Advances in carbohydrate chemistry and biochemistry最新文献_第2页

Nitrogen-containing macrocycles having a carbohydrate scaffold. 具有碳水化合物支架的含氮大环。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.1016/bs.accb.2024.10.003

Mykhaylo A Potopnyk, Sławomir Jarosz

{"title":"Nitrogen-containing macrocycles having a carbohydrate scaffold.","authors":"Mykhaylo A Potopnyk, Sławomir Jarosz","doi":"10.1016/bs.accb.2024.10.003","DOIUrl":"10.1016/bs.accb.2024.10.003","url":null,"abstract":"Nitrogen-containing macrocyclic compounds (amines, amides, and N-heterocyclic derivatives) are important targets in supramolecular chemistry. This article discusses the importance of aza-macrocycles in general and, in particular, those receptors containing sugar unit(s). The combination of a carbohydrate scaffold bearing nitrogen-containing functional groups in macrocyclic molecules opens a convenient route to chiral receptors having potentially useful properties.The carbohydrate-based macrocycles discussed are classified into several general groups: (1) aza-crown ethers containing a carbohydrate sub-unit, (2) cyclic homooligomers from amino sugars, (3) sugar-based cryptands, (4) cyclic peptides containing amino sugar units (including C2- and C3- symmetrical macrocyclic glycopeptides), (5) nitrogen- containing glycophanes, and (6) 1,2,3-triazoles containing synthetic cyclodextrin analogues. The general strategies employed, as well as specific ones leading to such complex derivatives are surveyed. Applications of such carbohydrate receptors, pointing to their importance as hosts in supramolecular chemistry, are discussed.","PeriodicalId":448936,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"86 ","pages":"15-79"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo asymmetric synthesis of the pyranoses: From monosaccharides to oligosaccharides. 吡喃糖的从头不对称合成：从单糖到寡糖。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2024-01-01 Epub Date: 2024-11-08 DOI: 10.1016/bs.accb.2024.10.001

Alhanouf Z Aljahdali, Pei Shi, Yashan Zhong, George A O'Doherty

引用次数: 0

1-Amino-1-deoxy-d-fructose ("fructosamine") and its derivatives. 1-氨基-1-脱氧-d-果糖(“果糖胺”)及其衍生物。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 Epub Date: 2023-11-07 DOI: 10.1016/bs.accb.2023.10.002

Valeri V Mossine, Thomas P Mawhinney

引用次数: 0

Preface. 前言。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 DOI: 10.1016/S0065-2318(23)00027-6

David C Baker

引用次数: 0

Computational modeling of protein-carbohydrate interactions: Current trends and future challenges. 蛋白质-碳水化合物相互作用的计算模型:当前趋势和未来挑战。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 Epub Date: 2023-11-07 DOI: 10.1016/bs.accb.2023.10.003

Serge Pérez

引用次数: 0

Preface. 前言。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 DOI: 10.1016/S0065-2318(23)00014-8

David C Baker

引用次数: 0

Mechanism of multivalent glycoconjugate-lectin interaction: An update. 多价糖缀合物-凝集素相互作用的机制:最新进展。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 Epub Date: 2023-11-10 DOI: 10.1016/bs.accb.2023.10.004

Tarun K Dam, Olivia Hohman, Lucas Sheppard, C Fred Brewer, Purnima Bandyopadhyay

引用次数: 0

Multivalent lectin-carbohydrate interactions: Energetics and mechanisms of binding. 多价凝集素-碳水化合物相互作用:结合的能量学和机制。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 Epub Date: 2023-11-07 DOI: 10.1016/bs.accb.2023.10.005

Tarun K Dam, C Fred Brewer

{"title":"Multivalent lectin-carbohydrate interactions: Energetics and mechanisms of binding.","authors":"Tarun K Dam, C Fred Brewer","doi":"10.1016/bs.accb.2023.10.005","DOIUrl":"10.1016/bs.accb.2023.10.005","url":null,"abstract":"The biological signaling properties of lectins, which are carbohydrate-binding proteins, are due to their ability to bind and cross-link multivalent glycoprotein receptors on the surface of normal and transformed cells. While the cross-linking properties of lectins with multivalent carbohydrates and glycoproteins are relatively well understood, the mechanisms of binding of lectins to multivalent glycoconjugates are less well understood. Recently, the thermodynamics of binding of lectins to synthetic clustered glycosides, a multivalent globular glycoprotein, and to linear glycoproteins (mucins) have been described. The results are consistent with a dynamic binding mechanism in which lectins bind and jump from carbohydrate to carbohydrate epitope in these molecules. Importantly, the mechanism of binding of lectins to mucins is similar to that for a variety of protein ligands binding to DNA. Recent analysis also shows that high-affinity lectin-mucin cross-linking interactions are driven by favorable entropy of binding that is associated with the bind and jump mechanism. The results suggest that the binding of ligands to biopolymers, in general, may involve a common mechanism that involves enhanced entropic effects which facilitate binding and subsequent complex formation including enzymology.","PeriodicalId":448936,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"84 ","pages":"23-48"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1-Amino-1-deoxy-d-fructose ("fructosamine") and its derivatives: An update. 1-氨基-1-脱氧-d-果糖(“果糖胺”)及其衍生物:最新进展。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2023-01-01 Epub Date: 2023-11-08 DOI: 10.1016/bs.accb.2023.10.001

Valeri V Mossine, Thomas P Mawhinney

引用次数: 0

Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones. 溶酶体的碳水化合物加工酶：由错误折叠突变体和糖模拟物作为纠正药理学伴侣引起的疾病。

Advances in carbohydrate chemistry and biochemistry Pub Date : 2016-01-01 Epub Date: 2016-10-17 DOI: 10.1016/bs.accb.2016.08.002

Arnold E Stütz, Tanja M Wrodnigg

{"title":"Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones.","authors":"Arnold E Stütz, Tanja M Wrodnigg","doi":"10.1016/bs.accb.2016.08.002","DOIUrl":"https://doi.org/10.1016/bs.accb.2016.08.002","url":null,"abstract":"Lysosomal storage diseases are hereditary disorders caused by mutations on genes encoding for one of the more than fifty lysosomal enzymes involved in the highly ordered degradation cascades of glycans, glycoconjugates, and other complex biomolecules in the lysosome. Several of these metabolic disorders are associated with the absence or the lack of activity of carbohydrate-processing enzymes in this cell compartment. In a recently introduced therapy concept, for susceptible mutants, small substrate-related molecules (so-called pharmacological chaperones), such as reversible inhibitors of these enzymes, may serve as templates for the correct folding and transport of the respective protein mutant, thus improving its concentration and, consequently, its enzymatic activity in the lysosome. Carbohydrate-processing enzymes in the lysosome, related lysosomal diseases, and the scope and limitations of reported reversible inhibitors as pharmacological chaperones are discussed with a view to possibly extending and improving research efforts in this area of orphan diseases.","PeriodicalId":448936,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"73 ","pages":"225-302"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0