Archaeological Journal最新文献

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East Yorkshire and York 东约克郡和约克郡
IF 0.5
Archaeological Journal Pub Date : 2023-05-02 DOI: 10.1080/00665983.2023.2204700
P. Stamper
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引用次数: 0
Wood in archaeology 考古学中的木材
IF 0.5
Archaeological Journal Pub Date : 2023-03-27 DOI: 10.1080/00665983.2023.2189356
J. Irwin
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引用次数: 0
Rethinking heritage for sustainable development 为可持续发展重新思考遗产
IF 0.5
Archaeological Journal Pub Date : 2023-03-27 DOI: 10.1080/00665983.2023.2189353
Hanneke Booij
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引用次数: 0
Bioarchaeology. An introduction to the archaeology and anthropology of the dead m.a.。死人考古学和人类学导论
IF 0.5
Archaeological Journal Pub Date : 2023-02-23 DOI: 10.1080/00665983.2023.2178177
Nivien Speith
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引用次数: 0
Iron Age and Roman coin hoards in Britain 铁器时代和罗马钱币在不列颠的储藏
IF 0.5
Archaeological Journal Pub Date : 2023-02-06 DOI: 10.1080/00665983.2022.2155385
Anna Booth
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引用次数: 3
Archaeology, heritage, and wellbeing: authentic, powerful, and therapeutic engagement with the past 考古、遗产和幸福:与过去真实、有力、有治疗作用的接触
IF 0.5
Archaeological Journal Pub Date : 2023-02-01 DOI: 10.1080/00665983.2023.2167684
Harriet Sams
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引用次数: 1
Life in Roman and Medieval Leicester: excavations in the town’s north-east quarter, 1958–2006 罗马和中世纪莱斯特的生活:1958-2006年城镇东北部的发掘
IF 0.5
Archaeological Journal Pub Date : 2023-02-01 DOI: 10.1080/00665983.2023.2167682
N. Holbrook
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引用次数: 1
Contrasts of the Nordic Bronze Age. Essays in honour of Christopher Prescott 北欧青铜时代的对比。纪念克里斯托弗·普雷斯科特的文章
IF 0.5
Archaeological Journal Pub Date : 2023-01-12 DOI: 10.1080/00665983.2022.2155386
A. Harding
{"title":"Contrasts of the Nordic Bronze Age. Essays in honour of Christopher Prescott","authors":"A. Harding","doi":"10.1080/00665983.2022.2155386","DOIUrl":"https://doi.org/10.1080/00665983.2022.2155386","url":null,"abstract":"","PeriodicalId":44491,"journal":{"name":"Archaeological Journal","volume":"25 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84866129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Design and connectivity. The case of Atlantic Rock Art 设计和连接。大西洋岩石艺术的案例
IF 0.5
Archaeological Journal Pub Date : 2022-12-15 DOI: 10.1080/00665983.2022.2132762
K. Brophy
{"title":"Design and connectivity. The case of Atlantic Rock Art","authors":"K. Brophy","doi":"10.1080/00665983.2022.2132762","DOIUrl":"https://doi.org/10.1080/00665983.2022.2132762","url":null,"abstract":"","PeriodicalId":44491,"journal":{"name":"Archaeological Journal","volume":"41 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88488039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting which genes will respond to transcription factor perturbations. 预测哪些基因会对转录因子扰动做出反应
IF 2.6
Archaeological Journal Pub Date : 2022-07-29 DOI: 10.1093/g3journal/jkac144
Yiming Kang, Wooseok J Jung, Michael R Brent
{"title":"Predicting which genes will respond to transcription factor perturbations.","authors":"Yiming Kang, Wooseok J Jung, Michael R Brent","doi":"10.1093/g3journal/jkac144","DOIUrl":"10.1093/g3journal/jkac144","url":null,"abstract":"<p><p>The ability to predict which genes will respond to the perturbation of a transcription factor serves as a benchmark for our systems-level understanding of transcriptional regulatory networks. In previous work, machine learning models have been trained to predict static gene expression levels in a biological sample by using data from the same or similar samples, including data on their transcription factor binding locations, histone marks, or DNA sequence. We report on a different challenge-training machine learning models to predict which genes will respond to the perturbation of a transcription factor without using any data from the perturbed cells. We find that existing transcription factor location data (ChIP-seq) from human cells have very little detectable utility for predicting which genes will respond to perturbation of a transcription factor. Features of genes, including their preperturbation expression level and expression variation, are very useful for predicting responses to perturbation of any transcription factor. This shows that some genes are poised to respond to transcription factor perturbations and others are resistant, shedding light on why it has been so difficult to predict responses from binding locations. Certain histone marks, including H3K4me1 and H3K4me3, have some predictive power when located downstream of the transcription start site. However, the predictive power of histone marks is much less than that of gene expression level and expression variation. Sequence-based or epigenetic properties of genes strongly influence their tendency to respond to direct transcription factor perturbations, partially explaining the oft-noted difficulty of predicting responsiveness from transcription factor binding location data. These molecular features are largely reflected in and summarized by the gene's expression level and expression variation. Code is available at https://github.com/BrentLab/TFPertRespExplainer.</p>","PeriodicalId":44491,"journal":{"name":"Archaeological Journal","volume":"151 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80995388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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