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Is Gentamicin Elution Influenced by the Timing of Antibiotic Addition to the Bone Cement? An In Vitro Study on Articulating Hip Spacers 庆大霉素洗脱是否受骨水泥添加抗生素时机的影响?关节髋关节垫片的体外研究

Prosthesis Pub Date : 2023-09-12 DOI: 10.3390/prosthesis5030066

Giorgio Cacciola, Francesco Bosco, Fortunato Giustra, Federico De Meo, Antongiulio Bruschetta, Luigi Sabatini, Stefano Artiaco, Diogenes Giraldo, Alessandro Massè, Pietro Cavaliere

{"title":"Is Gentamicin Elution Influenced by the Timing of Antibiotic Addition to the Bone Cement? An In Vitro Study on Articulating Hip Spacers","authors":"Giorgio Cacciola, Francesco Bosco, Fortunato Giustra, Federico De Meo, Antongiulio Bruschetta, Luigi Sabatini, Stefano Artiaco, Diogenes Giraldo, Alessandro Massè, Pietro Cavaliere","doi":"10.3390/prosthesis5030066","DOIUrl":"https://doi.org/10.3390/prosthesis5030066","url":null,"abstract":"Periprosthetic Joint Infection (PJI) is a challenging complication after joint replacements, and cement spacers are standard treatment in two-stage revision surgery. This experimental in vitro study aimed to evaluate the elution properties of different gentamicin formulations from commercially available intraoperative molded hip cement spacers. The study compared spacers prepared with premixed antibiotic bone cement, spacers with antibiotic powder added during preparation, spacers stored for two months, and spacers with an additional antibiotic. The results showed that the timing of antibiotic addition influenced gentamicin elution, with immediate elution resulting in higher levels than stored spacers. Spacers with antibiotic powder added during preparation exhibited higher elution than premixed antibiotic spacers. Furthermore, adding vancomycin to the bone cement significantly increased gentamicin elution. These findings suggest that optimizing the timing and method of antibiotic addition in cement spacers may enhance the effectiveness of antibiotic treatment in PJI. However, further research is needed to validate these findings and explore their clinical implications.","PeriodicalId":474580,"journal":{"name":"Prosthesis","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Roughness of Enamel and Dentin after Preparation Finishing with Rotary Burs or Piezoelectric Instruments 用旋转毛刺或压电仪器加工后牙釉质和牙本质的表面粗糙度

Prosthesis Pub Date : 2023-08-02 DOI: 10.3390/prosthesis5030050

Antonio Rapani, Federico Berton, Amedeo Tramontin, Gianluca Turco, Giulio Marchesi, Roberto Di Lenarda, Claudio Stacchi

{"title":"Surface Roughness of Enamel and Dentin after Preparation Finishing with Rotary Burs or Piezoelectric Instruments","authors":"Antonio Rapani, Federico Berton, Amedeo Tramontin, Gianluca Turco, Giulio Marchesi, Roberto Di Lenarda, Claudio Stacchi","doi":"10.3390/prosthesis5030050","DOIUrl":"https://doi.org/10.3390/prosthesis5030050","url":null,"abstract":"This study compares the effect of different handpieces (turbine, high-speed electric handpiece and piezoelectric device) on surface roughness of enamel and dentin when using diamond-coated working tips and burs of the same grit size. The experiment was conducted on 15 extracted first molars from patients aged 45 to 60 years. The occlusal portion was removed using a diamond-coated water wheel and then refined with a 120–130 μm grit bur in order to obtain a flat surface with an adequate exposition of the dentin core. Each surface was divided into three portions and every portion was finished with one of the three tested instruments. The rotary burs and piezoelectric tips had the same grit size (60 μm), and the load on handpiece during preparation never exceeded 150 g. Roughness parameters (Ra, Rsk, Rku) were recorded with a profilometer, and a SEM analysis of treated surfaces and working tips was conducted. Ra and Rsk differed significantly between enamel and dentin only after using turbine (p = 0.004 and p = 0.007, respectively). No significant differences were observed in Ra, Rsk and Rku between enamel and dentin when using a high-speed electric handpiece or piezoelectric device. The turbine produced higher Ra and Rsk values on dentin than the other devices, while no significant differences were found between piezoelectric handpiece and high-speed electric contra-angle on both substrates. Summarizing, the findings of the present study demonstrated that turbine generated rougher surfaces on dentin compared to the other handpieces. Moreover, the turbine produced more asymmetrical surface profiles on both enamel and dentin. However, it should be considered that these differences in roughness (Ra) were within the range of 0.25–0.30 μm: it is still unclear if these variations, although statistically significant, will influence final clinical outcomes.","PeriodicalId":474580,"journal":{"name":"Prosthesis","volume":"164 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135015985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictability and Effectiveness of Jaws Reconstructive Prosthesis after Tumor Removal: A Systematic Review and Meta-Analysis 肿瘤切除后颌骨重建假体的可预测性和有效性:系统回顾和荟萃分析

Prosthesis Pub Date : 2023-06-07 DOI: 10.3390/prosthesis5020039

Salvatore Crimi, Alberto Bianchi, Rocco Franco, Marco Cicciù, Giuseppe Minervini

{"title":"Predictability and Effectiveness of Jaws Reconstructive Prosthesis after Tumor Removal: A Systematic Review and Meta-Analysis","authors":"Salvatore Crimi, Alberto Bianchi, Rocco Franco, Marco Cicciù, Giuseppe Minervini","doi":"10.3390/prosthesis5020039","DOIUrl":"https://doi.org/10.3390/prosthesis5020039","url":null,"abstract":"Vascular-free flaps are the most frequently employed method in cases of jaws reconstruction after large tumor removal. This therapeutic choice is due to its intrinsic blood supply, which speeds up recovery and enables healing apart from the injured recipient site. This method is most commonly used in secondary reconstructions brought on by radiation, infection, or prior surgical intervention. In fact, with the help of 3d technology, guides can be designed to perform the grafting very smoothly. The purpose of this review with meta-analysis is to compare the two methods: the one using 3d and the freehand one. Methods: In accordance with the entered keywords, a literature search was conducted on PubMed, Lilacs, and Web of Science. Articles published between 2000 and 4 January 2023 were taken into consideration. Using the Boolean connective AND, the terms “jaw reconstruction”, “cad-cam”, and “cancer” have been joined. Results: After searching the three search motors, 148 articles were selected, and only 7 were chosen for this review. Conclusions: The pre-operative morphological position looks to be accurately restored using the CAD/CAM reconstructive methodology. Reconstruction using CAD-CAM and 3d technology allows for greater accuracy, less operative time, and improved aesthetics.","PeriodicalId":474580,"journal":{"name":"Prosthesis","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135449511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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