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Quantitative Biology最新文献

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Cell Architectonics 细胞结构设计
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2022-01-01 DOI: 10.1007/978-981-16-5018-5_2
A. Kimura
{"title":"Cell Architectonics","authors":"A. Kimura","doi":"10.1007/978-981-16-5018-5_2","DOIUrl":"https://doi.org/10.1007/978-981-16-5018-5_2","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51118870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of the Cell over Time (Perspectives) 细胞随时间的发展(视角)
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2022-01-01 DOI: 10.1007/978-981-16-5018-5_11
A. Kimura
{"title":"Development of the Cell over Time (Perspectives)","authors":"A. Kimura","doi":"10.1007/978-981-16-5018-5_11","DOIUrl":"https://doi.org/10.1007/978-981-16-5018-5_11","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51118820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomness, Diffusion, and Probability 随机、扩散和概率
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2022-01-01 DOI: 10.1007/978-981-16-5018-5_8
A. Kimura
{"title":"Randomness, Diffusion, and Probability","authors":"A. Kimura","doi":"10.1007/978-981-16-5018-5_8","DOIUrl":"https://doi.org/10.1007/978-981-16-5018-5_8","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51119526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Biology: A Practical Introduction 定量生物学:实用导论
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2022-01-01 DOI: 10.1007/978-981-16-5018-5
A. Kimura
{"title":"Quantitative Biology: A Practical Introduction","authors":"A. Kimura","doi":"10.1007/978-981-16-5018-5","DOIUrl":"https://doi.org/10.1007/978-981-16-5018-5","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51118711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Introduction to Quantitative Biology 定量生物学概论
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2022-01-01 DOI: 10.1007/978-981-16-5018-5_1
A. Kimura
{"title":"Introduction to Quantitative Biology","authors":"A. Kimura","doi":"10.1007/978-981-16-5018-5_1","DOIUrl":"https://doi.org/10.1007/978-981-16-5018-5_1","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51118747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Integrative modeling of transmitted and de novo variants identifies novel risk genes for congenital heart disease. 传播和新发变异的综合建模确定了先天性心脏病的新风险基因。
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2021-06-01 DOI: 10.15302/j-qb-021-0248
Mo Li, Xue Zeng, Chentian Jin, S. Jin, W. Dong, Martina Brueckner, R. Lifton, Q. Lu, Hongyu Zhao
{"title":"Integrative modeling of transmitted and de novo variants identifies novel risk genes for congenital heart disease.","authors":"Mo Li, Xue Zeng, Chentian Jin, S. Jin, W. Dong, Martina Brueckner, R. Lifton, Q. Lu, Hongyu Zhao","doi":"10.15302/j-qb-021-0248","DOIUrl":"https://doi.org/10.15302/j-qb-021-0248","url":null,"abstract":"Background\u0000Whole-exome sequencing (WES) studies have identified multiple genes enriched for de novo mutations (DNMs) in congenital heart disease (CHD) probands. However, risk gene identification based on DNMs alone remains statistically challenging due to heterogenous etiology of CHD and low mutation rate in each gene.\u0000\u0000\u0000Methods\u0000In this manuscript, we introduce a hierarchical Bayesian framework for gene-level association test which jointly analyzes de novo and rare transmitted variants. Through integrative modeling of multiple types of genetic variants, gene-level annotations, and reference data from large population cohorts, our method accurately characterizes the expected frequencies of both de novo and transmitted variants and shows improved statistical power compared to analyses based on DNMs only.\u0000\u0000\u0000Results\u0000Applied to WES data of 2,645 CHD proband-parent trios, our method identified 15 significant genes, half of which are novel, leading to new insights into the genetic bases of CHD.\u0000\u0000\u0000Conclusion\u0000These results showcase the power of integrative analysis of transmitted and de novo variants for disease gene discovery.","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"9 2 1","pages":"216-227"},"PeriodicalIF":3.1,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47316490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Phase separation in synthetic biology 合成生物学中的相分离
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2021-01-01 DOI: 10.15302/j-qb-021-0262
{"title":"Phase separation in synthetic biology","authors":"","doi":"10.15302/j-qb-021-0262","DOIUrl":"https://doi.org/10.15302/j-qb-021-0262","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67350850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput experimental methods for investigating biomolecular condensates 研究生物分子凝聚物的高通量实验方法
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2021-01-01 DOI: 10.15302/j-qb-021-0264
{"title":"High-throughput experimental methods for investigating biomolecular condensates","authors":"","doi":"10.15302/j-qb-021-0264","DOIUrl":"https://doi.org/10.15302/j-qb-021-0264","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67350960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional characterization of disease/comorbidity-associated lncRNA 疾病/合并症相关lncRNA的功能表征
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2021-01-01 DOI: 10.15302/j-qb-021-0247
{"title":"Functional characterization of disease/comorbidity-associated lncRNA","authors":"","doi":"10.15302/j-qb-021-0247","DOIUrl":"https://doi.org/10.15302/j-qb-021-0247","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67350990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive total variation constraint hypergraph regularized NMF for single-cell RNA-seq data analysis 单细胞RNA-seq数据分析的自适应全变异约束超图正则化NMF
IF 3.1 4区 生物学
Quantitative Biology Pub Date : 2021-01-01 DOI: 10.15302/j-qb-021-0261
{"title":"Adaptive total variation constraint hypergraph regularized NMF for single-cell RNA-seq data analysis","authors":"","doi":"10.15302/j-qb-021-0261","DOIUrl":"https://doi.org/10.15302/j-qb-021-0261","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67351244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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