{"title":"Laura Coates: all about the people","authors":"Heather Van Epps","doi":"10.1016/S2665-9913(25)00107-9","DOIUrl":"10.1016/S2665-9913(25)00107-9","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 5","pages":"Page e313"},"PeriodicalIF":15.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clément Triaille, Marie-Claude Miron, Patricia Egerszegi, Jean Jacques De Bruycker
{"title":"A cold case of joint injury.","authors":"Clément Triaille, Marie-Claude Miron, Patricia Egerszegi, Jean Jacques De Bruycker","doi":"10.1016/S2665-9913(25)00078-5","DOIUrl":"https://doi.org/10.1016/S2665-9913(25)00078-5","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":" ","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reasoning large language models in rheumatology: a call for responsible action","authors":"Vincenzo Venerito , Florenzo Iannone , Latika Gupta","doi":"10.1016/S2665-9913(25)00101-8","DOIUrl":"10.1016/S2665-9913(25)00101-8","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 6","pages":"Pages e384-e386"},"PeriodicalIF":15.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting the most vulnerable—a step too far","authors":"The Lancet Rheumatology","doi":"10.1016/S2665-9913(25)00103-1","DOIUrl":"10.1016/S2665-9913(25)00103-1","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 5","pages":"Page e303"},"PeriodicalIF":15.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gout: the deeply rooted image of the self-inflicted disease of kings comes from misinterpreting history","authors":"Tristan Pascart , Emmanuel Drouin","doi":"10.1016/S2665-9913(25)00069-4","DOIUrl":"10.1016/S2665-9913(25)00069-4","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 6","pages":"Pages e388-e390"},"PeriodicalIF":15.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is type I interferon score a promising circulating biomarker for systemic sclerosis?","authors":"Yuichiro Shirai , Masataka Kuwana","doi":"10.1016/S2665-9913(25)00030-X","DOIUrl":"10.1016/S2665-9913(25)00030-X","url":null,"abstract":"","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 6","pages":"Pages e379-e381"},"PeriodicalIF":15.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monique Hinchcliff MD , Prof Dinesh Khanna MD , Enrico De Lorenzis MD , Stefano Di Donato MD , Antonio Carriero MD , Rebecca L Ross PhD , Suiyuan Huang MPH , Kathleen A Aren MPH , Elana J Bernstein MD , Mary Carns MS , Flavia V Castelino MD , Robyn T Domsic MD , Tracy M Frech MD , Jessica K Gordon MD , Faye N Hant MD , Prof Ami A Shah MD , Victoria K Shanmugam MBBS , Prof Virginia D Steen MD , Prof Shervin Assassi MD , Prof Francesco Del Galdo PhD
{"title":"Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study","authors":"Monique Hinchcliff MD , Prof Dinesh Khanna MD , Enrico De Lorenzis MD , Stefano Di Donato MD , Antonio Carriero MD , Rebecca L Ross PhD , Suiyuan Huang MPH , Kathleen A Aren MPH , Elana J Bernstein MD , Mary Carns MS , Flavia V Castelino MD , Robyn T Domsic MD , Tracy M Frech MD , Jessica K Gordon MD , Faye N Hant MD , Prof Ami A Shah MD , Victoria K Shanmugam MBBS , Prof Virginia D Steen MD , Prof Shervin Assassi MD , Prof Francesco Del Galdo PhD","doi":"10.1016/S2665-9913(24)00403-X","DOIUrl":"10.1016/S2665-9913(24)00403-X","url":null,"abstract":"<div><h3>Background</h3><div>Type I interferon (IFN) pathway activation has been associated with severe systemic sclerosis. We aimed to examine the association of serum IFN scores with disease activity and outcomes in two cohorts of patients with diffuse cutaneous systemic sclerosis.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, we included adult (aged >18 years) patients with diffuse cutaneous systemic sclerosis enrolled in the US Prospective Registry of Early Systemic Sclerosis (PRESS; incident cohort) or in the UK observational cohort (Stratification for Risk of Progression in Scleroderma [STRIKE]; prevalent cohort) registries and healthy controls (volunteers). Sera were analysed by Myriad-Rules Based Medicine's Luminex xMAP Technology Multiplex Assay (Austin, TX, USA), and IFN scores were generated using concentrations of CCL2, CCL8, CCL19, CXCL9, CXCL10, and CXCL11. Patients were classified as IFN-high (<em>vs</em> IFN-low) when mean sum of the natural logarithm of the six chemokines was greater than (or within) two standard deviations of healthy controls. The main outcome measures were the baseline and the minimal clinically important differences for modified Rodnan Skin Score, forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO), and Health Assessment Questionnaire-Disability Index at 12 months. A person with lived experience of systemic sclerosis was involved in writing the report.</div></div><div><h3>Findings</h3><div>Patients with diffuse cutaneous systemic sclerosis in the PRESS incident cohort were recruited between April 1, 2012, and Jan 1, 2019, and healthy controls and patients in the STRIKE prevalent cohort were recruited between Dec 1, 2014, and Dec 1, 2018. IFN scores were generated for 110 patients in the incident cohort (mean age 50·2 years [SD 15·0], 76 [69%] women and 34 [31%] men, 87 [79%] White) and 72 patients in the prevalent cohort (mean age 51·7 years [SD 10·9], 50 [69%] women and 22 [31%] men, 64 [89%] White), and 32 healthy controls (mean age 47·0 years [SD 12·4]; 19 [59%] women and 13 [41%] men; 24 [75%] White). 50 (45%) of 110 patients in the incident cohort and 27 (38%) of 72 patients in the prevalent cohort were classified as IFN-high. In the incident cohort, patients classified as IFN-high had worse baseline disease compared with patients classified as IFN-low, as assessed by mean predicted FVC (72·0% [SD 18·9] <em>vs</em> 85·3% [18·5]; p=0·0028), DLCO (56·8% [SD 21·6] <em>vs</em> 76·6% [25·3]; p=0·0008), and median Health Assessment Questionnaire-Disability Index (1·4 [IQR 0·8–2·0] <em>vs</em> 0·8 [0·4–1·5]; p=0·0033). Differences in FVC and DLCO persisted at last follow-up (median 34 months [IQR 19·8– 54·0] for FVC and median 34 months [IQR 22·5– 54·0] for DLCO). In the prevalent cohort, patients classified as IFN-high had a shorter median disease duration (2·2 years [IQR 0·7–8·2] <em>vs</em> 5·0 years [1·9–10·0]; p=0·035) compared to those classified as IFN-","PeriodicalId":48540,"journal":{"name":"Lancet Rheumatology","volume":"7 6","pages":"Pages e403-e414"},"PeriodicalIF":15.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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