Subjectivity最新文献_第6页

Stories of earthly things: for a pragmatist approach of geostories 世俗事物的故事：对于地理保守主义的实用主义方法

IF 0.5

Subjectivity Pub Date : 2022-09-01 DOI: 10.1057/s41286-022-00134-7

Didier Debaise

引用次数: 3

Faith communities: immanence, aesthetics and thinking through figures 信仰共同体：内在性、美学与人物思维

IF 0.5

Subjectivity Pub Date : 2022-09-01 DOI: 10.1057/s41286-022-00137-4

A. Hickey-Moody

引用次数: 1

Geophilosophy as the end of philosophy 地球哲学是哲学的终结

IF 0.5

Subjectivity Pub Date : 2022-08-11 DOI: 10.1057/s41286-022-00136-5

C. Colebrook

引用次数: 3

From ‘world’ to ‘earth’: non-phenomenological subjectivity in Deleuze and Guattari's geophilosophy 从“世界”到“大地”：德勒兹和瓜塔里地质哲学中的非现象学主体性

IF 0.5

Subjectivity Pub Date : 2022-08-10 DOI: 10.1057/s41286-022-00135-6

T. Roberts, Andrew Lapworth, J. Dewsbury

引用次数: 2

Affectivity, subjectivity, and vulnerability: on the new forces of mass hysteria 情感、主观性和脆弱性:论群体性歇斯底里的新力量

IF 0.5

Subjectivity Pub Date : 2022-06-02 DOI: 10.1057/s41286-022-00127-6

Raymond L. M. Lee

{"title":"Affectivity, subjectivity, and vulnerability: on the new forces of mass hysteria","authors":"Raymond L. M. Lee","doi":"10.1057/s41286-022-00127-6","DOIUrl":"https://doi.org/10.1057/s41286-022-00127-6","url":null,"abstract":"Affect theory raises greater awareness of non-representational forces in social life that can shape different levels of subjectivity in ways that may not be immediately known to the subjects. In outbreaks of mass hysteria when subjects are suddenly exposed to bizarre and extreme behaviors, the question of affect becomes a key to understanding how their subjectivity is impacted by situations that seemingly slip immediate control. Hysterical subjectivity occurs not from unconscious forces but from affective contagions spreading throughout network assemblages. These are flows of fear and conflict that with non-conscious influences constitute the new forces of mass encounters. In these encounters, micro-flows of imitation are automatized by various assemblages of intention and action to produce repeatable contagions of affects and behaviors. The occurrence of the COVID-19 pandemic demonstrates the power of these flows as facilitating a global affectivity of mass hysteria. It is an affectivity in which imitation takes on a central role as technology of the social for the behavioral control of mass populations. Ubiquitous mask-wearing in the pandemic is not only seen as a prophylactic against viral infection but also intended as a mandated form of mimicry for propagating the new politics of virality. These are politics that empower fear as an agent of cascading contagions paralyzing social, cultural, and economic life around the world.","PeriodicalId":46273,"journal":{"name":"Subjectivity","volume":"31 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138504256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Sociology of Algorithms 论算法社会学

IF 0.5

Subjectivity Pub Date : 2022-06-01 DOI: 10.1057/s41286-022-00131-w

Richard Veryard

引用次数: 1

Hegel, subjectivity and youth 黑格尔，主体性与青年

IF 0.5

Subjectivity Pub Date : 2022-05-20 DOI: 10.1057/s41286-022-00130-x

Alexandre Pais

引用次数: 2

Calculation and contingency in contemporary global markets: the logistics of subjectivity 当代全球市场的计算与偶然性：主体性物流

IF 0.5

Subjectivity Pub Date : 2022-05-13 DOI: 10.1057/s41286-022-00128-5

Montserrat Cañedo-Rodríguez, J. C. Loredo-Narciandi

引用次数: 0

The dream as transdisciplinary territory: a psychoanalytically oriented method at the service of social research 作为跨学科领域的梦:为社会研究服务的精神分析导向的方法

IF 0.5

Subjectivity Pub Date : 2022-05-13 DOI: 10.1057/s41286-022-00129-4

Isis Castañeda Capriroli, Svenska Arensburg Castelli, Rodolfo Vásquez Torres

引用次数: 0

Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2. 调控亚基 NEMO 通过与上游激活因子 IKK2 的第二次靶向相互作用，促进多泛素依赖性 NF-κB 诱导。

Subjectivity Pub Date : 2022-05-01 Epub Date: 2022-03-24 DOI: 10.1016/j.jbc.2022.101864

Myung Soo Ko, Samantha N Cohen, Smarajit Polley, Sushil K Mahata, Tapan Biswas, Tom Huxford, Gourisankar Ghosh

{"title":"Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2.","authors":"Myung Soo Ko, Samantha N Cohen, Smarajit Polley, Sushil K Mahata, Tapan Biswas, Tom Huxford, Gourisankar Ghosh","doi":"10.1016/j.jbc.2022.101864","DOIUrl":"10.1016/j.jbc.2022.101864","url":null,"abstract":"Canonical NF-κB signaling through the inhibitor of κB kinase (IKK) complex requires induction of IKK2/IKKβ subunit catalytic activity via specific phosphorylation within its activation loop. This process is known to be dependent upon the accessory ubiquitin (Ub)-binding subunit NF-κB essential modulator (NEMO)/IKKγ as well as poly-Ub chains. However, the mechanism through which poly-Ub binding serves to promote IKK catalytic activity is unclear. Here, we show that binding of NEMO/IKKγ to linear poly-Ub promotes a second interaction between NEMO/IKKγ and IKK2/IKKβ, distinct from the well-characterized interaction of the NEMO/IKKγ N terminus to the \"NEMO-binding domain\" at the C terminus of IKK2/IKKβ. We mapped the location of this second interaction to a stretch of roughly six amino acids immediately N-terminal to the zinc finger domain in human NEMO/IKKγ. We also showed that amino acid residues within this region of NEMO/IKKγ are necessary for binding to IKK2/IKKβ through this secondary interaction in vitro and for full activation of IKK2/IKKβ in cultured cells. Furthermore, we identified a docking site for this segment of NEMO/IKKγ on IKK2/IKKβ within its scaffold-dimerization domain proximal to the kinase domain-Ub-like domain. Finally, we showed that a peptide derived from this region of NEMO/IKKγ is capable of interfering specifically with canonical NF-κB signaling in transfected cells. These in vitro biochemical and cell culture-based experiments suggest that, as a consequence of its association with linear poly-Ub, NEMO/IKKγ plays a direct role in priming IKK2/IKKβ for phosphorylation and that this process can be inhibited to specifically disrupt canonical NF-κB signaling.","PeriodicalId":46273,"journal":{"name":"Subjectivity","volume":"11 1","pages":"101864"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80840010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0