Фундаментальная и клиническая медицина最新文献_第2页

Optimization of anticoagulant therapy in patients undergoing mechanical heart valve replacement 心脏机械瓣膜置换术患者抗凝治疗的优化

Фундаментальная и клиническая медицина Pub Date : 2023-09-29 DOI: 10.23946/2500-0764-2023-8-3-131-142

S. A. Tkachenko, D. A. Astapov, A. V. Bogachev-Prokofiev, A. S. Zalesov, A. N. Pivkin, A. G. Makaev, Kh. A. Agaeva, R. M. Sharifulin

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Abdominal aortic diameter as a predictor of peripheral atherosclerosis progression in 40-64-year-old patients with cardiovascular risk factors 腹主动脉直径作为40-64岁有心血管危险因素患者外周动脉粥样硬化进展的预测因子

Фундаментальная и клиническая медицина Pub Date : 2023-09-29 DOI: 10.23946/2500-0764-2023-8-3-26-36

V. V. Genkel, A. S. Kuznetsova, A. I. Dolgushina, A. Yu. Savochkina, K. V. Nikushkina, V. A. Sumerkina, L. R. Pykhova, A. I. Smolensky, I. I. Shaposhnik

{"title":"Abdominal aortic diameter as a predictor of peripheral atherosclerosis progression in 40-64-year-old patients with cardiovascular risk factors","authors":"V. V. Genkel, A. S. Kuznetsova, A. I. Dolgushina, A. Yu. Savochkina, K. V. Nikushkina, V. A. Sumerkina, L. R. Pykhova, A. I. Smolensky, I. I. Shaposhnik","doi":"10.23946/2500-0764-2023-8-3-26-36","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-3-26-36","url":null,"abstract":"Aim . To study the prognostic significance of abdominal aorta (AA) diameter in progression of peripheral atherosclerosis in patients aged 40-64 years and without abdominal aortic dilation. Materials and Methods . The study included 157 outpatients aged 40-64 years who underwent Doppler ultrasonography of brachiocephalic arteries, lower extremity arteries, and abdominal aorta in order to assess cardiovascular risk. Upon the serum collection, we measured lipid fractions, creatinine, glycated hemoglobin, high-sensitivity C-reactive protein, pentraxin-3 and matrix metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-10). The criteria for the progression of peripheral atherosclerosis were: 1) the appearance of a new atherosclerotic plaque; 2) stenosis increase by ≥ 10%; 3) carotid plaque area increase by ≥ 0.106 cm 2 . Results . We found that 116 (73.9%) patients initially had low to moderate cardiovascular risk. Abdominal aortic diameter directly correlated with the level of glycated hemoglobin (r = 0.298; p = 0.003) and serum MMP-2 (r = 0.240; p = 0.041), whilst aortic size index directly correlated with serum MMP-9 (r = 0.319; p = 0.029). Repeated Doppler ultrasonography was performed in 120 (76.4%) patients, with the median period between two examinations was 14.4 (12.3; 20.8) months, and progression of peripheral atherosclerosis was identified in 26 (21.6%) patients. An increase in abdominal aortic diameter > 1.64 cm could predict atherosclerosis progression with sensitivity of 53.8% and specificity of 74.1%. According to Cox regression analysis, an increase in abdominal aortic diameter > 1.64 cm was associated with a 2.31-fold increased risk of atherosclerosis progression (95% CI = 1.06 - 5.00, p = 0.034). Conclusion . Abdominal aortic diameter can be considered as a predictor of peripheral atherosclerosis progression.","PeriodicalId":475390,"journal":{"name":"Фундаментальная и клиническая медицина","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135193455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an artificial intelligence system for the forecasting of infectious diseases 传染病预测人工智能系统的开发

Фундаментальная и клиническая медицина Pub Date : 2023-09-29 DOI: 10.23946/2500-0764-2023-8-3-143-154

A. A. Kuzin, R. I. Glushakov, S. A. Parfenov, K. V. Sapozhnikov, A. A. Lazarev

{"title":"Development of an artificial intelligence system for the forecasting of infectious diseases","authors":"A. A. Kuzin, R. I. Glushakov, S. A. Parfenov, K. V. Sapozhnikov, A. A. Lazarev","doi":"10.23946/2500-0764-2023-8-3-143-154","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-3-143-154","url":null,"abstract":"Aim . Here, we provided an overview of artificial intelligence (AI) approaches for developing a system for prediction of infectious diseases and designed a respective step-by-step protocol. Materials and Methods . Literature search in PubMed and Google Scholar and PubMed. Key Points . Infectious diseases impose a heavy burden on a healthcare, demanding the development of novel and efficient approaches to prevention as well as sensitive and specific diagnostic tests. Evolution of data science have led to the emergence of promising artificial intelligence (AI) algorithms and tools for the forecasting of infectious diseases. Employing machine learning algorithms, AI systems can rapidly analyze a large amount of data, extract specific disease patterns, and screen for the most efficient AI instruments in relation to specific tasks, thus contributing to prevention, diagnostics, and treatment of infectious diseases in the context of personalized medicine. Importantly, such AI-based systems can determine specific human motor patterns from videos and/or photographs in order to assist physicians in primary diagnosis. Integration of AI tools into the existing healthcare algorithms can be especially useful for public health.","PeriodicalId":475390,"journal":{"name":"Фундаментальная и клиническая медицина","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135193465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single or multiple arterial grafting to design a coronary bypass: a retrospective study 单动脉或多动脉移植设计冠状动脉旁路:一项回顾性研究

Фундаментальная и клиническая медицина Pub Date : 2023-09-29 DOI: 10.23946/2500-0764-2023-8-3-80-92

A. V. Frolov, N. I. Zagorodnikov, R. S. Tarasov, E. V. Grigoriev

{"title":"Single or multiple arterial grafting to design a coronary bypass: a retrospective study","authors":"A. V. Frolov, N. I. Zagorodnikov, R. S. Tarasov, E. V. Grigoriev","doi":"10.23946/2500-0764-2023-8-3-80-92","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-3-80-92","url":null,"abstract":"Aim . To compare the efficiency of single arterial grafting (SAG) and multiple arterial grafting (MAG) at coronary artery bypass graft (CABG) surgery in the long term. Material and Methods . To assess the angiographic outcomes, we evaluated the patency of 323 bypasses at 102 angiograms obtained during coronary angiography performed > 10 years post-CABG surgery. Results . Out of 323 analyzed bypasses, 230 (71.2%) showed physiological functioning, whereas stenosis, occlusions, and other coronary artery alterations were found in 93 (28.8%) bypasses. The most common cause for the failure of anastomoses was competitive flow (most frequently registered in the anastomoses between left internal thoracic artery and left anterior descending artery, left internal thoracic artery and diagonal branches of left anterior descending artery, right internal thoracic artery and left anterior descending artery, and between right internal thoracic artery and right coronary artery), poor distal bed (most frequently revealed in the anastomosis between left internal thoracic artery and obtuse marginal artery, saphenous vein and diagonal branches of left anterior descending artery, saphenous vein and obtuse marginal artery, and between saphenous vein and right coronary artery), progression of atherosclerosis in combination with poor distal bed (most frequently detected in the anastomosis between right internal thoracic artery and obtuse marginal artery), and combination of poor distal bed, competitive flow, and graft degeneration (most frequently found in the anastomoses between radial artery and obtuse marginal artery and between radial artery and right coronary artery). In 5 (5.4%) cases, the cause of coronary bypass dysfunction was unclear. Conclusion . The main causes for the coronary bypass failure included competitive flow (in case with multiple arterial grafting) and poor distal bed (in case with single arterial grafting).","PeriodicalId":475390,"journal":{"name":"Фундаментальная и клиническая медицина","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135195592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0