VNU Journal of Science:Natural Sciences and Technology最新文献

Unleashing Potential: First Vietnamese 3D in vitro Model using Induced Pluripotent Stem Cell-Derived Cardiomyocytes 释放潜能:越南首个使用诱导多能干细胞衍生心肌细胞的体外3D模型

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-11-11 DOI: 10.25073/2588-1140/vnunst.5581

Dang Thi Minh Anh, Nguyen Xuan Hung

{"title":"Unleashing Potential: First Vietnamese 3D in vitro Model using Induced Pluripotent Stem Cell-Derived Cardiomyocytes","authors":"Dang Thi Minh Anh, Nguyen Xuan Hung","doi":"10.25073/2588-1140/vnunst.5581","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5581","url":null,"abstract":"Advancements in studying cardiovascular diseases (CVDs) face challenges related to cell sources and utilizing animal models. To mitigate these limitations, three-dimensional (3D) in vitro modeling using human induced pluripotent stem cell-derived cardiomyocytes (iCMs) has emerged as a promising approach. In this study, human induced pluripotent stem cells (hiPSCs) were successfully differentiated into cardiomyocytes and subsequently used to generate spheroids via the hanging drop method. We comprehensively characterized the formation, fusion, and beating capability of the generated spheroids. The hiPSCs were efficiently differentiated into cardiomyocytes, exhibiting contractile activity and expressing cardiac-specific markers such as α-actinin and cardiac troponin. Subsequent results demonstrated the successful formation of iCM-derived cardiac spheroids within 48 hours, with beating activity observed after two days cultured in an ultra-low attachment 96-well plate. In addition, similar to the iCM monolayer, the established spheroids also positively expressed α-actinin. Notably, the spheroids exhibited rapid assembly and maintained survival and stable beating throughout the observation period. These findings highlight the potential of establishing a robust in vitro iCM-derived 3D spheroids model for drug testing and cardiovascular disease modeling, typically for Vietnamese people.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"51 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-TiO2/FeMIL-88B- A Promising Photocatalyst for Photoconversion of CO2 into Methanol N-TiO2/FeMIL-88B-一种有前途的CO2光转化为甲醇的光催化剂

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-11-11 DOI: 10.25073/2588-1140/vnunst.5597

Phung Thi Lan, Nguyen Hoang Hao, Nguyen Van Thuc, Nguyen Ngoc Ha, Le Minh Cam, Nguyen Thi Thu Ha

{"title":"N-TiO2/FeMIL-88B- A Promising Photocatalyst for Photoconversion of CO2 into Methanol","authors":"Phung Thi Lan, Nguyen Hoang Hao, Nguyen Van Thuc, Nguyen Ngoc Ha, Le Minh Cam, Nguyen Thi Thu Ha","doi":"10.25073/2588-1140/vnunst.5597","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5597","url":null,"abstract":"The present objective of this work is to find photoactive materials capable of facilitating visible light-driven redox reactions between CO2 and H2O. Our research is primarily focused on the incorporation of nitrogen (N) into the crystal lattice of titanium dioxide (TiO2) and its deposition onto Fe-MIL-88B to improve light absorption properties, minimize recombination of photo-generated electron-hole pairs, and increase CO2 adsorption capacity. The N-TiO2/Fe-MIL-88B composite was successfully prepared and characterized using SEM, XRD, and EDX techniques. The introduction of N-TiO2 into Fe-MIL-88B does not damage the crystal structure of Fe-MIL-88B. Anatase is the only crystalline phase observed from the XRD diffraction pattern. SEM images show that N-TiO2 is well dispersed on the Fe-MIL-88B surface. The results of quantum simulations indicate that TiO2 strongly interacts with Fe-MIL-88B. The binding energy is determined to be -78.2 kcal/mol. The calculated UV-Vis results revealed that the light absorption edge of the TiO2/Fe-MIL-88B was red-shifted in comparison with that of the pure TiO2 (from ca. 500 nm to 550 nm). The red-shifted light absorption of TiO2/FeMIL-88B suggests that the band gap of TiO2/Fe-MIL-88B is narrower compared to that of the pristine TiO2, indicating the better light utilization ability of the TiO2/Fe-MIL-88B. Results from high-performance liquid chromatography show that N-TiO2 has the capability to convert CO2, but at a significantly low rate. The methanol formation is distinctly observed only over the N-TiO2/Fe-MIL-88B catalyst. The CO2 conversion efficiency, estimated using gas chromatography, is calculated to be 11.94%.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"50 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the Influence of the Reduced Graphene Oxide Coating on the Hydrophobicity of PU Sponge for Oil Recovery 还原氧化石墨烯涂层对PU采油海绵疏水性影响的研究

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-11-03 DOI: 10.25073/2588-1140/vnunst.5574

Nguyen Ha Chi, Dao Thi Thu Huong, Nguyen Trung Son, Nguyen Minh Viet, Do Quang Trung, Nguyen Manh Tuong, Do Van Dang, Nguyen Minh Phuong

{"title":"Study on the Influence of the Reduced Graphene Oxide Coating on the Hydrophobicity of PU Sponge for Oil Recovery","authors":"Nguyen Ha Chi, Dao Thi Thu Huong, Nguyen Trung Son, Nguyen Minh Viet, Do Quang Trung, Nguyen Manh Tuong, Do Van Dang, Nguyen Minh Phuong","doi":"10.25073/2588-1140/vnunst.5574","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5574","url":null,"abstract":"In order to produce a hydrophobic material for oil removal from surface waters, in this study, the reduced graphene oxide coated PU sponges (rGO@PU) were prepared by ultrasonication of PU sponges with suspension of rGO in ethanol. The chemical structure of the rGO coatings was investigated by X-ray diffraction and FT-IR spectroscopy methods. The surface morphology of the obtained materials was also examined by SEM. The influence of the rGO loadings and the number of coatings on the hydrophobicity of the materials was investigated. The testing on the surface hydrophobicity indicated that the water drops were remained on the surface of rGO@PU for 4.5 - 5 hours. The results indicated that the best hydrophobic sponge was obtained at the rGO loading of 3 mg/mL and after three times of coatings. The water contact angle (WCA) of the optimal rGO@PU was up to 119°. The kerosene oil absorption capacity of the rGO@PU in 5 minutes is 32.34 g/g. Besides, the oil-water separation ability of the material was also investigated by passing the kerosene-water mixture through a filter funnel containing the synthesized porous material rGO@PU. The result indicated that the separation efficiency of the material was 85%. The recyling test was conducted by squeezing the saturated absorbed sponges and applying the desorbed sponges for the next cycle tests. After 10 times of recycling, the amounts of kerosene absorption on the rGO@PU were maintained from 4.39 - 5.33 g, implying the excellent recyclability of the material.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"67 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135868841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Study of Sunset Yellow and its Determination in Soft Drink by Differential Pulse Adsorptive Stripping Voltammetry Using Ag-ErGO/GCE Ag-ErGO/GCE差分脉冲吸附溶出伏安法测定饮料中日落黄的电化学研究

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-11-02 DOI: 10.25073/2588-1140/vnunst.5517

Le Thi Huong Giang, Doan Thi Thu Trang, Dang Minh Huong Giang, Pham Thi Thanh Nhan, Nguyen Thi Mai, Do Trong Bang, Nguyen Thi Kim Thuong

引用次数: 0

Study on Quantification and Toxicity Estimation of Perfluoroalkyl Substances in Vietnamese Fish and Food Packaging Materials 越南鱼类和食品包装材料中全氟烷基物质的定量和毒性评估研究

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-11-02 DOI: 10.25073/2588-1140/vnunst.5601

Nguyen Duc Hieu, Tran Thi Lieu, Hoang Quoc Anh, Le Huu Tuyen, Nguyen Trong Nghia, Nguyen Thi Chuc, Nguyen Thi Anh Huong, Nguyen Thi Quynh Hoa

{"title":"Study on Quantification and Toxicity Estimation of Perfluoroalkyl Substances in Vietnamese Fish and Food Packaging Materials","authors":"Nguyen Duc Hieu, Tran Thi Lieu, Hoang Quoc Anh, Le Huu Tuyen, Nguyen Trong Nghia, Nguyen Thi Chuc, Nguyen Thi Anh Huong, Nguyen Thi Quynh Hoa","doi":"10.25073/2588-1140/vnunst.5601","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5601","url":null,"abstract":"In this study, concentrations of perfluroalkyl substances (PFASs) including 7 perfluorocarboxylic acids (PFCAs) and 3 sulfonates (PFSs) were determined in fresh water fish and food packaging material samples collected from Hanoi, Vietnam. Concentrations of Σ10PFASs ranged from 0.24 to 1.73 (median 0.62) ng/g wet weight for fish samples, and from not detected to 536 (median 0.98) ng/g dry weight for food packaging materials. PFAS levels in our fish samples were within low to moderate ranges compared to other countries, implying relatively low contamination degree of water environment in Hanoi. PFAS contents in almost food packaging samples were generally low (<2 ng/g), except for 3 mochi papper trays (323-536 ng/g). The sources of some longchain PFCAs (e.g., PFOA and PFDA) in a few food packaging samples were still unclear. Relative potencies (REP) of PFASs to PFOA based on thyroid hormone disruption effects were reviewed and applied to estimate toxicity equivalents (PFOA-EQs) of PFAS mixtures in analyzed samples. In term of toxicity contributions, PFOS and PFOA were the most important compounds, accounting for about 70% of PFOA-EQs.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"22 23","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variable Temperature NMR Experiment Studying Cyanopyridone Structure 变温核磁共振实验研究氰吡啶酮结构

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-10-24 DOI: 10.25073/2588-1140/vnunst.5590

Bui Thai Thanh Thu, Mac Dinh Hung, Pham Quang Trung

引用次数: 0

Study on Conditions for Carboxymethyl Cellulose Synthesis from Pineapple Leaf Waste and Evaluation of its Thickening Performance 菠萝叶废合成羧甲基纤维素的条件研究及增稠性能评价

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-10-19 DOI: 10.25073/2588-1140/vnunst.5460

Nguyen Hai Linh, Dinh Mai Linh, Nguyen Thi Minh Chau, Ngo Hong Anh Thu, Nguyen Thi Son, Nguyen Truong Giang, Phan Thi Tuyet Mai

{"title":"Study on Conditions for Carboxymethyl Cellulose Synthesis from Pineapple Leaf Waste and Evaluation of its Thickening Performance","authors":"Nguyen Hai Linh, Dinh Mai Linh, Nguyen Thi Minh Chau, Ngo Hong Anh Thu, Nguyen Thi Son, Nguyen Truong Giang, Phan Thi Tuyet Mai","doi":"10.25073/2588-1140/vnunst.5460","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5460","url":null,"abstract":"Pineapple leaf waste, with its high cellulose content, can serve as alternative starting material for the production of carboxymethyl cellulose (CMC). In this study, cellulose was extracted from pineapple leaf waste by 0.5 M NaOH at 90 oC for 2 h and 0.5 M HNO3 at 90 oC for 2 h. The obtained cellulose, with average diameters of 3-7 μm, was converted to carboxymethyl cellulose (CMC) by esterification. Preparation of CMC was investigated by varying two factors, namely, sodium hydroxide (NaOH) dosage and monochloroacetic acid (MCA) dosage. The cellulose was soaked in a solution mixture of ethanol and NaOH for 2 h at room temperature. It was then reacted with chloroacetic acid (MCA) at 60 oC for 2 h. The optimum conditions for carboxymethylation were found to be 0.70 g of MCA/g cellulose, 0.75 g NaOH/g cellulose. The obtained CMC had a high degree of substitution (DS) of 1.0 with the CMC yield of 150%. The obtained CMC were characterized by FTIR spectroscopy, SEM images and XRD diffractions. Moreover, the thickerning performance of the obtained CMC was also determined.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135732300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of some N-hydroxycinnamamide and N-hydroxybenzamide Derivatives Bearing Amide Bonds Targeting HDAC 以HDAC为靶点的n -羟基肉桂酰胺和n -羟基苯酰胺酰胺衍生物的合成

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-10-17 DOI: 10.25073/2588-1140/vnunst.5406

Nguyen Cuong Quoc, Le Dang Quang, Nguyen Duy Tuan, Nguyen Thi Nhu Y, Tran Thanh Men, Nguyen Trong Tuan, Bui Thi Buu Hue, Nguyen Vu Linh, Lam Thi Ngoc Huong, Tran Quang De

{"title":"Synthesis of some N-hydroxycinnamamide and N-hydroxybenzamide Derivatives Bearing Amide Bonds Targeting HDAC","authors":"Nguyen Cuong Quoc, Le Dang Quang, Nguyen Duy Tuan, Nguyen Thi Nhu Y, Tran Thanh Men, Nguyen Trong Tuan, Bui Thi Buu Hue, Nguyen Vu Linh, Lam Thi Ngoc Huong, Tran Quang De","doi":"10.25073/2588-1140/vnunst.5406","DOIUrl":"https://doi.org/10.25073/2588-1140/vnunst.5406","url":null,"abstract":"Recently, hydroxamic acid has attracted considerable interest because of its ability to inhibit a variety of metal-containing enzymes such as metalloproteases, lipoxygenases, histone deacetylases, and cancer cells. For example, hydroxamic acid derivatives (vorinostat, belinostat, givinostat, panobinostat) have been approved by the US FDA for the treatment of various cancers. Based on the N-hydroxycinnamamide and N-hydroxybenzamide framework, the study described and synthesized N-hydroxycinnamamide and N-hydroxybenzamide derivatives bearing amide bonds as histone deacetylases enzyme inhibitors. The structures of the compounds were determined through modern NMR spectroscopy. The compounds were then molecularly docked to the active site of the HDAC6 enzyme, the results showed that the compounds strongly bound to the zinc ion and key amino acids. These results suggest that the synthesized N-hydroxycinnamamide and N-hydroxybenzamide derivatives are potential molecular targeted therapy for HDAC positive cancer in the future.","PeriodicalId":478486,"journal":{"name":"VNU Journal of Science:Natural Sciences and Technology","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135994006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Assitted Synthesis of Anti-Microbial Chromones 微波辅助合成抗微生物色素

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-09-26 DOI: 10.25073/2588-1140/vnunst.5413

Nguyen Thi Thanh Mai, Nguyen Manh Ha

引用次数: 0

Polyvinyl Butyral/Graphene Oxide Composite Coating for Properties Improvement 性能改进的聚乙烯醇丁醛/氧化石墨烯复合涂料

VNU Journal of Science:Natural Sciences and Technology Pub Date : 2023-09-22 DOI: 10.25073/2588-1140/vnunst.5498

Nguyen Trung Thanh

引用次数: 0