Clinical Cancer Investigation Journal最新文献_第9页

Evaluation of novel MicroRNA profile-21 and 191 in oral leukoplakia and oral squamous cell carcinoma in comparison with healthy tissues – A cross-sectional study 与健康组织相比，口腔白斑和口腔鳞状细胞癌中新型微小RNA谱-21和191的评估——一项横断面研究

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Clinical Cancer Investigation Journal Pub Date : 2021-11-01 DOI: 10.4103/ccij.ccij_54_21

K. Muth Lakshmi, K. Lakshmi, A. Kannan, Y. Aniyan

引用次数: 2

Exposure to water-pipe smoking dysregulates a set of genes associated with breast cancer development and an unfavorable outcome 暴露于水烟中会导致一系列与乳腺癌发展和不利结果相关的基因失调

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Clinical Cancer Investigation Journal Pub Date : 2021-11-01 DOI: 10.4103/ccij.ccij_109_21

V. López-Ozuna, I. Gupta, Ryan Chen Kiow, E. Matanes, A. Yasmeen, S. Vranić, A. Al Moustafa

{"title":"Exposure to water-pipe smoking dysregulates a set of genes associated with breast cancer development and an unfavorable outcome","authors":"V. López-Ozuna, I. Gupta, Ryan Chen Kiow, E. Matanes, A. Yasmeen, S. Vranić, A. Al Moustafa","doi":"10.4103/ccij.ccij_109_21","DOIUrl":"https://doi.org/10.4103/ccij.ccij_109_21","url":null,"abstract":"Background: Water-pipe smoking (WPS), a predominant method of tobacco consumption, is common amongst young females in the Middle East. WPS smoke consists of toxins analogous to the ones that exist in cigarette smoke and frequently correlates with the onset of several types of human cancers including breast. However, the potential target genes and their underlying mechanisms in the initiation and/ or progression of human cancers, especially breast, due to WPS exposure are still unknown. Materials and Methods: In this investigation, we explored the effect of WPS chronic exposure on human normal mammary epithelial cells and analyzed alterations in the differentially ex-pressed gene (DEG) targets using the NanoString nCounter PanCancer Pathways Panel consisting of 770 gene transcripts and a quantitative real-time polymerase chain reaction (PCR) analysis. Results: Our NanoString analysis identified 13 genes dysregulated under the effect of WPS exposure involved in regulating signal transduction, cell cycle, cell motility, proliferation and migration/invasion as well as the inflammatory response. We further performed an in silico analysis to investigate the effect of the identified genes in the prognosis of breast cancer patients and reported those DEGs that directly correlated with smoking and were upregulated in breast cancer in comparison with normal tissue. Moreover, the Kaplan–Meier curve analysis showed a significant correlation be-tween WPS-dysregulated genes (MX1, CCL8, GNGT1 and MMP9) and relapse-free survival in breast cancer patients. Conclusions: Our data clearly suggest that exposure to WPS can alter the expression of key regulator genes involved in the pathogenesis of breast cancer, thereby affecting the breast cancer prognosis.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43130850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paediatric cutaneous langerhans cell histiocytosis mimicking hemangioma: A deceitful entity 儿童皮肤朗格汉斯细胞组织细胞增生模拟血管瘤:一个欺骗性的实体

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_168_20

P. Pradhan, S. Raman, S. Mohanty, H. Tudu, Kanakalata Dash

引用次数: 0

Extraosseous Ameloblastoma of the buccal mucosa: A case report of a rare entity 颊粘膜骨外成釉细胞瘤一例报告

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_101_20

Ashwini Munnangi, A. Kadapathri, N. Oza, V. Bhushan

引用次数: 0

Epidemiology and clinical investigation of all cancer types in Kermanshah, Iran (2010–2019) 伊朗克尔曼沙赫所有癌症类型的流行病学和临床调查（2010-2019）

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_170_20

B. Izadi, M. Aznab, N. Roozbahani, M. Naderi, S. Khazaei

{"title":"Epidemiology and clinical investigation of all cancer types in Kermanshah, Iran (2010–2019)","authors":"B. Izadi, M. Aznab, N. Roozbahani, M. Naderi, S. Khazaei","doi":"10.4103/ccij.ccij_170_20","DOIUrl":"https://doi.org/10.4103/ccij.ccij_170_20","url":null,"abstract":"Background: Epidemiological studies of cancer worldwide can help identify the prevalence of common cancers in the region and may help to organize their control. The study's purpose was to investigate the frequency of cancer in the urban and rural areas in the West of Iran in both sexes based on the pathological data from a single clinical center (2010–2019). Subjects and Methods: A cross-sectional study was designed to assess the demographic and clinical information was obtained from the pathology reports. Organs involved in cancer based on the international classification of disease 10th revision were coded. The variables extracted were sex, age, time of diagnosis, cancer site, and residency status. Quantitative and qualitative variables were analyzed with an appropriate statically analyzing test using the SPSS software. Results: Of the 7728 registered cancers (2010–2019) with mean age 58 ± 17 years, 3384 (44%) were female, 4341 (56%) were male, 2025 cases (26.2%) were rural, and 5687 cases (73.8%) were urban. Regarding the frequency of cancers and the age of diagnosing cancer, there was a statistically significant association between the two genders (P < 0.05). However, no similar conclusion was reached concerning residence status. Conclusion: The most common cancer in both genders was bladder, colorectal, and breast cancer. The frequency of cancers, despite the differences in the percentage of cancers between the two sexes, did not follow the same pattern as other cities in Iran and the world. Our study confirmed that the prevalence of cancer may follow the pattern of the geographical area.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42134956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss to follow-up in clinical trials – Implications and prevention 临床试验随访失败——影响和预防

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_79_21

S. Bakshi, V. Kalidoss

引用次数: 0

Lipoblastomas at rare sites: A report of two cases 罕见部位成脂细胞瘤:附2例报告

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_56_21

P. Sathe

引用次数: 0

Role of platelet endothelial aggregation receptor 1 polymorphisms in idiopathic thrombocytopenic purpura: Is there an association? 血小板内皮聚集受体1多态性在特发性血小板减少性紫癜中的作用:是否存在关联?

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_174_20

S. Najafi, Mohammad Ali Jalali Far, G. Kaydani, K. Jaseb, N. Saki

{"title":"Role of platelet endothelial aggregation receptor 1 polymorphisms in idiopathic thrombocytopenic purpura: Is there an association?","authors":"S. Najafi, Mohammad Ali Jalali Far, G. Kaydani, K. Jaseb, N. Saki","doi":"10.4103/ccij.ccij_174_20","DOIUrl":"https://doi.org/10.4103/ccij.ccij_174_20","url":null,"abstract":"Background: Genetic risk factors are implicated in the etiology and pathogenesis of immune thrombocytopenic purpura (ITP). Platelet endothelial aggregation receptor 1 (PEAR1) plays an important role in regulating megakaryopoiesis and thrombopoiesis. rs12041331 and rs12566888 single-nucleotide polymorphisms of PEAR1 are associated with megakaryocyte differentiation and platelet function. Materials and Methods: To conduct this study, 68 peripheral blood samples of patients with ITP (56 acute and 12 chronic) were collected. The amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was used to detection of rs12041331 and rs12566888 PEAR1 polymorphisms. Results: Statistically significant differences were not seen between rs12041331 and rs12566888 genotypes in acute and chronic groups (P = 0.778, P = 0.844). The frequency of rs12041331 AG/AA genotypes and the rs12566888 GT genotype was more in acute ITP patients; on the other hand, the rs12566888 TT genotype was more in the chronic group. The highest platelet counts and platelet distribution width (PDW) were related to the rs12041331 AG allele. GT and TT of rs12566888 had more PDW and platelet count, respectively. Mean platelet volume values between alleles of both the polymorphisms were constant and did not differ much. In general, no statistically significant differences were observed between genotypes of polymorphisms and platelet parameters. Conclusions: There was no association between rs12041331 and rs12566888 with platelet parameters in ITP patients and the severity of this disease. Further investigation with a larger size is recommended.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47891241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and awareness assessment of dental students about malignant melanoma 牙科学生关于恶性黑色素瘤的知识和意识评估

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_74_21

Irfan Celik, Gaye Keser, F. Pekiner

{"title":"Knowledge and awareness assessment of dental students about malignant melanoma","authors":"Irfan Celik, Gaye Keser, F. Pekiner","doi":"10.4103/ccij.ccij_74_21","DOIUrl":"https://doi.org/10.4103/ccij.ccij_74_21","url":null,"abstract":"Background: Epidemiological studies have shown an increased tendency to malignant melanoma worldwide. Dentistry students need comprehensive up-to-date information about malignant melanoma to give their patients correct advice. The purpose of this study is to assess 3rd, 4th, and 5th grade students' level of knowledge and awareness about malignant melanoma. Materials and Methods: In our study, a questionnaire consisting of 11 questions was applied to a total of 229 students, 93 3rd grade, 64 4th grade, and 72 5th grade students who were educated at Marmara University, Faculty of Dentistry. In this survey, students' level of knowledge and awareness was examined. Results: A total of 75 (32.75%) male and 154 (67.25%) female students were included in the study. There was a statistically significant difference between grades in terms of participation rate to the statement “Oral melanomas are more aggressive than skin involvement” (P = 0.000). Participation rate of 3rd grades (30.11%) was significantly lower than 4th grades (45.31%) and 5th grades (48.61%) (P1 = 0.004; P2=, 0.000). There was a statistically significant difference between grades in terms of participation rate to the statement “Oral melanoma lesions are usually asymptomatic” (P = 0,000). Participation rate of 3rd grades (15.05%) was significantly lower than 4th grades (39.06%) and 5th grades (58.33%) (P1 = 0.002; P2 = 0.000). Participation rate of 4th grades was significantly lower than 5th grades (P = 0.033). Conclusion: Providing the necessary training on malignant melanoma will improve the knowledge and awareness of dentistry students.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42801373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology 类似鳞状细胞癌的小唾液腺肿瘤中广泛的鳞状化生:吸吸细胞学的诊断困境

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Clinical Cancer Investigation Journal Pub Date : 2021-09-01 DOI: 10.4103/ccij.ccij_145_20

R. Sukumaran, N. Nayak, Rari P. Mony

{"title":"Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology","authors":"R. Sukumaran, N. Nayak, Rari P. Mony","doi":"10.4103/ccij.ccij_145_20","DOIUrl":"https://doi.org/10.4103/ccij.ccij_145_20","url":null,"abstract":"The surgical management of salivary gland lesions depends on cytology diagnosis, in conjunction with clinical findings and imaging studies. It is extremely important to differentiate benign and malignant salivary gland lesions preoperatively. The distinction can be challenging in aspiration cytology due to metaplastic changes, cystic changes, variable cellular components within the lesions, variants of neoplasms, and sampling issues. We are presenting the case of a 42-year-old female patient who presented with a nodular lesion in the hard palate. Fine-needle aspiration cytology of the lesion was cellular and showed sheets and singly scattered squamous cells with minimal cytological atypia. As the differential diagnosis included variety of lesions ranging from nonneoplastic lesions to benign and malignant neoplasms, surgery under frozen section control was advised. Frozen sections also showed extensive squamous areas. A minor component showing bilayered ductal pattern in a background of chondromyxoid stroma also noted. Diagnosis of a salivary gland neoplasm, possibly pleomorphic adenoma with extensive squamous metaplasia was given. Although squamous metaplasia has been reported in salivary gland neoplasms, it is extremely rare to find extensive squamous metaplasia enough to cause significant diagnostic confusion. The awareness of this extensive squamous metaplasia in benign salivary gland lesions help to distinguish it from malignant lesions and to avoid unnecessarily aggressive therapy.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70699380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0