{"title":"Hypothalamic-Pituitary-Adrenal (HPA) Axis and Chronic Fatigue Syndrome in Older Adults: The Rehabilitation Perspectives","authors":"F. H. Lai, Maria Uscinska, Elaine Wai-hung Yan","doi":"10.5772/intechopen.92570","DOIUrl":"https://doi.org/10.5772/intechopen.92570","url":null,"abstract":"","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"13 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126017748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Yao, Xiaoli Wang, Shuzhang Zhang, Zhiping Zhang, Wei Wang, Yudan Zhu, Jiwei Cheng, Guoyi Li, J. Tao
{"title":"Targeting Neuroglial Sodium Channels in Neuroinflammatory Diseases","authors":"Yu Yao, Xiaoli Wang, Shuzhang Zhang, Zhiping Zhang, Wei Wang, Yudan Zhu, Jiwei Cheng, Guoyi Li, J. Tao","doi":"10.5772/intechopen.92127","DOIUrl":"https://doi.org/10.5772/intechopen.92127","url":null,"abstract":"The Hodgkin-Huxley model, at its 66th anniversary, remains a footing stone of neuroscience, which describes how the action potential (AP) is generated. As the core player of AP initiation, voltage-gated sodium channels (VGSCs) are always considered to be required for electrogenesis in excitable cells. Cells which are not traditionally been considered to be excitable, including glial cells, also express VGSCs in physiological as well as pathological conditions. The dysfunction of glial VGSCs is seemingly not related to abnormal excitation of neurons, but of importance in the astrogliosis and M1 polarization of microglia, which could induce refractory neuroinflammatory diseases, such as multiple sclerosis, stroke, epilepsy, and Alzheimer’s and Parkinson’s diseases. Therefore, in this chapter, we aim to describe the physiological and pathological roles of VGSCs contributing to the activity of glial cells and discuss whether VGSC subtypes could be used as a novel drug target, with an eye toward therapeutic implications for neuroinflammatory diseases.","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125901134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measurement and Evaluation of Brain Activity for Train Drivers Using Wearable NIRS","authors":"H. Tsunashima, Keita Aibara","doi":"10.5772/INTECHOPEN.90499","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.90499","url":null,"abstract":"Human errors of train drivers may cause serious damage. Therefore, research on human error prevention has been conducted by many researchers. In this context, brain activity measurement of train drivers using near-infrared spectroscopy (NIRS) has been conducted to monitor the condition of train drivers. In this study, we developed a compact wireless wearable NIRS that can be used in natural environments. The wearable NIRS has been used to measure train drivers ’ brain function using a train driving simulator. Experimental results showed that brain activity of the dorsolateral prefrontal cortex (DLPFC) increased when the driver made braking operation. The experiment for train driving with an accidental event was carried out to evaluate the relation between drivers ’ attention and the brain activity. As a result, there was a difference in brain activity between with and without prior notice. Results showed that the increased attention of the train driver can be shown in the NIRS signal from the outer part of the prefrontal cortex.","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116009157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electroencephalogram Based Biomarkers for Detection of Alzheimer’s Disease","authors":"Ali H. Al-nuaimi","doi":"10.5772/INTECHOPEN.90015","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.90015","url":null,"abstract":"Alzheimer’s disease (AD) is an age-related progressive and neurodegenerative disorder, which is characterized by loss of memory and cognitive decline. It is the main cause of disability among older people. The rapid increase in the number of people living with AD and other forms of dementia due to the aging population represents a major challenge to health and social care systems worldwide. Degeneration of brain cells due to AD starts many years before the clinical manifestations become clear. Early diagnosis of AD will contribute to the development of effective treatments that could slow, stop, or prevent significant cognitive decline. Consequently, early diagnosis of AD may also be valuable in detecting patients with dementia who have not obtained a formal early diagnosis, and this may provide them with a chance to access suitable healthcare facilities. An early diagnosis biomarker capable of measuring brain cell degeneration due to AD would be valuable. Potentially, electroencephalogram (EEG) can play a valuable role in the early diagnosis of AD. EEG is noninvasive and low cost, and provides valuable information about brain dynamics in AD. Thus, EEG-based biomarkers may be used as a first-line decisionsupport tool in AD diagnosis and could complement other AD biomarkers.","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131347606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroimaging Findings for Developmental Coordination Disorder (DCD) in Adults: Critical Evaluation and Future Directions","authors":"A. Reid","doi":"10.5772/intechopen.90400","DOIUrl":"https://doi.org/10.5772/intechopen.90400","url":null,"abstract":"Approximately 75% of those diagnosed with developmental coordination disorder (DCD) exhibit motor problems in adulthood. Neuroimaging studies promise to reveal the endophenotypes of mature brain systems affected by DCD. The aim here was to review these publications. Bibliographic searches identified papers published before June 2019. Neuroimaging results revealed: functional abnormalities in the prefrontal, frontal and occipital regions, superior parietal lobe and cerebellum; structural white matter abnormalities in the corticospinal tract, internal capsule and inferior and superior longitudinal fasciculi; significantly reduced interhemispheric cortical inhibition within the primary motor cortex (hPMC); lack of increased hPMC activity during a motor imagery task and a reduced leftwards brain asymmetry for speech. These results suggest complex endophenotypes for adults with DCD (DCDAs). However, the studies have shortcomings. For instance, all relied upon small and unrepresentative samples. Gender and age were not tested systematically. The effects of many co-occurring disorders were not controlled. Most studies relied on between group comparisons, which, given the heterogeneity of DCD, may obscure the results for underrepresented cases. Overall, the young field of neuroimaging studies of DCDAs reported interesting results; however, there is an urgent need for investigations to address these shortcomings. Future research directions, including cutting-edge neuroimaging techniques and imaging genetics, are discussed.","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128143238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas J. FitzGerald, M. Bishop‐Jodoin, F. Laurie, R. Hanusik, Matthew K. Iandoli, K. Karolczuk, S. Kessel, F. Prior, J. Saltz, Ashish Sharma, M. Knopp, M. Rosen, Ying Xiao, D. Followill, J. Michalski, M. Cicchetti, J. Moni
{"title":"Imaging and Neuro-Oncology Clinical Trials of the National Clinical Trials Network (NCTN)","authors":"Thomas J. FitzGerald, M. Bishop‐Jodoin, F. Laurie, R. Hanusik, Matthew K. Iandoli, K. Karolczuk, S. Kessel, F. Prior, J. Saltz, Ashish Sharma, M. Knopp, M. Rosen, Ying Xiao, D. Followill, J. Michalski, M. Cicchetti, J. Moni","doi":"10.5772/intechopen.89065","DOIUrl":"https://doi.org/10.5772/intechopen.89065","url":null,"abstract":"Imaging in neuro-oncology clinical trials can be used to validate patient eligibil-ity, stage at presentation, response to therapy, and radiation therapy. A number of National Clinical Trials Network trials illustrating this are presented. Through the Imaging and Radiation Oncology Core’s quality assurance processes for data acquisition and review, there are uniform data and imaging sets for review. Once the trial endpoints have been analyzed and published, the clinical trial information including pathology, imaging, and radiation therapy objects can be moved to a public archive for use by investigators interested in translational science and the application of new informatics tools for trial analysis.","PeriodicalId":442950,"journal":{"name":"Neuroimaging - Neurobiology, Multimodal and Network Applications","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131221792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}