Proceedings of the 2014 Biomedical Sciences and Engineering Conference最新文献

Associative memory in phasing neuron networks 相位神经元网络中的联想记忆

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-07-31 DOI: 10.1109/BSEC.2014.6867743

N. Nair, E. Bochove, Y. Braiman

引用次数: 1

An experimental study on SpO2 data acquisition and processing in a general body area network 体域网络中SpO2数据采集与处理的实验研究

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867737

Austin Shores, C. Vang, Yaoqing Yang

引用次数: 0

Multi-scale applications of neutron scattering and imaging 中子散射与成像的多尺度应用

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.7024523

H. Bilheux, J. Katsaras, Christopher B. Stanley, A. Ramanathan, D. Myles, Maria Cekanova

引用次数: 1

Nonlinear two stage mechanotransduction model and neural response of Pacinian Corpuscle 太平洋小体非线性两阶段力学转导模型与神经反应

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867740

A. Biswas, M. Manivannan, M. Srinivasan

引用次数: 3

Neutron imaging: Detection of cancer using animal model 中子成像:利用动物模型检测癌症

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867752

Maria Cekanova, R. Donnell, H. Bilheux, J. Bilheux

{"title":"Neutron imaging: Detection of cancer using animal model","authors":"Maria Cekanova, R. Donnell, H. Bilheux, J. Bilheux","doi":"10.1109/BSEC.2014.6867752","DOIUrl":"https://doi.org/10.1109/BSEC.2014.6867752","url":null,"abstract":"Imaging modalities for cancer detection include X-ray, computed tomography, magnetic resonance imaging, ultrasound, positron emission tomography, and optical imaging. Each imaging technology has advantages and disadvantages with limitations either in spatial resolution or sensitivity for cancer detection. Hydrogen nuclei scatter cold neutrons stronger than any other atomic nuclei; therefore hydrogen is a primary contributor to neutron contrast in biological specimens. Neutron imaging for cancer research is an emerging and highly innovative tool that has been intensively exploring over the past three years at the Oak Ridge National Laboratory. Spontaneous cancers in companion animals offer unique models for human cancer biology. We have demonstrated the uniqueness of neutron radiography to objectively detect tumors from surrounding normal lung tissues at an unprecedented spatial resolution of approximately 100 μm. The neutron images of cancer were correlated and matched with histology data. Neutron imaging has the potential to non-destructively provide complementary information about the structure of cancers in biospecimens.","PeriodicalId":445578,"journal":{"name":"Proceedings of the 2014 Biomedical Sciences and Engineering Conference","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127701130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Neutron imaging at the Oak Ridge National Laboratory: Application to biological research 橡树岭国家实验室的中子成像:在生物学研究中的应用

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867751

H. Bilheux, J. Bilheux, W. B. Bailey, W. Keener, L. E. Davis, K. Herwig, Maria Cekanova

引用次数: 15

LRP-1 modulates glutamate-induced phase shifting in the mouse SCN circadian clock LRP-1调节谷氨酸诱导的小鼠SCN生物钟相移

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867742

Joanna M. Cooper, R. Prosser

{"title":"LRP-1 modulates glutamate-induced phase shifting in the mouse SCN circadian clock","authors":"Joanna M. Cooper, R. Prosser","doi":"10.1109/BSEC.2014.6867742","DOIUrl":"https://doi.org/10.1109/BSEC.2014.6867742","url":null,"abstract":"In the mammalian circadian clock located in the suprachiasmatic nucleus (SCN) glutamate mimics light-induced phase shifts through activating NMDA receptors (NMDAR). These phase shifts require concurrent activation of TrkB receptors by brain-derived neurotrophic factor (BDNF). tPA contributes to phase shifting by influencing mBDNF generation. tPA also binds to receptors, including LRP-1 and may modulate phase shifting through non-proteolytic mechanisms related to such receptor binding. Here we investigate the effects of inhibiting LRP-1 on glutamate induced phase shifts, using either receptor associated protein (RAP) or an anti-LRP-1 polyclonal antibody to inhibit LRP-1 activity. SCN brain slices from adult male C57BL/6 mice were treated with glutamate (1mM) +/- RAP (500nM) or anti-LRP-1 antibody (75μg/mL) at ZT 16 or ZT 23 (where ZT 0=lights-on in the animal colony) for 10 minutes. The following day we recorded SCN single-unit neuronal activity (SUA) to determine the time of peak activity. Concurrent application of RAP or anti-LRP-1 with glutamate prevents the normal shifts, while RAP alone has no effect on clock phase, suggesting that in the SCN LRP-1 activity is important for glutamate-dependent clock phase regulation. We investigated the potential interaction between tPA and LRP-1 in SCN clock phase shifting using tPA knockout (KO) mice, B6.129S2-PlattmlMlg/J. First we characterized the SUA rhythm in control tPA KO brain slices and after glutamate treatment. SCN slices from adult male tPA KO mice exhibit normally phased neuronal activity rhythms, and 10μM glutamate at ZT16 and ZT23 induces phase delays and phase advances, respectively. Thus, tPA KO mice do not exhibit severe deficiencies in clock phase regulation, possibly reflecting redundant mBDNF-generating pathways. Finally, RAP inhibits glutamate phase resetting in tPA KO slices, indicating LRP-1 does not act exclusively through interactions with tPA. Future studies will continue exploring tPA and LRP-1regulation of SCN circadian clock phase.","PeriodicalId":445578,"journal":{"name":"Proceedings of the 2014 Biomedical Sciences and Engineering Conference","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132697971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neuroscience-inspired inspired dynamic architectures 受神经科学启发的动态架构

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867735

Catherine D. Schuman, J. Birdwell, Mark E. Dean

引用次数: 15

On neural substrates of cognition: Theory, experiments and application in brain computer interfaces 认知的神经基础:脑机接口的理论、实验与应用

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867749

R. Kozma, W. Freeman

引用次数: 5

Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes 在一项对大学运动员的前瞻性队列研究中，APOE和其他基因多态性与前瞻性脑震荡风险的关联

Proceedings of the 2014 Biomedical Sciences and Engineering Conference Pub Date : 2014-05-06 DOI: 10.1109/BSEC.2014.6867745

T. Terrell, R. Bostick, Gary L. Rogers, M. Langston, Jeffery T. Barth, E. Bennett, R. Sloane, Leslie Galloway, R. Cantu, F. Mihelic

引用次数: 3