Iranian Journal of Neurology最新文献_第9页

The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis. TBX21-1514T>C多态性在多发性硬化易感性中的保护作用

Iranian Journal of Neurology Pub Date : 2018-07-06

Fatemeh Akbarian, Mitra Ataei, Zivar Salehi, Masoud Nabavi, Mohammad Hossein Sanati

{"title":"The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis.","authors":"Fatemeh Akbarian, Mitra Ataei, Zivar Salehi, Masoud Nabavi, Mohammad Hossein Sanati","doi":"","DOIUrl":"","url":null,"abstract":"Background: As a T-cell mediated disease, multiple sclerosis (MS) pathogenesis might be associated with the immune system and its involved genes. TBX21, which encodes T-bet transcription factor, is a critical regulator of the commitment to the Th1 lineage and Interferon gamma (IFNγ) production. Investigation of the association of -1514T > C polymorphism located upstream of TBX21 gene with MS susceptibility is reasonable due to its demonstrated significant association with some other immune-mediated diseases. Methods: We analyzed the genotype frequencies of -1514T > C polymorphism between 248 Iranian patients with MS and 163 matched healthy controls. By applying polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP)- technique, the single-strand conformation patterns of the amplicons were compared and sequenced. Results: Strong association between the wild -1514T allele and MS susceptibility was found with the allelic frequency of 99.6% in patients vs. 95.1% in controls (P = 0.002), and the CC genotype frequency of the TBX21 polymorphism (-1514T > C) reported potential protective effect against the disease (P = 0.014). Conclusion: The TBX21-1514T > C polymorphism confers possible protective effect on MS in Iranian population. Further comprehensive studies in different settings are required to clarify the exact role of TBX21 gene in MS disease.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37069709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction or aggravation of other immune-mediated disorders by disease-modifying therapy in treatment of multiple sclerosis. 在多发性硬化症的治疗中，疾病修饰疗法诱导或加重其他免疫介导的疾病。

Iranian Journal of Neurology Pub Date : 2018-07-06

Seyed Mohammad Baghbanian, Mohammad Ali Sahraian

引用次数: 0

Hypothyroidism among patients with glioblastoma multiforme. 多形性胶质母细胞瘤患者的甲状腺功能减退。

Iranian Journal of Neurology Pub Date : 2018-07-06

Morteza Faghih-Jouybari, Soheil Naderi, Sara Mashayekhi, Tahereh Padeganeh, Sina Abdollahzade

引用次数: 0

Transcranial sonography in carriers of Gaucher disease Gaucher病携带者的经颅多普勒超声检查

Iranian Journal of Neurology Pub Date : 2018-07-06 DOI: 10.18502/IJNL.V17I3.374

Fateme Omrani, Shahla Ansari-Damavandi, B. Zamani, Zahra Omrani, Nahid Mohammadzade, Sadra Rohani, M. Rohani

引用次数: 3

Hypothyroidism among patients with glioblastoma multiforme 多形性胶质母细胞瘤患者甲状腺功能减退

Iranian Journal of Neurology Pub Date : 2018-07-06 DOI: 10.18502/IJNL.V17I3.375

Morteza Faghih-Jouybari, S. Naderi, Sara Mashayekhi, Tahereh Padeganeh, S. Abdollahzade

引用次数: 0

Neurobrucellosis with intramedullary spinal cord involvement: A case report. 神经布鲁氏菌病伴髓内脊髓受累1例。

Iranian Journal of Neurology Pub Date : 2018-07-06

Vida Mohammadzadeh, Samira Akbarieh, Seyed Abdolreza Ghoreishi, Manizheh Jozpanahi

引用次数: 0

Validation of the Persian version of dysphagia in multiple sclerosis questionnaire for the assessment of dysphagia in multiple sclerosis. 波斯语版多发性硬化症吞咽困难问卷用于评估多发性硬化症吞咽困难的有效性。

Iranian Journal of Neurology Pub Date : 2018-07-06

Zahra Jafari, Mohammad Rahim Shahbodaghi, Saman Maroufizadeh, Abdorreza Naser Moghadasi

{"title":"Validation of the Persian version of dysphagia in multiple sclerosis questionnaire for the assessment of dysphagia in multiple sclerosis.","authors":"Zahra Jafari, Mohammad Rahim Shahbodaghi, Saman Maroufizadeh, Abdorreza Naser Moghadasi","doi":"","DOIUrl":"","url":null,"abstract":"Background: About one third of patients with multiple sclerosis (MS) experience dysphagia. Dysphagia can cause complications such as malnutrition, lung infections, aspiration pneumonia and dehydration, thus it is very helpful to diagnose dysphagia as soon as possible. The aim in this study was to translate dysphagia in multiple sclerosis (DYMUS) questionnaire into Farsi and and validate it. Methods: Forward-backward method was used to translate original English version of DYMUS into farsi, and then the questionnaire (one for each patient) was filled in through asking questions from 200 patients with MS by a speech and language pathologist. Confirmatory factor analysis (CFA) was used to examine the construct validity. Internal consistency and test-retest reliability of the DYMUS were evaluated using Cronbach's alpha and the intraclass correlation coefficient (ICC), respectively. Results: CFA showed that a two-factor model of DYMUS including \"dysphagia for solid\" and \"dysphagia for liquid\" fitted the data well [relative chi-square [χ2/degree of freedom (df) = 1.55, CFI = 0.967, Tucker-Lewis index (TLI) = 0.957, root mean square error of approximation (RMSEA) = 0.053, and weighted root mean square residual (WRMR) = 0.874]. The Cronbach's alpha for total score and liquid and solid subscales were 0.776, 0.557, and 0.725, respectively. The DYMUS showed adequate test-retest reliability for the total and subscales (ICC: 0.880-0.956). Moreover, this study has shown a significant relationship between DYMUS score and Expanded Disability Status Scale (EDSS) score, disease duration, type of MS, and self-reported dysphagia. Conclusion: The Persian version of DYMUS is a reliable and valid tool to screen dysphagia among patients with MS.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37069708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis. 多发性硬化症患者血清素转运体基因多态性与心理状态的关系

Iranian Journal of Neurology Pub Date : 2018-07-06

Shirin Farjadian, Bahareh Fakhraei, Zahra Niknam, Mahboubeh Nasiri, Aslan Azad, Mojtaba Farjam, Alireza Nikseresht

{"title":"Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis.","authors":"Shirin Farjadian, Bahareh Fakhraei, Zahra Niknam, Mahboubeh Nasiri, Aslan Azad, Mojtaba Farjam, Alireza Nikseresht","doi":"","DOIUrl":"","url":null,"abstract":"Background: Multiple sclerosis (MS) is the most common neuroinflammatory disease in young adults. Anxiety and depression may predispose individuals to MS and flare-ups. Serotonin transmission is modified in some brain regions of patients with MS, and these changes may contribute to their psychiatric abnormalities. We studied the frequencies of common polymorphisms of the serotonin reuptake transporter (SERT) gene in patients with MS according to their psychological status. Methods: The 5-HTTLPR, rs25531, and STin2VNTR polymorphisms of the SERT gene were genotyped by polymerase chain reaction (PCR)-based methods in 100 patients with MS and 100 healthy controls. Results: There were no remarkable differences in SERT gene polymorphisms between patients with MS and healthy controls. Unlike the control group, 41% of the patients showed some degree of depression based on Beck Depression Inventory (BDI), but no association was observed between SERT gene polymorphisms after the patients were stratified by depression status. Conclusion: In addition to SERT gene polymorphisms, modulation of serotonin at the synapses may also be regulated by genetic variations in tryptophan hydroxylase type 2 and serotonin receptors. Further studies with functional brain imaging of the serotonergic system in patients with MS can provide information on the role of serotonin in this disease.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37069710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis 多发性硬化患者5-羟色胺转运蛋白基因多态性与心理状况

Iranian Journal of Neurology Pub Date : 2018-07-06 DOI: 10.18502/IJNL.V17I3.366

S. Farjadian, B. Fakhraei, Z. Niknam, M. Nasiri, A. Azad, M. Farjam, A. Nikseresht

{"title":"Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis","authors":"S. Farjadian, B. Fakhraei, Z. Niknam, M. Nasiri, A. Azad, M. Farjam, A. Nikseresht","doi":"10.18502/IJNL.V17I3.366","DOIUrl":"https://doi.org/10.18502/IJNL.V17I3.366","url":null,"abstract":"Background: Multiple sclerosis (MS) is the most common neuroinflammatory disease in young adults. Anxiety and depression may predispose individuals to MS and flare-ups. Serotonin transmission is modified in some brain regions of patients with MS, and these changes may contribute to their psychiatric abnormalities. We studied the frequencies of common polymorphisms of the serotonin reuptake transporter (SERT) gene in patients with MS according to their psychological status. Methods: The 5-HTTLPR, rs25531, and STin2VNTR polymorphisms of the SERT gene were genotyped by polymerase chain reaction (PCR)-based methods in 100 patients with MS and 100 healthy controls. Results: There were no remarkable differences in SERT gene polymorphisms between patients with MS and healthy controls. Unlike the control group, 41% of the patients showed some degree of depression based on Beck Depression Inventory (BDI), but no association was observed between SERT gene polymorphisms after the patients were stratified by depression status. Conclusion: In addition to SERT gene polymorphisms, modulation of serotonin at the synapses may also be regulated by genetic variations in tryptophan hydroxylase type 2 and serotonin receptors. Further studies with functional brain imaging of the serotonergic system in patients with MS can provide information on the role of serotonin in this disease.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43471525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis 帕金森病的氧化应激相关生物标志物:系统综述和荟萃分析

Iranian Journal of Neurology Pub Date : 2018-07-06 DOI: 10.18502/IJNL.V17I3.373

Z. Khan, Sharique A. Ali

{"title":"Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis","authors":"Z. Khan, Sharique A. Ali","doi":"10.18502/IJNL.V17I3.373","DOIUrl":"https://doi.org/10.18502/IJNL.V17I3.373","url":null,"abstract":"Parkinson’s disease (PD) is a neurodegenerative disease characterized with the loss of dopamine-producing neurons in a mid-brain. This loss is believed to be associated with number of environmental and genetic factors. Oxidative stress is found to be one of the factors responsible for the initiation and progression of PD. However, studies are still continued to confirm the connection and mechanism associated with oxidative stress and PD. This systematic review and meta-analysis aimed to assess the association between oxidative stress markers and PD, and explore factors that may elucidate the contradictions in these results. As per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline systematic literature search was carried out. Meta-analysis was carried out on pooled standardized mean differences with 95% confidence interval (CI) of patients with PD and controls using random effect model in comprehensive meta-analysis statistical software. Total 17 studies were included into which 25 oxidative stress markers were analyzed. The results revealed that oxidative stress markers [nitrate and nitric oxide (NO)] and antioxidant markers [total antioxidant status (TAS) and thiols] were not statistically different between the PD and control group (P > 0.05). In case of oxidative stress markers, levels of malondialdehyde (MDA), 8-Oxo-2'-deoxyguanosine (8-oxo-dG), and lipid hydro-peroxide (LPO) were found to be high in patients with PD as compared to controls with P < 0.05, whereas lower levels of antioxidant activity of superoxide dismutase (SOD), glucose 6 phosphate dehydrogenase (G6PD), catalase (CAT), and glutathione peroxidase (GPx) were noticed in the PD group as compared to controls (P < 0.05 for all). From the results, it is concluded that patients with PD have high oxidative stress and lower antioxidant activity, and these studied biomarkers would be used as potential diagnostic tool to measure oxidative stress in patients with PD.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30