Clinical Cancer Investigation Journal最新文献_第2页

Adenoid Cystic Carcinoma of the Breast: A Case Report 乳腺腺样囊性癌1例报告

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/c9m7tisulk

T. H. Alhussan, Ahmad Hadad, S. Shah

引用次数: 0

Assessment of 8-OHDG, SOD, and GPx Levels in OPMD and OSCC Patients OPMD和OSCC患者8-OHDG、SOD和GPx水平的评估

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/gxbko0irbp

S. Ashwin, P. Sinduja, Selvaraj Jayaraman, R. Priyadharshini

{"title":"Assessment of 8-OHDG, SOD, and GPx Levels in OPMD and OSCC Patients","authors":"S. Ashwin, P. Sinduja, Selvaraj Jayaraman, R. Priyadharshini","doi":"10.51847/gxbko0irbp","DOIUrl":"https://doi.org/10.51847/gxbko0irbp","url":null,"abstract":"Free radicals define oxidative stress as the condition in which the body's antioxidant repair systems cannot keep up with the rate of cell oxidation. Oxidative stress and reactive oxygen species (free radicals) work together to damage cellular components, encourage cell neoplastic transformation, and actively affect all three stages of carcinogenesis. The most prevalent potentially cancerous conditions on the Indian subcontinent are leukoplakia and oral submucous fibrosis, which are mostly brought on by cigarette use and areca nut consumption. Assessment of 8-OHDG, SOD, and GPx levels in saliva of OPMD and OSCC patients with and without diabetes mellitus. ELISA ASSAY was used for finding the levels of 8-OHDG, SOD, and GPx. Add salivary samples and diluent 40 μL into the testing sample. Then add some 10 μL sample into the testing sample well, Cover it properly, and incubate for some 45 minutes at 37 °C. Aspirate each well and wash, repeat the process four times for a total of five washes, 1-3 minutes per time. HRP-conjugated detection antibody is added to each well. This study is one of the first attempts to find the Assessment of 8-OHDG, SOD, and GPx levels in the saliva of OPMD and OSCC patients with and without diabetes mellitus.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-CRT Versus SIB IMRT Acute Toxicity Outcomes in Preoperative Concurrent Chemo-Radiotherapy for Locally Advanced Rectal Cancer 局部晚期直肠癌术前同步放化疗的3D-CRT与SIB IMRT的急性毒性结果

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/uban5n4ccd

K. Mashhour, E. Saad, Hoda Abdelghany, W. Hashem

{"title":"3D-CRT Versus SIB IMRT Acute Toxicity Outcomes in Preoperative Concurrent Chemo-Radiotherapy for Locally Advanced Rectal Cancer","authors":"K. Mashhour, E. Saad, Hoda Abdelghany, W. Hashem","doi":"10.51847/uban5n4ccd","DOIUrl":"https://doi.org/10.51847/uban5n4ccd","url":null,"abstract":"The primary aim of this study is to compare the acute toxicity profiles between locally advanced rectal cancer (LARC) patients treated with preoperative 3-dimensional conformal radiotherapy (3D-CRT) and simultaneous integrated intensity modulated radiation therapy (SIB-IMRT). 40 patients with LARC were equally divided into 2 groups; arm A received preoperative 3D-CRT concurrent with Capecitabine, while arm B received preoperative SIB-IMRT concurrent with Capecitabine. All patients were seen and evaluated once a week during chemo-radiation and any acute toxicity was recorded. Significantly fewer patients experienced grade 3 genitourinary toxicities in arm B vs arm A with a p-value = 0.048. Regarding grade 2 and grade 3 gastrointestinal toxicities, it was significantly higher in arm A compared to arm B with p-values of 0.043 and 0.021 respectively. There were no statically significant differences between Dmean & Dmax of the urinary bladder (UB) and small bowel (SB) in both techniques. The V45 of the UB was higher significantly in the 3D-CRT plans compared to the SIB-IMRT plans, with a p-value of 0.003. The V45 of SB was higher in the 3D-CRT arm with a p-value of 0.001. The V45 of UB & SB was statistically less in the IMRT plans compared to the 3DCRT plans. This was reflected in the toxicity profile of the patients, grade 2 GU as well as grades 2 & 3 GI toxicities were statistically of lower frequency in the IMRT group compared to the 3DCRT group.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70835970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study 使用IMRT/VMAT对LAHNSCC进行低分割加速放疗并发化疗与传统分割:一项试点研究

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/vpfpxwghhc

E. Saad, M. Kamaleldin, Asmaa Zaghloul, E. Habib, K. Mashhour

{"title":"Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study","authors":"E. Saad, M. Kamaleldin, Asmaa Zaghloul, E. Habib, K. Mashhour","doi":"10.51847/vpfpxwghhc","DOIUrl":"https://doi.org/10.51847/vpfpxwghhc","url":null,"abstract":"In fast-growing tumors such as locally advanced head and neck cancers (LA-HNC), hypofractionation effectively overcomes tumor repopulation. We aimed at evaluating the safety and efficacy of moderately hypofractionated radiotherapy with concurrent cisplatin in comparison to the conventional concurrent chemoradiotherapy (CCRT) in LA-HNC. Fifty-four patients with LA-HNC were randomized to receive either: 70Gy in 35 fractions in 7 weeks concurrently with weekly cisplatin 40 mg/m2 (Arm A), or 55Gy in 20 fractions in 4 weeks concurrently with weekly cisplatin 35mg/m2 (Arm B). Volumetric modulated arc therapy/ Intensity-modulated radiotherapy (VMAT/IMRT) plans were done for both arms. Local control (LC), acute toxicity, and progression-free survival (PFS) were recorded and compared between both arms. A total of 34 patients were in arm A versus 20 patients in arm B, with a median follow-up period of 14.2 months (range 5.1-43.6 months). There was no significant difference in LC, PFS, or acute toxicity between both arms. Complete response occurred in 52.9%(18/34) and 45 %(9/20) in arm A and arm B respectively. In LA-HNC, moderate hypofractionation concurrently with cisplatin appears to be safe and feasible and is associated with a comparable response rate, PFS, and acute toxicity with conventional CCRT protocol.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metachronous Carcinoma at Colostomy Site Post Abdominoperineal Resection – A Rare Presentation Case Report 腹部会阴切除术后结肠造口部位异时性癌一例罕见病例报告

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/zp8hs1y926

Muhammed Huzaifa, Ankita Singh, Vaibhav Aggarwal, A. Dhar

引用次数: 0

Molecular Mechanisms Underlying Chemopreventive Anticancer Activity of Stevioside on Human Prostate Cancer Cell Line in vitro 甜菊糖苷对人前列腺癌细胞体外化学预防抗癌活性的分子机制

Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/lvxdmvxrty

Preethi Raj, R Priyadharshini, Selvaraj Jayaraman, Palati Sinduja

{"title":"Molecular Mechanisms Underlying Chemopreventive Anticancer Activity of Stevioside on Human Prostate Cancer Cell Line in vitro","authors":"Preethi Raj, R Priyadharshini, Selvaraj Jayaraman, Palati Sinduja","doi":"10.51847/lvxdmvxrty","DOIUrl":"https://doi.org/10.51847/lvxdmvxrty","url":null,"abstract":"The burden of cancer incidence and mortality is rapidly increasing worldwide. The second most frequent cancer in men is prostate cancer which affects 1.41 million people worldwide (WHO statistics). Stevioside is an easily available item and it was observed to significantly inhibit cancer cell growth. Our study aims to analyze Molecular mechanisms underlying the chemopreventive anticancer activity of Stevioside on human prostate cancer cell lines. Prostate cancer cells were treated with Stevioside and the level of Bcl-2, Mcl-1, and Caspase-3 was estimated respectively. Data were expressed as the mean ± SD of 3 individual experiments performed in triplicate. Statistical analysis was performed using one-way ANOVA. In PC-3 cells, the effect of Stevioside extracts on cell viability was analyzed through MTT assay with a significant decrease in the percentage of viable cells with an increase in concentration, while the Mcl-1 gene with a decrease in fold change with a rise in concentration. Caspase 3 with a significant increase in fold change with an increase in concentration indicates effective apoptosis and also inhibits the Bcl-2 gene with a decrease in fold change with a rise in concentration with a significance of p<0.05. According to the results Stevioside extract considerably and strongly (by a significant fold change) suppresses the proliferation of cancer cells. The results imply that Stevioside may be turned into a natural prostate cancer medication and further investigation is necessary to establish the daily intake of Stevia products that is both safe and beneficial to the health of the human body.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Methods of Treatment of Hemangiomas 血管瘤的治疗方法

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/3rby3fhp0j

Luliia Vyacheslavna Nebotova, Elnur Gasanov, Sevil Husynbekovna Makhsubova, Zaira Arazovna Abdullayeva, Said-Magomed Said-Ibragimovich Shabaev, Ismail Askhatovich Kadiev

{"title":"Methods of Treatment of Hemangiomas","authors":"Luliia Vyacheslavna Nebotova, Elnur Gasanov, Sevil Husynbekovna Makhsubova, Zaira Arazovna Abdullayeva, Said-Magomed Said-Ibragimovich Shabaev, Ismail Askhatovich Kadiev","doi":"10.51847/3rby3fhp0j","DOIUrl":"https://doi.org/10.51847/3rby3fhp0j","url":null,"abstract":"The prevalence of hemangiomas in children reaches 45.7% of all benign childhood tumors, among newborns up to 1/4 of children are affected by the disease. The complexity of diagnosing and treating hemangiomas is exacerbated by the lack of a unified classification capable of providing mutual understanding between pediatricians, dermatologists, pediatric surgeons, and oncologists. One of the generally recognized problems in the treatment of hemangiomas is the definition of indications for the start of treatment. A serious problem is the treatment of ulcerated hemangiomas, accompanied by infection and bleeding. The tactics of managing a patient with hemangioma require an individual approach. For example, propranolol therapy and laser removal of hemangiomas are the most effective, safe, and cosmetically acceptable methods of removal. Surgical treatment and electrocoagulation show a persistent, relapse-free effect. As part of the scientific work, a statistical study of 40 case histories of children was carried out. The article presents data on the distribution of the disease by sex, and age, as well as by location and method of treatment.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition 呋喃酮及其衍生物抑制eeg -1治疗癌症的理论评价

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/iviqzrp5lt

Magdalena Alvarez-Ramirez, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, M. Lopez-Ramos, Virginia Mateu-Armand, Lopez-Gutierrez Tomas

{"title":"Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition","authors":"Magdalena Alvarez-Ramirez, L. Figueroa-Valverde, F. Díaz-Cedillo, M. Rosas-Nexticapa, M. Lopez-Ramos, Virginia Mateu-Armand, Lopez-Gutierrez Tomas","doi":"10.51847/iviqzrp5lt","DOIUrl":"https://doi.org/10.51847/iviqzrp5lt","url":null,"abstract":"Several studies suggest that some drugs such as astemizole and tetrandine can inhibit the expression of Eag-1 in cancer cells. Analyzing these data, this study aimed to evaluate the theoretical interaction of furanone (compound 1) and its derivatives (compounds 2 to 30) with Eag-1 using the 7CN1 protein as a theoretical model; in addition, astemizole, tetrandine, N-(4-(2-(Diethylamino)ethoxy)phenyl)-2- nitro-4-(trifluoromethyl)-aniline (DNTA), 1-Dimethylamino-3-[4-(2-nitro-4-trifluoromethyl-phenyl-amino)-phenoxy]-propan-2-ol (ZVS-08), and 3-Chloro-N-{2-[3,5-dibromo-4-(3-di-methyl-amino-propoxy)-phenyl]-ethyl}-4-metho-xy-benzamide (PD) were used as controls in the DockingServer software. Results showed that interaction of compounds 1-30, DNTA, ZVS-08, and PD with 7CN1 protein surface involves different aminoacid residues. Besides, inhibition constant was lower for furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 compared to astemizole, tetrandine, DNTA, ZVS-08, and PD. These data suggest that furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 could act as Eag-1 inhibitors in cancer cells. Therefore, these furenone derivatives could be good candidates for the treatment of cancer.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chondroblastoma in a Distal Phalanx of the Great Toe – A Rare Case Report 大脚趾远端指骨成软骨细胞瘤1例罕见病例报告

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/ognfaljlxq

Vijaya B. Ghule, A. Deshpande, Sushma G Gurwale, Tushar Kambale, Banymeen Iqbal

{"title":"Chondroblastoma in a Distal Phalanx of the Great Toe – A Rare Case Report","authors":"Vijaya B. Ghule, A. Deshpande, Sushma G Gurwale, Tushar Kambale, Banymeen Iqbal","doi":"10.51847/ognfaljlxq","DOIUrl":"https://doi.org/10.51847/ognfaljlxq","url":null,"abstract":"Chondroblastoma is a rare benign appearing lesion arising in the epiphysis of long bones in skeletally immature individuals. It is a cartilage-producing neoplasm constituting < 1% of all bone tumors. A 16 years old girl presented to orthopedic OPD of tertiary care hospital with swelling of her left great toe for 3 years. The swelling was insidious at onset and gradually progressed to the present size of 3.5x2.5x2 cm. Radiographic examination shows an osteolytic lesion and coarse trabeculation in the distal phalanx of the great toe suggestive of a benign bone tumor. Histopathological examination showed classical features of chondroblastoma. Post-operative follow-up was uneventful and radiological examination was normal. Flat bones like the pelvis, ribs, vertebrae, scapula, and craniofacial bones are other uncommon locations. The tumor recurrence rate is increased when the tumor is having limited resection due to the site of the tumor. Turcotte et al . reported the highest recurrence rate of tumors in flat temporal bones with recurrence within 6 months to 8 years. Chondroblastoma, an uncommon primary bone tumor presenting at the distal phalanx of the great toe was extremely rare.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Mapping Study of detection of Tumor Cell Targeted by Enzymes though Cerebrospinal Fluid 脑脊液酶靶向肿瘤细胞检测的系统定位研究

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Clinical Cancer Investigation Journal Pub Date : 2023-01-01 DOI: 10.51847/vqorizlqm3

S. Saeed, Aurazaib Abbasi, Abdul Sattar Muhammad Hashim

{"title":"A Systematic Mapping Study of detection of Tumor Cell Targeted by Enzymes though Cerebrospinal Fluid","authors":"S. Saeed, Aurazaib Abbasi, Abdul Sattar Muhammad Hashim","doi":"10.51847/vqorizlqm3","DOIUrl":"https://doi.org/10.51847/vqorizlqm3","url":null,"abstract":"Cancers, especially of the neural tissue, are often deemed a death sentence. There is, however, still no clear understanding of the underlying causes nor the cellular and molecular mechanisms of this disease. The spread and collateral damage caused by various types of brain tumors remain poorly understood, despite the information that is currently available about these diseases. A common means of diagnosing tumors is through cerebrospinal fluid (CSF) leakage, and the enzymes from brain cancer cases were investigated within this hypothesis. The purpose of this study was to investigate the role of CSF in brain cancer and BBB. This study conducted a systematic study of leakage that typically occurs at the spine level, namely in the thoracic spine region and the base of the brain along the cardiothoracic connection. This study investigated the bacteria sampling of brain cancer in CSF and determined the common method of targeting cancer cells in the brain and enzymes contained within the CSF. A further finding reveals the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage, as well as evidence that the release of tumor components damages the CSF. As a result of these observations, enzymes and tumor cells are detected, and a new component identifies tumor-related CSF.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0