Fei Liu, Ya-nan Zhao, Li-qian Zhang, Nai-kun Gao, Zhi-fei Qiao, Jie Yao
{"title":"Observing the Effects of Probiotics Combined with Rexine and Peptisonide Enteral Nutrition Guidance in Postoperative Intracerebral Hemorrhage Patients","authors":"Fei Liu, Ya-nan Zhao, Li-qian Zhang, Nai-kun Gao, Zhi-fei Qiao, Jie Yao","doi":"10.53964/jmpp.2024006","DOIUrl":"https://doi.org/10.53964/jmpp.2024006","url":null,"abstract":"Objective: To investigate the therapeutic effects of probiotics combined with Rexine or Peptisonide enteral nutrition guidance in postoperative intracerebral hemorrhage (ICH) patients. Methods: Clinical data of 60 ICH patients treated at our hospital from May 2022 to January 2024 were retrospectively analyzed. The patients were divided into an observation group (OG) (probiotics combined with Peptisonide) and a control group (CG) (probiotics combined with Rexine), with 30 cases in each group. The comparison of neurological function scores, immunoglobulin levels, inflammation and infection markers, and adverse reactions between the two groups was conducted during the treatment process. Results: Before treatment, the two groups were comparable in terms of The National Institutes of Health Stroke Scale (NIHSS) scores, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin M (IgM), D-lactic acid, and Procalcitonin (PCT) levels (P>0.05). After treatment, the NIHSS scores significantly decreased in both groups, with a more pronounced reduction observed in the OG (P<0.05). Levels of IgA, IgG, and IgM significantly increased, with a more substantial rise in the OG (P<0.05). The D-lactic acid levels significantly decreased, and both the D-lactic acid and PCT levels were lower in the OG (P<0.05). The incidence of vomiting, gastric retention, and gastrointestinal bleeding did not differ significantly between the two groups (P>0.05), but the incidence of diarrhea and constipation was notably lower in the OG compared to the CG (P<0.05). Conclusion: The probiotic combined with Peptisonide enteral nutrition scheme significantly improves neurological function, enhances immunity, reduces inflammatory response, and decreases adverse reactions.","PeriodicalId":484143,"journal":{"name":"Journal of modern pharmacology and pathology","volume":" 69","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ze-Chao Zhang, Yu Chen, Xuejin Ye, Botao Tang, Shuping Huang, Zesen Lin, Fang Hu, Qingyun Yang, Min Zhu
{"title":"Computer Prediction and Experimental Verification of Guizhi Fuling Pill in the Treatment of Benign Prostatic Hyperplasia","authors":"Ze-Chao Zhang, Yu Chen, Xuejin Ye, Botao Tang, Shuping Huang, Zesen Lin, Fang Hu, Qingyun Yang, Min Zhu","doi":"10.53964/jmpp.2024003","DOIUrl":"https://doi.org/10.53964/jmpp.2024003","url":null,"abstract":"Objective: Benign prostatic hyperplasia (BPH) is a prevalent condition among middle-aged and elderly males. The hypoxia-inducible factor-1α (HIF-1α) / vascular endothelial growth factor A (VEGF-A) signaling pathway plays a key role in proliferative disorders. Guizhi Fuling Pill (GFP) provides significant clinical efficacy in addressing BPH and related hyperplastic ailments. This study aims to elucidate the potential involvement of the HIF-1α / VEGF-A signaling pathway in the therapeutic action of GFP against BPH. Methods: Employing network pharmacology and molecular docking techniques, the mechanism underlying GFP against BPH was anticipated. A rat model of BPH was established to validate the primary targets identified via molecular docking. Subcutaneous administration of testosterone propionate was conducted to induce the BPH rat model for experimental validation. Immunohistochemistry was performed to assess the expression of HIF-1α and VEGF-A in prostate tissue across different experimental groups. Results: The network pharmacology analysis unveiled 111 potential constituents of GFP, with key components such as ent-Epicatechin, quercetin, and Mairin exerting influence on BPH. Essential targets encompass ESR1 and HSP90AA1, with signaling pathways like HIF-1, PI3K-AKT, and VEGF prominently associated with cellular apoptosis, angiogenesis, and proliferation. Molecular docking projections underscored the propensity of core components to interact with key targets, exhibiting favorable binding characteristics. In the context of animal experiments, GFP significantly reduced the expression of HIF-1α and VEGF-A in BPH-afflicted rats as compared to the model group. Conclusion: Collectively, this investigation suggests that GFP’s therapeutic potential for BPH could be attributed to its modulation of multifaceted targets, including HIF-1α and VEGF-A.","PeriodicalId":484143,"journal":{"name":"Journal of modern pharmacology and pathology","volume":"52 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140434047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Benefits of Puerarin in Attenuating Various Diseases","authors":"Zhenhang Wang, Jing Gu, Qi Zhang, Jiaxi Sun, Yunlai Zhou, Lifen Zhu, Wentao Hu, Chenchuan Cui, Lu Zhang","doi":"10.53964/jmpp.2024002","DOIUrl":"https://doi.org/10.53964/jmpp.2024002","url":null,"abstract":"Puerarin, an isoflavone derivative isolated from the traditional Chinese medicine Pueraria lobata, has garnered significant attention from researchers due to its potential health benefits. In recent years, there have been many studies on puerarin, but there are few reviews on puerarin. This article aims to introduce the pharmacological effects of puerarin, points out the shortcomings of existing research, and puts forward future research directions.","PeriodicalId":484143,"journal":{"name":"Journal of modern pharmacology and pathology","volume":"36 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Efficacy of the Traditional Chinese Medicine Compound Formulas Qianlong Shutong Formula in the Treatment of Benign Prostatic Hyperplasia","authors":"Ze-Chao Zhang, Shuping Huang, Changjie Shang, Zesen Lin, Qinyun Yang, Fang Hu, Min Zhu","doi":"10.53964/jmpp.2024001","DOIUrl":"https://doi.org/10.53964/jmpp.2024001","url":null,"abstract":"Objective: This study aimed to assess the efficacy of the compound formula Qianlong Shutong Formula (QLSTF) in the treatment of benign prostatic hyperplasia (BPH) and its impact on hepatic and renal function. This assessment was conducted through randomized controlled trials and animal experimentation. Methods: A total of 160 BPH patients aged between 50 and 70 years were randomly allocated into two groups: The tamsulosin hydrochloride sustained-release capsules group (n=80) and the QLSTF + tamsulosin hydrochloride sustained-release capsules group (n=80). Both groups received a 12-week treatment regimen. In the animal experiments, 12 Sprague Dawley rats were categorized into three groups: The control group (n=4), the model group (n=4), and the QLSTF group (n=4). The latter group received herbal treatment for a duration of 28 days. Results: The current results showed, substantial improvements were observed in the clinical symptoms and signs of BPH within both drug groups. Additionally, no adverse effects on hepatic or renal function were detected. The QLSTF group exhibited a total effective rate of 90.41%, while the control group recorded 77.33%. During the course of treatment, three patients experienced dizziness, and two patients reported nausea and reduced appetite. However, these adverse reactions subsided after a rest period of 4-6h. Conclusion: Our findings underscore the advantages and safety of orally administered QLSTF. In the treatment of BPH, the combined treatment approach using QLSTF demonstrated a higher clinical efficacy rate when compared to the use of tamsulosin hydrochloride sustained-release capsules alone.","PeriodicalId":484143,"journal":{"name":"Journal of modern pharmacology and pathology","volume":"141 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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