Autoimmune Diseases最新文献_第2页

Thrombosis and Anticoagulation Therapy in Systemic Lupus Erythematosus. 系统性红斑狼疮的血栓形成和抗凝治疗。

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Autoimmune Diseases Pub Date : 2022-06-27 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3208037

Wenjun Yuan, Fengjun Guan

引用次数: 3

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis. 作为igg4相关疾病，T细胞在慢性硬化性涎腺炎中的作用和活性:免疫发病机制的最新概念

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Autoimmune Diseases Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5689883

Hazim Mahmoud Ibrahem

引用次数: 0

Management and Outcomes of ANCA-Associated Vasculitis at a Tertiary Healthcare Facility. 三级医疗机构anca相关性血管炎的管理和结果

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Autoimmune Diseases Pub Date : 2022-02-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4808806

Nabeehah Moollan, Adeel Rafi Ahmed, Mark Denton

引用次数: 2

Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment. 14-3-3η会成为类风湿关节炎新的诊断和预后生物标志物吗?它在早期诊断和治疗反应中的应用的前瞻性研究。

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Autoimmune Diseases Pub Date : 2022-01-04 eCollection Date: 2022-01-01 DOI: 10.1155/2022/1497748

Doaa Shawky Alashkar, Radwa Mostafa Elkhouly, Amira Yousef Abd Elnaby, Doaa Waseem Nada

引用次数: 3

Protective Effect of Hyperbaric Oxygen Treatment on Axon Degeneration after Acute Motor Axonal Neuropathy. 高压氧治疗对急性运动轴索神经病后轴突变性的保护作用。

IF 4

Autoimmune Diseases Pub Date : 2021-11-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6627779

Ni Komang Sri Dewi Untari, Kurnia Kusumastuti, Guritno Suryokusumo, I Ketut Sudiana

{"title":"Protective Effect of Hyperbaric Oxygen Treatment on Axon Degeneration after Acute Motor Axonal Neuropathy.","authors":"Ni Komang Sri Dewi Untari, Kurnia Kusumastuti, Guritno Suryokusumo, I Ketut Sudiana","doi":"10.1155/2021/6627779","DOIUrl":"10.1155/2021/6627779","url":null,"abstract":"Objectives: Acute motor axonal neuropathy (AMAN) is a disease that leads to acute flaccid paralysis and may result from the binding of antibody and antigen to the spinal cord. The objective of this study is to evaluate the protective effect of hyperbaric oxygen treatment (HBOT) on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit. Axonal degeneration was assessed by evaluating glutathione (GSH) activity, interleukin-1β (IL-1β) expression, and clinical and histopathological features.Methods: Twenty-one New Zealand rabbits were divided into three groups. The treatment group was exposed to 100% oxygen at 2.4 ATA 90 minutes for 10 days at a decompression rate of 2.9 pounds per square inch/minute. GSH level was evaluated using an enzyme-linked immune-sorbent assay. An expression of IL-1β in the spinal cord was determined by immunohistochemistry. Clinical appearances were done by motor scale and body weight. Histological features observed neuronal swelling and inflammatory infiltration in the sagittal lumbar region and the undulation of the longitudinal sciatic nerve.Results: Rabbits exposed to HBO had high GSH activity levels (p < 0.05) but unexpectedly had high IL1β expression (p > 0.05). In addition, the HBO-exposed rabbits had a better degree of undulation, the size of neuronal swelling was smaller, the number of macrophages was higher, and motor function was better than the AMAN model rabbits (p < 0.05).Conclusions: These findings indicate that HBO therapy can decrease axon degeneration by triggering GSH activity, increasing IL-1β level, and restoring tissues and motor status. In conclusion, HBO has a protective effect on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"6627779"},"PeriodicalIF":4.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39633371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fungal Infections among Psoriatic Patients: Etiologic Agents, Comorbidities, and Vulnerable Population. 银屑病患者的真菌感染:病因、合并症和易感人群。

IF 4

Autoimmune Diseases Pub Date : 2021-09-15 eCollection Date: 2021-01-01 DOI: 10.1155/2021/1174748

Mostafa Chadeganipour, Shahla Shadzi, Rasoul Mohammadi

{"title":"Fungal Infections among Psoriatic Patients: Etiologic Agents, Comorbidities, and Vulnerable Population.","authors":"Mostafa Chadeganipour, Shahla Shadzi, Rasoul Mohammadi","doi":"10.1155/2021/1174748","DOIUrl":"https://doi.org/10.1155/2021/1174748","url":null,"abstract":"Background: Psoriasis is a chronic inflammatory disorder of the skin and joint, affecting nearly 2-3% of the general population. It is assumed that imbalance between the types of natural microflora can accelerate the onset of the disease. Some fungi can play the role of superantigens and prolong chronic inflammation in the skin of psoriatic patients. The aim of the present investigation was to identify fungal species isolated from patients with psoriasis.Methods: From March 2016 to May 2019, 289 patients with prior diagnosis of psoriasis were included in this survey. Direct microscopy with potassium hydroxide (KOH 10%), culture, urea hydrolysis, hair perforation test, and growth on rice grains were used to identify clinical isolates, phenotypically. For molecular identification of Candida species and Malassezia species, PCR-RFLP and PCR-sequencing were used, respectively.Results: Forty-six out of 289 psoriatic patients had fungal infections (15.9%). Dermatophytes (54.3%), Candida spp. (19.5%), Malassezia spp. (15.2%), Aspergillus spp. (6.5%), and Fusarium spp. (4.3%) were the causative agents of fungal infections. Among Malassezia and Candida species, M. restricta (10.8%) and C. glabrata (8.7%) were the most prevalent species, respectively.Conclusion: Our findings suggested that fungal pathogens, particularly dermatophytes, may play an important role in the pathogenicity of psoriasis. Also, due to the high rate of yeast colonization in the clinical samples of psoriatic patients, concomitant use of anti-inflammatory drugs and antifungals may represent an effective therapeutic approach for better management of chronic lesions among these patients. Mycological tests should be applied to indicate the incidence of fungal diseases in psoriatic patients.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"1174748"},"PeriodicalIF":4.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39452625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Corrigendum to "Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis". “重症肌无力临床和实验室特征的性别和种族差异”的勘误表。

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Autoimmune Diseases Pub Date : 2021-05-29 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9862946

Fawzi Abukhalil, Ayyaz Alam Sultan, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray

引用次数: 0

Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It? 巴西类风湿关节炎患者的白细胞介素-18：来氟米特能降低白细胞介素 18 吗？

IF 4

Autoimmune Diseases Pub Date : 2021-05-10 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6672987

Pablo Ramon Gualberto Cardoso, Claudia Diniz Lopes Marques, Kamila de Melo Vilar, Andrea Tavares Dantas, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo

{"title":"Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It?","authors":"Pablo Ramon Gualberto Cardoso, Claudia Diniz Lopes Marques, Kamila de Melo Vilar, Andrea Tavares Dantas, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo","doi":"10.1155/2021/6672987","DOIUrl":"10.1155/2021/6672987","url":null,"abstract":"Objectives: Rheumatoid arthritis affects about 1% of the world's population. This is a chronic autoimmune disease. It is predominant in females with progressive joint damage. Immune cells are involved, especially Th1/Th17 lymphocytes and their inflammatory cytokines. These proteins have different functions in the immune system, such as IL-16 is a chemotactic factor; IL-18 can activate NFκB transcription producing inflammatory proteins; IL-31 can activate the JAK/STAT pathway which leads to the production of inflammatory factors in chronic diseases; IL-33 promotes IL-16 secretion which causes lymphocyte recruitment, and IL-32 and IL-34 appear to increase TNF secretion by macrophages activation in AR. The aim of this study was to evaluate serum levels of IL-16, IL-18, IL-31, IL-32, IL-33, and IL-34 and compare them with the severity and treatment of RA patients if there are any correlations.Methods: A total of 140 RA patients and 40 healthy donors were recruited from the Department of Rheumatology at Hospital das Clínicas from the Federal University of Pernambuco. 60 AR patients were naïve for any treatment. Serum cytokine levels were determined using an ELISA kit.Results: Serum IL-16 (p = 0.0491), IL-18 (p < 0.0001), IL-31 (p = 0.0004), and IL-32 (p = 0.0040) levels were significantly increased in RA patients compared with healthy donors. It was observed that patients using leflunomide had the lowest IL-18 levels, close to controls levels (p = 0.0064).Conclusion: IL-16, IL-18, IL-31, and IL-32 are increased in the serum of RA patients. IL-18 is at lower levels in those AR who are taking leflunomide as treatment.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"6672987"},"PeriodicalIF":4.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora. 类风湿关节炎发病机制与胶原诱导和胶原抗体诱导关节炎模型的新研究:涉及细菌菌群的新见解。

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Autoimmune Diseases Pub Date : 2021-03-25 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7385106

Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Takaki Waritani, Kuniaki Terato

{"title":"New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora.","authors":"Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Takaki Waritani, Kuniaki Terato","doi":"10.1155/2021/7385106","DOIUrl":"https://doi.org/10.1155/2021/7385106","url":null,"abstract":"Much public research suggests that autoimmune diseases such as rheumatoid arthritis (RA) are induced by aberrant \"self\" immune responses attacking autologous tissues and organ components. However, recent studies have reported that autoimmune diseases may be triggered by dysbiotic composition changes of the intestinal bacteria and an imbalance between these bacteria and intestinal immune systems. However, there are a few solid concepts or methods to study the putative involvement and relationship of these inner environmental factors in RA pathogenesis. Fortunately, Collagen-Induced Arthritis (CIA) and Collagen Antibody-Induced Arthritis (CAIA) models have been widely used as animal models for studying the pathogenesis of RA. In addition to RA, these models can be extensively used as animal models for studying complicated hypotheses in many diseases. In this review, we introduce some basic information about the CIA and CAIA models as well as how to apply these models effectively to investigate relationships between the pathogenesis of autoimmune diseases, especially RA, and the dysbiosis of intestinal bacterial flora.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"7385106"},"PeriodicalIF":4.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25573329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden. 瑞典人口恶性贫血和其他自身免疫性疾病之间的家族风险

IF 4

Autoimmune Diseases Pub Date : 2021-01-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8815297

Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki

{"title":"Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.","authors":"Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki","doi":"10.1155/2021/8815297","DOIUrl":"https://doi.org/10.1155/2021/8815297","url":null,"abstract":"Background: Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients.Methods: We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks.Results: The number of PA patients in the offspring generation (for which the familial risk was calculated) was 7701; 278 (3.6%) patients had a family history of PA. The population prevalence of PA was 0.9/1000. The familial risk for PA was 3.88 when any first-degree relative was the proband, equal for men and women. The familial risk was two times higher between siblings than between offspring and parents which may be due to complex genetic background. Associations of PA with 14 discordant AIDs were significant; these included some AIDs that have previously been described as comorbidities in PA patients and several yet unreported associations, including rheumatoid arthritis and other AIDs.Conclusions: The familial risks for PA were high suggesting multifactorial genetic etiology. The results call for further population-level studies to unravel mechanisms of familial PA which may help to understand the etiology of this disease.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2021 ","pages":"8815297"},"PeriodicalIF":4.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3