Open Ophthalmology Journal最新文献

{"title":"A Narrative Review of Morquio Syndrome: Mucopolysaccharidosis (MPS) Type IV","authors":"Andrew C.W. Robart, Abbey F. J. Alexander, Adil Al-Mehiawi, Ismael Abuallut, Nir Shoham Hazon","doi":"10.2174/18743641-v17-230822-2022-61","DOIUrl":"https://doi.org/10.2174/18743641-v17-230822-2022-61","url":null,"abstract":"Background: Morquio Syndrome or Mucopolysaccharidosis Type IV (MPS IV) is a rare inherited metabolic disorder characterized by the deficiency of certain lysosomal enzymes involved in the breakdown of mucopolysaccharides. The deficiency results in proteoglycan accumulation, particularly keratan sulfate in various tissues in the body. Morquio Syndrome is classified into two subtypes: Morquio A and Morquio B, which are distinguished by the specific enzyme deficiency involved, with Morquio A being more prevalent. Morquio Syndrome commonly affects the eyes with 46.7% of diagnosed patients experiencing ocular symptoms related to the disorder. Objective: To perform a comprehensive review of the existing literature and summarize the ophthalmological manifestations of Morquio Syndrome. Methods: A methodical literature search was conducted, including papers with abstracts discussing ophthalmology or ocular pathology of “Mucopolysaccharidosis Type IV” or ” Morquio Syndrome.” Twelve relevant articles met the inclusion criteria and were included in the review. Seven of the articles consisted of case reports, collectively reporting on forty-one patients with Morquio Syndrome, primarily Morquio A. The outcome of the narrative review is an overview of the existing literature on ocular presentations of Morquio Syndrome and a summary of case report findings. Results: Forty-one different patients were identified from the included case reports, and forty patients were included as they presented with ocular pathology related to Morquio Syndrome. Corneal opacification was the most common presentation where twenty-seven patients had significant corneal opacification and seven patients had slight corneal opacification. Small, gray, spherical, dust-like opacities that dispersed among the stroma were most commonly seen in cases with corneal opacification. Other ocular presentations included decreased visual acuity, astigmatism, lens opacities, and glaucoma. Conclusion: Morquio syndrome, a rare genetic disorder, exhibits multiple ocular symptoms, with corneal opacification being the most common. While most research has concentrated on Morquio A, the more severe subtype, there's limited information on Morquio B, highlighting a need for more comparative studies. As the syndrome remains incurable, exploring new treatment avenues and understanding the reasons behind these ocular manifestations can significantly improve the quality of life for Morquio patients.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135923083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MGrx - A Novel Multi-modal Thermal Device for Treating Moderate to Severe Meibomian Gland Dysfunction and Dry Eye","authors":"Brittany J. McMurren, Michael A. Kling, Andrew Fasciani, M. Henrietta Nymark-McMahon","doi":"10.2174/18743641-v17-231005-2023-13","DOIUrl":"https://doi.org/10.2174/18743641-v17-231005-2023-13","url":null,"abstract":"Background: MGD (meibomian gland dysfunction) is a chronic cause of dry eyes. Thermal expression of the meibomian glands, along with massage and debridement, is an effective treatment for MGD. Objective: We describe a multi-modal thermal device (MGrx) to manage meibomian gland dysfunction (MGD). We observed the efficacy and safety of the MGrx to manage MGD in one 15-minute in-office session. Methods: We enrolled 37 patients in a prospective, open-label trial of the novel MGrx. Patients were enrolled with a Standard Patient Evaluation for Eye Dryness (SPEED) score > 12 or a Tear Breakup Time (TBUT) of < 6 seconds in at least one eye. After screening for eligibility, one 15-minute MGrx treatment was provided to each patient. The patient assessment consisted of a SPEED score, TBUT, and a Meibomian gland score (MGS) obtained pre-treatment and at a follow-up visit 30 days after the treatment. Results: Dry eye symptoms improved in the patient population, as measured by SPEED score, MGS, and TBUT, by 40%, 341%, and 145%, respectively (p<0.05). No adverse reactions were noted among the patients. Conclusion: A single 15-minute MGrx treatment was effective at significantly improving dry eye symptoms secondary to MGD in adult patients, as measured by SPEED score. Additionally, a single MGrx treatment improved meibomian gland function and all measures of MGD in the adult patients treated. Given the relatively low risk and efficient delivery of the MGrx treatment, a single MGrx treatment should be considered as a first-line treatment for MGD.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Refractive Errors on School-going Children Attending Ophthalmic Clinic of AlMoosa Hospital in Saudi Arabia","authors":"Ayoob Lone, Fahad Abdullah Saeed AlWadani, Abdulrahman Alnaim","doi":"10.2174/18743641-v17-e230925-2023-7","DOIUrl":"https://doi.org/10.2174/18743641-v17-e230925-2023-7","url":null,"abstract":"Objective: The risk factors for vision problems in youngsters are relatively unknown in Saudi Arabia. The purpose of this study was to examine the determinants of refractive errors among school-going children attending the ophthalmic clinic of AlMoosa Hospital in Saudi Arabia. Methodology: A sample of 161 school-going children were recruited voluntarily to complete a set of measures examining the determinants of refractive errors. The binary logistic regression model was applied to determine the relationship between independent and dependent variables. Results: Refractive errors were common among Saudi school-going children, with myopia being the most common type of refractive error. About 96 (59.6%) samples had myopia, 28 (17.4%) children had hyperopia and 27 (16.8%) children did not have any refractive error. Genetic traits and machine dependence were found to be significant predictors of refractive error. Conclusion: The preschool eye test and routine vision investigation should be performed on children to detect refractive errors early.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-analysis of Convergence Insufficiency Prevalence and Management Options","authors":"Zoelfigar Mohamed, Saif Hassan Alrasheed","doi":"10.2174/18743641-v17-20230712-2023-8","DOIUrl":"https://doi.org/10.2174/18743641-v17-20230712-2023-8","url":null,"abstract":"Background: Convergence insufficiency (CI) is one of the most common binocular vision disorders. The condition negatively affects the quality of life through its impact on near activities, while there is a large gap in the information on its global prevalence and consensus on treatment. Objectives: The purpose of this systematic review and meta-analysis was to assess the prevalence and treatment options available for convergence insufficiency. Methods: The study was performed in 2023 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-2020) guidelines. The authors have searched Google Scholar, Research Gate, Scopus, PubMed, Index Medicus, Web of Science, and the JAMA network. This review included peer-reviewed studies published between January 2000 to January 2023 that assessed the prevalence and treatment modalities of convergence insufficiency. Results: The authors screened 13250 studies, 20 for prevalence and 15 for treatment from 12 countries that met the inclusion criteria for the study. The overall pooled prevalence of convergence insufficiency was 7.98%, and the heterogeneity between the studies was highly significant P < 0.0001. Majorities of the studies 12(80%) reported that office-based vision therapy is the most effective treatment of CI, form those studies 5(42.0%) highlighted that office-based vergence/accommodative therapy with home reinforcement is the best modality of treatment. Whereas, home-based pencil push-up therapy, vision therapy with modified refractive correction, and vision therapy with prismatic correction were reported as effective treatment options for CI. The reviewed studies showed that vision therapy is highly effective to recover from symptomatic CI in both adults and children. Conclusion: The prevalence of convergence insufficiency was high, there was highly significant heterogeneity between the reviewed studies. Office-based vergence/accommodative therapy with home reinforcement is the best modality of treatment, followed by home-based pencil push-up therapy, vision therapy with modified refractive correction, and vision therapy with prismatic correction. There is consensus among reviewed studies that vision therapy is highly effective to recover from symptomatic CI in both adults and children.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic and Anti-VEGF Therapy for Polypoidal Choroidal Vasculopathy - ‘Real World’ Outcomes in a Caucasian Population","authors":"Kenneth M. Gilmour, David Young, Aaron Jamison, Monica Precup, David F. Gilmour","doi":"10.2174/18743641-v17-e230214-2022-44","DOIUrl":"https://doi.org/10.2174/18743641-v17-e230214-2022-44","url":null,"abstract":"Background: The prevalence of polypoidal choroidal vasculopathy (PCV) is significantly higher amongst Asian populations compared to Caucasian, and evidence regarding the clinical outcomes of Caucasian patients is limited. Objective: This retrospective study sought to investigate real-world clinical outcomes of Caucasian PCV patients treated with polypoidal verteporfin photodynamic therapy (PDT) in combination with anti-VEGF therapy up to 36 months post-treatment. Methods: Consecutive PCV patients who received PDT between 2011 and 2017 were included. Mean change in visual acuity (VA) measured by ETDRS letter score and mean change in central subfield thickness (CST) were the main outcome measures. Data were collected at baseline, 3, 12, 24 and 36 months. Regression analyses were carried out on pre-treatment clinical features to determine if there were any factors associated with a good visual outcome (better than or equal to 70 ETDRS letters at 12 months). Results: Seventy six patients (96% Caucasian) and seventy eight eyes were included in the analysis. Mean change in VA was -1, -4, and 0 ETDRS letters at 12, 24, and 36 months, respectively. CST was reduced by a mean of -51, -54, and -55 microns at 12, 24, and 36 months, respectively. Better pre-treatment VA was the only pre-treatment clinical feature associated with a good visual outcome at 12 months (OR 1.16, p<0.001). Conclusion: PDT, in combination with anti-VEGF therapy, maintains VA and may reduce the anti-VEGF therapy burden in Caucasian patients with PCV. Better pre-treatment VA is associated with a good visual outcome.","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134946413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphisms of Aldose Reductase (ALR2) Regulatory Gene are Risk Factors for Diabetic Retinopathy in Type-2 Diabetes Mellitus Patients in Bali, Indonesia.","authors":"Desak Made Wihandani,&nbsp;Ketut Suastika,&nbsp;I Nyoman Agus Bagiada,&nbsp;Safarina G Malik","doi":"10.2174/1874364101812010281","DOIUrl":"https://doi.org/10.2174/1874364101812010281","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to elucidate whether the polymorphisms of the aldose reductase regulatory gene were risk factors for Diabetic Retinopathy (DR) in type-2 diabetes mellitus (T2DM) patients in Bali.</p><p><strong>Methods: </strong>This is a case-control study including 35 cases of T2DM patients with DR paired with 35 cases with non-DR as controls. PCR analysis and DNA-sequencing were carried out to detect the C(-106)T and C(-12)G polymorphisms at the regulatory region of Aldose Reductase (ALR2) gene. Genotype and allele distributions were analyzed by Chi-squared test and independent t-and Mann-Whitney U tests were used to analyze other data.</p><p><strong>Results: </strong>Among all subjects in both groups, the baseline characteristics were homogenous except for systolic blood pressure, fasting blood glucose and 2-hours post-prandial blood glucose. This study found two polymorphisms, C(-104)T and C(-9)G, in the regulatory region of ALR2 gene. The result showed that the C(-104)T polymorphism was a risk factor for DR (OR=36; 95% CI = 4.43-292.85; <i>p</i>=0.001), but not the C(-9)G polymorphism (OR=1.28; 95% CI=0.48-3.38; <i>p</i>=0.621). Other findings in the study revealed that CC/CC haplotype is a protective factor for DR (OR=0.198; <i>p</i>=0.002), whereas CT/CC and CT/CG haplotypes as risk factors for DR with OR=15.58; <i>p</i>=0.002 and OR=2.29; <i>p</i>=0.005 respectively.</p><p><strong>Conclusion: </strong>It can be concluded that C(-104)T polymorphism in the regulatory region of Aldose Reductase (ALR2) gene was the risk factor for DR among T2DM patients in Bali, Indonesia. However, small sample size, systolic blood pressure, fasting blood glucose and 2-hours post-prandial blood glucose could affect our finding.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2018-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36742323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximising Refractive Outcomes with an Extended Depth of Focus IOL.","authors":"Barry Power,&nbsp;Rory Murphy,&nbsp;Antonio Leccisotti,&nbsp;Tara Moore,&nbsp;William Power,&nbsp;Paul O'Brien","doi":"10.2174/1874364101812010273","DOIUrl":"https://doi.org/10.2174/1874364101812010273","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of the magnitude of preoperative and postoperative corneal astigmatism on refractive outcomes in patients undergoing cataract surgery or lens exchange with an extended depth of focus intraocular lens. To compare visual outcomes of steep and temporal on-axis corneal incisions.</p><p><strong>Setting: </strong>Department of Ophthalmology, Blackrock Clinic, Dublin, Ireland.</p><p><strong>Design: </strong>Prospective cohort analysis.</p><p><strong>Methods: </strong>Fifty-three consecutive adult patients (94 eyes) undergoing routine phacoemulsification with Symfony IOL implantation were analysed. Exclusion criteria: targets for mini-monovision, incomplete data, other ocular pathology. Data were prospectively collected on pre- and postoperative refraction, keratometry, distance vision, near vision, surgical wound site and Surgically Induced Astigmatism (SIA).</p><p><strong>Results: </strong>The average postoperative monocular Uncorrected Distance and Near visual acuities (UDVA and UNVA) were 0.12 LogMAR (± 0.1) (6/7.5⁺¹) and 0.34 LogMAR (± 0.09) respectively. The average binocular UDVA and UNVA were 0.05 (± 0.07) and 0.29 LogMAR (± 0.06) respectively. Low levels of preoperative corneal astigmatism (0-0.99 D) were associated with better LogMAR UDVA and UNVA when compared with higher levels (> 0.99 D): 0.11 (CI 0.103-0.107) <i>vs.</i> 0.206 (CI 0.122-0.290) (<i>p</i> =0.015, CI 95%) and 0.33 (CI 0.316 - 0.356) <i>vs.</i> 0.39 (CI 0.34-0.43) (<i>p</i> =0.034, CI 95%) respectively. When patients with steep on-axis corneal incisions were compared with temporal on-axis corneal incisions, no difference was detected in visual outcome or SIA.</p><p><strong>Conclusion: </strong>The Symfony IOL is an effective surgical means of addressing presbyopia and reducing postoperative spectacle dependence. We stress caution when offering potential spectacle independence for patients with over 1D of preoperative corneal astigmatism as these patients achieve statistically significantly inferior and less predictable visual results.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874364101812010273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36614306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Error among Male Primary School Students in Jazan, Saudi Arabia: Prevalence and Associated Factors.","authors":"Tariq Al Bahhawi,&nbsp;Anwar M Makeen,&nbsp;Hadi Hassan Daghreeri,&nbsp;Mohannad Faisal Tobaigy,&nbsp;Abdulrahman Mohammed Adawi,&nbsp;Faisal Mohammed Guhal,&nbsp;Murad Abdullah Akkur,&nbsp;Mohsen Jaber Alotayfi,&nbsp;Mutaz Mohammed Otayf,&nbsp;Meshal Salem Bajoned,&nbsp;Mohamed Salih Mahfouz","doi":"10.2174/1874364101812010264","DOIUrl":"https://doi.org/10.2174/1874364101812010264","url":null,"abstract":"<p><strong>Background: </strong>Refractive error is a common and serious eye disorder that affects more than 153 million people globally. The aim of this study was to estimate the prevalence and pattern of refractive error among male primary school children in Jazan region, Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among a randomly selected group of 395 students (aged 6-14 years) in Jazan region, Southwest Saudi Arabia. An optometrist and medical students assessed the refraction error using an autorefractor, a Snellen E chart and retinoscopy.</p><p><strong>Results: </strong>The overall prevalence of uncorrected refractive error in either eye was, 22% higher among rural students. The most prevalent refractive error was hyperopia (32.2%) followed by myopic astigmatism (31%) then myopia (17.2%). Next were hyperopic astigmatism (16.1%) and mixed astigmatism (3.5%). The following variables were associated with a higher risk of refractive errors and myopia: living in rural areas, having parents with refractive errors, spending more time on electronic devices and shorter visual distances.</p><p><strong>Conclusion: </strong>Refractive error was highly prevalent among primary school children in Jazan, Saudi Arabia. The rural students were more affected by refractive errors, mainly hyperopia. The preschool vision test should be reconsidered, and a periodic vision examination should be applied to detect vision problems as early as possible.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874364101812010264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36614305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Wavefront-Optimized Laser-Assisted <i>In-Situ</i> Keratomileusis and Photorefractive Keratectomy for correction of Myopia and Myopic Astigmatism over One Year Follow-Up.","authors":"Mohammad M Shehadeh,&nbsp;Mohammad T Akkawi,&nbsp;Ammar A Aghbar,&nbsp;Muna T Musmar,&nbsp;Malak N Khabbas,&nbsp;Marah F Kharouf,&nbsp;Liana Al-Labadi","doi":"10.2174/1874364101812010256","DOIUrl":"https://doi.org/10.2174/1874364101812010256","url":null,"abstract":"<p><strong>Background: </strong>Laser corneal refractive surgery suits, technology and nomograms are improving with time. This may improve the refractive and visual outcomes of the patients.</p><p><strong>Objectives: </strong>To evaluate the safety, efficacy, stability, and predictability of wavefront-optimized photorefractive keratectomy and Laser-assisted <i>in-situ</i> keratomileusis in patients with myopia and myopic astigmatism over 1-year using WaveLight^® EX500 Excimer Laser machine.</p><p><strong>Methods: </strong>In this prospective cohort study, refractive and visual outcomes in 596 eyes (365 patients), either having myopia or myopic astigmatism were assessed. Patients were divided into Two groups: 1) Patients who underwent PRK (53 eyes have myopia and 217 eyes have myopic astigmatism), 2) Patients who underwent LASIK (53 eyes have myopia and 273 eyes have myopic astigmatism).</p><p><strong>Results: </strong>At 12 months postoperatively 94.3% of the myopic patients reached their preoperative best corrected distance visual acuity at the final one year follow up visit post PRK and LASIK. In patients with myopic astigmatism who underwent LASIK and PRK, 95.2%, and 96.3% of the patients reached their preoperative best corrected distance visual acuity at the final one year follow up visit post LASIK and PRK, respectively. The efficacy and safety indices were 1.00 or more for all groups with no eye lost any line of best corrected distance visual acuity.</p><p><strong>Conclusion: </strong>Our study results confirm the excellent efficacy, safety, good predictability and stability of myopia / myopic astigmatism correction by either wavefront- optimized LASIK or PRK over 1-year follow-up without significant differences between them using the WaveLight^® EX500 excimer laser system.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874364101812010256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36553117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Treatment Outcomes and Predictive Factors in Optic Neuritis.","authors":"Linda Hansapinyo,&nbsp;Chayanee Vivattanaseth","doi":"10.2174/1874364101812010247","DOIUrl":"https://doi.org/10.2174/1874364101812010247","url":null,"abstract":"<p><strong>Background: </strong>The causes, clinical presentations and treatment outcomes of optic neuritis are distinct among different populations. Early diagnosis based on clinical presentations plays an important role in treating optic neuritis patients.</p><p><strong>Objective: </strong>The study aimed to determine clinical characteristics, treatment outcomes and predictive factors of treatment outcomes in optic neuritis patients with and without demyelinating disease.</p><p><strong>Methods: </strong>A retrospective descriptive study of optic neuritis patients carried out between January 2009 and December 2016 was done. Univariate analysis and multivariate logistic regression analysis were used to evaluate the predictive factors of treatment outcomes.</p><p><strong>Results: </strong>Among 150 patients with optic neuritis, 58 patients were diagnosed with Neuromyelitis Optica Spectrum Disease (NMOSD), 23 patients were diagnosed with Multiple Sclerosis (MS) and 69 patients were idiopathic. The age at presentation in the NMOSD group was significantly younger than the MS group and the idiopathic group. The female:male ratio was significantly lower in the idiopathic group than in the NMOSD group. The initial Best Corrected Visual Activity (BCVA) of 20/20-20/60 (<i>p</i> = 0.001) and the idiopathic group (<i>p</i> =0.030) was associated with good visual outcomes. Initial BCVA of < 20/200 (<i>p</i> = 0.009) and the NMOSD group (<i>p</i> < 0.001) was associated with poor visual outcomes.</p><p><strong>Conclusion: </strong>NMOSD is a more common cause of optic neuritis than MS in Thai population. Female patients with poor initial VA, poor response to steroids treatment, and presenting recurrent attacks are highly suspicious for NMOSD. Optic neuritis without associated demyelinating disease has a better visual outcome and lower recurrence rate.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874364101812010247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36523665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}