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Obstacles to Clinical Research 临床研究的障碍
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.61
J. Marshall
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引用次数: 0
Competing Immune Biomarkers in the Selection of First-line Therapy in Non-small Cell Lung Cancer 非小细胞肺癌一线治疗选择中的竞争性免疫生物标志物
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.67
K. Tolba
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引用次数: 0
Treatment Disparities in Small Cell Lung Cancer 小细胞肺癌的治疗差异
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.70
S. Chun
{"title":"Treatment Disparities in Small Cell Lung Cancer","authors":"S. Chun","doi":"10.17925/OHR.2018.14.2.70","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.2.70","url":null,"abstract":"","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"70-71"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet Biomarkers for Precision Medicine in Hematology and Oncology 血小板生物标志物在血液学和肿瘤学精准医学中的应用
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.72
W. Bahou
{"title":"Platelet Biomarkers for Precision Medicine in Hematology and Oncology","authors":"W. Bahou","doi":"10.17925/OHR.2018.14.2.72","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.2.72","url":null,"abstract":"","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"72"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The PACIFIC Trial—Where Do We Go from Here in Immunotherapy for Non-small Cell Lung Cancer? 太平洋试验:非小细胞肺癌的免疫治疗将何去何从?
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.65
M. Edelman
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引用次数: 0
Personalized Therapy in Advanced Renal Cancer 晚期肾癌的个性化治疗
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.74
U. Vaishampayan
{"title":"Personalized Therapy in Advanced Renal Cancer","authors":"U. Vaishampayan","doi":"10.17925/OHR.2018.14.2.74","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.2.74","url":null,"abstract":"Support: No funding was received in the publication of this article. In recent years, personalized therapies have transformed the management of many advanced malignancies. However, despite advances in targeted therapy and immunotherapy that have expanded the treatment options for patients with metastatic kidney cancer, we are unable to predict which patients are most likely to respond to individual treatments. With a number of highly effective therapies available, it is becoming increasingly important to develop a more tailored approach to treatment selection.","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"74"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing Paradigms in the Treatment of Renal Cancer 肾癌治疗模式的改变
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.1.20
U. Vaishampayan
{"title":"Changing Paradigms in the Treatment of Renal Cancer","authors":"U. Vaishampayan","doi":"10.17925/OHR.2018.14.1.20","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.1.20","url":null,"abstract":"","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"20"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in the Treatment of Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma, and Follicular Lymphoma 慢性淋巴细胞白血病、弥漫性大b细胞淋巴瘤和滤泡性淋巴瘤的治疗进展
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.2.63
I. Flinn
{"title":"Recent Advances in the Treatment of Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma, and Follicular Lymphoma","authors":"I. Flinn","doi":"10.17925/OHR.2018.14.2.63","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.2.63","url":null,"abstract":"","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"63"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Advances in the Treatment of Non-Small Cell Lung Cancer 非小细胞肺癌治疗的新进展
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.1.18
S. Ramalingam
{"title":"New Advances in the Treatment of Non-Small Cell Lung Cancer","authors":"S. Ramalingam","doi":"10.17925/OHR.2018.14.1.18","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.1.18","url":null,"abstract":"Support: No funding was received in the publication of this article. Q. Could you tell us a little about the PACIFIC trial in stage III nonsmall cell lung cancer (NSCLC)? The PACIFIC trial evaluated the role of durvalumab, a programmed death-ligand 1 (PD-L1) antibody, in patients with locally advanced, surgically unresectable stage III NSCLC. Following completion of chemotherapy and radiation, patients were randomized to receive one year of durvalumab or placebo. There was a significant improvement in progression-free survival (PFS) with durvalumab, with a hazard ratio of 0.52. The survival data are awaited. The results of the PACIFIC study have defined a new role for immunotherapy in the treatment of NSCLC. Clinical benefit was seen regardless of PD-L1 expression status.","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"18"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Detecting an ALK Rearrangement via Liquid Biopsy Enabled a Targeted Therapy-based Approach for Treating a Patient with Advanced Non-small Cell Lung Cancer 通过液体活检检测ALK重排为晚期非小细胞肺癌患者提供了一种基于靶向治疗的方法
IF 1.1 1区 历史学
Oral History Review Pub Date : 2018-01-01 DOI: 10.17925/OHR.2018.14.1.38
A. Calvo, Gabriel Ibarra, C. Vibat, Veena Singh
{"title":"Detecting an ALK Rearrangement via Liquid Biopsy Enabled a Targeted Therapy-based Approach for Treating a Patient with Advanced Non-small Cell Lung Cancer","authors":"A. Calvo, Gabriel Ibarra, C. Vibat, Veena Singh","doi":"10.17925/OHR.2018.14.1.38","DOIUrl":"https://doi.org/10.17925/OHR.2018.14.1.38","url":null,"abstract":"Initial diagnostic biopsy procedures often yield insufficient tissue for molecular testing, and invasive surgical biopsies can be associated with significant cost as well as risk to the patient. Liquid biopsy offers an alternative and economical means for molecular characterization of tumors via a simple peripheral blood draw. This case report describes the ability of liquid biopsy to detect an ALK translocation where tissue analysis by fluorescence in situ hybridization was negative for the genetic alteration. Identification of an ALK rearrangement in circulating tumor cells from a blood specimen led to sequential targeted therapies that included crizotinib followed by alectinib. The patient demonstrated outstanding clinical response during treatment with each of the prescribed ALK inhibitors. This case demonstrates the clinical utility of Biocept’s liquid biopsy to detect actionable biomarkers by surveying the systemic landscape of a patient’s disease where identification of the same genetic drivers may be missed in analyses of heterogeneous tumor tissue.","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"38"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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