Biologic orthopedic journal最新文献

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Very Small Embryonic-Like Stem Cells 非常小胚胎样干细胞

Biologic orthopedic journal Pub Date : 2023-05-09 DOI: 10.22374/boj.v5i1.30

Pierdanilo Sanna, Loubna Abdel Hadi, Rene Antonio Rivero-Jimenez, Antonio Alfonso Bencomo-Hernandez, Yasmine Maher Ahmed, Gina Marcela Torres-Zambrano, Yendry Ventura-Carmenate

{"title":"Very Small Embryonic-Like Stem Cells","authors":"Pierdanilo Sanna, Loubna Abdel Hadi, Rene Antonio Rivero-Jimenez, Antonio Alfonso Bencomo-Hernandez, Yasmine Maher Ahmed, Gina Marcela Torres-Zambrano, Yendry Ventura-Carmenate","doi":"10.22374/boj.v5i1.30","DOIUrl":"https://doi.org/10.22374/boj.v5i1.30","url":null,"abstract":"Continuous and growing research studies regarding the clinical applications of the pluripotent or multipo-tent stem cells with their potential to differentiate into three germ layers are very well conducted in regenerative medicine (RM). In this review, we report the recent clinical applications and potential use of very small embryonic-like stem cells (VSELs) in orthopedics. VSELs are nonhematopoietic (CD45 - / Lin -), rare, and very small cells; they were reported as “dormant” cells in the bone marrow (BM), but are also found in cord blood, peripheral blood (PB), and in adult organs. Based on their capability to express markers of pluripotency (such as Oct-4 +/Nanog +/SSEA-1/4+/CXCR4+), it has been hypothesized that these cells could be early deposited during the embryonic development as descendants of epiblast-derived stem cells and perhaps from some primordial germ cells. VSELs can be released or mobilized from the BM to the PB during tissue injury and stress, facilitating the regeneration of damaged tissues. As well as mesenchymal stem cells, nowadays VSELs can be expanded ex vivo. Their pluripotency could be suitable for applications in RM, solving several problems regarding the use of both controversial embryonic stem cells and induced pluripotent stem cells. VSELs studies will hopefully open new frontiers to better understand their potential that would be relevant for future applications in RM and translational research.","PeriodicalId":472435,"journal":{"name":"Biologic orthopedic journal","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135757806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteonecrosis of the Femoral Head: Current state of Therapy and Outcomes 股骨头坏死:目前的治疗状况和结果

Biologic orthopedic journal Pub Date : 2023-05-05 DOI: 10.22374/boj.v3isp1.22

Ziad El Rabih, Anton Doro, Yusuke Kubo, Thomas Pufe, Wolf Drescher

引用次数: 0