Iranian Journal of Neurology最新文献_第3页

An overview of motor unit number index reproducibility in amyotrophic lateral sclerosis 肌萎缩侧索硬化症运动单位数指数再现性综述

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1635

D. Fathi, S. Nafissi, S. Attarian, C. Neuwirth, F. Fatehi

引用次数: 4

Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article. 富马酸二甲酯在治疗多形性胶质母细胞瘤中的作用：一篇综述文章。

Iranian Journal of Neurology Pub Date : 2019-07-06

Reza Ahmadi-Beni, Ali Najafi, Seyed Mehrdad Savar, Niayesh Mohebbi, Alireza Khoshnevisan

引用次数: 0

Intractable headache with autonomic features after gamma knife radiosurgery: A case report 伽玛刀治疗后顽固性头痛伴自主神经功能1例

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/ijnl.v18i3.1638

M. Togha, A. Moghadasi, S. Haghighi, M. Motamedi

引用次数: 0

The effects of botulinum toxin type A injection on pain symptoms, quality of life, and sleep quality of patients with diabetic neuropathy: A randomized double-blind clinical trial A型肉毒杆菌毒素注射液对糖尿病神经病变患者疼痛症状、生活质量和睡眠质量的影响：一项随机双盲临床试验

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1632

Hossein Salehi, Moein Moussaei, Z. Kamiab, A. Vakilian

{"title":"The effects of botulinum toxin type A injection on pain symptoms, quality of life, and sleep quality of patients with diabetic neuropathy: A randomized double-blind clinical trial","authors":"Hossein Salehi, Moein Moussaei, Z. Kamiab, A. Vakilian","doi":"10.18502/IJNL.V18I3.1632","DOIUrl":"https://doi.org/10.18502/IJNL.V18I3.1632","url":null,"abstract":"Background: Neuropathic pain is one of the most common problems in patients with diabetes mellitus (DM). In this study, the effect of botulinum toxin type A (BTX-A) on neuropathic pain, quality of sleep, and quality of life of diabetic patients with sensorimotor polyneuropathy was studied. Methods: This randomized placebo-controlled trial study was carried out in a double-blind (patient-researcher) method. The study was performed on 32 patients with type 2 DM. Neuropathy was confirmed by Douleur Neuropathique 4 (DN4) Questionnaire and nerve conduction study (NCS). The patients were randomly assigned to two intervention and control groups based on the random numbers table. After selecting the subjects, we used 36-Item Short Form Health Survey (SF-36), Neuropathic Pain Scale (NPS), Visual Analogue Scale (VAS), and Pittsburgh Sleep Quality Index (PSQI) questionnaires before and after 3 months of 100 units BTX-A injection (as intervention group) or same amount of chloride sodium (as control group) to the subjects' feet. The data were analyzed by SPSS software using independent two-sample t-test, chi-square test, and one-way repeated measures analysis of variance (ANOVA). Results: 12 male and 20 female patients participated in this study. There was a significant difference in the mean VAS, PSQI, physical dimension of the SF-36, and some NPS indices over time (12 weeks) (P < 0.001). Conclusion: The results of this study showed that BTX-A reduced neuropathic pain and improved the quality of life and sleep in people with diabetic neuropathy.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43585339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Association of cigarette smoking with neuromyelitis optica-immunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder 吸烟与视神经脊髓炎谱系障碍患者视神经脊髓免疫球蛋白G血清阳性的关系

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1631

S. Eskandarieh, A. Moghadasi, M. A. Sahraiain, A. Azimi, N. Molazadeh

{"title":"Association of cigarette smoking with neuromyelitis optica-immunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder","authors":"S. Eskandarieh, A. Moghadasi, M. A. Sahraiain, A. Azimi, N. Molazadeh","doi":"10.18502/IJNL.V18I3.1631","DOIUrl":"https://doi.org/10.18502/IJNL.V18I3.1631","url":null,"abstract":"Background: Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory demyelinating disease caused by the presence of a highly specific serum autoantibody marker, NMO-immunoglobulin G (NMO-IgG), that reacts against the water channel aquaporin-4 (AQP4). The present study examined the association between NMO-IgG sero-positivity and environmental factors such as cigarette smoking. Methods: A cross-sectional study was conducted in Sina Hospital, a tertiary referral center in Tehran, Iran. All the patients with a definite diagnosis of NMOSD were involved in this study. The enzyme-linked immunosorbent assay (ELISA) was used to examine the AQP4-IgG status. To assess the association between NMO-IgG sero-positivity and cigarette smoking, a researcher-made questionnaire covering patients’ lifestyle information on smoking habits was designed and administered using the structured face-to-face interviews with the patients. Results: The positive and negative NMO-IgG results were found in 44 (46.8%) and 50 (53.2%) patients, respectively. The increased NMO-IgG sero-positivity odds were observed among the lifetime smokers [odds ratio (OR) = 3.24, 95% confidence interval (CI): 1.16-9.08], current smokers (OR = 6.08, 95% CI: 1.26-29.39), and passive smokers (OR = 2.22, 95% CI: 1.10-4.50). Conclusion: Lifetime and current smoking as well as passive smoking can be regarded as risk factors for NMO-IgG sero-positivity. Smoking with its immunological effects can lead to the production of autoantibodies such as NMO-IgG.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48652545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article 富马酸二甲酯在多形性胶质母细胞瘤治疗中的作用：一篇综述

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1636

R. Ahmadi-Beni, A. Najafi, S. Savar, Niayesh Mohebbi, A. Khoshnevisan

引用次数: 13

Recurrent ischemic stroke in a case of Takayasu’s arteritis, mimicking multiple sclerosis 大动脉炎的复发性缺血性中风，模拟多发性硬化

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1639

P. Sasannejad, Mahdieh Verdipour, M. Asadi, Hamideh Ahmadi

引用次数: 1

The trend of incidence and burden of neurological disease in Iran between 1990 and 2017: Based on global burden of disease estimations 1990年至2017年间伊朗神经系统疾病的发病率和负担趋势：基于全球疾病负担估计

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1637

H. Abbastabar, S. Bitarafan, M. Harirchian

{"title":"The trend of incidence and burden of neurological disease in Iran between 1990 and 2017: Based on global burden of disease estimations","authors":"H. Abbastabar, S. Bitarafan, M. Harirchian","doi":"10.18502/IJNL.V18I3.1637","DOIUrl":"https://doi.org/10.18502/IJNL.V18I3.1637","url":null,"abstract":"Neurological disease contributes significantly to morbidity and mortality in different ages and geographic areas around the world. The purpose of the current study was to investigate the incidence and disability-adjusted life years (DALYs) trend of neurological disease in Iran during 27 years ago. We used the data of the Global Burden of Disease (GBD) Study to estimate the incidence and DALYs of neurological disease in Iran in different age groups between 1990 and 2017. Age groups were defined in 5 groups including < 5 years, 5-14 years, 15-49 years, 50-69 years, and ≥ 70 years. The incidence number of neurological disease during 1990 to 2017 increased from 7.5 million to more than 12 million and the incidence rate grew as much as 1400 per 100000 populations in Iran. Totally, headache, epilepsy, and Alzheimer were the most common neurological diseases according to incidence and had the most values of DALY in Iran. The highest incidence and DALY of neurological disease was observed in the age group of 15-49 years. This study showed that the incidence and burden of neurological diseases had a dramatic increasing trend during 27 years ago in Iran. Consequently, it is necessary to investigate the causes of the growing trend in future studies.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48726234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Herbopathy-induced Cephalalgia: Remedy gone wrong 草药引起的头痛：补救措施出了问题

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/ijnl.v18i3.1640

A. Mittal, Alessandro Iliceto, B. Yegneswaran

引用次数: 1

Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2 富马酸二甲酯对脑卒中的神经保护作用：核因子红系2相关因子2的作用

Iranian Journal of Neurology Pub Date : 2019-07-06 DOI: 10.18502/IJNL.V18I3.1633

A. Safari, Hamzeh Badeli-Sarkala, M. Namavar, Elias Kargar-Abarghouei, Neda Anssari, S. Izadi, A. Borhani-Haghighi

{"title":"Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2","authors":"A. Safari, Hamzeh Badeli-Sarkala, M. Namavar, Elias Kargar-Abarghouei, Neda Anssari, S. Izadi, A. Borhani-Haghighi","doi":"10.18502/IJNL.V18I3.1633","DOIUrl":"https://doi.org/10.18502/IJNL.V18I3.1633","url":null,"abstract":"Background: There is evidence that supports the neuroprotective effects of dimethyl fumarate (DMF) in stroke. Nuclear factor erythroid 2-related factor 2 (Nrf2) has both anti-oxidant and anti-inflammatory mechanisms. We investigated the neuroprotective effects of DMF via Nrf2 activation in the cortex, striatum, and diencephalon in a middle cerebral artery occlusion (MCAO) model of stroke. Methods: 22 Sprague-Dawley male rats were randomized into 3 groups. In DMF-treated group (n = 8), rats received 15 mg/kg oral DMF twice daily by gavage from day 0 to 14 after a 60-minute MCAO. The vehicle group (n = 7) underwent MCAO and were given methocel/H2O, using the same method and schedule. In the sham group (n = 7), neck was opened, but neither middle cerebral artery (MCA) was occluded nor any drug was administered. After 14 days, the animals were sacrificed. The infarct volume were assessed by stereology method. Nrf2 expression was evaluated in the cortex, striatum, and diencephalon by immunohistochemistry method. Results: Ratio of infarct to total brain volume was significantly lower in the DMF-treated group (5.76%) in comparison with the vehicle group (22.39%) (P < 0.0001). Nrf2 expression was higher in DMF-treated group in comparison with both the vehicle and sham groups in cortex, striatum, diencephalon, and total brain (P < 0.0001). In the DMF-treated group, significant negative correlation between Nrf2 expression and infarct volume was observed in cortex, striatum, diencephalon, and total brain. Conclusion: DMF induces Nrf2 expression and its neuroprotective effects in different brain anatomical regions.","PeriodicalId":45759,"journal":{"name":"Iranian Journal of Neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41295074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15