International journal of pharmaceutical sciences and medicine最新文献

Black Garlic (Allium sativum L.) Ethanol Extract: Total Phenolic Content and Antioxidant Activity Test Determination Using the Soxhletation Method 黑蒜（Allium sativum L.）乙醇提取物：采用索氏蒸馏法测定总酚含量和抗氧化活性试验

International journal of pharmaceutical sciences and medicine Pub Date : 2024-01-30 DOI: 10.47760/ijpsm.2024.v09i01.002

Zikra Azizah, Dinda Salsa Titania, Rusdi Rusdi, Ulfa Ismirza, S. Misfadhila

引用次数: 0

Characterization and Improvement Dissolution Profile of the Hydrochlorothiazide-β-Cyclodextrin Inclusion Complex using Kneading Method 使用捏和法表征氢氯噻嗪-β-环糊精包合物并改善其溶解曲线

International journal of pharmaceutical sciences and medicine Pub Date : 2024-01-30 DOI: 10.47760/ijpsm.2024.v09i01.003

M. D. Octavia, Nia Dwi Agraini, Rina Wahyuni, Yeni Novita Sari, Addina Zafrul

{"title":"Characterization and Improvement Dissolution Profile of the Hydrochlorothiazide-β-Cyclodextrin Inclusion Complex using Kneading Method","authors":"M. D. Octavia, Nia Dwi Agraini, Rina Wahyuni, Yeni Novita Sari, Addina Zafrul","doi":"10.47760/ijpsm.2024.v09i01.003","DOIUrl":"https://doi.org/10.47760/ijpsm.2024.v09i01.003","url":null,"abstract":"Hydrochlorothiazide is a drug antihypertensives are classified into Biopharmaceutics Classification System (BCS) class IV, so required technique formulation to improve solubility, one of them with complex inclusion. The inclusion complex was prepared with a kneading method with a comparison amount of hydrochlorothiazide - β- cyclodextrin 1:1 (F1) mol, 2:1 (F2) mol, and a physical mixture prepared in a ratio of 1:1 mol. This research aims to see the effect of complex formation inclusion on dissolution rate and characteristics of physicochemical properties of hydrochlorothiazide. Complex inclusions formed are characterized by scanning electron microscopy (SEM), and infrared spectrophotometer (FT-IR). X-ray diffraction, differential scanning calorimetry (DSC), and dissolution profiles. Characterization of physicochemical results analysis diffraction X-rays show that powder complex inclusion hydrochlorothiazide with β-cyclodextrin experiences decline peak intensity approaches a more amorphous nature. Characterization results FT-IR analysis shows No interaction chemistry exists between hydrochlorothiazide β-cyclodextrin. SEM analysis shows morphology substance active Already coated with β- cyclodextrin. DSC analysis shows a decline in enthalpy of the complex inclusions that indicate physical interactions form a simple eutectic mixture. Research results show that complex inclusion hydrochlorothiazide - β-cyclodextrin can repair characteristic physicochemical and can increase hydrochlorothiazide dissolution profile in a way significant (p<0.05) compared with powder The physical mixture with the highest dissolution results was shown by the F1 inclusion complex (82.843 %).","PeriodicalId":479312,"journal":{"name":"International journal of pharmaceutical sciences and medicine","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Oral Dispersible Tablet of Poorly Water-Soluble Drug ‘Glimepiride’ by Using Solubility Enhancement Technique 利用溶解度增强技术配制和评价水溶性差的药物 "格列美脲 "口服分散片

International journal of pharmaceutical sciences and medicine Pub Date : 2024-01-30 DOI: 10.47760/ijpsm.2024.v09i01.005

Nimisha Solanki, Arpit Gawshinde, Komal Tikariya, Dharmendra Solanki, U. Atneriya

{"title":"Formulation and Evaluation of Oral Dispersible Tablet of Poorly Water-Soluble Drug ‘Glimepiride’ by Using Solubility Enhancement Technique","authors":"Nimisha Solanki, Arpit Gawshinde, Komal Tikariya, Dharmendra Solanki, U. Atneriya","doi":"10.47760/ijpsm.2024.v09i01.005","DOIUrl":"https://doi.org/10.47760/ijpsm.2024.v09i01.005","url":null,"abstract":"The present study is regarding Glimepiride (GMP) is poorly water-soluble drug. According to the BCS, Glimepiride undergoes Class II - High Permeability and Low Solubility. The objective of the research project is to enhance the solubility of Glimepiride by using solubility enhancement techniques. The endeavor is to improve its solubility by using super disintegrating agent to enhance the ability of disintegration of Oro dispersible tablet. To enhance of solubility of GMP, our select the method i.e. solid dispersion technique because Solid dispersion is an effective way of improving the dissolution rate of poorly water-soluble drugs and hence its bioavailability. The polymers used were PEG 4000 and PEG 6000 for prepared solid dispersions in different ratio by two method i.e. Fusion and solvent evaporation method. The solvent evaporation method is better result of drug for enhancement of solubility. Oral dispersible tablet of Glimepiride was prepared by direct compression method. ODTs of glimepiride by using different super disintegrants such as sodium starch glycolate, cross povidone and croscarmellose sodium. Further, post evaluation parameters like Shape and Color of Tablets, Thickness, hardness, friability, weight variation, Uniformity of Drug Content, In vitro Dissolution Rate Studies and In-vitro disintegration time were also evaluated and the results were discussed.","PeriodicalId":479312,"journal":{"name":"International journal of pharmaceutical sciences and medicine","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of Quality, Safety and Efficacy of Ashwagandhadi Leha Using Chromatographic Technique 利用色谱技术评估阿什瓦甘地利哈的质量、安全性和功效

International journal of pharmaceutical sciences and medicine Pub Date : 2024-01-30 DOI: 10.47760/ijpsm.2024.v09i01.001

Juliyas Shrotriya, Arpit Gawshinde, Komal Tikariya, Pushpanjali Chaurasia, Shivam Soni

引用次数: 0

A REVIEW: NATURAL POLYMER LOADED MATRIX TABLETS OF ANTIPYRETIC DRUG 综述：天然聚合物装载的解热镇痛药基质片剂

International journal of pharmaceutical sciences and medicine Pub Date : 2024-01-30 DOI: 10.47760/ijpsm.2024.v09i01.004

Shrashti Agarwal, Shalini Singh

{"title":"A REVIEW: NATURAL POLYMER LOADED MATRIX TABLETS OF ANTIPYRETIC DRUG","authors":"Shrashti Agarwal, Shalini Singh","doi":"10.47760/ijpsm.2024.v09i01.004","DOIUrl":"https://doi.org/10.47760/ijpsm.2024.v09i01.004","url":null,"abstract":"Natural Polymer Loaded Matrix Tablets for Antipyretic Drugs represent a promising advancement in pharmaceutical formulations, emphasizing the integration of natural polymers known for their biocompatibility and sustainability. This study delves into the innovative approach of utilizing matrix tablets, loaded with natural polymers, to optimize the delivery of antipyretic medications. The controlled-release mechanism offered by these tablets ensures a sustained and steady release of antipyretic drugs, addressing challenges related to peak concentrations and enhancing therapeutic efficacy while minimizing potential side effects. The incorporation of natural polymers not only contributes to improved patient safety but also aligns with global efforts towards eco-friendly pharmaceutical practices. As a focal point of ongoing research, natural polymer-loaded matrix tablets for antipyretic drugs hold significant promise in advancing pharmaceutical sciences, offering a holistic approach to patient well-being and environmental sustainability. The future and scope of matrix tablets unfold promising prospects, envisioning advanced formulations, personalized medicine, and targeted drug delivery as key areas of exploration. The study highlights the pivotal role matrix tablets play in shaping the pharmaceutical landscape, aligning with the industry's shift towards eco-friendly practices and patient-centric care.","PeriodicalId":479312,"journal":{"name":"International journal of pharmaceutical sciences and medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0