Journal of Inonu Liver Transplantation Institute最新文献

{"title":"A Novel Technique for Cadaveric Organ Procurement: Exposure with Internal Transverse Fascia and Vertical Skin Incision","authors":"Tuğrul Çakır","doi":"10.14744/jilti.2023.43531","DOIUrl":"https://doi.org/10.14744/jilti.2023.43531","url":null,"abstract":"male and 22 was female. Median intensive care unit stay was 10 days. The technique provided good exposure for abdominal closure, allowing for the retrieval of the liver, kidneys, and spleen. Aesthetic results and respect for the donor's body were also achieved. Conclusion: Internal transverse fascia and vertical skin incision is a feasible and efficient method for abdominal organ procurement in cadaveric donors. Further studies are needed to validate and compare technique to other established methods.","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About the Book 'The Puzzle People' by Thomas Earl Starzl","authors":"Sezai Yılmaz","doi":"10.14744/jilti.2023.07379","DOIUrl":"https://doi.org/10.14744/jilti.2023.07379","url":null,"abstract":"","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Variations and Reconstruction Techniques of the Left Hepatic Vein in Pediatric Living Donor Liver Transplantation","authors":"Sertaç Usta","doi":"10.14744/jilti.2023.43534","DOIUrl":"https://doi.org/10.14744/jilti.2023.43534","url":null,"abstract":"","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"390 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Underlying Chronic Liver Disease on Lysosomal Acid Lipase Activity: Case-Control Study","authors":"Zeynep Küçükakçalı","doi":"10.14744/jilti.2023.35744","DOIUrl":"https://doi.org/10.14744/jilti.2023.35744","url":null,"abstract":"Objectives: The goal of the current study is to examine the diagnostic usefulness of lysosomal acid lipase (LAL) activity in cirrhotic patients according to healthy control groups utilizing assessment methods including machine learning methods. Methods: An open-access dataset was used in the current study and included 63 patients with cryptogenic cirrhosis (cryptogenic group), 88 patients with cirrhosis of known underlying causes (non-cryptogenic group), and 97 healthy individuals (control group). Mann Whitney U test was utilized for comparisons between cirrhosis groups and control group and for comparisons between cirrhosis groups. The Stochastic Gradient Boosting (SGB) method was utilized to model the patients with cirrhosis and the control group. Results: LAL activity was observed to be reduced in cirrhotic patients (cryptogenic and known etiology cirrhosis) when compared to control groups. The machine learning modelling algorithm showed that the cirrhotic group and the control group were distinguished from each other with an accuracy of 93.2%. The platelets, LAL activity, ALT, AST, and white blood cells were obtained as the most important variables according to variable importance values. Conclusion: LAL activity value can be evaluated diagnostic marker in cirrhotic patients. However, it is not a discriminative marker that differentiates different etiologies (cryptogenic and cirrhosis of known etiology).","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterotopic Reversed Position Technique in Pediatric Liver Transplantation","authors":"Veysel Ersan","doi":"10.14744/jilti.2023.13007","DOIUrl":"https://doi.org/10.14744/jilti.2023.13007","url":null,"abstract":"Objectives: Many challenges persist, especially when transplanting large grafts into small pediatric patients in liver transplantation (LT). In this study, we will discuss the details of the \"heterotopic reversed position technique\" in LT, which is applied to prevent complications and allows primary closure of the abdomen in the initial surgery without causing an increase in intra-abdominal pressure. Methods: From March 2002 to December 2021, our institution performed 3121 LT of these 691 (22.1%) were pediatric LT. We pres-ent the outcomes of 11 pediatric patients who underwent LT using this method. Results: In the postoperative phase, none of the 11 cases had vascular complications. Five of the cases were alive for an average of 9.2 years. The causes of mortality in the three cases were due to persistent hepatic encephalopathy after surgery in one case, another due to hemodynamic instability in the early postoperative period, and the third due to graft-versus-host disease that manifested two months after surgery. Conclusion: The reversed positioning technique offers a promising solution to the challenges of pediatric liver transplant, especially in cases of acute fulminant liver failure.","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compression of Left Portal Vein By Giant Hydatid Cyst Extending from the Caudate Lobe to the Foramen of Winslow","authors":"Sami Akbulut","doi":"10.14744/jilti.2023.57966","DOIUrl":"https://doi.org/10.14744/jilti.2023.57966","url":null,"abstract":"and","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel Perforation due to Complicated Meckel’s Diverticulum in an Adult Living Donor Liver Transplant Recipient","authors":"Tevfik Tolga Sahin","doi":"10.14744/jilti.2023.25733","DOIUrl":"https://doi.org/10.14744/jilti.2023.25733","url":null,"abstract":"[8]","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver Transplantation for Severe Hepatic Trauma: Historical Review","authors":"Ez Eldin Abu Zeid","doi":"10.14744/jilti.2023.70298","DOIUrl":"https://doi.org/10.14744/jilti.2023.70298","url":null,"abstract":"Review Address for correspondence: Sami Akbulut, MD. Department of Surgery and Liver Transplantation, Inonu University Liver Transplant Institute, Malatya, Türkiye Phone: +90 532 325 12 12 E-mail: akbulutsami@gmail.com Submitted Date: 05.05.2023 Revised Date: 05.05.2023 Accepted Date: 10.05.2023 Available Online Date: 25.09.2023 ©Copyright 2023 by Journal of Inonu Liver Transplantation Institute Available online at www.jilti.org OPEN ACCESS This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). DOI: 10.14744/jilti.2023.70298 J Inonu Liver Transpl Inst 2023;1(2):31–34 JOURNAL OF INONU LIVER TRANSPLANTATION INSTITUTE JILTI 32 Journal of Inonu Liver Transplantation Institute the possibilities of giving blood components and giving appropriate clotting factors have significantly reduced the needs for major liver surgeries in order to stop bleeding, or to repair the damage resulting from the injuries, at a time when researches have shownthe efficacy of these treatments may succeed in high rates and may reach 90%, also the failure of this treatment may not increase the risk.[3] When the hepatic trauma was classified into grades 1-5 according to the AAST, it was mostly observed that the nonsurgical treatment such as monitoring only or interventional radiologytreatment may be more effective with a grade of 1-3, and this of course refers to hemodynamically stable patients, while in cases of Grades 4-5 and unstable cases of patients may complicate matters further and the urgent need to resort to surgeries for damage control strategies such perihepatic packing, direct repair of vascular injuries, hepatectomies, and even liver transplantation.[4] Over the past three decades, some case reports and retrospective trials have been published about liver transplantation in trauma situations. Despite this, there are no clear and explicit lines which patients may benefit from liver transplantation, and what are the factors that may reduce or increase the success rate of liver transplantation for a trauma patient. By looking at the history of liver transplantation in trauma cases, our aim to mark important points that may help, and to consider future research for a better explanation. The Beginning of Liver Transplantation in Trauma Setting For the first time in 1984, liver transplantation was done in patients who had suffered from liver trauma. It was published by Carlos O. et.al in the case report in which he talked about two cases of blunt trauma, the first transplant for a patient at the age of 24 years, the transplant took place after nearly two months due to liver failure and injury to the unrepairable bile ducts. The patient was discharged from the hospital after three weeks without significant complications. The second case, it occurred at the age of 17, and after three days from the injury only due to liver failure and damage to the bile ducts. He died after two weeks due to the CMV infection.[5] In all the","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"167 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Respiratory Complications Among Living Liver Donors: A Single-Center Retrospective Observational Study","authors":"Sami Akbulut","doi":"10.14744/jilti.2023.54254","DOIUrl":"https://doi.org/10.14744/jilti.2023.54254","url":null,"abstract":"Dear Editor; We read with great interest the recent article ''Respiratory Complications Among Living Liver Donors: A Single-Center Retrospective Observational Study'' published by Elbeialy and colleagues.[1] The authors stated that despite the low incidence of significant respiratory complications among their living liver donor cohort, close monitoring and early management are essential to achieve better prognosis, especially in donors older than 35 years or those with previous surgery. We would like to draw attention to a few points. Authors state that they routinely use conventional angiography to evaluate the suitability of the living liver donor candidates. In the earlier times of living donor liver transplantation, the imaging techniques had an insufficient quality and conventional angiography was routinely used to avoid unnecessary laparotomy. However, in the last decade, there is a great number of advancements in the accuracy and quality of the non-invasive imaging techniques that resulted in the abandonment of the conventional angiography for the evaluation of the living liver donors.[2] Currently, conventional angiography is only used for the evaluation of vascular anatomy under certain exceptional conditions. In our institute, we use conventional angiography in less than 0.1 % of living liver donor candidates. Similarly, if preoperative ultrasonography, dynamic computerized tomography, and dynamic magnetic resonance imaging are performed appropriately, the fibrosis and hepatosteatosis can be evaluated accurately and occasionally there will be nor need for preoperative liver biopsy. In recent years, transient elastography (Fibroscan) can help determine the texture and steatosis of the liver, and together with using a specific formula, steatosis rates can be determined which is comparable with the histopathological evaluation.[3,4] The authors have stated that they have used PASS software to calculate the sample size of 124 patients. In our opinion, there is no need for sample size and power analysis calculation in the present study because the authors have included all living liver donors’ in the designated period which makes alpha value to be 0.05 at the minimum and the power would be 100%. If the authors were to use a statistical method, they should have performed propensity score matching analysis on the 10 patients with complications by choosing a 1:2 matched control group with similar demographic and clinical characteristics. This approach would Please cite this article as ”Akbulut S. Comment on Respiratory Complications Among Living Liver Donors: A Single-Center Retrospective Observational Study. J Inonu Liver Transpl Inst 2023;1(2):79–80”. Sami Akbulut","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Gene Up- and Down-Regulation as Potential Predictors of the Behavior of HBV-Associated Hepatocellular Carcinoma?","authors":"Zeynep Küçükakçalı","doi":"10.14744/jilti.2023.68077","DOIUrl":"https://doi.org/10.14744/jilti.2023.68077","url":null,"abstract":"Objectives: The current study aimed to identify genes that show differential expression in tumor tissue by performing bioinformatic analysis from matched tumor and non-tumoral liver tissue samples obtained from HBV-HCC patients. Methods: mRNA data from 21 HBV-HCC patients were used in this open-access database-based study. The mRNA sequence data were obtained from 21 pairs of tumors and non-tumoral liver tissue samples. Gene expression analysis was used in bioinformatics analyses and log2FC value was used to identify genes showing up-and down-regulation. To illustrate differentially expressed genes, the volcano plot was utilized. Results: Our analysis showed that many genes showed quite different expression levels in tumor tissues. Among these genes, the genes that showed very high fold upregulation were GNG4, IGF2BP1, GPC3, PEG10, AFP, SPINK1, EPS8L3, MYCN, DUSP9, and DKK1 genes, respectively. The down-regulated genes were CNDP1, WAKMAR1, LINC01818, TH, LINC01093, MARCO, LOC101927078, LOC105372263, FCN2, and CLEC4M. Conclusion: Our study defined various genes that might be utilized as potential biomarkers for HBV-related HCC. Targeted treat-ment for these genes can be developed and verified for efficacy in treatment.","PeriodicalId":484735,"journal":{"name":"Journal of Inonu Liver Transplantation Institute","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}