Harry Flanagan, Robert Cooper, Keith P George, Daniel X Augustine, Aneil Malhotra, Maria F Paton, Shaun Robinson, David Oxborough
{"title":"The athlete's heart: insights from echocardiography.","authors":"Harry Flanagan, Robert Cooper, Keith P George, Daniel X Augustine, Aneil Malhotra, Maria F Paton, Shaun Robinson, David Oxborough","doi":"10.1186/s44156-023-00027-8","DOIUrl":"10.1186/s44156-023-00027-8","url":null,"abstract":"<p><p>The manifestations of the athlete's heart can create diagnostic challenges during an echocardiographic assessment. The classifications of the morphological and functional changes induced by sport participation are often beyond 'normal limits' making it imperative to identify any overlap between pathology and normal physiology. The phenotype of the athlete's heart is not exclusive to one chamber or function. Therefore, in this narrative review, we consider the effects of sporting discipline and training volume on the holistic athlete's heart, as well as demographic factors including ethnicity, body size, sex, and age.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"15"},"PeriodicalIF":6.3,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lynsey Forsythe, Keith George, Michael Papadakis, Nathan Mill, Matt Daniels, David Oxborough
{"title":"Seasonal variation of cardiac structure and function in the elite rugby football league athlete.","authors":"Lynsey Forsythe, Keith George, Michael Papadakis, Nathan Mill, Matt Daniels, David Oxborough","doi":"10.1186/s44156-023-00026-9","DOIUrl":"10.1186/s44156-023-00026-9","url":null,"abstract":"<p><strong>Background: </strong>Pre-participation cardiac screening (PCS) of \"Super-League\" rugby football league (RFL) athletes is mandatory but may be completed at any time point. The aim of this study was to assess cardiac electrical, structural and functional variation across the competitive season.</p><p><strong>Methods: </strong>Elite, male, RFL athletes from a single Super-League club underwent cardiac evaluation using electrocardiography (ECG), 2D echocardiography and speckle tracking echocardiography (STE) at four time points across the RFL season; (1) End pre-season (ENDPRE), (2) mid-season (MIDCOMP), (3) end-season (ENDCOMP) and (4) End off-season (ENDOFF). Training loads for each time point were also determined. One-way ANOVA with post-hoc Bonferroni were used for statistical analyses.</p><p><strong>Results: </strong>Total workload undertaken by athletes was lower at both MIDCOMP and ENDCOMP compared to ENDPRE (P < 0.001). ECG patterns were normal with training-related changes that were largely consistent across assessments. Structural data did not vary across assessment points. Standard functional data was not different across assessment points but apical rotation and twist were higher at ENDPRE (9.83˚ and 16.55˚, respectively compared to all other time points (MIDCOMP, 6.13˚ and 12.62˚; ENDCOMP, 5.84˚ and 12.12˚; ENDOFF 6.60˚ and 12.35˚).</p><p><strong>Conclusions: </strong>Despite some seasonal variation in training load, the athletes' ECG and cardiac structure were stable across a competitive season. Seasonal variation in left ventricular (LV) apical rotation and twist, associated with higher training loads, should be noted in the context of PCS.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"16"},"PeriodicalIF":6.3,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Kandels, S Stöbe, A Kogel, P Hepp, H Riepenhof, J N Droste, T Stoeggl, R P Marshall, U Rudolph, U Laufs, S Fikenzer, A Hagendorff
{"title":"Effect of maximum exercise on left ventricular deformation and its correlation with cardiopulmonary exercise capacity in competitive athletes.","authors":"J Kandels, S Stöbe, A Kogel, P Hepp, H Riepenhof, J N Droste, T Stoeggl, R P Marshall, U Rudolph, U Laufs, S Fikenzer, A Hagendorff","doi":"10.1186/s44156-023-00029-6","DOIUrl":"10.1186/s44156-023-00029-6","url":null,"abstract":"<p><strong>Background: </strong>Global longitudinal strain (GLS) and global myocardial work index (GWI) allow early detection of subclinical changes in left ventricular (LV) systolic function. The aim of the study was to investigate the immediate effects of maximum physical exercise by different exercise testing methods on early post exercise LV deformation parameters in competitive athletes and to analyze their correlation with cardiopulmonary exercise capacity.</p><p><strong>Methods: </strong>To reach maximum physical exercise, cardiopulmonary exercise testing (CPET) was performed by semi-recumbent ergometer in competitive handball players (n = 13) and by treadmill testing in competitive football players (n = 19). Maximum oxygen uptake (VO<sub>2max</sub>) indexed to body weight (relative VO<sub>2max</sub>) was measured in all athletes. Transthoracic echocardiography and blood pressure measurements were performed at rest and 5 min after CPET in all athletes. GLS, GWI and their changes before and after CPET (ΔGLS, ΔGWI) were correlated with (relative) VO<sub>2max</sub>.</p><p><strong>Results: </strong>In handball and football players, GLS and GWI did not differ significantly before and after CPET. There were no significant correlations between GLS and relative VO<sub>2max</sub>, but moderate correlations were found between ΔGWI and relative VO<sub>2max</sub> in handball (r = 0.631; P = 0.021) and football players (r = 0.592; P = 0.008). Furthermore, handball (46.7 ml/min*kg ± 4.7 ml/min*kg vs. 37.4 ml/min*kg ± 4.2; P = 0.004) and football players (58.3 ml/min*kg ± 3.7 ml/min*kg vs. 49.7 ml/min*kg ± 6.8; P = 0.002) with an increased ΔGWI after CPET showed a significant higher relative VO<sub>2max</sub>.</p><p><strong>Conclusion: </strong>Maximum physical exercise has an immediate effect on LV deformation, irrespective of the used testing method. The correlation of relative VO<sub>2max</sub> with ΔGWI in the early post exercise period, identifies ΔGWI as an echocardiographic parameter for characterizing the current individual training status of athletes.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"17"},"PeriodicalIF":6.3,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meeting Abstracts from the British Society of Echocardiography Annual Meeting: BSEcho 2022.","authors":"","doi":"10.1186/s44156-023-00030-z","DOIUrl":"https://doi.org/10.1186/s44156-023-00030-z","url":null,"abstract":"","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 Suppl 1","pages":"18"},"PeriodicalIF":6.3,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panagiotis Savvoulidis, M Adnan Nadir, William E Moody, Richard Steeds, Peter F Ludman, Joseph R Bradley, Aldrin Singh, Ewa Lawton, Sagar N Doshi
{"title":"Intraprocedural versus next day transthoracic echocardiography following minimalist transfemoral TAVI.","authors":"Panagiotis Savvoulidis, M Adnan Nadir, William E Moody, Richard Steeds, Peter F Ludman, Joseph R Bradley, Aldrin Singh, Ewa Lawton, Sagar N Doshi","doi":"10.1186/s44156-023-00025-w","DOIUrl":"10.1186/s44156-023-00025-w","url":null,"abstract":"<p><strong>Background: </strong>Routine pre-discharge echocardiography (ECHO) is recommended post transcatheter aortic valve implantation (TAVI) as a baseline for future comparison. However, there is no clear guidance on the optimal timing of this study.</p><p><strong>Aim: </strong>The purpose of this retrospective study was to investigate the safety and work-force efficiency of intraprocedural same-day ECHO versus next-day ECHO, following transfemoral TAVI.</p><p><strong>Methods and results: </strong>In this retrospective study 100 consecutive patients who underwent intraprocedural ECHO only were compared with 100 consecutive patients undergoing both intraprocedural and routine next-day ECHO following elective transfemoral TAVI. All patients received the Sapien 3/Ultra transcatheter heart valve and were treated with a minimalist procedure with conscious sedation. The composite of in-hospital mortality, urgent ECHO and new tamponade after leaving the cath lab and before discharge was not different between the two groups (4 vs. 4%, P = 1). There was no paravalvular leak more than mild in any of the cases. Length of stay was similar (1 day).</p><p><strong>Conclusions: </strong>Intraprocedural post-TAVI ECHO appears as safe as next day pre-discharge ECHO and obviates the need for a routine next day study, thereby reducing burden on echocardiography services and allows better utilisation of resources.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"14"},"PeriodicalIF":6.3,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William E Moody, Lauren Turvey-Haigh, Daniel Knight, Caroline J Coats, Robert M Cooper, Rebecca Schofield, Shaun Robinson, Allan Harkness, David L Oxborough, Julian D Gillmore, Carol Whelan, Daniel X Augustine, Marianna Fontana, Richard P Steeds
{"title":"British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis.","authors":"William E Moody, Lauren Turvey-Haigh, Daniel Knight, Caroline J Coats, Robert M Cooper, Rebecca Schofield, Shaun Robinson, Allan Harkness, David L Oxborough, Julian D Gillmore, Carol Whelan, Daniel X Augustine, Marianna Fontana, Richard P Steeds","doi":"10.1186/s44156-023-00028-7","DOIUrl":"10.1186/s44156-023-00028-7","url":null,"abstract":"<p><p>These guidelines form an update of the BSE guideline protocol for the assessment of restrictive cardiomyopathy (Knight et al. in Echo Res Prac, 2013). Since the original recommendations were conceived in 2013, there has been an exponential rise in the diagnosis of cardiac amyloidosis fuelled by increased clinician awareness, improvements in cardiovascular imaging as well as the availability of new and effective disease modifying therapies. The initial diagnosis of cardiac amyloidosis can be challenging and is often not clear-cut on the basis of echocardiography, which for most patients presenting with heart failure symptoms remains the first-line imaging test. The role of a specialist echocardiographer will be to raise the suspicion of cardiac amyloidosis when appropriate, but the formal diagnosis of amyloid sub-type invariably requires further downstream testing. This document seeks to provide a focused review of the literature on echocardiography in cardiac amyloidosis highlighting its important role in the diagnosis, prognosis and screening of at risk individuals, before concluding with a suggested minimum data set, for use as an aide memoire when reporting.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"13"},"PeriodicalIF":6.3,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apurva H Bharucha, John Moore, Patrick Carnahan, Philip MacCarthy, Mark J Monaghan, Max Baghai, Ranjit Deshpande, Jonathan Byrne, Rafal Dworakowski, Mehdi Eskandari
{"title":"Three-dimensional printing in modelling mitral valve interventions.","authors":"Apurva H Bharucha, John Moore, Patrick Carnahan, Philip MacCarthy, Mark J Monaghan, Max Baghai, Ranjit Deshpande, Jonathan Byrne, Rafal Dworakowski, Mehdi Eskandari","doi":"10.1186/s44156-023-00024-x","DOIUrl":"https://doi.org/10.1186/s44156-023-00024-x","url":null,"abstract":"<p><p>Mitral interventions remain technically challenging owing to the anatomical complexity and heterogeneity of mitral pathologies. As such, multi-disciplinary pre-procedural planning assisted by advanced cardiac imaging is pivotal to successful outcomes. Modern imaging techniques offer accurate 3D renderings of cardiac anatomy; however, users are required to derive a spatial understanding of complex mitral pathologies from a 2D projection thus generating an 'imaging gap' which limits procedural planning. Physical mitral modelling using 3D printing has the potential to bridge this gap and is increasingly being employed in conjunction with other transformative technologies to assess feasibility of intervention, direct prosthesis choice and avoid complications. Such platforms have also shown value in training and patient education. Despite important limitations, the pace of innovation and synergistic integration with other technologies is likely to ensure that 3D printing assumes a central role in the journey towards delivering personalised care for patients undergoing mitral valve interventions.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"12"},"PeriodicalIF":6.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feasibility of 2-dimensional speckle tracking echocardiography strain analysis of the right ventricle with trans-thoracic echocardiography in intensive care: a literature review and meta-analysis.","authors":"James McErlane, Ben Shelley, Philip McCall","doi":"10.1186/s44156-023-00021-0","DOIUrl":"https://doi.org/10.1186/s44156-023-00021-0","url":null,"abstract":"<p><strong>Objectives: </strong>To identify variables that affect the feasibility of 2-dimensional right ventricular speckle tracking echocardiography (RV-STE) in the intensive care unit.</p><p><strong>Background: </strong>Trans-thoracic echocardiography (TTE) of the right ventricle is challenging. RV-STE is a novel echocardiography method thought to measure global RV function more fully than conventional TTE parameters. The feasibility of RV-STE in ICU populations has not been well described, and variables influencing RV-STE in ICU have not been investigated. This study aimed to address this.</p><p><strong>Methods: </strong>A literature review using Ovid MEDLINE(R) was undertaken. We performed meta-analysis with subgroup analysis of; RV-STE type (RV free-wall [RVFWLS] versus RV global longitudinal strain [RVGLS]), study design (prospective versus retrospective), coronavirus disease-19 (COVID-19) study or not, and strain software used. This was followed by meta-regression of proportion of invasive mechanical ventilation (IMV), with and without COVID-19 studies as a co-variate.</p><p><strong>Results: </strong>Eleven relevant studies from the literature search were identified, reporting an overall feasibility of RV-STE of 83.3% (95%CI 74.6-89.4%). Prospective study design was associated with higher feasibility compared with retrospective studies (p = 0.02). There were no statistical differences on univariate analysis between RVFWLS versus RVGLS, COVID-19 study or not, or strain software used. Meta-regression with COVID-19 study as a covariate demonstrated that higher proportions of IMV were significantly associated with worse feasibility (p = 0.04), as were COVID-19 studies (p < 0.01).</p><p><strong>Conclusions: </strong>We have identified three variables associated with poor feasibility; retrospective study design, COVID-19 studies, and proportion of IMV. A prospective study design should be viewed as gold standard to maximise RV-STE feasibility.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"11"},"PeriodicalIF":6.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vivek Jani, Ling Li, Mary Craft, Federico Veronesi, Nee Khoo, David Danford, Denisa Muraru, Shelby Kutty
{"title":"Semi-automated quantification of tricuspid valve dynamics and structure in tetralogy of Fallot and hypoplastic left heart syndrome using three-dimensional echocardiography.","authors":"Vivek Jani, Ling Li, Mary Craft, Federico Veronesi, Nee Khoo, David Danford, Denisa Muraru, Shelby Kutty","doi":"10.1186/s44156-023-00023-y","DOIUrl":"https://doi.org/10.1186/s44156-023-00023-y","url":null,"abstract":"<p><p>Anomalies of the tricuspid valve (TV) are associated with worsened prognosis in congenital heart disease (CHD). Here, we present a descriptive study examining changes in TV morphology in two CHD conditions-repaired tetralogy of Fallot (rTOF) and hypoplastic left heart syndrome (HLSH), using three-dimensional echocardiography. Full volume acquisitions of the TV and right ventricle (RV) were performed from an RV-focused apical view using ECG gating over 2-5 consecutive cardiac cycles using 3D echocardiography, from which TV annulus and leaflet parameters were quantified. A total of 40 rTOF patients (age 14 ± 9.8 years), 40 HLHS patients (age1.0 ± 1.5 years) and 80 age and gender matched controls were included. Among leaflet parameters, antero-posterior and posterior-septal TV coaptation heights were smaller in rTOF (p < 0.001) vs. control. Conversely, only the short-axis TV height was different in HLHS vs. controls (HLHS 1.6 ± 0.4 cm vs. control 1.4 ± 0.3 cm). TV leaflet parameters tended to be larger in HLHS, while leaflet coaptation distances were similar between groups. We demonstrate that 3D echocardiography for assessment of the TV is feasible in rTOF and HLHS patients and identifies unique differences in TV morphology. Future studies should clarify the clinical significance of TV morphology in these patient populations.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"10"},"PeriodicalIF":6.3,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9806765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aldo Pérez-Manjarrez, Edgar García-Cruz, Rodrigo Gopar-Nieto, Gian Manuel Jiménez-Rodríguez, Emmanuel Lazcano-Díaz, Gustavo Rojas-Velasco, Daniel Manzur-Sandoval
{"title":"Usefulness of the velocity-time integral of the left ventricular outflow tract variability index to predict fluid responsiveness in patients undergoing cardiac surgery.","authors":"Aldo Pérez-Manjarrez, Edgar García-Cruz, Rodrigo Gopar-Nieto, Gian Manuel Jiménez-Rodríguez, Emmanuel Lazcano-Díaz, Gustavo Rojas-Velasco, Daniel Manzur-Sandoval","doi":"10.1186/s44156-023-00022-z","DOIUrl":"https://doi.org/10.1186/s44156-023-00022-z","url":null,"abstract":"<p><strong>Background: </strong>Haemodynamic monitoring of patients after cardiac surgery using echocardiographic evaluation of fluid responsiveness is both challenging and increasingly popular. We evaluated fluid responsiveness in the first hours after surgery by determining the variability of the velocity-time integral of the left ventricular outflow tract (VTI-LVOT).</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 50 consecutive adult patients who underwent cardiac surgery and in whom it was possible to obtain VTI-LVOT measurements. We then determined the variability and correlations with our pulse pressure variation (PPV) measurements to predict fluid responsiveness.</p><p><strong>Results: </strong>A strong positive correlation was seen between the VTI-LVOT variability index absolute values and PPV for predicting fluid responsiveness in the first hours after cardiac surgery. We also found that the VTI-LVOT variability index has high specificity and a high positive likelihood ratio compared with the gold standard using a cut-off point of ≥ 12%.</p><p><strong>Conclusions: </strong>The VTI-LVOT variability index is a valuable tool for determining fluid responsiveness during the first 6 postoperative hours in patients undergoing cardiac surgery.</p>","PeriodicalId":45749,"journal":{"name":"Echo Research and Practice","volume":"10 1","pages":"9"},"PeriodicalIF":6.3,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}