span> and conservative kidney care, and this second iteration was to describe the availability, accessibility, quality, and affordability of kidney failure (KF) care worldwide. This report presents results for the International Society of Nephrology North America and the Caribbean region. Relative to other regions, the North America and Caribbean region had better infrastructure and funding for health care<span> and more health care workers relative to the population. Various essential medicines were also more available and accessible. There was substantial variation in the prevalence of treated KF in the region, ranging from 137.4 per million population (pmp) in Jamaica to 2196 pmp in the United States. A mix of public and private funding systems cover costs for nondialysis chronic kidney disease care in 60% of countries and for dialysis in 70% of countries. Although the median number of nephrologists is 18.1 (interquartile range, 15.3–29.5) pmp, which is approximately twice the global median of 9.9 (interquartile range, 1.2–22.7) pmp, some countries reported shortages of other health care workers. Dialysis was available in all countries, but </span></span></span>peritoneal dialysis<span> was underutilized and unavailable in Barbados, Cayman Islands, and Turks and Caicos. Kidney transplantation<span> was primarily available in Canada and the United States. Economic factors were the major barriers to optimal KF care in the Caribbean countries, and few countries in the region have chronic kidney disease–specific national health care policies. To address regional gaps in KF care delivery, efforts should be directed toward augmenting the workforce, improving the monitoring and reporting of kidney replacement therapy indicators, and implementing noncommunicable disease and chronic kidney disease–specific policies in all countries.</span></span></p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"11 2","pages":"Pages e66-e76"},"PeriodicalIF":5.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2021.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Latin America","authors":"Marina Wainstein ,&nbsp;Aminu K. Bello ,&nbsp;Vivekanand Jha ,&nbsp;David C.H. Harris ,&nbsp;Adeera Levin ,&nbsp;Maria C. Gonzalez-Bedat ,&nbsp;Guillermo J. Rosa-Diez ,&nbsp;Alejandro Ferreiro Fuentes ,&nbsp;Laura Sola ,&nbsp;Roberto Pecoits-Filho ,&nbsp;Rolando Claure-Del Granado ,&nbsp;Magdalena Madero ,&nbsp;Mohamed A. Osman ,&nbsp;Syed Saad ,&nbsp;Deenaz Zaidi ,&nbsp;Meaghan Lunney ,&nbsp;Feng Ye ,&nbsp;Ivor J. Katz ,&nbsp;Maryam Khan ,&nbsp;Sally Shrapnel ,&nbsp;David W. Johnson","doi":"10.1016/j.kisu.2021.01.005","DOIUrl":"10.1016/j.kisu.2021.01.005","url":null,"abstract":"<div><p><span><span><span>Latin America is a region with a widely variable socioeconomic landscape, facing a surge in noncommunicable diseases<span>, including chronic kidney disease and kidney failure, exposing significant limitations in the delivery of care. Despite region-wide efforts to explore and address these limitations, much uncertainty remains as to the capacity, accessibility, and quality of kidney failure care in Latin America. Through this second iteration of the International Society of </span></span>Nephrology Global Kidney Health Atlas, we aimed to report on these indicators to provide a comprehensive map of kidney failure care in the region. Survey responses were received from 18 (64.2%) countries, representing 93.8% of the total population in Latin America. The median prevalence and incidence of treated kidney failure in Latin America were 715 and 157 per million population, respectively, the latter being higher than the global median (142 per million population), with Puerto Rico, Mexico, and El Salvador experiencing much of this growing burden. In most countries, public and private systems collectively funded most aspects of </span>kidney replacement therapy<span> (dialysis and transplantation) care, with patients incurring at least 1% to 25% of out-of-pocket costs. In most countries, &gt;90% of dialysis patients able to access kidney replacement therapy received hemodialysis (n = 11; 5 high income and 6 upper-middle income), and only a small minority began with </span></span>peritoneal dialysis (1%–10% in 67% of countries; n = 12). Few countries had chronic kidney disease registries or targeted detection programs. There is a large variability in the availability, accessibility, and quality of kidney failure care in Latin America, which appears to be subject to individual countries’ funding structures, underreliance on cheap kidney replacement therapy, such as peritoneal dialysis, and limited chronic kidney disease surveillance and management initiatives.</p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"11 2","pages":"Pages e35-e46"},"PeriodicalIF":5.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2021.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding distribution and variability in care organization and services for the management of kidney care across world regions","authors":"Aminu K. Bello ,&nbsp;Ikechi G. Okpechi ,&nbsp;Vivekanand Jha ,&nbsp;David C.H. Harris ,&nbsp;Adeera Levin ,&nbsp;David W. Johnson","doi":"10.1016/j.kisu.2021.01.010","DOIUrl":"10.1016/j.kisu.2021.01.010","url":null,"abstract":"","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"11 2","pages":"Pages e4-e10"},"PeriodicalIF":5.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2021.01.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43658974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in South Asia","authors":"Smita S. Divyaveer ,&nbsp;Raja Ramachandran ,&nbsp;Manisha Sahay ,&nbsp;Dibya Singh Shah ,&nbsp;Fazal Akhtar ,&nbsp;Aminu K. Bello ,&nbsp;Arpana Iyengar ,&nbsp;David W. Johnson ,&nbsp;David C.H. Harris ,&nbsp;Adeera Levin ,&nbsp;Meaghan Lunney ,&nbsp;Muhibur Rahman ,&nbsp;Harun-Ur Rashid ,&nbsp;Syed Saad ,&nbsp;Deenaz Zaidi ,&nbsp;Mohamed A. Osman ,&nbsp;Santosh Varughese ,&nbsp;Eranga S. Wijewickrama ,&nbsp;Maryam Khan ,&nbsp;Feng Ye ,&nbsp;Vivekanand Jha","doi":"10.1016/j.kisu.2021.01.006","DOIUrl":"10.1016/j.kisu.2021.01.006","url":null,"abstract":"<div><p><span><span>Information about disease burden<span> and the available infrastructure and workforce to care for patients with kidney disease was collected for the second edition of the International Society of </span></span>Nephrology<span><span> Global Kidney Health Atlas. This paper presents findings for the 8 countries in the South Asia region. The World Bank categorizes Afghanistan and Nepal as low-income; Bangladesh, Bhutan, India, and Pakistan as lower-middle-income; and Sri Lanka and the Maldives as upper-middle-income countries. The prevalence of chronic kidney disease (CKD) in South Asia ranged from 5.01% to 13.24%. Long-term </span>hemodialysis and long-term </span></span>peritoneal dialysis<span> are available in all countries, but Afghanistan lacks peritoneal dialysis services. Kidney transplantation<span> was available in all countries except Bhutan and Maldives. Hemodialysis was the dominant modality of long-term dialysis, peritoneal dialysis was more expensive than hemodialysis, and kidney transplantation overwhelmingly depended on living donors. Bhutan provided public funding for kidney replacement therapy<span> (dialysis and transplantation); Sri Lanka, India, Pakistan, and Bangladesh had variable funding mechanisms; and Afghanistan relied solely on out-of-pocket expenditure. There were shortages of health care personnel across the entire region. Reporting was variable: Afghanistan and Sri Lanka have dialysis registries but publish no reports, whereas Bangladesh has a transplant registry. South Asia has a large, but poorly documented burden of CKD. Diabetes and hypertension are the major causes of CKD throughout the region with a higher prevalence of infectious causes in Afghanistan and a high burden of CKD of an unknown cause in Sri Lanka and parts of India. The extent and quality of care delivery is suboptimal and variable. Sustainable strategies need to be developed to address the growing burden of CKD in the region.</span></span></span></p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"11 2","pages":"Pages e97-e105"},"PeriodicalIF":5.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2021.01.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38976567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in the Middle East","authors":"Atefeh Amouzegar ,&nbsp;Ali K. Abu-Alfa ,&nbsp;Mona N. Alrukhaimi ,&nbsp;Aminu K. Bello ,&nbsp;Mohammad A. Ghnaimat ,&nbsp;David W. Johnson ,&nbsp;Vivekanand Jha ,&nbsp;David C.H. Harris ,&nbsp;Adeera Levin ,&nbsp;Marcello Tonelli ,&nbsp;Meaghan Lunney ,&nbsp;Syed Saad ,&nbsp;Maryam Khan ,&nbsp;Deenaz Zaidi ,&nbsp;Mohamed A. Osman ,&nbsp;Feng Ye ,&nbsp;Ikechi G. Okpechi ,&nbsp;Shahrzad Ossareh ,&nbsp;ISN Middle East Regional Board","doi":"10.1016/j.kisu.2021.01.002","DOIUrl":"10.1016/j.kisu.2021.01.002","url":null,"abstract":"<div><p>Kidney failure is the permanent impairment of kidney function associated with increased morbidity, hospitalization, and requirement for kidney replacement therapy<span>. A total of 11 countries in the Middle East region (84.6%) responded to the survey. The prevalence of chronic kidney disease<span><span><span> in the region ranged from 5.2% to 10.6%, whereas prevalence of treated kidney failure ranged from 152 to 826 per million population. Overall, the incidence of kidney transplantation<span> was highest in Iran (30.9 per million population) and lowest in Oman and the United Arab Emirates (2.2 and 3.0 per million population, respectively). Long-term hemodialysis services were available in all countries, long-term </span></span>peritoneal dialysis services were available in 9 (69.2%) countries, and transplantation services were available in most countries of the region. Public funding covered the costs of nondialysis chronic </span>kidney disease<span><span> care in two-thirds of countries, and kidney replacement therapy in nearly all countries. More than half of the countries had dialysis registries; however, national noncommunicable disease<span> strategies were lacking in most countries. The Middle East is a region with high burden of kidney disease and needs cost-effective measures through effective health care funding to be available to improve kidney care in the region. Furthermore, well-designed and sustainable </span></span>health information systems are needed in the region to address current gaps in kidney care in the region.</span></span></span></p></div>","PeriodicalId":48895,"journal":{"name":"Kidney International Supplements","volume":"11 2","pages":"Pages e47-e56"},"PeriodicalIF":5.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.kisu.2021.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}