International Journal of Current Innovations in Advanced Research最新文献

International Journal of Current Innovations in Advanced Research Pub Date : 2024-07-22 DOI: 10.47957/ijciar.v7i2.174

Suresh Chappa

引用次数: 0

Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis 米利珠单抗作为溃疡性结肠炎的诱导和维持疗法

International Journal of Current Innovations in Advanced Research Pub Date : 2024-07-22 DOI: 10.47957/ijciar.v7i2.176

Ventakata Raju Cheedarala

{"title":"Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis","authors":"Ventakata Raju Cheedarala","doi":"10.47957/ijciar.v7i2.176","DOIUrl":"https://doi.org/10.47957/ijciar.v7i2.176","url":null,"abstract":"A monoclonal antibody called mirikizumab is used to treat ulcerative colitis. It is marketed under the Omvoh brand. It is intended to bind to interleukin-23 (IL-23) and obstruct its function. Upper respiratory tract (nose and throat) infections, headaches, rashes, and injection site responses (when administered by subcutaneous injection) are the most frequent adverse effects. In the United States in October 2023 and the European Union in May 2023, mirikizumab was authorized for medicinal use. For the treatment of people with moderately to highly active ulcerative colitis who have not responded well to, have lost responsiveness to, or are intolerant to either biologic therapy or conventional therapy, mirikizumab is suggested. A subset of people with ulcerative colitis (UC) do not react to currently available medications, despite advancements in UC medical therapy. Many innovative medications have recently acquired regulatory approval for use in UC, or are in the latter stages of development. The novel antibody mirikizumab, which is given intravenously (IV), binds to the inflammatory protein interleukin 23 and inhibits its function, preventing inflammation from being triggered. For individuals with moderately to highly active UC, mirikizumab would therefore provide an additional therapy choice if legalized.","PeriodicalId":474394,"journal":{"name":"International Journal of Current Innovations in Advanced Research","volume":"2 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Saliva as a Sensor Detector in Marking Oral Cancer 唾液作为口腔癌标记传感器的意义

International Journal of Current Innovations in Advanced Research Pub Date : 2024-07-22 DOI: 10.47957/ijciar.v7i2.175

Tirsa Chebrolu

{"title":"Significance of Saliva as a Sensor Detector in Marking Oral Cancer","authors":"Tirsa Chebrolu","doi":"10.47957/ijciar.v7i2.175","DOIUrl":"https://doi.org/10.47957/ijciar.v7i2.175","url":null,"abstract":"One of the most deadly forms of cancer is oral cancer. Since the screening methods currently in use are poor, a consistent portion of oral health issues are diagnosed at any late stage. Because existing diagnostic processes are complex and imprecise, it would be imperative to enhance them. The possibility of diagnosis by the discovery of biomarkers from biological fluids. The salivary glands secrete protein, peptides, electrolytes, organic and inorganic salts, and gingival crevicular fluids and mucosal transudates, which contribute in a complementary manner to human whole mouth saliva. This study focuses on biosensors that work at the molecular level, such as DNA, RNA, and protein biosensors, and it discusses tactics that use diverse biosensors to target different types of biomarkers. We also looked at non-invasive electrochemical techniques, optical techniques, and nanobiosensors for analyzing the cancer biomarkers found in bodily fluids including serum and saliva. Consequently, this review clarifies the advancements made in the creation of novel biosensors for the early identification and diagnosis of oral cancer. To clearly clarify the clinical situation, an introduction to oral cancer diagnosis, prognosis, and treatment is provided. Saliva is then offered as an alternative biofluid, along with its benefits, drawbacks, and methods of collection. It is suggested that salivary biomarkers be used as non-invasive diagnostic instruments.","PeriodicalId":474394,"journal":{"name":"International Journal of Current Innovations in Advanced Research","volume":"20 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization heart disease prediction using independent component analysis and support vector machine 利用独立成分分析和支持向量机优化心脏病预测

International Journal of Current Innovations in Advanced Research Pub Date : 2024-04-11 DOI: 10.47957/ijciar.v7i1.168

Abbas Nawar Khalifa

{"title":"Optimization heart disease prediction using independent component analysis and support vector machine","authors":"Abbas Nawar Khalifa","doi":"10.47957/ijciar.v7i1.168","DOIUrl":"https://doi.org/10.47957/ijciar.v7i1.168","url":null,"abstract":"Prediction models play a crucial role in early detection and intervention for cardiac diseases. However, their effectiveness is often hindered by limitations inherent in current methodologies. This paper proposes a novel approach to address these challenges by integrating Independent Component Analysis (ICA) with the Support Vector Machine (SVM) technique. Utilizing a comprehensive Cleveland dataset, our model achieves notable performance metrics, including an accuracy of 90.16%, an Area Under the Curve (AUC) of 96.66%, precision of 90.02%, recall of 90.00%, F1-score of 90.00%, and a minimal log loss of 3.54. Our methodology not only surpasses previous methodologies through extensive comparative analysis but also addresses common constraints identified in existing literature. These limitations encompass insufficient feature representation, overfitting, and a lack of proactive intervention strategies. By amalgamating ICA with SVM, our model enhances feature extraction, mitigates overfitting, and facilitates proactive diagnosis and intervention in individuals suspected of having heart disease. This study underscores the importance of mitigating current literature limitations and underscores the potential of integrating contemporary machine-learning techniques to advance prediction models for heart disease.","PeriodicalId":474394,"journal":{"name":"International Journal of Current Innovations in Advanced Research","volume":"25 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140715232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current therapies of urinary tract infections and prevention of multi drug resistance 尿路感染的当前疗法和多重抗药性的预防

International Journal of Current Innovations in Advanced Research Pub Date : 2024-02-24 DOI: 10.47957/ijciar.v7i1.167

Krishna Kumari Balusupati, Srivardhini Sura, Ruchitha Pavani Pinneboina, Venakata Nagaraju. Gorre

引用次数: 0

In vitro Antioxidant, Cytotoxic, and Anti-Tubercular activities of Cleome gynandrawhole plant extracts 金缕梅全植物提取物的体外抗氧化、细胞毒和抗结核活性

International Journal of Current Innovations in Advanced Research Pub Date : 2023-09-16 DOI: 10.47957/ijciar.v6i3.156

Pavani Gayatri Alluri, Saikrishna N, Mohan Gandhi Bonthu

{"title":"In vitro Antioxidant, Cytotoxic, and Anti-Tubercular activities of Cleome gynandrawhole plant extracts","authors":"Pavani Gayatri Alluri, Saikrishna N, Mohan Gandhi Bonthu","doi":"10.47957/ijciar.v6i3.156","DOIUrl":"https://doi.org/10.47957/ijciar.v6i3.156","url":null,"abstract":"The current study investigates the antioxidant, anticancer, and anti-TB characteristics of Cleome gynandra, a traditional medicine herb. The research shows that C. gynandra has significant radical scavenging activity, suggesting it may be a natural antioxidant that can reduce oxidative stress and cancer. Several cell lines were cytotoxic by plant extracts. The ethanol extract had the maximum cytotoxicity against MCF-7 cells, while the diethyl ether extract had the highest against HCT-116 cells. The hexane extract cytotoxically affected HepG2, HCT-116, and L6 cells. The aqueous extract of C. gynandra had the lowest cytotoxicity of the cell lines studied. The cytotoxic effects of C. gynandra extracts were highly selective, especially when targeting MCF-7 and HCT-116 cell lines. The study found that the hexane extract had the strongest anti-tuberculosis (TB) effects, with an IC50 of 1.01 µg/ml. The ethanol extract had a substantially lower IC50 value of 7.599 µg/ml, while the ether extract had an IC50 value of 32.7 µg/ml. Finally, the aqueous extract had the highest IC50 value of 793.3 µg/ml. The results suggest that C. gynandra could be used to generate natural anticancer drugs with fewer side effects. The plant's potential anticancer effect's mechanism needs further in vitro and in vivo research.","PeriodicalId":474394,"journal":{"name":"International Journal of Current Innovations in Advanced Research","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135353313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0