Panoeconomicus最新文献

Evolvability of cancer-associated genes under APOBEC3A/B selection. 癌症相关基因在 APOBEC3A/B 选择下的进化性。

4区经济学

Panoeconomicus Pub Date : 2023-12-05 DOI: 10.1101/2023.08.27.554991

Joon-Hyun Song, Liliana M Dávalos, Thomas MacCarthy, Mehdi Damaghi

{"title":"Evolvability of cancer-associated genes under APOBEC3A/B selection.","authors":"Joon-Hyun Song, Liliana M Dávalos, Thomas MacCarthy, Mehdi Damaghi","doi":"10.1101/2023.08.27.554991","DOIUrl":"10.1101/2023.08.27.554991","url":null,"abstract":"<p><p>Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and, ultimately, genetic variation. Mutations generated by APOBEC3 cytidine deaminases can contribute to genetic variation and the consequences of APOBEC activation differ depending on the stage of cancer, with the most significant impact observed during the early stages. However, how APOBEC activity shapes evolutionary patterns of genes in the host genome and differential impacts on cancer-associated and non-cancer genes remain unclear. Analyzing over 40,000 human protein-coding transcripts, we identified distinct distribution patterns of APOBEC3A/B TC motifs between cancer-related genes and controls, suggesting unique associations with cancer. Studying a bat species with many more APOBEC3 genes, we found diverse motif patterns in orthologs of cancer genes compared to controls, similar to humans and suggesting APOBEC evolution to reduce impacts on the genome rather than the converse. Simulations confirmed that APOBEC-induced heterogeneity enhances cancer evolution, shaping clonal dynamics through bimodal introduction of mutations in certain classes of genes. Our results suggest that a major consequence of the bimodal distribution of APOBEC affects greater cancer heterogeneity.</p>","PeriodicalId":45222,"journal":{"name":"Panoeconomicus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90589327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural change, labor market and employment in brazil after the 2017 labor market reform 2017年巴西劳动力市场改革后的结构性变化、劳动力市场与就业

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan2304627a

E. Araujo, Rinaldo Galete, C. Caldarelli

{"title":"Structural change, labor market and employment in brazil after the 2017 labor market reform","authors":"E. Araujo, Rinaldo Galete, C. Caldarelli","doi":"10.2298/pan2304627a","DOIUrl":"https://doi.org/10.2298/pan2304627a","url":null,"abstract":"The objective of this study is to analyze the effects of the set of measures adopted by the labor reform of 2017 on the generation of employment and income in Brazil. The study is based on the literature that highlights the importance of structural change in employment as a key element for economic growth and development, emphasizing that in Brazil, there is still a view that the labor market should take on more flexible work relationships to advance in the improvement of jobs, levels of employment, productivity and income. Subsequently, the article summarizes and critically comments on the main measures of the labor law reforms adopted in post-2017 Brazil. Finally, it presents an analysis of the behavior of the labor market in Brazil between 2012 and 2022 based on data from the PNADC/IBGE survey. The main results of the survey confirm that the labor reform of 2017 has not shown advances in labor market indicators or in the main macroeconomic aggregates of the country. In contrast, the data suggest deterioration in the indicators of employment, income and allocation of workers in occupations with low productivity and income characteristics.","PeriodicalId":45222,"journal":{"name":"Panoeconomicus","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68608532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An emprical study to investigate the size of non-governmental organizations in OECD countries 一项调查经合组织国家非政府组织规模的实证研究

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan211130011t

A. Tosun, A. Yilmaz

引用次数: 0

Labour market reforms in brazil (2017-2021): An analysis of the effects of recent flexibilization on labor market legislation 巴西劳动力市场改革(2017-2021):近期劳动力市场立法灵活性影响分析

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan2304601o

J. Oreiro, L. Gabriel, Stefan D’Amato, Kalinka da Silva

引用次数: 1

The impacts of the Brazilian Labour Reform on employment, output, and labour productivity 巴西劳动改革对就业、产出和劳动生产率的影响

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan2304647a

C. Amitrano, Alanna de Oliveira, Gabriel Squeff

引用次数: 0

Sectoral distribution of FDI and employment: Evidence from post- transitional European countries 外国直接投资和就业的部门分布:来自转型后欧洲国家的证据

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan2304573j

Kosta Josifidis, Novica Supic

{"title":"Sectoral distribution of FDI and employment: Evidence from post- transitional European countries","authors":"Kosta Josifidis, Novica Supic","doi":"10.2298/pan2304573j","DOIUrl":"https://doi.org/10.2298/pan2304573j","url":null,"abstract":"This paper examines, from the perspective of Post-Keynesian economics, the effects of Foreign Direct Investment (FDI) on the employment rate in 18 post-transitional European countries from 1995 to 2021. Using a two-step system Generalised Method of Moments (GMM) panel data estimator, we test the hypothesis that the employment impact of investment depends on the interaction of FDI and domestic investment in terms of crowding-in and crowding-out relationships, assuming that this relationship is sensitive to the sectoral distribution of FDI stock. Our findings suggest that the reallocation of FDI inflows from the manufacturing sector to the less labour intensive financial and information and communication technology (ICT) sectors tends to reduce the employment effect of FDI both directly and indirectly by reducing the magnitude of the crowding- in effect of FDI on domestic investment. The outcome of our study is of great interest to economic policy makers. If foreign investment displaces domestic investment and reduces employment in high value-added sectors, policies intended to attract foreign capital could be challenged and undermined. Otherwise, if foreign and domestic investment in sectors with high added value are complementary, it justifies policies aimed at attracting foreign investment.","PeriodicalId":45222,"journal":{"name":"Panoeconomicus","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68608632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contingent claims analysis as a credit risk metric: Evidence from Turkey 或有债权分析作为信用风险度量:来自土耳其的证据

4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan220516019c

Şaban Çelik, Burcu Baskurt

{"title":"Contingent claims analysis as a credit risk metric: Evidence from Turkey","authors":"Şaban Çelik, Burcu Baskurt","doi":"10.2298/pan220516019c","DOIUrl":"https://doi.org/10.2298/pan220516019c","url":null,"abstract":"Credit ratings have become open to dispute in recent years regarding their objectivity, timeliness, and the criteria considered in the assignment process, which resulted in an inclination toward other methods to measure credit risk. This study applies contingent claims analysis, a novel risk analysis technique, in Turkey to assess their credit risk appropriately and investigate the determinants of the sovereign credit risk correctly. While the technique has been applied in Turkey before, the study contributes to the results of the preceding literature by applying the technique at a wider spectrum in terms of regarding the assessed risk indicators, time horizon considered, diagnosis tests, and sensitivity analyses. Risk indicators are calculated by applying this method to Turkey between July 2009 and December 2020. Results highlight that the movements in the risk indicators reflect the market. To ensure robustness, the Spearman rank-order correlations of the model risk measures with three market indicators are calculated, and sensitivity analyses are done. The credit default swaps are found to be correlated with all of the model risk measures, while the distance to distress is correlated with sovereign bond spreads, affirming model robustness. Analysis results highlight that among the variables for which sensitivities are assessed, changes occurring in the volatility of local currency liabilities heavily impact the risk indicators. Hence, the contingent claims approach model is robust in considering the correlations of model risk indicators with actual market data. Therefore, the model can be used in policymaking for realistic results.","PeriodicalId":45222,"journal":{"name":"Panoeconomicus","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136206862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The short- and long-run relationship between house prices and bank credit in developed and emerging market economies: A comparative study 发达经济体和新兴市场经济体房价与银行信贷的短期和长期关系:比较研究

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan181004012d

T. Dawood

引用次数: 0

A proper developmental state framework for Greece 为希腊建立一个适当的发展性国家框架

IF 1 4区经济学

Panoeconomicus Pub Date : 2023-01-01 DOI: 10.2298/pan220511002a

P. Arestis, N. Karagiannis

引用次数: 0

The asymmetric effects of third-country exchange rate volatility on Turkish-German commodity trade 第三国汇率波动对土德商品贸易的不对称影响