American Journal of Perinatology Reports最新文献

A Case of Congenital Myasthenia Gravis Due to ChAT Gene Mutation in a Term Neonate: A Case Report 一例足月新生儿因 ChAT 基因突变导致的先天性肌无力：病例报告

American Journal of Perinatology Reports Pub Date : 2024-07-10 DOI: 10.1055/a-2363-6319

Maya Soufan, Haya Soufan, Kushagra Chaudhari, Judith Klarr

{"title":"A Case of Congenital Myasthenia Gravis Due to ChAT Gene Mutation in a Term Neonate: A Case Report","authors":"Maya Soufan, Haya Soufan, Kushagra Chaudhari, Judith Klarr","doi":"10.1055/a-2363-6319","DOIUrl":"https://doi.org/10.1055/a-2363-6319","url":null,"abstract":"Congenital myasthenia gravis syndrome (CMS) is a rare genetic heterogeneous disorder due to abnormal neuromuscular transmission caused by several genes. CMS caused by ChAT gene mutations have been reported in fifty-three cases since 2020, and only three of them have been identified as hemizygous mutations. \u0000 A 1-day-old term neonate was transferred from the nursery to the neonatal intensive care unit (NICU) on 10 L of oxygen by face mask due to respiratory distress. Family history includes two ChAT gene variants in the elder brother and carrier genes in both parents. She was transitioned to CPAP +5 and chest x-ray showed poor chest expansion. Sepsis workup was negative. She was intubated due to worsening respiratory distress three days later. She was started on pyridostigmine, and genetic testing was done, which confirmed two ChAT gene mutations present. The patient had a tracheostomy placed on day 50 and was discharged on day 94 of life on tracheostomy and G-tube given feeding intolerance. \u0000 This case illustrates the value of genetic testing in determining the type of CMS to guide management and the importance of obtaining family history to have such syndromes earlier in the differential diagnosis to initiate treatment promptly.\u0000","PeriodicalId":470378,"journal":{"name":"American Journal of Perinatology Reports","volume":"6 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abdominal Fibromyxoid Sarcoma in Pregnancy: An Unusual Cause of Preterm Labor and Sepsis 妊娠期腹部纤维肉瘤：早产和败血症的不寻常原因

American Journal of Perinatology Reports Pub Date : 2024-05-24 DOI: 10.1055/a-2332-6187

Abigail Barger, Maya Vishnia, Marie Hanna, Rebecca Horgan, Juliana Gevaerd Martins

{"title":"Abdominal Fibromyxoid Sarcoma in Pregnancy: An Unusual Cause of Preterm Labor and Sepsis","authors":"Abigail Barger, Maya Vishnia, Marie Hanna, Rebecca Horgan, Juliana Gevaerd Martins","doi":"10.1055/a-2332-6187","DOIUrl":"https://doi.org/10.1055/a-2332-6187","url":null,"abstract":"Cancer in pregnancy is rare with most common cancers being melanomas, breast and cervical. Fibromyxoid sarcoma is a soft tissue tumor involving deep soft tissues of the extremities and trunk, rarely located in the abdomen. A low-grade fibromyxoid sarcoma (LGFMS) falls in the family of fibrosarcoma. Only two cases of LGFMS in pregnancy have been reported.\u0000We report a case of abdominal LGFMS in pregnancy leading to preterm labor, sepsis and an acute abdomen requiring surgery in the third trimester. 19-year-old woman, gravida 1 at 32 weeks and 5 days presented to an outside hospital with preterm contractions and cervical effacement. She had a known abdominal mass, suspected to be accessory liver lobe, measuring 9.0 x 6.4 x 7.7 cm in the right upper quadrant. At 33 weeks of gestation, she had developed fever and hypotension. MRI confirmed findings however visualized in the left side of the abdomen with suspected abscess. She underwent cesarean delivery, and complete surgical resection of the mass along with a small bowel resection. Final pathology of the mass revealed a LGFMS. This case also highlights the need for a multidisciplinary approach to manage a rare presentation of sepsis and preterm labor in pregnancy","PeriodicalId":470378,"journal":{"name":"American Journal of Perinatology Reports","volume":"70 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141101788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemic hepatitis and septic shock secondary to murine typhus infection in pregnancy 妊娠期感染鼠伤寒继发缺血性肝炎和脓毒性休克

American Journal of Perinatology Reports Pub Date : 2024-05-21 DOI: 10.1055/a-2330-4249

Marissa Berry, Amanda Wang, Rana Lahham, Xue Zhang, Luis Pacheco

引用次数: 0

Buprenorphine induction using microdosing for the management of opioid use disorder in pregnancy 利用微剂量丁丙诺啡诱导治疗妊娠期阿片类药物使用紊乱症

American Journal of Perinatology Reports Pub Date : 2024-01-22 DOI: 10.1055/a-2250-6419

Neil B Patel, Barbara Parilla

{"title":"Buprenorphine induction using microdosing for the management of opioid use disorder in pregnancy","authors":"Neil B Patel, Barbara Parilla","doi":"10.1055/a-2250-6419","DOIUrl":"https://doi.org/10.1055/a-2250-6419","url":null,"abstract":"Conventional buprenorphine inductions require patients to abstain from full agonist opioids until they experience mild to moderate opioid withdrawal. We describe a successful buprenorphine induction case in a pregnant patient using microdosing, which avoided withdrawal symptoms.\u0000\u0000Case: \u0000The patient is a 29 year old G2P1001 at 18 2/7 weeks of gestation, who desired a switch from methadone to buprenorphine to minimize neonatal opioid withdrawal syndrome (NOWS), which complicated her last pregnancy. She was given increasing microdoses of buprenorphine over a 7 day period, while continuing her daily dose of methadone. She discontinued the methadone on day 8. She did well during the week of buprenorphine microdosing, with no complaints of withdrawal or cravings. She was engaged in her prenatal care. Her dose of buprenorphine was increased to 8 mg bid in the third trimester for some withdrawal symptoms in the evening consisting of new onset nausea and vomiting.\u0000The patient underwent an elective 39 week induction of labor and had a spontaneous vaginal delivery of an appropriately grown male fetus. Only non-pharmacologic interventions were used.\u0000\u0000Conclusion: \u0000Buprenorphine microdosing was well tolerated in this patient and avoided withdrawal symptoms in the mothers, and NOWS. A microdosing study in pregnancy is indicated","PeriodicalId":470378,"journal":{"name":"American Journal of Perinatology Reports","volume":"19 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Drug Induced Liver Injury from Labetalol During the Postpartum Period: A Case Report 产后拉贝他洛尔致慢性药物性肝损伤1例

American Journal of Perinatology Reports Pub Date : 2023-11-11 DOI: 10.1055/a-2209-4636

Bruce Lee, Suriya Xiong, Elizabeth A. Westen, JulieAnn N. Warner

引用次数: 0

Lung Protective Ventilation During Pregnancy: An Observational Cohort Study 妊娠期肺保护性通气:一项观察性队列研究

American Journal of Perinatology Reports Pub Date : 2023-11-09 DOI: 10.1055/a-2207-9917

Yasaswi Kislovskiy, Alisse Hauspurg, Chenell Donadee, Sara Sakamoto, Raghavan Murugan

{"title":"Lung Protective Ventilation During Pregnancy: An Observational Cohort Study","authors":"Yasaswi Kislovskiy, Alisse Hauspurg, Chenell Donadee, Sara Sakamoto, Raghavan Murugan","doi":"10.1055/a-2207-9917","DOIUrl":"https://doi.org/10.1055/a-2207-9917","url":null,"abstract":"Objectives: We sought to describe characteristics of mechanically ventilated pregnant patients, evaluate utilization of low tidal volume ventilation (LTVV) and high tidal volume ventilation (HTVV) by trimester, and describe maternal and fetal outcomes by ventilation strategy. Study Design: This is a retrospective cohort study of pregnant women with mechanical ventilation for > 24 hours between July 2012 and August 2020 at a tertiary care academic medical center. We defined LTVV as average daily tidal volume ≤8 mL/kg of predicted body weight, and HTVV as >8ml/kg. We examined demographic characteristics, maternal and fetal characteristics and outcomes by ventilation strategy. Results: We identified 52 ventilated pregnant women, 43 had LTVV and 9 had HTVV. Acute respiratory distress syndrome occurred in 73% (N=38) of patients, and infection was a common indication for ventilation (N=33, 63%). Patients had LTVV more often than HTVV in all trimesters. Obstetric complications occurred frequently, 21% (N=11) experienced preeclampsia or eclampsia, and among 43 patients with available delivery data, 60% delivered preterm (N=26) and 16% had fetal demise (N=7). Conclusions: LTVV was utilized more often than HTVV among pregnant women in all trimesters. There was a high prevalence of maternal and fetal morbidity and fetal mortality among our cohort.","PeriodicalId":470378,"journal":{"name":"American Journal of Perinatology Reports","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135291197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case series of reproductive outcomes after surgical correction of obstructed hemi-vagina in OHVIRA OHVIRA半阴道梗阻手术矫正后生殖结局的病例系列分析

American Journal of Perinatology Reports Pub Date : 2023-11-09 DOI: 10.1055/a-2208-0032

Megan Bunnell, Marc Laufer, Danielle T Cipres

引用次数: 0

A case of an obstructed delivery by a large, lower uterine segment fibroid interlocked with a fetal mentum 一个大的，较低的子宫段肌瘤与胎心互锁导致难产的病例

American Journal of Perinatology Reports Pub Date : 2023-11-01 DOI: 10.1055/a-2202-4234

Sarah Elizabeth Miller, Hayley E Miller, Anne R Waldrop, Scarlett Karakash, Kate A Shaw

引用次数: 0

A spontaneous tubal heterotopic triplet pregnancy resulting in viable twin deliveries. 自然输卵管异位三胞胎妊娠导致有活力的双胞胎分娩。

American Journal of Perinatology Reports Pub Date : 2023-10-30 DOI: 10.1055/a-2201-5796

Luce A Kassi, Emma Lantos, Jordan Sheran, Lynn M Yee

引用次数: 0

A rare case of obstructive shock due to cardiac tamponade in a term pregnancy 足月妊娠心包填塞致梗阻性休克一例

American Journal of Perinatology Reports Pub Date : 2023-10-27 DOI: 10.1055/a-2200-3497

Megan Masten, Haya Kaliounji, Josephine Chou, Alexis Tumolo, Jonathan S Hirshberg, Lauren Sayres

{"title":"A rare case of obstructive shock due to cardiac tamponade in a term pregnancy","authors":"Megan Masten, Haya Kaliounji, Josephine Chou, Alexis Tumolo, Jonathan S Hirshberg, Lauren Sayres","doi":"10.1055/a-2200-3497","DOIUrl":"https://doi.org/10.1055/a-2200-3497","url":null,"abstract":"Background Obstructive shock due to cardiac tamponade is a rare, life-threatening occurrence in the peripartum period. Etiologies include preeclampsia, infection, autoimmune conditions, and malignancy. Early recognition of the underlying disease process allows for multidisciplinary treatment and a favorable outcome. Case A 33 year-old presented for cardiac tamponade identified in the peripartum period. She was diagnosed with preeclampsia with severe features immediately prior to her repeat Cesarean delivery and received magnesium prophylaxis. Postoperatively, she developed hypotension, tachycardia, and shortness of breath and was found to have a pericardial effusion with tamponade physiology. She underwent pericardial drain placement which was initially successful. However, she had recurrent symptomatic tamponade and thus a pericardial window was performed resulting in improvement of her symptoms. Workup revealed pericardial inflammation possibly secondary to a viral source, and she was successfully treated with anti-inflammatory therapy. Conclusion We hypothesize that this patient’s cardiac tamponade was caused by inflammatory pericarditis exacerbated by severe preeclampsia. Preeclampsia is a disease characterized by cardiovascular remodeling and fluid shifts in other compartments and thus is theorized to have contributed to this patient’s effusion. Cardiac tamponade should be considered in the differential for any parturient presenting with hypotension and shortness of breath.","PeriodicalId":470378,"journal":{"name":"American Journal of Perinatology Reports","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136316404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0