Autoimmune Diseases最新文献_第2页

Corrigendum to "Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis". “重症肌无力临床和实验室特征的性别和种族差异”的勘误表。

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Autoimmune Diseases Pub Date : 2021-05-29 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9862946

Fawzi Abukhalil, Ayyaz Alam Sultan, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray

引用次数: 0

Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It? 巴西类风湿关节炎患者的白细胞介素-18：来氟米特能降低白细胞介素 18 吗？

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Autoimmune Diseases Pub Date : 2021-05-10 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6672987

Pablo Ramon Gualberto Cardoso, Claudia Diniz Lopes Marques, Kamila de Melo Vilar, Andrea Tavares Dantas, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo

{"title":"Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It?","authors":"Pablo Ramon Gualberto Cardoso, Claudia Diniz Lopes Marques, Kamila de Melo Vilar, Andrea Tavares Dantas, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo","doi":"10.1155/2021/6672987","DOIUrl":"10.1155/2021/6672987","url":null,"abstract":"Objectives: Rheumatoid arthritis affects about 1% of the world's population. This is a chronic autoimmune disease. It is predominant in females with progressive joint damage. Immune cells are involved, especially Th1/Th17 lymphocytes and their inflammatory cytokines. These proteins have different functions in the immune system, such as IL-16 is a chemotactic factor; IL-18 can activate NFκB transcription producing inflammatory proteins; IL-31 can activate the JAK/STAT pathway which leads to the production of inflammatory factors in chronic diseases; IL-33 promotes IL-16 secretion which causes lymphocyte recruitment, and IL-32 and IL-34 appear to increase TNF secretion by macrophages activation in AR. The aim of this study was to evaluate serum levels of IL-16, IL-18, IL-31, IL-32, IL-33, and IL-34 and compare them with the severity and treatment of RA patients if there are any correlations.Methods: A total of 140 RA patients and 40 healthy donors were recruited from the Department of Rheumatology at Hospital das Clínicas from the Federal University of Pernambuco. 60 AR patients were naïve for any treatment. Serum cytokine levels were determined using an ELISA kit.Results: Serum IL-16 (p = 0.0491), IL-18 (p < 0.0001), IL-31 (p = 0.0004), and IL-32 (p = 0.0040) levels were significantly increased in RA patients compared with healthy donors. It was observed that patients using leflunomide had the lowest IL-18 levels, close to controls levels (p = 0.0064).Conclusion: IL-16, IL-18, IL-31, and IL-32 are increased in the serum of RA patients. IL-18 is at lower levels in those AR who are taking leflunomide as treatment.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"6672987"},"PeriodicalIF":4.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora. 类风湿关节炎发病机制与胶原诱导和胶原抗体诱导关节炎模型的新研究:涉及细菌菌群的新见解。

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Autoimmune Diseases Pub Date : 2021-03-25 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7385106

Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Takaki Waritani, Kuniaki Terato

{"title":"New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora.","authors":"Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Takaki Waritani, Kuniaki Terato","doi":"10.1155/2021/7385106","DOIUrl":"https://doi.org/10.1155/2021/7385106","url":null,"abstract":"Much public research suggests that autoimmune diseases such as rheumatoid arthritis (RA) are induced by aberrant \"self\" immune responses attacking autologous tissues and organ components. However, recent studies have reported that autoimmune diseases may be triggered by dysbiotic composition changes of the intestinal bacteria and an imbalance between these bacteria and intestinal immune systems. However, there are a few solid concepts or methods to study the putative involvement and relationship of these inner environmental factors in RA pathogenesis. Fortunately, Collagen-Induced Arthritis (CIA) and Collagen Antibody-Induced Arthritis (CAIA) models have been widely used as animal models for studying the pathogenesis of RA. In addition to RA, these models can be extensively used as animal models for studying complicated hypotheses in many diseases. In this review, we introduce some basic information about the CIA and CAIA models as well as how to apply these models effectively to investigate relationships between the pathogenesis of autoimmune diseases, especially RA, and the dysbiosis of intestinal bacterial flora.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"7385106"},"PeriodicalIF":4.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25573329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden. 瑞典人口恶性贫血和其他自身免疫性疾病之间的家族风险

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Autoimmune Diseases Pub Date : 2021-01-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8815297

Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki

{"title":"Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.","authors":"Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki","doi":"10.1155/2021/8815297","DOIUrl":"https://doi.org/10.1155/2021/8815297","url":null,"abstract":"Background: Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients.Methods: We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks.Results: The number of PA patients in the offspring generation (for which the familial risk was calculated) was 7701; 278 (3.6%) patients had a family history of PA. The population prevalence of PA was 0.9/1000. The familial risk for PA was 3.88 when any first-degree relative was the proband, equal for men and women. The familial risk was two times higher between siblings than between offspring and parents which may be due to complex genetic background. Associations of PA with 14 discordant AIDs were significant; these included some AIDs that have previously been described as comorbidities in PA patients and several yet unreported associations, including rheumatoid arthritis and other AIDs.Conclusions: The familial risks for PA were high suggesting multifactorial genetic etiology. The results call for further population-level studies to unravel mechanisms of familial PA which may help to understand the etiology of this disease.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"8815297"},"PeriodicalIF":4.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Retracted: Galectin-1, -4, and -7 Were Associated with High Activity of Disease in Patients with Rheumatoid Arthritis. 缩回:半乳糖凝集素-1、-4和-7与类风湿关节炎患者的疾病高活性相关。

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Autoimmune Diseases Pub Date : 2020-11-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8364502

Autoimmune Diseases

引用次数: 0

Therapeutic Plasma Exchange as a Treatment for Autoimmune Neurological Disease. 血浆置换治疗自身免疫性神经系统疾病

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Autoimmune Diseases Pub Date : 2020-07-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3484659

Ivana Nieto-Aristizábal, Álvaro J Vivas, Pablo Ruiz-Montaño, Cristian C Aragón, Iván Posso-Osorio, Jairo Quiñones, Julián Alejandro Rivillas, Gabriel J Tobón

{"title":"Therapeutic Plasma Exchange as a Treatment for Autoimmune Neurological Disease.","authors":"Ivana Nieto-Aristizábal, Álvaro J Vivas, Pablo Ruiz-Montaño, Cristian C Aragón, Iván Posso-Osorio, Jairo Quiñones, Julián Alejandro Rivillas, Gabriel J Tobón","doi":"10.1155/2020/3484659","DOIUrl":"https://doi.org/10.1155/2020/3484659","url":null,"abstract":"Introduction: Therapeutic plasma exchange (TPE) is commonly used as treatment of certain autoimmune neurological diseases (ANDs), and its main objective is the removal of pathogenic autoantibodies. Our aim was to describe the clinical profile and the experience with the usage of TPE in patients with ANDs at our institution.Methods: This is an observational retrospective study, including medical records of patients with diagnosis of ANDs who received TPE, between 2011 and 2018. Characteristics of TPE, such as number of cycles, type of replacement solution, and adverse effects, were evaluated. The modified Rankin Scale (mRS) was applied to measure the clinical response after the therapy.Results: 187 patients were included with the following diagnoses: myasthenia gravis (MG), n = 70 (37%); Guillain-Barré syndrome (GBS), n = 53 (28.3%), neuromyelitis optica spectrum disorders (NMOSD), n = 35 (18.7%); chronic inflammatory demyelinating polyneuropathy (CIDP), n = 23 (12.2%); and autoimmune encephalitis (AE), n = 6 (3.2%). The most used types of replacement solution were albumin (n = 131, 70%) and succinylated gelatin (n = 45, 24%). All patients received a median of five cycles (IQR 5-5). Hypotension and hydroelectrolytic disorders were the main complications. After TPE, 99 patients (52.9%) showed improvement in the mRS scores and a statistical significance (p < 0.05) was seen between the admission score and after TPE for every diagnosis except for CIDP.Conclusion: TPE has an adequate safety profile, and improvement in functionality in treated patients reflects its effectiveness.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2020 ","pages":"3484659"},"PeriodicalIF":4.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3484659","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38271529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis. 活性氧对免疫系统的影响及多发性硬化的发病机制。

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Autoimmune Diseases Pub Date : 2020-06-25 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5793817

Mohammad Javad Tavassolifar, Mohammad Vodjgani, Zahra Salehi, Maryam Izad

{"title":"The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis.","authors":"Mohammad Javad Tavassolifar, Mohammad Vodjgani, Zahra Salehi, Maryam Izad","doi":"10.1155/2020/5793817","DOIUrl":"https://doi.org/10.1155/2020/5793817","url":null,"abstract":"Multiple roles have been indicated for reactive oxygen species (ROS) in the immune system in recent years. ROS have been extensively studied due to their ability to damage DNA and other subcellular structures. Noticeably, they have been identified as a pivotal second messenger for T-cell receptor signaling and T-cell activation and participate in antigen cross-presentation and chemotaxis. As an agent with direct toxic effects on cells, ROS lead to the initiation of the autoimmune response. Moreover, ROS levels are regulated by antioxidant systems, which include enzymatic and nonenzymatic antioxidants. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Nonenzymatic antioxidants contain vitamins C, A, and E, glutathione, and thioredoxin. Particularly, cellular antioxidant systems have important functions in maintaining the redox system homeostasis. This review will discuss the significant roles of ROS generation and antioxidant systems under normal conditions, in the immune system, and pathogenesis of multiple sclerosis.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2020 ","pages":"5793817"},"PeriodicalIF":4.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5793817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38267329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome. 干扰素过敏和神经退行性疾病的自身免疫机制:唐氏综合征。

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Autoimmune Diseases Pub Date : 2020-06-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6876920

Ashraya Jagadeesh, Leonard E Maroun, Lisa M Van Es, Richard M Millis

{"title":"Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome.","authors":"Ashraya Jagadeesh, Leonard E Maroun, Lisa M Van Es, Richard M Millis","doi":"10.1155/2020/6876920","DOIUrl":"https://doi.org/10.1155/2020/6876920","url":null,"abstract":"Down syndrome (DS), also known as trisomy 21 (T21), is associated with interferon (IFN) hypersensitivity, as well as predilections for Alzheimer's dementia (AD) and various autoimmune diseases. IFN-α and IFN-γ receptors are encoded on chromosome 21 (Ch21). It remains unclear how other Ch21 genes contribute to the neuropathological features of DS/T21. This study tests the hypothesis that identifying IFN-stimulated response element (ISRE) control sites on Ch21 will mark novel candidate genes for DS/T21-related IFN hypersensitivity and neuropathology not previously reported to be associated with IFN functions. We performed whole chromosome searches of online databases. The general ISRE consensus and gamma interferon activation consensus sequences (GAS) were used for identifying IFN-stimulated response elements. Candidate genes were defined as those possessing two or more ISRE and/or GAS control sites within and/or upstream of the transcription start site. A literature search of gene functions was used to select the candidate genes most likely to explain neuropathology associated with IFN hypersensitivity. DOPEY2, TMEM50B, PCBP3, RCAN1, and SIM2 were found to meet the aforementioned gene search and functional criteria. These findings suggest that DOPEY2, TMEM50B, PCBP3, RCAN1, and SIM2 are genes which may be dysregulated in DS/T21 and may therefore serve as novel targets for treatments aimed at ameliorating the neuropathological features of DS/T21. Future studies should determine whether these genes are dysregulated in patients with DS, DS-related AD, and autoimmune diseases.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2020 ","pages":"6876920"},"PeriodicalIF":4.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6876920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38072545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients. 间隔日使用皮质类固醇治疗自身免疫性疾病的效果

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Autoimmune Diseases Pub Date : 2020-05-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8719284

Genny Margarita Chaia-Semerena, María Eugenia Vargas-Camaño, Cesar Daniel Alonso-Bello, Jorge Javier Guillén-Toledo, Ricardo Leopoldo Guido-Bayardo, Fernando Lozano-Patiño, Mariano Daniel Temix-Delfín, María Isabel Castrejón-Vázquez

{"title":"The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients.","authors":"Genny Margarita Chaia-Semerena, María Eugenia Vargas-Camaño, Cesar Daniel Alonso-Bello, Jorge Javier Guillén-Toledo, Ricardo Leopoldo Guido-Bayardo, Fernando Lozano-Patiño, Mariano Daniel Temix-Delfín, María Isabel Castrejón-Vázquez","doi":"10.1155/2020/8719284","DOIUrl":"https://doi.org/10.1155/2020/8719284","url":null,"abstract":"Introduction: Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients. For this reason, the current recommendation for the use of these medications is in a short cycle to avoid adverse effects when used frequently and for prolonged periods of time.Objectives: To learn variations in serum levels of autoantibodies in autoimmune diseases treated with steroids on alternate days, as well as whether there are differences in the response to them depending on the type of disease. Study Design. A descriptive, retrospective, and cross-sectional study was conducted in which serum autoantibody levels were compared at the time of diagnosis and three months after alternate-day corticosteroid therapy.Results: We included 106 patients from three autoimmune connective tissue diseases (systemic lupus erythematosus, Sjögren syndrome, and Hashimoto's thyroiditis) and observed a statistically significant decrease in serum autoantibody levels both in patients with lupus and those with Hashimoto's thyroiditis, regardless of the sex of the patients, as well as the type of steroids used.Conclusions: Treatment with alternate-day corticosteroids achieved a statistically significant decrease in serum autoantibody levels in patients with systemic lupus erythematosus and Hashimoto's thyroiditis.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2020 ","pages":"8719284"},"PeriodicalIF":4.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8719284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38019523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Vitamin D and Demyelinating Diseases: Neuromyelitis Optica (NMO) and Multiple Sclerosis (MS). 维生素D和脱髓鞘疾病:视神经脊髓炎(NMO)和多发性硬化(MS)。

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Autoimmune Diseases Pub Date : 2020-01-19 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8718736

Cady Rodney, Sherriann Rodney, Richard M Millis

引用次数: 12