Medical-Surgical Journal-Revista Medico-Chirurgicala最新文献

{"title":"TYPES OF DYSPLASTIC LESIONS AND COMPLIANCE WITH FOLLOW UP IN NORTHEASTERN ROMANIA – A RETROSPECTIVE STUDY","authors":"I.L. Stoian","doi":"10.22551/msj.2023.03.08","DOIUrl":"https://doi.org/10.22551/msj.2023.03.08","url":null,"abstract":"TYPES OF DYSPLASTIC LESIONS AND COMPLIANCE WITH FOLLOW UP IN NORTHEASTERN ROMANIA - A RETROSPECTIVE STUDY (Abstract): Cervical cancer is a worrisome condition as it correlates with a high mortality rate although being one of the most preventable cancer types. Material and methods : The medical data of all patients subjected to an excisional procedure between 2000 and 2020 were retrospectively analyzed. Thus, data regarding age, obstetric history, types of dysplastic lesions in the history, HPV infection status, colposcopic findings, identified dysplastic lesions, and the number of screening tests performed were analyzed. Data entry and analysis were performed using SPSS software version 20. Results: The study included 455 patients aged between 19 and 62 years old, mean age of 36 years and a standard deviation of 9.07. The analysis of the initial cytology results revealed that the most frequently identified dysplastic lesion was HSIL (High Grade Squamous Intraepithelial Lesion), closely followed by LSIL (Low-grade squamous intraepithelial lesion). The analysis of HPV DNA test recommendations highlighted the fact that in over 50% of cases this test was not performed. In the cases in which DNA HPV test was performed, strains 16 and 18 were most frequently identified. The colposcopic examination revealed that the lesions located within the transformation zone were the most numerous. Of the described lesions, the acetowhite epithelium was most often identified, either isolated or in combination with punctation, mosaic pattern of vascularization or leukoplakia. Conization and LLETZ (Large Loop Excision of the Transformation Zone) were the two excisional procedures used in 46.4% and 44% of the patients, respectively. Histopathological examination showed: 12.5% of the patients presented high-grade HSIL (CIN3) lesions, 47.5% low-grade CIN 1 lesions, and 7% were diagnosed with carcinoma in situ. In the post-intervention follow-up, a total of 202 patients (44.39%) showed up for the first and only 66 patients (14.5%) returned for the second post-intervention follow-up. Conclusions : The types of dysplastic lesions identified by cytology were found to be in percentages similar to those reported in the literature, with the exception of HSIL diagnosis, which was the most frequently identified. This high rate could explain the increased incidence of cervical cancer in our country. Conization and excision procedures represent a valuable method of conservative treatment, preserving at the same time patient’s fertility and avoiding a radical intervention. Low compliance with follow-up among patients from the northeastern region of Romania and the increasing migration of the groups at high risk made us use these excisional procedures even in the case of low-grade lesions in an attempt to reduce the incidence of this disease","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIDEMIOLOGY OF CHRONIC KIDNEY DISEASE AND COMORBID ILLNESS IN HOSPITALIZED GERIATRIC PATIENTS","authors":"Andra Nastasa","doi":"10.22551/msj.2023.03.06","DOIUrl":"https://doi.org/10.22551/msj.2023.03.06","url":null,"abstract":"EPIDEMIOLOGY OF CHRONIC KIDNEY DISEASE AND COMORBID ILLNESS IN HOSPITALIZED GERIATRIC PATIENTS (Abstract): Background and aims : The number of older people in Europe is expanding. Although chronic kidney disease (CKD) becomes more common with increasing age, data concerning epidemiology of CKD in older people are scarce, especially in Eastern Europe countries. In the current analysis, we aimed to fill the gap on CKD epidemiology in older people from Romania, by describing a large population of hospitalized geriatric patients. Material and methods: In this retrospective cohort study we included all patients aged ≥ 65 years hospitalized in the Geriatric Department of “Dr. C. I. Parhon” Hospital from Iași, Romania, between 2012 – 2022. CKD was identified as decreased estimated glomerular filtration rate (<60 mL/min/1.73 m 2 ) according to CKD-EPI equation. Investigated comorbid conditions included diabetes mellitus, hypertension/hypertensive heart disease, coronary artery disease, congestive heart failure, atrial fibrillation, chronic respiratory failure and anemia. Results : 3,563 geriatric patients (59.2% females) were hospitalized between 2012-2022. 3116 patients (87.4% of the total population) had a serum creatinine assay. Among these patients, the prevalence of CKD using the CKD-EPI equation was 38%. We found an unequal annually distribution between the number of patients with a diagnosis of CKD according to electronic health records and the number of patients with estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 . 86,7% of the patients with eGFR < 60 mL/min/1.73 m 2 had at least 2 comorbidities. Only 2,4% of the patients with eGFR < 60 mL/min had no other chronic condition. Conclusions: In Romanian older hospitalized patients, the prevalence of individuals with eGFR <60 mL/min/1.73 m2 is higher than previous reports from our country. In geriatric adults, CKD is not an isolated entity, and the burden of cardiovascular comorbid illness is high.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BLOOD PRESSURE LOWERING EFFECTS OF CENTRAL TNF- BLOCKADE DEPENDS ON FUNCTIONAL LEPTIN SIGNALING","authors":"I. Tudorancea","doi":"10.22551/msj.2023.03.13","DOIUrl":"https://doi.org/10.22551/msj.2023.03.13","url":null,"abstract":"BLOOD","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATIONS BETWEEN THE LYMPHOID INFILTRATE AND THE STEROID HORMONE RECEPTORS IN ENDOMETRIOSIS","authors":"Ioana Pavaleanu","doi":"10.22551/msj.2023.03.11","DOIUrl":"https://doi.org/10.22551/msj.2023.03.11","url":null,"abstract":"CORRELATIONS BETWEEN THE LYMPHOID INFILTRATE AND THE STEROID HORMONE RECEPTORS IN ENDOMETRIOSIS (Abstract): Aim : Endometriosis, a chronic estrogen-dependent disease, is associated with persistent pelvic pain and is classified as a neu-ro-inflammatory disorder. This study aimed to decipher the inflammatory milieu in endometriosis, focusing on the lymphoid infiltrate represented by the CD4+ cells, CD8+ cells, and CD68+ macrophages, and the possible correlation with steroid hormone receptor expressions. Material and methods : Research conducted at the “Elena Doamna” Clinical Hospital and the “Grigore T. Popa” University of Medicine and Pharmacy in Iași, Romania, involved retrospective analysis of 53 patients with endometriosis from 2018 to 2023. Results: Through immuno-histochemical assays, we observed correlations between CD4 and CD8 expressions, and be-tween CD4, CD68, and the PR score. Also, a possible causality between the macrophage infiltrate and PR expression could be suggested. Conclusions: The inflammatory infiltrate’s analysis in endometriosis provides a deeper knowledge of its pathological development and the interplay of inflammatory cells. Understanding these receptors might guide future treatment strategies for better disease management","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONVENTIONAL VERSUS ENDOVENOUS TREATMENT IN CHRONIC VENOUS DISEASE - A COMPARATIVE STUDY BASED ON QUALITY OF LIFE","authors":"Cristina Strobescu-Ciobanu","doi":"10.22551/msj.2023.03.10","DOIUrl":"https://doi.org/10.22551/msj.2023.03.10","url":null,"abstract":"CONVENTIONAL VERSUS ENDOVENOUS TREATMENT","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHEMICAL ASSESSMENT AND BIOLOGIC POTENTIAL OF A SPECIAL LESPEDEZA CAPITATA EXTRACT","authors":"Roxana-Delia Chitiala","doi":"10.22551/msj.2023.03.16","DOIUrl":"https://doi.org/10.22551/msj.2023.03.16","url":null,"abstract":"CAPITATA EXTRACT (Abstract): Secondary metabolites are natural compounds synthesized by plants as an adaptation to environmental factors. Humans use such components for the prevention and treatment of minor or mild conditions. Lespedeza capitata is a medicinal and melliferous plant known for its various beneficial properties (antioxidant, antiaging, an-tiedematous, etc.). The objectives of this study were to identify and quantify the secondary metabolites from a selective L. capitata extract. Moreover, the evaluation of the antioxidant activity was part of the present research. Material and methods: Identification and semi-quantification were assessed by liquid chromatography (HPLC/MS), and the total flavonoids and polyphenols were determined by spectrophotometry according to European Pharmacope-ia indications. DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and iron chelation test were used to establish the antioxidant putative effects of the investigated extract. Results : Among the identified compounds different quercetin derivatives, chlorogenic acid, and rosmarinic acid were found. The total polyphenols amounted to 174.24 mg/g GAE and flavonoids measured 95.65 mg/g rutoside equivalents. The antioxidant activity showed a good capacity to scavenge free radicals and a higher potential to chelate ferrous ions. The intensity of the effect was correlated to concentration. All in all, the investigated L. capitata extract demonstrated a polyphenol and flavonoid-rich content with good antioxidant potential.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE MORPHOLOGIC AND CHEMICAL PRELIMINARY ASSESSMENT OF THREE ROMANIAN AGASTACHE SPECIES","authors":"Magdalena-Mihaela Fluture","doi":"10.22551/msj.2023.03.17","DOIUrl":"https://doi.org/10.22551/msj.2023.03.17","url":null,"abstract":"ASSESSMENT OF THREE ROMANIAN AGASTACHE SPECIES (Abstract): Phenolic compounds, such as flavonoids and phenolic acids, are classified as secondary metabolites in plants. The increasing interest in utilizing these components in traditional medicine for the prevention or treatment of diverse pathologies based on their antioxidant properties. The objectives of this study were to identify the microscopic characteristics and to quantify the levels of total phenolics and flavonoids of three different Agastache species: A. foeniculum , A. mexicana , and A. ur-ticifolia . Material and methods: Microscopy followed 10 th European Pharmacopoeia (Ph. Eur.) provision regarding the evaluation of plant products. The quantification of phenolic content was conducted using the Folin-Ciocalteu method, while the determination of total flavonoids was conducted using the aluminum chloride and sodium nitrate method. Results : Microscopic features showed similar structures for leaves and flowers. Differences were given by the density of stomata and glandular or surface trichomes. The total phenolic content of the extracts varied from 213 to 642 mg % and the maximum was determined for A. foe-niculum . Also, the measured total flavonoid content was found to be between 29.4 mg % and 58 mg %, the same sample having the highest amount. Conclusions: The methanolic extracts of this plant exhibits a notable concentration of phenolic and flavonoid compounds, suggesting its potential as a therapeutic agent for various diseases. However, further investigation is required to fully understand its efficacy and safety profile","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUDDEN DEATH IN THE CARDIOLOGIST’S VIEW - BETWEEN LITERATURE AND EPIDEMIOLOGY","authors":"Irina Iuliana Costache","doi":"10.22551/msj.2023.03.01","DOIUrl":"https://doi.org/10.22551/msj.2023.03.01","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of liver fibrosis and steatosis using vibration-controlled transient elastography in individuals employed in a North-Eastern Romanian Industrial Company","authors":"R. Nastasa","doi":"10.22551/msj.2023.02.05","DOIUrl":"https://doi.org/10.22551/msj.2023.02.05","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77485850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The proinflammatory role of serum IL-6 in acute otitis media in children","authors":"Cristina Gavrilovici","doi":"10.22551/msj.2023.02.09","DOIUrl":"https://doi.org/10.22551/msj.2023.02.09","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88454584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}