Southeast Asian Bulletin of Mathematics最新文献

{"title":"The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity.","authors":"Su Gao, Sarbani Ghoshal, Liyan Zhang, Joseph R Stevens, Kyle S McCommis, Brian N Finck, Gary D Lopaschuk, Andrew A Butler","doi":"10.1074/jbc.RA119.008967","DOIUrl":"10.1074/jbc.RA119.008967","url":null,"abstract":"<p><p>The peptide hormone adropin regulates energy metabolism in skeletal muscle and plays important roles in the regulation of metabolic homeostasis. Besides muscle, the liver has an essential role in regulating glucose homeostasis. Previous studies have reported that treatment of diet-induced obese (DIO) male mice with adropin^34-76 (the putative secreted domain) reduces fasting blood glucose independently of body weight changes, suggesting that adropin suppresses glucose production in the liver. Here, we explored the molecular mechanisms underlying adropin's effects on hepatic glucose metabolism in DIO mice. Male DIO B6 mice maintained on a high-fat diet received five intraperitoneal injections of adropin^34-76 (450 nmol/kg/injection) over a 48-h period. We found that adropin^34-76 enhances major intracellular signaling activities in the liver that are involved in insulin-mediated regulation of glucose homeostasis. Moreover, treatment with adropin^34-76 alleviated endoplasmic reticulum stress responses and reduced activity of c-Jun N-terminal kinase in the liver, explaining the enhanced activities of hepatic insulin signaling pathways observed with adropin^34-76 treatment. Furthermore, adropin^34-76 suppressed cAMP activated protein kinase A (PKA) activities, resulting in reduced phosphorylation of inositol trisphosphate receptor, which mediates endoplasmic reticulum calcium efflux, and of cAMP-responsive element-binding protein, a key transcription factor in hepatic regulation of glucose metabolism. Adropin^34-76 directly affected liver metabolism, decreasing glucose production and reducing PKA-mediated phosphorylation in primary mouse hepatocytes <i>in vitro</i> Our findings indicate that major hepatic signaling pathways contribute to the improved glycemic control achieved with adropin^34-76 treatment in situations of obesity.</p>","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"2 1","pages":"13366-13377"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88910666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Stable Exchange Rings","authors":"Huanyin Chen","doi":"10.1007/S10012-000-0019-4","DOIUrl":"https://doi.org/10.1007/S10012-000-0019-4","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"24 1","pages":"19-24"},"PeriodicalIF":0.2,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10012-000-0019-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52231151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representations of G-Brauer Algebras","authors":"M. Parvathi, D. Savithri","doi":"10.1007/S10012-002-0453-6","DOIUrl":"https://doi.org/10.1007/S10012-002-0453-6","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"117 1","pages":"453-468"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10012-002-0453-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52242676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ideals and Subalgebras in BCI-Algebras","authors":"Wen-Chung Huang, Y. Jun","doi":"10.1007/S100120200060","DOIUrl":"https://doi.org/10.1007/S100120200060","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"567-573"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S100120200060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52247547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectivity and Graded Injectivity","authors":"Tang Jianliang, Yi Zhong, Cheng Fuchang","doi":"10.1007/S100120200073","DOIUrl":"https://doi.org/10.1007/S100120200073","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"11 1","pages":"685-691"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S100120200073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52248102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Hyers-Ulam Stability Problem for Quadratic Multi-dimensional Mappings on the Gaussian Plane","authors":"J. Rassias","doi":"10.1007/S10012-002-0483-0","DOIUrl":"https://doi.org/10.1007/S10012-002-0483-0","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"483-502"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10012-002-0483-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52242923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Adjoint Monoids of Implicative BCK-algebras","authors":"Shao-Xian Xu","doi":"10.1007/S10012-002-0535-5","DOIUrl":"https://doi.org/10.1007/S10012-002-0535-5","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"535-540"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10012-002-0535-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52244252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On Positive and Weakly Positive Implicative BCI-Algebras","authors":"Yisheng Huang","doi":"10.1007/S100120200061","DOIUrl":"https://doi.org/10.1007/S100120200061","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"575-582"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S100120200061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52247613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration by Parts for the Denjoy-Bochner Integral","authors":"Ye Guoju, W. Congxin, Lee Peng Yee","doi":"10.1007/S100120200074","DOIUrl":"https://doi.org/10.1007/S100120200074","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"693-700"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S100120200074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52248170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Continuation at the Boundary for Elliptic Operators in Dini Domains","authors":"Xiangxing Tao, Songyan Zhang","doi":"10.1007/S10012-002-0523-9","DOIUrl":"https://doi.org/10.1007/S10012-002-0523-9","url":null,"abstract":"","PeriodicalId":45966,"journal":{"name":"Southeast Asian Bulletin of Mathematics","volume":"26 1","pages":"523-534"},"PeriodicalIF":0.2,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S10012-002-0523-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52244193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}