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Detection of Cell Separation-Induced Gene Expression Through a Penalized Deconvolution Approach 通过惩罚反褶积方法检测细胞分离诱导的基因表达
IF 1
Statistics in Biosciences Pub Date : 2022-05-20 DOI: 10.1007/s12561-022-09344-8
An-Shun Tai, Chun-Chao Wang, Wen-Ping Hsieh
{"title":"Detection of Cell Separation-Induced Gene Expression Through a Penalized Deconvolution Approach","authors":"An-Shun Tai, Chun-Chao Wang, Wen-Ping Hsieh","doi":"10.1007/s12561-022-09344-8","DOIUrl":"https://doi.org/10.1007/s12561-022-09344-8","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45317080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Discriminatory capacity of prenatal ultrasound measures for large-for-gestational-age birth: A Bayesian approach to ROC analysis using placement values. 产前超声测量对大胎龄分娩的歧视性能力:使用放置值的贝叶斯方法进行ROC分析。
IF 1
Statistics in Biosciences Pub Date : 2022-04-01 DOI: 10.1007/s12561-021-09311-9
Soutik Ghosal, Zhen Chen
{"title":"Discriminatory capacity of prenatal ultrasound measures for large-for-gestational-age birth: A Bayesian approach to ROC analysis using placement values.","authors":"Soutik Ghosal,&nbsp;Zhen Chen","doi":"10.1007/s12561-021-09311-9","DOIUrl":"https://doi.org/10.1007/s12561-021-09311-9","url":null,"abstract":"<p><p>Predicting large fetuses at birth is of great interest to obstetricians. Using an NICHD Scandinavian Study that collected longitudinal ultrasound examination data during pregnancy, we estimate diagnostic accuracy parameters of estimated fetal weight (EFW) at various times during pregnancy in predicting large-for-gestational-age. We adopt a placement value based Bayesian regression model with random effects to estimate ROC curves. The use of placement values allows us to model covariate effects directly on the ROC curves and the adoption of a Bayesian approach accommodates the <i>a priori</i> constraint that an ROC curve of EFW near delivery should dominate another further away. The proposed methodology is shown to perform better than some alternative approaches in simulations and its application to the Scandinavian Study data suggests that diagnostic accuracy of EFW can improve about 65% from week 17 to 37 of gestation.</p>","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12561-021-09311-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Simple Approach to Incorporating Historical Control Data in Clinical Trial Design and Analysis 将历史对照数据纳入临床试验设计和分析的一种简单方法
IF 1
Statistics in Biosciences Pub Date : 2022-03-31 DOI: 10.1007/s12561-022-09342-w
Lanju Zhang, Zailong Wang, Li Wang, Lu Cui, J. Sokolove, Ivan S. F. Chan
{"title":"A Simple Approach to Incorporating Historical Control Data in Clinical Trial Design and Analysis","authors":"Lanju Zhang, Zailong Wang, Li Wang, Lu Cui, J. Sokolove, Ivan S. F. Chan","doi":"10.1007/s12561-022-09342-w","DOIUrl":"https://doi.org/10.1007/s12561-022-09342-w","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43178218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Trials with External Control: Beyond Propensity Score Matching 临床试验与外部控制:超越倾向得分匹配
IF 1
Statistics in Biosciences Pub Date : 2022-03-24 DOI: 10.1007/s12561-022-09341-x
Hongwei Wang, Yixin Fang, Weili He, Ruizhe Chen, Su Chen
{"title":"Clinical Trials with External Control: Beyond Propensity Score Matching","authors":"Hongwei Wang, Yixin Fang, Weili He, Ruizhe Chen, Su Chen","doi":"10.1007/s12561-022-09341-x","DOIUrl":"https://doi.org/10.1007/s12561-022-09341-x","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48725713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of the Proportional Mean Residual Life Model with Internal and Longitudinal Covariates 含内、纵向协变量的比例平均剩余寿命模型的估计
IF 1
Statistics in Biosciences Pub Date : 2022-03-04 DOI: 10.1007/s12561-022-09339-5
Ruiwen Zhou, Jianguo Sun
{"title":"Estimation of the Proportional Mean Residual Life Model with Internal and Longitudinal Covariates","authors":"Ruiwen Zhou, Jianguo Sun","doi":"10.1007/s12561-022-09339-5","DOIUrl":"https://doi.org/10.1007/s12561-022-09339-5","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43677213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simulation-Based Evaluation of Statistical Methods for Hybrid Real-World Control Arms in Clinical Trials 临床试验中混合现实世界对照臂统计方法的模拟评估
IF 1
Statistics in Biosciences Pub Date : 2022-02-16 DOI: 10.1007/s12561-022-09334-w
Mingyang Shan, D. Faries, A. Dang, Xiang Zhang, Z. Cui, K. Sheffield
{"title":"A Simulation-Based Evaluation of Statistical Methods for Hybrid Real-World Control Arms in Clinical Trials","authors":"Mingyang Shan, D. Faries, A. Dang, Xiang Zhang, Z. Cui, K. Sheffield","doi":"10.1007/s12561-022-09334-w","DOIUrl":"https://doi.org/10.1007/s12561-022-09334-w","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48937504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Building an External Control Arm for Development of a New Molecular Entity: An Application in a Recurrent Glioblastoma Trial for MDNA55 为开发一种新的分子实体构建外部控制臂:MDNA55在复发性胶质母细胞瘤试验中的应用
IF 1
Statistics in Biosciences Pub Date : 2022-02-08 DOI: 10.1007/s12561-022-09337-7
A. Majumdar, Ruthanna C Davi, M. Bexon, C. Chandhasin, M. Coello, F. Merchant, N. Merchant
{"title":"Building an External Control Arm for Development of a New Molecular Entity: An Application in a Recurrent Glioblastoma Trial for MDNA55","authors":"A. Majumdar, Ruthanna C Davi, M. Bexon, C. Chandhasin, M. Coello, F. Merchant, N. Merchant","doi":"10.1007/s12561-022-09337-7","DOIUrl":"https://doi.org/10.1007/s12561-022-09337-7","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46910445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
scPI: A Scalable Framework for Probabilistic Inference in Single-Cell RNA-Sequencing Data Analysis scPI:单细胞RNA测序数据分析中概率推断的可扩展框架
IF 1
Statistics in Biosciences Pub Date : 2022-01-31 DOI: 10.1007/s12561-022-09335-9
Jingsi Ming, Jia Zhao, Can-Hua Yang
{"title":"scPI: A Scalable Framework for Probabilistic Inference in Single-Cell RNA-Sequencing Data Analysis","authors":"Jingsi Ming, Jia Zhao, Can-Hua Yang","doi":"10.1007/s12561-022-09335-9","DOIUrl":"https://doi.org/10.1007/s12561-022-09335-9","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42161841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times. 更正:14天是COVID-19的合理隔离时间吗?以COVID-19潜伏期为例探讨相关问题。
IF 1
Statistics in Biosciences Pub Date : 2022-01-01 Epub Date: 2021-09-21 DOI: 10.1007/s12561-021-09322-6
Yasin Khadem Charvadeh, Grace Y Yi, Yuan Bian, Wenqing He
{"title":"Correction to: Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times.","authors":"Yasin Khadem Charvadeh,&nbsp;Grace Y Yi,&nbsp;Yuan Bian,&nbsp;Wenqing He","doi":"10.1007/s12561-021-09322-6","DOIUrl":"https://doi.org/10.1007/s12561-021-09322-6","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s12561-021-09320-8.].</p>","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39452012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times. 14天是COVID-19合理的隔离时间吗?以COVID-19潜伏期为例探讨相关问题。
IF 1
Statistics in Biosciences Pub Date : 2022-01-01 Epub Date: 2021-09-09 DOI: 10.1007/s12561-021-09320-8
Yasin Khadem Charvadeh, Grace Y Yi, Yuan Bian, Wenqing He
{"title":"Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times.","authors":"Yasin Khadem Charvadeh,&nbsp;Grace Y Yi,&nbsp;Yuan Bian,&nbsp;Wenqing He","doi":"10.1007/s12561-021-09320-8","DOIUrl":"https://doi.org/10.1007/s12561-021-09320-8","url":null,"abstract":"<p><p>To confine the spread of an infectious disease, setting a sensible quarantine time is crucial. To this end, it is imperative to well understand the distribution of incubation times of the disease. Regarding the ongoing COVID-19 pandemic, 14-days is commonly taken as a quarantine time to curb the virus spread in balancing the impacts of COVID-19 on diverse aspects of the society, including public health, economy, and humanity perspectives, etc. However, setting a sensible quarantine time is not trivial and it depends on various underlying factors. In this article, we take an angle of examining the distribution of the COVID-19 incubation time using likelihood-based methods. Our study is carried out on a dataset of 178 COVID-19 cases dated from January 20, 2020 to February 29, 2020, with the information of exposure periods and dates of symptom onset collected. To gain a good understanding of possible scenarios, we employ different models to describe incubation times of COVID-19. Our findings suggest that statistically, the 14-day quarantine time may not be long enough to control the probability of an early release of infected individuals to be small. While the size of the study data is not large enough to offer us a definitely acceptable quarantine time, and further in practice, the decision-makers may take account of other factors related to social and economic concerns to set up a practically acceptable quarantine time, our study demonstrates useful methods to determine a reasonable quarantine time from a statistical standpoint. Further, it reveals some associated complexity for fully understanding the COVID-19 incubation time distribution.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12561-021-09320-8.</p>","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39416422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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