Papillomavirus Research最新文献

{"title":"Erratum regarding missing Declaration of Competing Interest statements in previously published articles","authors":"P. K. Surendran","doi":"10.1016/j.wse.2020.10.002","DOIUrl":"https://doi.org/10.1016/j.wse.2020.10.002","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"10 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wse.2020.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46227514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of human papillomaviruses in paired healthy skin and actinic keratosis by next generation sequencing","authors":"Luisa Galati ,&nbsp;Rosario Nicola Brancaccio ,&nbsp;Alexis Robitaille ,&nbsp;Cyrille Cuenin ,&nbsp;Fabiola Luzi ,&nbsp;Gianna Fiorucci ,&nbsp;Maria Vincenza Chiantore ,&nbsp;Nadia Marascio ,&nbsp;Giovanni Matera ,&nbsp;Maria Carla Liberto ,&nbsp;Maria Gabriella Donà ,&nbsp;Paola Di Bonito ,&nbsp;Tarik Gheit ,&nbsp;Massimo Tommasino","doi":"10.1016/j.pvr.2020.100196","DOIUrl":"10.1016/j.pvr.2020.100196","url":null,"abstract":"<div><p>Actinic keratosis (AK) arises on photo-damaged skin and is considered to be the precursor lesion of cutaneous squamous cell carcinoma (cSCC). Many findings support the involvement of β human papillomaviruses (HPVs) in cSCC, while very little is known on γ HPV types. The objective of this study was to characterize the spectrum of PV types in healthy skin (HS) and AK samples of the same immunocompetent individuals using next generation sequencing (NGS). Viral DNA of 244 AK and 242 HS specimens were amplified by PCR using two different sets of primers (FAP59/64 and FAPM1). Purified amplicons were pooled and sequenced using NGS. The study resulted in the identification of a large number of known β and γ PV types. In addition, 27 putative novel β and 16 γ and 4 unclassified PVs were isolated. HPV types of species γ-1 (e.g. HPV4) appeared to be strongly enriched in AK versus HS. The NGS analysis revealed that a large spectrum of known and novel PVs is present in HS and AK. The evidence that species γ-1 HPV types appears to be enriched in AK in comparison to HS warrants further studies to evaluate their role in development of skin (pre)cancerous lesions.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100196"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37779706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia","authors":"Felix Jede ,&nbsp;Theresa Brandt ,&nbsp;Molla Gedefaw ,&nbsp;Solomon Berhe Wubneh ,&nbsp;Tamrat Abebe ,&nbsp;Brhanu Teka ,&nbsp;Kassahun Alemu ,&nbsp;Binyam Tilahun ,&nbsp;Temesgen Azemeraw ,&nbsp;Abebaw Gebeyehu ,&nbsp;Dietmar Schmidt ,&nbsp;Aleksandra Pesic ,&nbsp;Andreas M. Kaufmann ,&nbsp;Bewketu Abebe ,&nbsp;Zelalem Ayichew ,&nbsp;Michael Byczkowski ,&nbsp;Timoté Vaucher ,&nbsp;Heike Sartor ,&nbsp;Gashaw Andargie ,&nbsp;Till Bärnighausen ,&nbsp;Hermann Bussmann","doi":"10.1016/j.pvr.2020.100198","DOIUrl":"10.1016/j.pvr.2020.100198","url":null,"abstract":"<div><p>Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place.</p><p>A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25–65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital.</p><p>Of 749 enumerated age-eligible women 634 (85%, (95% CI 82–88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53–62). The hrHPV prevalence was 14% (95% CI 5–22), 72% (95% CI 60–84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100198"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37942049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IPVS Policy Statement addressing the burden of HPV disease for Indigenous peoples","authors":"Beverley Lawton ,&nbsp;Margaret Heffernan ,&nbsp;George Wurtak ,&nbsp;Marc Steben ,&nbsp;Pema Lhaki ,&nbsp;Fiona Cram ,&nbsp;Magaly Blas ,&nbsp;Merilyn Hibma ,&nbsp;Anna Adcock ,&nbsp;Kendall Stevenson ,&nbsp;Lisa Whop ,&nbsp;Julia Brotherton ,&nbsp;Suzanne M. Garland","doi":"10.1016/j.pvr.2019.100191","DOIUrl":"10.1016/j.pvr.2019.100191","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100191"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.100191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37458199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Efficacy of strategies to increase participation in cervical cancer screening: GPs offering self-sampling kits for HPV testing versus recommendations to have a pap smear taken - A randomised controlled trial” [Papillomavirus Res. 9 (2020) 100194]","authors":"E. Peeters ,&nbsp;K. Cornet ,&nbsp;H. Cammu ,&nbsp;V. Verhoeven ,&nbsp;D. Devroey ,&nbsp;M. Arbyn","doi":"10.1016/j.pvr.2020.100201","DOIUrl":"10.1016/j.pvr.2020.100201","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100201"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37962328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylation analysis in urine fractions for optimal CIN3 and cervical cancer detection","authors":"Rianne van den Helder ,&nbsp;Nienke E. van Trommel ,&nbsp;Annina P. van Splunter ,&nbsp;Birgit I. Lissenberg-Witte ,&nbsp;Maaike C.G. Bleeker ,&nbsp;Renske D.M. Steenbergen","doi":"10.1016/j.pvr.2020.100193","DOIUrl":"10.1016/j.pvr.2020.100193","url":null,"abstract":"<div><h3>Introduction</h3><p>Urine sampling is an interesting solution for CIN3 and cervical cancer detection. Urine can be separated in different fractions: full void urine, urine sediment and urine supernatant. We aimed to determine which urine fraction is most competent for CIN3 and cervical cancer detection by methylation analysis.</p></div><div><h3>Methods</h3><p>Urine samples (27 controls, 30 CIN3 and 17 cervical cancer) were processed into 3 fractions and tested for 5 methylation markers (<em>ASCL1</em>, <em>GHSR</em>, <em>LHX8</em>, <em>SST</em>, <em>ZIC1</em>). We determined Spearman correlation coefficients between fractions, compared methylation levels and calculated AUCs for CIN3 and cancer detection.</p></div><div><h3>Results</h3><p>In general strong correlations (r &gt; 0.60) were found between urine fractions. Methylation levels increased significantly with severity of underlying disease in all urine fractions. CIN3 and controls differed significantly for 2 markers in full void urine, 4 markers in urine sediment and 1 marker in urine supernatant, with AUCs of 0.55–0.79. Comparison of cancer to controls was highly significant for all markers in all fractions, yielding AUCs of 0.87–0.99.</p></div><div><h3>Conclusion</h3><p>Methylation analysis performs excellent in all urine fractions for cervical cancer detection. Our results indicate the potential of CIN3 detection by urinary methylation analysis, and demonstrate that urine sediment performs best to detect CIN3.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100193"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37738341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IPVS policy statement. Equity in cervical cancer prevention: for all and not just for some","authors":"Julia Brotherton ,&nbsp;Cristyn Davies","doi":"10.1016/j.pvr.2019.100192","DOIUrl":"10.1016/j.pvr.2019.100192","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100192"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.100192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47221628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of strategies to increase participation in cervical cancer screening: GPs offering self-sampling kits for HPV testing versus recommendations to have a pap smear taken - A randomised controlled trial","authors":"E. Peeters ,&nbsp;K. Cornet ,&nbsp;D. Devroey ,&nbsp;M. Arbyn","doi":"10.1016/j.pvr.2020.100194","DOIUrl":"10.1016/j.pvr.2020.100194","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100194"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37742657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IPVS statement on “Temporary HPV vaccine shortage: Implications globally to achieve equity”","authors":"Suzanne M. Garland,&nbsp;Margaret A. Stanley,&nbsp;Anna R. Giuliano,&nbsp;Anna-Barbara Moscicki,&nbsp;Andreas Kaufmann,&nbsp;Neerja Bhatla,&nbsp;Yin Ling Woo","doi":"10.1016/j.pvr.2020.100195","DOIUrl":"10.1016/j.pvr.2020.100195","url":null,"abstract":"","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100195"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37764924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral HPV prevalence assessment by Linear Array vs. SPF10 PCR-DEIA-LiPA25 system in the HPV Infection in Men (HIM) study","authors":"Deepti Bettampadi ,&nbsp;Bradley A. Sirak ,&nbsp;William J. Fulp ,&nbsp;Martha Abrahamsen ,&nbsp;Luisa L. Villa ,&nbsp;Eduardo Lazcano-Ponce ,&nbsp;Jorge Salmeron ,&nbsp;Kimberly A. Isaacs-Soriano ,&nbsp;Maria L. Baggio ,&nbsp;Manuel Quiterio Trenado ,&nbsp;Anna R. Giuliano","doi":"10.1016/j.pvr.2020.100199","DOIUrl":"10.1016/j.pvr.2020.100199","url":null,"abstract":"<div><h3>Introduction</h3><p>Oral human papillomavirus (HPV) attributable oropharyngeal cancers are on the rise in many countries. Oral HPV infections among healthy individuals are commonly detected using oral gargle samples. However, the optimal method for HPV genotyping oral gargle specimens in research studies has not been previously evaluated.</p></div><div><h3>Materials and methods</h3><p>Oral gargle samples from 1455 HPV Infection in Men (HIM) study participants were HPV genotyped using two different methods: Linear Array and the SPF₁₀ PCR-DEIA-LiPA₂₅. The sensitivity of the two tests for detecting individual HPV types and grouped HPV types, high-risk HPV, low-risk HPV, grouped 4-HPV-vaccine types, and grouped 9-HPV-vaccine-types, and the degree of concordance between the two tests was assessed. We also examined whether socio-demographic-behavioral factors were associated with concordance between the two assays.</p></div><div><h3>Results</h3><p>The sensitivity of SPF₁₀ PCR-DEIA-LiPA₂₅ was higher than Linear Array, with the exception of HPV 70, for the detection of oral HPV. The prevalence ratio of SPF₁₀ PCR-DEIA-LiPA₂₅ to Linear Array varied between 1.0 and 9.0 for individual HPV genotypes, excluding HPV 70, and between 3.8 and 4.4 for grouped 4-valent and 9-valent HPV vaccine types, respectively. There was no association between socio-demographic-behavioral factors and discordance in results between the two tests for oral HPV 16 detection.</p></div><div><h3>Discussion</h3><p>SPF₁₀ PCR-DEIA-LiPA₂₅ was more sensitive than Linear Array for detecting HPV in oral gargle samples. Given the growing importance of detecting oral HPV infection for research studies of oral HPV natural history and vaccine effectiveness evaluation, we recommend using methods with higher sensitivity such as SPF₁₀ PCR-DEIA-LiPA₂₅ for detecting HPV in oral gargle samples.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"9 ","pages":"Article 100199"},"PeriodicalIF":3.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2020.100199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37982421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}