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Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies 坎地沙坦口服固体自纳米乳化给药系统:配方、表征及体外释药研究
AAPS Open Pub Date : 2017-06-15 DOI: 10.1186/s41120-017-0015-8
H. H. Ali, A. Hussein
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引用次数: 2
A review of in vivo and in vitro aspects of alcohol-induced dose dumping 酒精诱导的剂量倾倒在体内和体外的研究进展
AAPS Open Pub Date : 2017-06-07 DOI: 10.1186/s41120-017-0014-9
Susan D'Souza, S. Mayock, Alger D. Salt
{"title":"A review of in vivo and in vitro aspects of alcohol-induced dose dumping","authors":"Susan D'Souza, S. Mayock, Alger D. Salt","doi":"10.1186/s41120-017-0014-9","DOIUrl":"https://doi.org/10.1186/s41120-017-0014-9","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73734802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies 坎地沙坦西蕾地酯口服纳米乳:配方、表征及体外释药研究
AAPS Open Pub Date : 2017-06-02 DOI: 10.1186/s41120-017-0016-7
H. H. Ali, A. Hussein
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引用次数: 59
Relative bioavailability of diazoxide, manufactured at two different international locations, in healthy participants under fasting conditions: an open-label, two-stage, adaptive, sequential two-period crossover study 在两个不同的国际地点生产的二氮氧化物在禁食条件下的健康参与者中的相对生物利用度:一项开放标签、两阶段、适应性、连续两期交叉研究
AAPS Open Pub Date : 2017-05-05 DOI: 10.1186/s41120-017-0013-x
M. Behm, Jialin Xu, D. Panebianco, P. Fackler
{"title":"Relative bioavailability of diazoxide, manufactured at two different international locations, in healthy participants under fasting conditions: an open-label, two-stage, adaptive, sequential two-period crossover study","authors":"M. Behm, Jialin Xu, D. Panebianco, P. Fackler","doi":"10.1186/s41120-017-0013-x","DOIUrl":"https://doi.org/10.1186/s41120-017-0013-x","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86757745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface 线性加热非等温稳定性:一种在发现和开发界面进行药物预配制稳定性筛选的快速方法
AAPS Open Pub Date : 2017-04-26 DOI: 10.1186/s41120-017-0012-y
Agnes Kairer, Shaoxin Feng, V. Stella, Thomas K. Karami
{"title":"Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface","authors":"Agnes Kairer, Shaoxin Feng, V. Stella, Thomas K. Karami","doi":"10.1186/s41120-017-0012-y","DOIUrl":"https://doi.org/10.1186/s41120-017-0012-y","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74041187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Analytical approaches to ensure product quality -- AAPS Joint Face-to-Face Meeting of the Stability, the Pharmaceutical Impurities, and the CMC Statistics Focus Groups, April 6th, 2016 in Gaithersburg, MD 确保产品质量的分析方法——AAPS稳定性、药物杂质和CMC统计焦点小组联合面对面会议，2016年4月6日在马里兰州盖瑟斯堡举行
AAPS Open Pub Date : 2017-01-14 DOI: 10.1186/s41120-017-0011-z
Kim Huynh-Ba, Greg Larner, Helen Strickland, Dilip Choudhury, Yan Wu, J. Hofer, Zhenyu Wang, Timothy Schofield
{"title":"Analytical approaches to ensure product quality -- AAPS Joint Face-to-Face Meeting of the Stability, the Pharmaceutical Impurities, and the CMC Statistics Focus Groups, April 6th, 2016 in Gaithersburg, MD","authors":"Kim Huynh-Ba, Greg Larner, Helen Strickland, Dilip Choudhury, Yan Wu, J. Hofer, Zhenyu Wang, Timothy Schofield","doi":"10.1186/s41120-017-0011-z","DOIUrl":"https://doi.org/10.1186/s41120-017-0011-z","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76908833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Development of an algorithm to identify mass production candidate molecules to develop children’s oral medicines: a North American perspective 开发一种算法，以确定用于开发儿童口服药物的大规模生产候选分子:北美视角
AAPS Open Pub Date : 2016-11-07 DOI: 10.1186/s41120-016-0009-y
V. Bhatt-Mehta, R. MacArthur, R. Löbenberg, J. Cies, I. Cernak, R. Parrish
{"title":"Development of an algorithm to identify mass production candidate molecules to develop children’s oral medicines: a North American perspective","authors":"V. Bhatt-Mehta, R. MacArthur, R. Löbenberg, J. Cies, I. Cernak, R. Parrish","doi":"10.1186/s41120-016-0009-y","DOIUrl":"https://doi.org/10.1186/s41120-016-0009-y","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81680307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®) 使用加速稳定性评估程序(ASAPprime®)预测含有两种活性药物成分的速释片剂药物溶出度的变化
AAPS Open Pub Date : 2016-11-03 DOI: 10.1186/s41120-016-0010-5
Hanlin Li, David Nadig, A. Kuzmission, C. Riley
{"title":"Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®)","authors":"Hanlin Li, David Nadig, A. Kuzmission, C. Riley","doi":"10.1186/s41120-016-0010-5","DOIUrl":"https://doi.org/10.1186/s41120-016-0010-5","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78847972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Scientific and regulatory approaches to confirm quality and improve patient perceptions of generic drug products in Japan 采用科学和监管方法确认日本仿制药产品的质量，并改善患者对仿制药产品的认知
AAPS Open Pub Date : 2016-10-07 DOI: 10.1186/s41120-016-0008-z
H. Shibata, H. Yoshida, K. Izutsu, C. Yomota, Y. Goda, H. Okuda
{"title":"Scientific and regulatory approaches to confirm quality and improve patient perceptions of generic drug products in Japan","authors":"H. Shibata, H. Yoshida, K. Izutsu, C. Yomota, Y. Goda, H. Okuda","doi":"10.1186/s41120-016-0008-z","DOIUrl":"https://doi.org/10.1186/s41120-016-0008-z","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77849776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
FDA draft guidance on compounding animal drugs from bulk drug substances: a commentary FDA原料药复合动物药指南草案:评论
AAPS Open Pub Date : 2016-07-07 DOI: 10.1186/s41120-016-0007-0
A. Karara
{"title":"FDA draft guidance on compounding animal drugs from bulk drug substances: a commentary","authors":"A. Karara","doi":"10.1186/s41120-016-0007-0","DOIUrl":"https://doi.org/10.1186/s41120-016-0007-0","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82228939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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