Clinical Reviews in Bone and Mineral Metabolism最新文献_第7页

Erratum to: Locomotive Syndrome: Definition and Management 机车综合症：定义与管理

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-03-01 DOI: 10.1007/s12018-016-9224-2

Kozo Nakamura, T. Ogata

引用次数: 0

Current Knowledge, Drug-Based Therapeutic Options and Future Directions in Managing Osteoporosis 目前的知识，以药物为基础的治疗选择和未来的方向管理骨质疏松症

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-03-01 DOI: 10.1007/s12018-016-9207-3

A. Moshiri, A. Sharifi, A. Oryan

引用次数: 4

Osteoarthritis: More than Cartilage Degeneration 骨关节炎：不仅仅是软骨退化

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-02-16 DOI: 10.1007/s12018-017-9228-6

S. Castañeda, E. Vicente

引用次数: 15

Osteocytes and Their Messengers as Targets for the Treatment of Multiple Myeloma 骨细胞及其信使作为治疗多发性骨髓瘤的靶点

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-02-03 DOI: 10.1007/s12018-017-9227-7

J. Delgado-Calle

引用次数: 4

Clinical and Genetic Advances in Paget's Disease of Bone: a Review. 骨佩吉特病的临床和遗传学进展综述。

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-01-01 Epub Date: 2016-12-19 DOI: 10.1007/s12018-016-9226-0

N Alonso, I Calero-Paniagua, J Del Pino-Montes

{"title":"Clinical and Genetic Advances in Paget's Disease of Bone: a Review.","authors":"N Alonso, I Calero-Paniagua, J Del Pino-Montes","doi":"10.1007/s12018-016-9226-0","DOIUrl":"https://doi.org/10.1007/s12018-016-9226-0","url":null,"abstract":"Paget's disease of bone (PDB) is the second most common metabolic bone disorder, after osteoporosis. It is characterised by focal areas of increased and disorganised bone turnover, coupled with increased bone formation. This disease usually appears in the late stages of life, being slightly more frequent in men than in women. It has been reported worldwide, but primarily affects individuals of British descent. Majority of PDB patients are asymptomatic, but clinical manifestations include pain, bone deformity and complications, like pathological fractures and deafness. The causes of the disease are poorly understood and it is considered as a complex trait, combining genetic predisposition with environmental factors. Linkage analysis identified SQSTM1, at chromosome 5q35, as directly related to the disease. A number of mutations in this gene have been reported, pP392L being the most common variant among different populations. Most of these variants affect the ubiquitin-associated (UBA) domain of the protein, which is involved in autophagy processes. Genome-wide association studies enlarged the number of loci associated with PDB, and further fine-mapping studies, combined with functional analysis, identified OPTN and RIN3 as causal genes for Paget's disease. A combination of risk alleles identified by genome-wide association studies led to the development of a score to predict disease severity, which could improve the management of the disease. Further studies need to be conducted to elucidate other important aspects of the trait, such as its focal nature and the epidemiological changes found in some populations. In this review, we summarize the clinical characteristics of the disease and the latest genetic advances to identify susceptibility genes. We also list current available treatments and prospective options.","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"15 1","pages":"37-48"},"PeriodicalIF":1.8,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-016-9226-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34779119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

A Review on Bone Mineral Density Loss in Total Knee Replacements Leading to Increased Fracture Risk. 全膝关节置换术中骨密度下降导致骨折风险增加的研究综述。

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2017-01-01 Epub Date: 2017-10-27 DOI: 10.1007/s12018-017-9238-4

M Gundry, S Hopkins, K Knapp

引用次数: 22

Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale. 骨质量评估技术:从宏观尺度到纳米尺度的几何、成分和力学表征。

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2016-09-01 Epub Date: 2016-08-22 DOI: 10.1007/s12018-016-9222-4

Heather B Hunt, Eve Donnelly

{"title":"Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale.","authors":"Heather B Hunt, Eve Donnelly","doi":"10.1007/s12018-016-9222-4","DOIUrl":"https://doi.org/10.1007/s12018-016-9222-4","url":null,"abstract":"This review presents an overview of the characterization techniques available to experimentally evaluate bone quality, defined as the geometric and material factors that contribute to fracture resistance independently of areal bone mineral density (aBMD) assessed by dual energy x-ray absorptiometry. The methods available for characterization of the geometric, compositional, and mechanical properties of bone across multiple length scales are summarized, along with their outcomes and their advantages and disadvantages. Examples of how each technique is used are discussed, as well as practical concerns such as sample preparation and whether or not each testing method is destructive. Techniques that can be used in vivo and those that have been recently improved or developed are emphasized, including high resolution peripheral quantitative computed tomography to evaluate geometric properties and reference point indentation to evaluate material properties. Because no single method can completely characterize bone quality, we provide a framework for how multiple characterization methods can be used together to generate a more comprehensive analysis of bone quality to complement aBMD in fracture risk assessment.","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"14 3","pages":"133-149"},"PeriodicalIF":1.8,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-016-9222-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35427671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Effects of Drugs on Bone Quality 药物对骨质量的影响

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2016-08-24 DOI: 10.1007/s12018-016-9220-6

L. Imbert, A. Boskey

引用次数: 8

Bone Quality and Quantity are Mediated by Mechanical Stimuli 骨的质量和数量是由机械刺激介导的

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2016-08-17 DOI: 10.1007/s12018-016-9221-5

A. Berman, Joseph M. Wallace

引用次数: 5

Understanding Bone Strength from Finite Element Models: Concepts for Non-engineers 从有限元模型理解骨强度:非工程师的概念

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2016-08-08 DOI: 10.1007/s12018-016-9218-0

C. Hernandez, E. N. Cresswell

引用次数: 4