IP international journal of comprehensive and advanced pharmacology最新文献

{"title":"Critical review on analytical detection of first line and second line anti tubercular agent by various modern analytical method","authors":"TS Basuri, Ranjit Mohapatra","doi":"10.18231/j.ijcaap.2024.014","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.014","url":null,"abstract":"Tuberculosis is a chronic inflammatory, granulomatous bacterial infectious disease caused by Mycobacterium tuberculosis. About 10 million people worldwide are ill with MTB in 2018, 5.7 million are males, 3.2 million are females and 1.1 million are infants, 1.6 million died from the disease. This article includes epidemiology, classification, pathogenesis, diagnosis and treatment of Tuberculosis. It includes the drug profile of antitubercular agents such as isoniazid, pyrazinamide, ethambutol, rifampicin, paraminosalicylic acid, thiacetazone, ethionamide, kanamycin, amikacin. cycloserine, viomycin, morphazinamide and some newer drugs such as ofloxacin, ciprofloxacin, clarithromycin and rifabutin. It contains analytical detection methods of antitubercular agents by HPLC.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound-healing effects of curcumin and its nano formulation","authors":"Punam Kisan Ghude, Vaishali Pandurang Kandalkar, Tejal Kaluram Bhoir, S. S. Nimase, P. Bhoir","doi":"10.18231/j.ijcaap.2024.016","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.016","url":null,"abstract":"Wound healing is a method of tissue repair or regeneration. Section Damages. Plants and plant-derived bioactive substances have been found effective in the treatment of many diseases. Types of wounds. Curcumin is a natural polyphenol that has been used since ancient times. Ayurveda is used times for its healing properties to relieve pain and aid in many healing processes. Plates. Various studies of curcumin administration to the site of pain have reported the following effects: Curcumin eliminates reactive oxygen species and increases the ability to improve collagen deposition, Chapter: Granulation data finally makes the wound contract. Curcumin is widely available and has been studied for its ability to relieve pain, but in addition it has low solubility and rapid metabolism. The short plasma half-life limits its application in wound healing. Since nanotechnology existed Chapter Proven to be a good method for wound healing with proper support Chapter injury sites. This review highlights the potential of curcumin and its Nano formulations; Preparation of liposomes, nanoparticles, nano emulsions, etc. usage This article is about Curcumin’s many biomedical applications underlie its anti-biofilm properties Chapter and its wound healing effect.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of pharmacokinetic properties and release of aceclofenac swellable matrix tablets utilizing okra (Abelmoschus Esculentus) and Hibiscus Leaf (Hibiscus Rosa-Sinensis) natural polymer mucilage","authors":"B. Prajapati, Rajdip Goswami, Saikat Santra, Bhaskar Pal, Biswajit Basu","doi":"10.18231/j.ijcaap.2024.019","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.019","url":null,"abstract":"To Development and Evaluation of Aceclofenac Swellable Matrix Tablets Utilizing Okra (Abelmoschus Esculentus) and Hibiscus Leaf (Hibiscus Rosa-Sinensis) Natural Polymer Mucilage as Release Modifier. This study investigates the development of sustained-release Aceclofenac tablets using natural polymers, Okra Gum and Hibiscus Leaf Mucilage, to enhance drug efficacy, reduce dosing frequency, and minimize adverse effects in the treatment of inflammation and pain.: Sustained-release NSAID formulations using natural polymers like Okra Gum and Hibiscus Leaf Mucilage enhance drug efficacy, patient adherence, and safety by reducing dosing frequency and adverse effects. Non-steroidal anti-inflammatory drugs (NSAIDs), like Aceclofenac, are commonly prescribed for managing inflammation and pain associated with various conditions such as arthritis, musculoskeletal disorders, and post-operative recovery. Despite their effectiveness, traditional NSAIDs often exhibit rapid-release kinetics, necessitating frequent dosing intervals to maintain therapeutic efficacy. However, frequent dosing increases the risk of adverse effects such as gastrointestinal complications, renal impairment, and cardiovascular events. To address these challenges, sustained-release formulations have been developed to prolong drug action and reduce dosing frequency. Natural polymers, such as Okra Gum and Hibiscus Leaf Mucilage, have emerged as promising excipients for sustained drug delivery systems. These natural polymers offer several advantages, including biocompatibility, biodegradability, and the ability to modulate drug release kinetics. By incorporating Okra Gum and Hibiscus Leaf Mucilage into pharmaceutical formulations can improve patient adherence and therapeutic effectiveness while minimizing adverse effects. Fourier Transform Infrared analysis conducted as part of this study demonstrated no chemical interaction between Aceclofenac and the natural polymers, confirming their compatibility for formulation purposes. The formulated tablets met pharmacopoeial specifications for physicochemical properties, ensuring quality and consistency in manufacturing. The optimized formulation exhibited prolonged drug release lasting up to 12 hours, with release kinetics inversely proportional to polymer concentration. Stability studies conducted over a specified period indicated no significant changes in tablet attributes, affirming the robustness of the formulation. The findings of this study confirm the suitability of Okra Gum and Hibiscus Leaf Mucilage as effective release modifiers for Aceclofenac, offering potential benefits for sustained drug delivery in inflammation therapy. By providing valuable insights into the development of improved drug delivery systems using natural polymers, this research contributes to enhanced patient care and treatment outcomes in inflammatory conditions. Further exploration and optimization of natural polymer-based formulations hold promise for advancing drug d","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"5 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-leech activity of asparagus racemosus and anogeissus latifolia roxb extracts against Piscicola Geometra","authors":"Anubhav Dubey, Mamta Kumari, Ghosh Niladry","doi":"10.18231/j.ijcaap.2024.018","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.018","url":null,"abstract":"Piscicola geometra leeches are naturally parasitizing Cobia juveniles. The leeches adhere to cobia by suctioning and biting its surface, thereby facilitating the entry of a secondary infection. The anti-leech action An in vitro technique investigated the anti-leech action against Piscicola geometra using water extracts of Asparagus racemosus seeds and Anogeissus latifolia roxb leaves, preparing a grand total of 800 afflicted cobia leeches. We compared the anti-leech activity of water extracts from Asparagus racemosus seeds and Anogeissus latifolia leaves. We diluted the plant extracts to various concentrations and observed the activity over a duration of 96 hours. The seeds and leaves of Asparagus racemosus exhibited significant anti-leech activity, resulting in 80% of the leeches dying. Anogeissus latifolia leaves exhibited a greater degree of anti-leech action, resulting in the complete killing of leeches. The average duration required for Anogeissus latifolia leaves to immobilise and eliminate the leeches ranged from 8 hours to 96 hours, depending on the different concentrations of Anogeissus latifolia leaves used. This research has shown that the aqueous extract of Anogeissus latifolia leaves has strong potential as a novel anti-leech agent.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial applications of herbal medicine in the problems associated with women health: A review","authors":"Aman B. Upaganlawar, Yogeshwari D. Lohar, Manoj Mahajan","doi":"10.18231/j.ijcaap.2024.011","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.011","url":null,"abstract":"The social, economic and psychological facets of life are significantly impacted by health issues affecting women. Despite the widespread lack of understanding and health care systems, they are the lifeblood of all living things. In light of this, an effort has been undertaken to compile data on medicinal plants utilized in various women's health-related issues through literature reviews and field research. The findings showed that native plants are widely used worldwide as significant healing agents for women's health issues. Medicinal plants play a major role in women's healthcare in many rural places. For common disorders affecting women, such as urinary tract infections, pubertal changes, after-menopause syndrome, hot flashes, menopause, polycystic ovarian syndrome, vaginosis from bacteria, yeast-related infections, infertility, delayed labor, low breast milk production, abortion, and other female disorders, there are several medicinal and ayurvedic herbal remedies accessible. This article raises awareness of the issues facing women and the value of using medicinal herbs to heal them.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"9 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug development of paracetamol derivative as antimicrobial activity","authors":"S. Shaikh","doi":"10.18231/j.ijcaap.2024.020","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.020","url":null,"abstract":"Paracetamol derivatives with their N-subsitituted Acyclic Analogues and then subsitituted with a pro drug to enhance its activity by forming cocrystal of Antibacterial & Antifungal and then enhancing the analgesic activity of Paracetamol by attaching it to Dendrimers which enhance it activities against E. Coli & Staphylococcus Auerus and they exhibit high to moderate antimicrobial activity.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"87 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in diabetes mellitus: Advancements, challenges, and future perspectives","authors":"A. K. Prajapati, Ashish Kumar Jha, Devang Sheth","doi":"10.18231/j.ijcaap.2024.012","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.012","url":null,"abstract":"Diabetes mellitus (DM) represents a multifaceted metabolic disorder characterized by hyperglycemia and dysregulated metabolism, stemming from a myriad of factors including insulin insufficiency and impaired glucose utilization. Its complications span a broad spectrum, encompassing vascular diseases and neurological impairments. While some risk factors are beyond control, such as age and genetics, others like diet and exercise offer avenues for risk mitigation. This review delineates the distinct pathogenic processes of the two primary forms of DM, type 1 and type 2, emphasizing their differential etiologies and epidemiological trends. Biomarkers play a pivotal role in the diagnosis and management of DM, offering insights into disease progression, beta-cell function, and therapeutic responses. Traditional biomarkers, alongside predictive markers like autoantibodies, facilitate early detection and intervention strategies. Moreover, advancements in high-throughput \"-omics\" technologies have unraveled the molecular intricacies underlying disease progression, heralding the discovery of potential serum protein biomarkers in type 1 DM and unveiling promising candidates such as unmethylated insulin DNA and dysregulated microRNAs. In type 2 DM, traditional biomarkers like fructosamine, glycated albumin, and 1,5-anhydroglucitol offer valuable tools for glycemic control assessment, with emerging biomarkers like zinc-alpha-2-glycoprotein holding promise for diabetic nephropathy detection. Despite challenges, ongoing research endeavors hold promise for refining these biomarkers and enhancing diabetes management strategies, thus improving patient outcomes.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"6 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance and neurodegenerative diseases","authors":"A. K. Prajapati, Akshmita Gairola, Mustakim Mansuri","doi":"10.18231/j.ijcaap.2024.013","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.013","url":null,"abstract":"Insulin resistance is a condition where normal or elevated insulin levels fail to elicit the expected biological response, with significant implications for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Despite extensive research, the precise cellular mechanisms driving insulin resistance and its role in neurodegeneration remain elusive. Insights into insulin signaling dysregulation, amyloid-beta accumulation, neuroinflammation, and impaired mitochondrial function shed light on the complex interplay between insulin resistance and neurodegeneration. Various therapeutic strategies targeting insulin resistance, including insulin interventions, GLP-1 analogs, intranasal insulin, and lifestyle interventions, offer promising avenues for mitigating disease progression. This review provides a comprehensive overview of insulin resistance and its association with neurodegenerative disorders, highlighting key molecular and cellular insights, therapeutic approaches, and future directions.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review article of pharmacovigilance and studies of clinical research for health care","authors":"S. Shaikh, Anuja Bharati, T. Dubey, Ruchi Thakur, Kadambari Bhosale, P. Bhoir","doi":"10.18231/j.ijcaap.2024.017","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.017","url":null,"abstract":"Pharmacovigilance, the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug- related problems, is intrinsically linked to effective information management. The pivotal role of information in pharmacovigilance encompassing data collection, analysis, and dissemination for optimal patient safety. The foundation of pharmacovigilance lies in robust information system that facilitate the collection of adverse event reports from healthcare professionals, patients, and other stakeholder. The evolution of data sources, emphasizing the integration of electronic health records, wearable devices and real world evidence to enhance the depth and breadth of information available for analysis. Innovative technologies, including artificial intelligence and machine learning, are transforming pharmacovigilance by automating signal detection and predictive modeling. How those tools are utilized to sift through vast datasets, identifying potential safety concerns and aiding regulatory decision-making. Furthermore, the abstract delves into the importance of structured information sharing between regulatory agencies, pharmaceutical companies, healthcare providers. Timely transparent communication of safety information ensure a proactive response to emerging risk and enable the development of effective risk management strategies.The continues evaluation of information management strategies to adapt to the complexities of modern healthcare and pharmaceutical innovation. In essence, this abstract illuminates the symbiotic relationship between pharmacovigilance and information management, showcasing how the effective utilization of diverse and high quality data is fundamental to advancing drug safety practices and safeguarding public health.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"4 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tandam mass spectrometry instrumentation and application in pharmaceutical analysis","authors":"Tarashankar Basuri, Swatika S. Varli","doi":"10.18231/j.ijcaap.2024.015","DOIUrl":"https://doi.org/10.18231/j.ijcaap.2024.015","url":null,"abstract":"Proteins and peptides can be analyzed using mass spectrometry (MS) using a range of techniques, including matrix-aided laser desorption ionization-mass spectrometry (MALDI-MS) and electrospray ionization-mass spectrometry (ESI-MS). These techniques make it possible to determine a protein's mass as an intact molecule or to identify a protein using peptide-mass fingerprinting that is produced during enzymatic digestion. The amino acid sequence of proteins (top-down and middle-down proteomics) and peptides (bottom-up proteomics) can be ascertained by fragmenting the proteins and peptides using tandem mass spectrometry (MS/MS). Furthermore, post-translational modifications (PTMs) of proteins and peptides can be identified using tandem mass spectrometry. In this article, we go over the use of MS/MS in biomedical research and provide concrete examples of how to identify proteins, peptides, and their PTMs as useful biomarkers for diagnosis and treatment. In numerous applications, tandem mass spectrometry (MS/MS) has shown to be a practical and efficient analytical method for the direct detection of target compounds in food samples. It combines the power of MS/MS as an identification and confirmation approach with the separation capabilities of chromatography when used with chromatographic techniques.","PeriodicalId":475182,"journal":{"name":"IP international journal of comprehensive and advanced pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}