Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine最新文献

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Ultrasound for the Pulmonary Consultant. 肺科会诊医师超声检查。
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-06-29 eCollection Date: 2016-01-01 DOI: 10.4137/CCRPM.S33382
Astha Chichra, Mina Makaryus, Parag Chaudhri, Mangala Narasimhan
{"title":"Ultrasound for the Pulmonary Consultant.","authors":"Astha Chichra,&nbsp;Mina Makaryus,&nbsp;Parag Chaudhri,&nbsp;Mangala Narasimhan","doi":"10.4137/CCRPM.S33382","DOIUrl":"https://doi.org/10.4137/CCRPM.S33382","url":null,"abstract":"<p><p>Bedside ultrasonographic assessment of the lung and pleura provides rapid, noninvasive, and essential information in diagnosis and management of various pulmonary conditions. Ultrasonography helps in diagnosing common conditions, including consolidation, interstitial syndrome, pleural effusions and masses, pneumothorax, and diaphragmatic dysfunction. It provides procedural guidance for various pulmonary procedures, including thoracentesis, chest tube insertion, transthoracic aspiration, and biopsies. This article describes major applications of ultrasonography for the pulmonary consultant along with illustrative figures and videos. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"10 ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2016-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S33382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34654854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Up-to-Date Information on Rheumatoid Arthritis-Associated Interstitial Lung Disease. 类风湿性关节炎相关间质性肺疾病的最新信息。
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-05-31 eCollection Date: 2015-01-01 DOI: 10.4137/CCRPM.S23289
Takafumi Suda
{"title":"Up-to-Date Information on Rheumatoid Arthritis-Associated Interstitial Lung Disease.","authors":"Takafumi Suda","doi":"10.4137/CCRPM.S23289","DOIUrl":"https://doi.org/10.4137/CCRPM.S23289","url":null,"abstract":"<p><p>Pulmonary involvement is common in rheumatoid arthritis (RA) and affects all the components of the lung. Interstitial lung disease (ILD) is the most predominant pulmonary manifestation and has been identified as the main cause of morbidity and mortality in RA. Clinically significant RA-ILD occurs in approximately 10% of RA patients. Several risk factors, such as old age, male gender, and smoking, have been reported to date. Histologically, the proportion of the usual interstitial pneumonia (UIP) pattern is higher in RA-ILD than in ILD associated with other connective tissue diseases, and RA-ILD also shows nonspecific interstitial pneumonia and organizing pneumonia patterns. High-resolution computed tomography scans are highly predictive of the histological UIP pattern with a specificity of 96%-100%. Acute exacerbation, which is the acute deterioration of the respiratory status characterized by newly developed bilateral infiltrates with unknown etiologies, has been reported in RA-ILD. Although acute exacerbation of RA-ILD has high mortality, similar to that of idiopathic pulmonary fibrosis, its incidence is lower in RA-ILD than in idiopathic pulmonary fibrosis. A consensus treatment has not yet been established. Current therapeutic regimens typically include corticosteroids with or without cytotoxic agents. Recent large longitudinal studies reported that the prognosis of RA-ILD was poor with a median survival of 2.6-3.0 years. Furthermore, histological and/or radiological patterns, such as UIP or non-UIP, have significant prognostic implications. RA-ILD patients with histological or radiological UIP patterns have poorer prognoses than those with non-UIP patterns. This review assessed the characteristics of RA-ILD by overviewing recent studies in the field and focused on the clinical significance of histological and/or radiological patterns in RA-ILD. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"9 Suppl 1","pages":"155-62"},"PeriodicalIF":2.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S23289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34560704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Levels of Soluble Receptor for Advanced Glycation End Products in Bronchoalveolar Lavage Fluid in Patients with Various Inflammatory Lung Diseases. 各种炎症性肺病患者支气管肺泡灌洗液中晚期糖基化终产物可溶性受体的水平
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-04-28 eCollection Date: 2015-01-01 DOI: 10.4137/CCRPM.S23326
Tetsuro Kamo, Sadatomo Tasaka, Yuriko Tokuda, Shoji Suzuki, Takanori Asakura, Kazuma Yagi, Ho Namkoong, Makoto Ishii, Naoki Hasegawa, Tomoko Betsuyaku
{"title":"Levels of Soluble Receptor for Advanced Glycation End Products in Bronchoalveolar Lavage Fluid in Patients with Various Inflammatory Lung Diseases.","authors":"Tetsuro Kamo,&nbsp;Sadatomo Tasaka,&nbsp;Yuriko Tokuda,&nbsp;Shoji Suzuki,&nbsp;Takanori Asakura,&nbsp;Kazuma Yagi,&nbsp;Ho Namkoong,&nbsp;Makoto Ishii,&nbsp;Naoki Hasegawa,&nbsp;Tomoko Betsuyaku","doi":"10.4137/CCRPM.S23326","DOIUrl":"https://doi.org/10.4137/CCRPM.S23326","url":null,"abstract":"<p><p>Receptor for advanced glycation end products (RAGE) is a multiligand receptor of S100/calgranulins, high-mobility group box 1, and others, and it is associated with the pathogenesis of various inflammatory and circulatory diseases. The soluble form of RAGE (sRAGE) is a decoy receptor and competitively inhibits membrane-bound RAGE activation. In this study, we measured sRAGE levels in bronchoalveolar lavage fluid (BALF) of 78 patients, including 41 with interstitial pneumonia, 11 with sarcoidosis, 9 with respiratory infection, 7 with ARDS, 5 with lung cancer, and 5 with vasculitis. Among them, sRAGE was detectable in BALF of 73 patients (94%). In patients with ARDS and vasculitis, the sRAGE levels were significantly higher than in the control subjects and those with interstitial pneumonia. The sRAGE levels were positively correlated with total cell counts in BALF and serum levels of surfactant protein-D, lactate dehydrogenase, and C-reactive protein. There was an inverse correlation between PaO2/FIO2 ratio and sRAGE levels. These results indicate that sRAGE in BALF might be considered as a biomarker of lung inflammatory disorders, especially ARDS and vasculitis. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"9 Suppl 1","pages":"147-54"},"PeriodicalIF":2.0,"publicationDate":"2016-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S23326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34456723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Biomarkers and Autoantibodies of Interstitial Lung Disease with Idiopathic Inflammatory Myopathies. 特发性炎性肌病间质性肺疾病的生物标志物和自身抗体。
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-04-03 eCollection Date: 2015-01-01 DOI: 10.4137/CCRPM.S36748
Hajime Yoshifuji
{"title":"Biomarkers and Autoantibodies of Interstitial Lung Disease with Idiopathic Inflammatory Myopathies.","authors":"Hajime Yoshifuji","doi":"10.4137/CCRPM.S36748","DOIUrl":"https://doi.org/10.4137/CCRPM.S36748","url":null,"abstract":"<p><p>Various autoantibodies are seen in idiopathic inflammatory myopathies. Among myositis-specific antibodies, anti-aminoacyl-tRNA synthetase and anti-melanoma differentiation-associated protein 5 (MDA5) antibodies are associated with interstitial lung disease (ILD). Anti-MDA5 antibodies are associated with dermatomyositis (DM) or clinically amyopathic DM complicated with rapidly progressive ILD. In anti-MDA5-positive patients, a random ground-glass attenuation pattern is a characteristic finding of ILD in chest high-resolution computed tomography. Conversely, anti-aminoacyl-tRNA synthetase antibodies are not associated with rapidly progressive ILD but with chronic ILD. DM or clinically amyopathic DM patients with anti-MDA5, and characteristic high-resolution computed tomography findings are highly likely to have devastating ILD and need aggressive treatment. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"9 Suppl 1","pages":"141-6"},"PeriodicalIF":2.0,"publicationDate":"2016-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S36748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34464396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
The COPD Assessment Test as a Prognostic Marker in Interstitial Lung Disease COPD评估试验作为间质性肺疾病的预后标志物
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-01-01 DOI: 10.4137/CCRPM.S40792
F. Someya, T. Nakagawa, Naoki Mugii
{"title":"The COPD Assessment Test as a Prognostic Marker in Interstitial Lung Disease","authors":"F. Someya, T. Nakagawa, Naoki Mugii","doi":"10.4137/CCRPM.S40792","DOIUrl":"https://doi.org/10.4137/CCRPM.S40792","url":null,"abstract":"The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), which was developed to measure the health status of patients with COPD, was applied to patients with interstitial lung disease, aiming to examine the CAT as a predictor of outcome. Over a follow-up period of more than one year, 101 consecutive patients with interstitial lung disease were evaluated by the CAT. The CAT scores of 40 in total were categorized into four subsets according to the severity. Patients with higher (more severe) scores exhibited lower forced vital capacity and lung diffusion capacity for carbon monoxide. The survival rate was significantly lower in patients with higher scores (log-rank test, P = 0.0002), and the hazard ratios for death of the higher scores and lower lung diffusion capacity for carbon monoxide were independently significant. These findings suggest that CAT can indicate the risk of mortality in patients with interstitial lung disease.","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"4 1","pages":"27 - 31"},"PeriodicalIF":2.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86384247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Short-Term Pulmonary Rehabilitation for a Female Patient with Chronic Scleroderma under a Single-Case Research Design 单例慢性硬皮病女性患者的短期肺部康复研究
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-01-01 DOI: 10.4137/CCRPM.S40050
J. Leelarungrayub, Decha Pinkaew, Khanittha Wonglangka, W. Eungpinichpong, J. Klaphajone
{"title":"Short-Term Pulmonary Rehabilitation for a Female Patient with Chronic Scleroderma under a Single-Case Research Design","authors":"J. Leelarungrayub, Decha Pinkaew, Khanittha Wonglangka, W. Eungpinichpong, J. Klaphajone","doi":"10.4137/CCRPM.S40050","DOIUrl":"https://doi.org/10.4137/CCRPM.S40050","url":null,"abstract":"Although previously proposed that chronic scleroderma should be cared for clinically and early rehabilitation should be performed in hospital by a chest physical therapist, little evidence is currently available on its benefits. Therefore, this study demonstrated the benefits of short-term pulmonary rehabilitation during hospitalization in a female patient with chronic scleroderma. The aim of rehabilitation was to improve ventilation and gas exchange by using airway clearance, chest mobilization, and breathing-relearning techniques, including strengthening the respiratory system and the muscles of the limbs by using the Breath Max® device and elastic bands. Gross motor function and activities of daily life were regained by balancing, sitting, and standing practices. Data on minimal chest expansion, high dyspnea, high respiratory rate, and low maximal inspiratory mouth pressure were recorded seven days before rehabilitation or at the baseline period. But there was a clinically significant improvement in dyspnea, chest expansion, maximal inspiratory mouth pressure, and respiratory rate, when compared to baseline data, which were recorded by a chest physical therapist during seven days of rehabilitation. Furthermore, physicians decided to stop using a mechanical ventilator, and improvement in functional capacity was noted. Therefore, in the case of chronic and stable scleroderma, short-term rehabilitation during hospitalization for chest physical therapy possibly shows clinical benefits by improving both pulmonary function and physical performance.","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"111 1","pages":"11 - 17"},"PeriodicalIF":2.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82298964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease 利钠肽和高敏感肌钙蛋白T浓度与阻塞性睡眠呼吸暂停和冠状动脉疾病患者短期CPAP有效性相关
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-01-01 DOI: 10.4137/CCRPM.S40939
Ralf Strehmel, Misa Valo, C. Teupe
{"title":"Natriuretic Peptide and High-Sensitive Troponin T Concentrations Correlate with Effectiveness of Short-Term CPAP in Patients with Obstructive Sleep Apnea and Coronary Artery Disease","authors":"Ralf Strehmel, Misa Valo, C. Teupe","doi":"10.4137/CCRPM.S40939","DOIUrl":"https://doi.org/10.4137/CCRPM.S40939","url":null,"abstract":"The risk of cardiovascular complications is increased in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the most effective way to treat clinically significant OSA. We hypothesized that the concentrations of the cardiac risk markers N-terminal brain natriuretic peptide (NT-proBNP) and high-sensitive troponin T (hs-TropT) correlate with the effectiveness of CPAP therapy in patients with OSA and coexisting coronary artery disease (CAD). Twenty-one patients with severe OSA and coexisting CAD (group 1) and 20 control patients with severe OSA alone (group 2) were treated with CPAP and monitored by laboratory-based polysomnography. NT-proBNP and hs-TropT levels were measured before and after CPAP. Apnea-hypopnea index (AHI) and oxygen desaturation were similar in both groups. In group 1, hs-TropT levels correlated with AHI and oxygen desaturation upon CPAP. Elevated NT-proBNP levels in group 1 were significantly reduced by CPAP. NT-proBNP levels correlated with AHI and showed negative correlation with ST-segment depression. No such correlations were found in group 2. CPAP has the potential to normalize elevated NT-proBNP serum levels in patients with severe OSA and coexisting CAD. Levels of NT-proBNP and hs-TropT correlated with AHI and oxygen desaturation.","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"129 1","pages":"33 - 39"},"PeriodicalIF":2.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86379202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans 沙丁胺醇改善健康人肺泡-毛细血管膜传导
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2016-01-01 DOI: 10.4137/CCRPM.S30251
Natalie E. Taylor, S. Baker, T. Olson, S. Lalande, Bruce D. Johnson, E. Snyder
{"title":"Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans","authors":"Natalie E. Taylor, S. Baker, T. Olson, S. Lalande, Bruce D. Johnson, E. Snyder","doi":"10.4137/CCRPM.S30251","DOIUrl":"https://doi.org/10.4137/CCRPM.S30251","url":null,"abstract":"Background Beta-2 adrenergic receptors (β2ARs) are located throughout the body including airway and alveolar cells. The β2ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β2-agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC) in healthy humans. Methods We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2.5 mg, diluted in 3 mL normal saline) in 45 healthy subjects. Seventeen subjects repeated these measures following nebulized normal saline (age = 27 ± 9 years, height = 165 ± 21 cm, weight = 68 ± 12 kg, BMI = 26 ± 9 kg/m2). Cardiac output (Q), heart rate, systemic vascular resistance (SVR), blood pressure, oxygen saturation, forced expiratory volume at one-second (FEV1), and forced expiratory flow at 50% of forced vital capacity (FEF50) were assessed at baseline, 30 minutes, and 60 minutes following the administration of albuterol or saline. Results Albuterol resulted in a decrease in SVR, and an increase in Q, FEV1, and FEF50 compared to saline controls. Albuterol also resulted in a decrease in VC at 60 minutes post albuterol. Both albuterol and normal saline resulted in no change in DLCO or DM when assessed alone, but a significant increase was observed in DM when accounting for changes in VC. Conclusion These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/ VC.","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"140 1","pages":"19 - 25"},"PeriodicalIF":2.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77608433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Interstitial Lung Disease in Childhood: Clinical and Genetic Aspects. 儿童间质性肺疾病:临床和遗传方面。
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2015-10-11 eCollection Date: 2015-01-01 DOI: 10.4137/CCRPM.S23282
Hiroshi Kitazawa, Shigeo Kure
{"title":"Interstitial Lung Disease in Childhood: Clinical and Genetic Aspects.","authors":"Hiroshi Kitazawa,&nbsp;Shigeo Kure","doi":"10.4137/CCRPM.S23282","DOIUrl":"https://doi.org/10.4137/CCRPM.S23282","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) in childhood is a heterogeneous group of rare pulmonary conditions presenting chronic respiratory disorders. Many clinical features of ILD still remain unclear, making the treatment strategies mainly investigative. Guidelines may provide physicians with an overview on the diagnosis and therapeutic directions. However, the criteria used in different clinical studies for the classification and diagnosis of ILDs are not always the same, making the development of guidelines difficult. Advances in genetic testing have thrown light on some etiologies of ILD, which were formerly classified as ILDs of unknown origins. The need of genetic testing for unexplained ILD is growing, and new classification criteria based on the etiology should be adopted to better understand the disease. The purpose of this review is to give an overview of the clinical and genetic aspects of ILD in children. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"9 Suppl 1","pages":"57-68"},"PeriodicalIF":2.0,"publicationDate":"2015-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S23282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34193993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Interstitial Lung Disease with ANCA-associated Vasculitis. 间质性肺病伴anca相关血管炎。
IF 2
Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2015-09-23 eCollection Date: 2015-01-01 DOI: 10.4137/CCRPM.S23314
Yasuhiro Katsumata, Yasushi Kawaguchi, Hisashi Yamanaka
{"title":"Interstitial Lung Disease with ANCA-associated Vasculitis.","authors":"Yasuhiro Katsumata,&nbsp;Yasushi Kawaguchi,&nbsp;Hisashi Yamanaka","doi":"10.4137/CCRPM.S23314","DOIUrl":"https://doi.org/10.4137/CCRPM.S23314","url":null,"abstract":"<p><p>The association between interstitial lung disease (ILD) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), particularly microscopic polyangiitis (MPA), has been described in a number of case reports and case series reports in the last 2 decades. In addition, patients with pulmonary fibrosis and ANCA positivity but without other manifestations of systemic vasculitis have also been reported. Pulmonary fibrosis was clinically manifested at the time of diagnosis in the majority of AAV patients that developed this condition. Moreover, ANCA-positive conversion occurs in patients initially diagnosed with idiopathic pulmonary fibrosis, and as a result, other manifestations of systemic vasculitis develop in some of these patients. There is significant predominance of myeloperoxidase (MPO)-ANCA and MPA in patients with AAV and ILD. Radiological and pathological findings generally demonstrate usual interstitial pneumonia (pattern) in the lungs of these patients. In most studies, AAV patients with ILD have a worse prognosis than those without it. </p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"9 Suppl 1","pages":"51-6"},"PeriodicalIF":2.0,"publicationDate":"2015-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CCRPM.S23314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34071663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
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