COAST Journal of the School of Science最新文献

THERMAL STABILITY STUDY OF METAL CARBOXYLATES OF Cucurbita pepo SEED OIL 葫芦籽油金属羧酸盐的热稳定性研究

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.1

O. M. Folarin

引用次数: 0

DECIPHERING HUMAN ESTROGEN RECEPTOR-2 INHIBITOR FROM Momordica charantia: COMPUTATIONAL MODELS AGAINST BREAST CANCER. 从 Momordica charantia 中提取人类表皮生长因子受体-2 抑制剂：抗乳腺癌的计算模型。

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.4

J. A. Saliu

{"title":"DECIPHERING HUMAN ESTROGEN RECEPTOR-2 INHIBITOR FROM Momordica charantia: COMPUTATIONAL MODELS AGAINST BREAST CANCER.","authors":"J. A. Saliu","doi":"10.61281/coastjss.v6i1.4","DOIUrl":"https://doi.org/10.61281/coastjss.v6i1.4","url":null,"abstract":"HER-2, or Human Epidermal Growth Factor Receptor-2, is a constituent of the epidermal growth factor receptor family, possessing tyrosine kinase properties. Its over-expression has been correlated with breast cancer. On the other hand, the pharmacological potential of Momordica charantia has been attributed to the phytocompounds. Herein, the inhibiting potential of phytocompounds from M. charantia against HER-2 was investigated using computational approaches. Maestro Schrodinger software (2021 v 12.1) was used to perform molecular docking, molecular mechanics generalized Born surface area (MM/GBSA), and pharmacokinetics prediction of a hundred phytocompounds from M. charantia against HER-2. The result revealed that among the phytocompounds, ve (5) showed promising inhibitory potential comparable to the standard drug, Getinib. The MM/GBSA result showed that Rutin, Quercetin, Isoquerrcitrin, Folic Acid, and riboavin formed a more stable complex with HER-2 than Getinib. The pharmacokinetics prole of the hit compounds showed that the hit compounds except riboavin violated two or more of Lipinski's rule of ve. In conclusion, the bioactive compounds found in M. charantia could potentially act as primary candidates for the creation of effective inhibitors targeting HER-2 in the treatment of breast cancer.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"34 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETECTION OF UNHEALTHY WEBSITES USING MACHINE LEARNING 利用机器学习检测不健康网站

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.5

O. A. Gbadamosi, A. M. Oduwale

{"title":"DETECTION OF UNHEALTHY WEBSITES USING MACHINE LEARNING","authors":"O. A. Gbadamosi, A. M. Oduwale","doi":"10.61281/coastjss.v6i1.5","DOIUrl":"https://doi.org/10.61281/coastjss.v6i1.5","url":null,"abstract":"In recent years, advancements in Internet and cloud technologies have led to a signicant increase in electronic trading in which consumers make online purchases and transactions. Accompanying this achievement are vices like unauthorized access to users' sensitive information and damages to enterprise resources. Phishing is one of the familiar attacks that trick users to access malicious content and gain their information. This study aims to develop an efcient machine-learning program to detect phishing websites with high accuracy. Most phishing webpages look identical to the actual web pages and various strategies for detecting phishing websites, such as blacklisting, and heuristics, among others have been suggested. Existing research works showed that the performance of the phishing detection system is limited and there is a demand for intelligent techniques to protect users from cyber-attacks. A Uniform resource locator (URL) detection technique based on a supervised machine learning approach – Naïve Bayes is employed and implemented in Python programming language. The efcacy of this approach was determined on a phishing dataset made up of 7900 malicious and 5800 legitimate sites, respectively. The results show that using the proposed methodology an accuracy of 96% can be achieved by using stacking, ltering along the Naïve Bayes and logistic regression. This study thoroughly investigates the use of machine laearning with features extracted from the URLs and was able to showcase common words for the identication of either phishing (unhealthy) or good websites and proffered a guide to end users against the recent approaches in malicious URLs detection.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"177 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARATIVE WOOD ANATOMY OF FOUR Vernonia delile SPECIES (ASTERACEAE) IN SOUTHWESTERN NIGERIA. 尼日利亚西南部四个 Vernonia delile 品种（ASTERACEAE）的木材解剖比较。

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.2

T. A. Abeegunrin

{"title":"COMPARATIVE WOOD ANATOMY OF FOUR Vernonia delile SPECIES (ASTERACEAE) IN SOUTHWESTERN NIGERIA.","authors":"T. A. Abeegunrin","doi":"10.61281/coastjss.v6i1.2","DOIUrl":"https://doi.org/10.61281/coastjss.v6i1.2","url":null,"abstract":"Wood anatomy of four Vernonia Delile species in Southwestern States of Nigeria was investigated with a view to identifying the anatomical features of the genus that could be used to delimit the taxa. Plant samples were collected from Oyo, Ekiti, Osun and Ondo States. Transverse, tangential and radial longitudinal sections were made from the wood of the species of Vernonia using Reichert sliding microtome at 10μm thickness. The woods were also macerated with Schultze's uid to separate the tissues and cells. The macerates and cut sections were stained with Safranine O reagent to reveal the differences in tissue arrangements, shapes and cell inclusions. The four species showed common anatomical features: pore shape at transverse plane are oval, round, rectangular circular to cylindrical, simple pitting of vessel elements and presence of - uniseriate, biseriate and multiseriate rays. The wood characteristics that can be used to distinguish the taxa are absent and presence of : tylose, bre length and percentage of solitary vessel, axial parenchyma type and its absence. These features conferred signicant taxonomic difference in the species and members were categorized into three major groups. These ndings serve as baseline for further research such as molecular studies.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SYNTHESIS OF STRUCTURED ZINC SELENIDE FOR OPTOELECTRONIC APPLICATIONS 合成用于光电应用的结构化硒化锌

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.3

O. Olubosede, A. Faremi, O. Fadipe, O. S. Adigbo, C.Y. Daramola

引用次数: 0

EXPLORING THE THERAPEUTIC POTENTIAL OF TOMATO VARIETIES IN ALZHEIMER'S DISEASE: A FOCUS ON RADICAL SCAVENGING ABILITIES AND ACETYLCHOLINESTERASE INHIBITION. 探索番茄品种对老年痴呆症的治疗潜力：重点关注自由基清除能力和乙酰胆碱酯酶抑制作用。

COAST Journal of the School of Science Pub Date : 2024-06-03 DOI: 10.61281/coastjss.v6i1.6

O. Y. Adeniran

{"title":"EXPLORING THE THERAPEUTIC POTENTIAL OF TOMATO VARIETIES IN ALZHEIMER'S DISEASE: A FOCUS ON RADICAL SCAVENGING ABILITIES AND ACETYLCHOLINESTERASE INHIBITION.","authors":"O. Y. Adeniran","doi":"10.61281/coastjss.v6i1.6","DOIUrl":"https://doi.org/10.61281/coastjss.v6i1.6","url":null,"abstract":"Alzheimer's disease presents a signicant global health challenge, with limited effective treatments available. Natural compounds, particularly those found in fruits and vegetables, have garnered attention for their potential therapeutic benets in Alzheimer's disease. In this study, investigation was carried out on the antioxidant and neuroprotective properties of three tomato varieties Trichosanthes cucumerina (Snake tomato), Solanum lycopersicum Linn (Hausa variety), and Solanum lycopersicum Linn (Yoruba variety) in an Alzheimer's disease model induced by aluminum chloride using Drosophila melanogaster. Through in vivo and in vitro analysis, the radical scavenging abilities and acetylcholinesterase inhibition of each tomato variety was assessed. Findings reveal that Snake tomato exhibits potent radical scavenging abilities and signicant AChE inhibition, suggesting its therapeutic potential in mitigating Alzheimer's disease pathology. Additionally, the antioxidant properties of Snake tomato correlated with its phenolic and avonoid contents, highlighting its neuroprotective effects. While Solanum lycopersicum Linn (Hausa and Yoruba varieties) also demonstrated antioxidant properties, Snake tomato emerged as the most promising candidate for Alzheimer's disease management. These results show the importance of exploring natural compounds as alternative therapeutic approaches for Alzheimer's disease and warrant further investigation into the mechanisms underlying the therapeutic effects of tomato varieties.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMBIENT AIR QUALLTY MONITORING OF AN EDUCATIONAL INSTITUTION IN NIGERIA 尼日利亚某教育机构环境空气质量监测

COAST Journal of the School of Science Pub Date : 2023-05-01 DOI: 10.61281/coastjss.v5i1.4

O Itebimien

{"title":"AMBIENT AIR QUALLTY MONITORING OF AN EDUCATIONAL INSTITUTION IN NIGERIA","authors":"O Itebimien","doi":"10.61281/coastjss.v5i1.4","DOIUrl":"https://doi.org/10.61281/coastjss.v5i1.4","url":null,"abstract":"Air quality monitoring was conducted for 15 outdoor locations within an educational institution in Nigeria for 3 consecutive months during dry season using portable pre-calibrated gas monitors to obtain a scientific data on the ambient air quality status. Pollutants which include total volatile organic compounds (TVOCs) and formaldehyde (HCHO) were monitored using Air Ae Steward Air quality monitor. Carbon monoxide (CO), nitrogen dioxide (NO2), sulphur dioxide (SO2), hydrogen sulphide (H2S) hydrogen cyanide (HCN), ammonia (NH3) and chlorine (Cl2) were measured using gasman portable monitors. Meteorological parameters including temperature, relative humidity and wind speed were measured using Air Ae Steward Air quality monitor and MASTECH Anemometer, respectively. The pollutants concentrations ranges between 0.1±0.0 - 2.8±1.0 mg/m3 (TVOCs), 0.1±0.0 - 0.8±0.0 mg/m3 (HCHO), 0.1±0.0 - 0.3±0.0 ppm (NO2), 0.1±0.0 - 0.3±0.0 ppm (SO2), 2.0±0.0 - 6.5±0.5 ppm (CO), 2.0±0.0 - 6.0±0.0 ppm (NH3), 0.3±0.0 - 0.7±0.1 ppm (Cl2), 0.1±0.0 - 0.3±0.0 ppm (H2S), 0.1±0.0 ppm (HCN). The results obtained were analysed by comparing with FEPA, WHO and US EPA guidelines and NO2, NH3 and Cl2 were found in concentrations that exceeded recommended limits across all the locations while SO2, H2S and HCHO exceeded in some locations and CO, HCN and TVOCs were below the recommended limit across all the locations.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135563565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forage nutritional properties of Four Accessions of Andropogon gayanus-Andropogon tectorum in Southwestern Nigeria 奈及利亚西南部4个雄性雄性的饲料营养特性

COAST Journal of the School of Science Pub Date : 2023-05-01 DOI: 10.61281/coastjss.v5i1.2

F.M Ojo

{"title":"Forage nutritional properties of Four Accessions of Andropogon gayanus-Andropogon tectorum in Southwestern Nigeria","authors":"F.M Ojo","doi":"10.61281/coastjss.v5i1.2","DOIUrl":"https://doi.org/10.61281/coastjss.v5i1.2","url":null,"abstract":"Accessions of Andropogon gayanus-Andropogon tectorum collected from Southwestern Nigeria were evaluated for their forage nutritional properties and potentials as fodder using standard procedures. Field trips for plant collection covered the agro-ecological zones of the following states in Nigeria: Ekiti, Ogun, Ondo, Osun and Oyo and the parts used were leaves and young stems. The proximate analysis revealed that moisture contents were moderate in all plant parts used (45.56%-71.46%) and the highest were recorded in the stem of A. gayanus. The percentage fat and nitrogen contents were low in all the accessions studied (0.20-0.38%) and (0.60-0.90%) respectively. The lowest value of crude fibre, ash and dry matter contents were recorded in the leaves and stems of A. gayanus. The lowest and the highest values of Lignin contents and carbohydrate contents were recorded in the leaves and stems of A. gayanus. A. gayanus had the lowest source of protein (3.75-3.78%). The concentrations of these mineral elements are within recommended range for animal feeds except for phosphorous. The study revealed the species (A. gayanus and A. tectorum) are good sources of proteins and carbohydrates, calcium, magnesium, potassium, sodium, manganese, iron, copper and zinc and are high enough to meet the requirements of animals; sheep and most especially cattle (for beef and dairy). . The presence of these substances in good quantities indicates the potentials of the examined Andropogon species as good fodders.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135563563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETERMINATION OF POLYCHLORINATED BIPHENYLS (PCBs) IN SURFACE WATER IN ONDO STATE NIGERIA 尼日利亚昂多州地表水中多氯联苯的测定

COAST Journal of the School of Science Pub Date : 2023-05-01 DOI: 10.61281/coastjss.v5i1.3

T.F Ediagbonya

{"title":"DETERMINATION OF POLYCHLORINATED BIPHENYLS (PCBs) IN SURFACE WATER IN ONDO STATE NIGERIA","authors":"T.F Ediagbonya","doi":"10.61281/coastjss.v5i1.3","DOIUrl":"https://doi.org/10.61281/coastjss.v5i1.3","url":null,"abstract":"Polychlorinated biphenyl compounds (PCBs) were included to the Stockholm Convention's list of typical persistent organic pollutants on May 22, 2001. (POPs). Humans have produced PCBs, which are pervasive in the environment. They are a concern for people all around the world because of their toxic, bioaccumulative, long-lasting, hydrophobic, and transboundary characteristics. The study's goals included describing how PCBs are distributed in surface water and evaluating how certain physiochemical factors affect PCB concentrations. Five separate Okitipupa locations—OAUSTECH, Igodan, Okunmo, Idepe, and Lebi/Ofe River—had their water samples taken. The overall average concentration of PCBs discovered in the samples taken from five (5) distinct places was determined to be as follows: OAUSTECH (5.720.13), Igodan (5.520.00), Okunmo (3.480.03), Idepe (21.830.02), and Lebi/Ofe (0.160.00), with their combined probability being determined to be 0.001. Twenty-five (25) PCB congeners were examined using a gas chromatography-electron capture detector (GC-ECD). The majority of congeners were below the detection threshold at every site. Total PCB values varied from 0.16 g/L to 21.83 g/L. The correlation between the overall level of polychlorinated biphenyls and the total organic carbon was positive (0.214), but it was weak (PCBs) and pH, positive (0.096) but poor correlation between the electrical conductivity, and a positive (0.220). The levels found in this investigation, with the exception of one area, were obviously lower than the 0.5μg/l level advised by the WHO. The water's concentration of polychlorinated biphenyls (PCBs) is not significantly impacted by the physicochemical characteristics, and the water is safe to use for household purposes.","PeriodicalId":474287,"journal":{"name":"COAST Journal of the School of Science","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135563564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0