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Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A syntaxin 1A对安非他明诱导的血清素和多巴胺能外排的差异调节
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-09-05 DOI: 10.1186/1471-2210-11-S2-A38
Therese R. Montgomery, S. Sucic, T. Steinkellner, M. Freissmuth, H. Sitte
{"title":"Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A","authors":"Therese R. Montgomery, S. Sucic, T. Steinkellner, M. Freissmuth, H. Sitte","doi":"10.1186/1471-2210-11-S2-A38","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S2-A38","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"A38 - A38"},"PeriodicalIF":2.9,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S2-A38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65612073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments 129S1/SvImJ小鼠表现出情境恐惧消退受损、恐惧孵育增强和缺陷消退巩固表型:通过药物和非药物治疗进行拯救
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-09-05 DOI: 10.1186/1471-2210-11-S2-A39
N. Whittle, Markus Hauschild, M. Camp, A. Holmes, N. Singewald
{"title":"129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments","authors":"N. Whittle, Markus Hauschild, M. Camp, A. Holmes, N. Singewald","doi":"10.1186/1471-2210-11-S2-A39","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S2-A39","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"A39 - A39"},"PeriodicalIF":2.9,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S2-A39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65612118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Inhibition of breast cancer resistance protein at the murine blood-brain barrier by Ko143 studied with [11C]tariquidar and PET 用[11C] tariquar和PET研究Ko143对小鼠血脑屏障乳腺癌耐药蛋白的抑制作用
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-09-05 DOI: 10.1186/1471-2210-11-S2-A48
T. Wanek, C. Kuntner, J. Bankstahl, M. Bankstahl, J. Stanek, M. Sauberer, Markus Müller, W. Löscher, O. Langer
{"title":"Inhibition of breast cancer resistance protein at the murine blood-brain barrier by Ko143 studied with [11C]tariquidar and PET","authors":"T. Wanek, C. Kuntner, J. Bankstahl, M. Bankstahl, J. Stanek, M. Sauberer, Markus Müller, W. Löscher, O. Langer","doi":"10.1186/1471-2210-11-S2-A48","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S2-A48","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"A48 - A48"},"PeriodicalIF":2.9,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S2-A48","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65612346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
PI3Kδ is indispensable for CTL-mediated cytotoxicity PI3Kδ在ctl介导的细胞毒性中是不可或缺的
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-09-05 DOI: 10.1186/1471-2210-11-S2-A7
E. Putz, M. Prchal, O. Simma, F. Forster, Xaver Koenig, R. Piekorz, M. Freissmuth, V. Sexl, E. Zebedin
{"title":"PI3Kδ is indispensable for CTL-mediated cytotoxicity","authors":"E. Putz, M. Prchal, O. Simma, F. Forster, Xaver Koenig, R. Piekorz, M. Freissmuth, V. Sexl, E. Zebedin","doi":"10.1186/1471-2210-11-S2-A7","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S2-A7","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"A7 - A7"},"PeriodicalIF":2.9,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S2-A7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65612497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capsaicin-sensitive sensory nerves, TRPV1 receptors and tachykinins play important roles in mast cell tryptase-induced arthritis and hyperalgesia 辣椒素敏感感觉神经、TRPV1受体和速激素在肥大细胞胰蛋白酶诱导的关节炎和痛觉过敏中起重要作用
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-09-05 DOI: 10.1186/1471-2210-11-S2-A50
Z. Helyes, É. Borbély, K. Sandor, Adrienn Markovics, E. Pintér, J. Szolcsányi, J. Quinn, J. McDougall
{"title":"Capsaicin-sensitive sensory nerves, TRPV1 receptors and tachykinins play important roles in mast cell tryptase-induced arthritis and hyperalgesia","authors":"Z. Helyes, É. Borbély, K. Sandor, Adrienn Markovics, E. Pintér, J. Szolcsányi, J. Quinn, J. McDougall","doi":"10.1186/1471-2210-11-S2-A50","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S2-A50","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"A50 - A50"},"PeriodicalIF":2.9,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S2-A50","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65612521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors. 新型布鲁氏锥虫RNA编辑连接酶1抑制剂的研制。
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-08-30 DOI: 10.1186/1471-2210-11-9
Jacob D Durrant, J Andrew McCammon
{"title":"Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors.","authors":"Jacob D Durrant,&nbsp;J Andrew McCammon","doi":"10.1186/1471-2210-11-9","DOIUrl":"https://doi.org/10.1186/1471-2210-11-9","url":null,"abstract":"<p><strong>Background: </strong>Trypanosoma brucei (T. brucei) is an infectious agent for which drug development has been largely neglected. We here use a recently developed computer program called AutoGrow to add interacting molecular fragments to S5, a known inhibitor of the validated T. brucei drug target RNA editing ligase 1, in order to improve its predicted binding affinity.</p><p><strong>Results: </strong>The proposed binding modes of the resulting compounds mimic that of ATP, the native substrate, and provide insights into novel protein-ligand interactions that may be exploited in future drug-discovery projects.</p><p><strong>Conclusions: </strong>We are hopeful that these new predicted inhibitors will aid medicinal chemists in developing novel therapeutics to fight human African trypanosomiasis.</p>","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 ","pages":"9"},"PeriodicalIF":2.9,"publicationDate":"2011-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30107777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Interaction between bradykinin and urodilatin - a possible mechanism of clinical relevance 缓激肽和尿扩张素的相互作用——一种可能的临床相关性机制
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-08-01 DOI: 10.1186/1471-2210-11-S1-P21
Marina Dobrivojević, Aleksandra Sinđić, Bojana Nikitović, B. Edemir, E. Schlatter, W. Forssmann, J. Hirsch
{"title":"Interaction between bradykinin and urodilatin - a possible mechanism of clinical relevance","authors":"Marina Dobrivojević, Aleksandra Sinđić, Bojana Nikitović, B. Edemir, E. Schlatter, W. Forssmann, J. Hirsch","doi":"10.1186/1471-2210-11-S1-P21","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S1-P21","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"P21 - P21"},"PeriodicalIF":2.9,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S1-P21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65610297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDE expression and contractility of seminiferous tubules of the human testis 人睾丸精小管PDE表达与收缩性的关系
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-08-01 DOI: 10.1186/1471-2210-11-S1-P23
Caroline Feuerstacke, Sabine Tasch, J. Volkmann, D. Müller, R. Middendorff
{"title":"PDE expression and contractility of seminiferous tubules of the human testis","authors":"Caroline Feuerstacke, Sabine Tasch, J. Volkmann, D. Müller, R. Middendorff","doi":"10.1186/1471-2210-11-S1-P23","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S1-P23","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"P23 - P23"},"PeriodicalIF":2.9,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S1-P23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65610352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New vitamin B12 derivatives activates sGC 新的维生素B12衍生物激活sGC
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-08-01 DOI: 10.1186/1471-2210-11-S1-P32
D. Gryko, E. Martin
{"title":"New vitamin B12 derivatives activates sGC","authors":"D. Gryko, E. Martin","doi":"10.1186/1471-2210-11-S1-P32","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S1-P32","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"10 1","pages":"P32 - P32"},"PeriodicalIF":2.9,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S1-P32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65610357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice BAY 41-2272和BAY 58-2667在载脂蛋白sgc小鼠胃肠道中的松弛作用
IF 2.9 3区 医学
BMC Pharmacology & Toxicology Pub Date : 2011-08-01 DOI: 10.1186/1471-2210-11-S1-P19
S. Cosyns, J. Stasch, P. Brouckaert, R. Lefebvre
{"title":"Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice","authors":"S. Cosyns, J. Stasch, P. Brouckaert, R. Lefebvre","doi":"10.1186/1471-2210-11-S1-P19","DOIUrl":"https://doi.org/10.1186/1471-2210-11-S1-P19","url":null,"abstract":"","PeriodicalId":48846,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"11 1","pages":"P19 - P19"},"PeriodicalIF":2.9,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1471-2210-11-S1-P19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65610399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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