Erciyes Medical Journal最新文献_第10页

Bacterial Bloodstream Infection in Renal Transplant Recipients: 15 years experience in an university hospital 肾移植受者细菌性血流感染:15年大学医院经验

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.63600

Nursel Çalık Başaran

引用次数: 1

The Effect of Sex-Specific Genetic Factors on the Host Immune Response to COVID-19: A Pilot Study 性别特异性遗传因素对宿主COVID-19免疫反应的影响:一项初步研究

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.32955

D. Akin

{"title":"The Effect of Sex-Specific Genetic Factors on the Host Immune Response to COVID-19: A Pilot Study","authors":"D. Akin","doi":"10.14744/etd.2022.32955","DOIUrl":"https://doi.org/10.14744/etd.2022.32955","url":null,"abstract":"Objective: The aim of this study was to investigate the impact of sex-specific genetic factors in the pathogenesis and prog-nosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-induced macrophage activation syndrome (MAS), independent of age and comorbidity presence. Material(s) and Method(s): Patients aged 18-50 years who had been diagnosed with coronavirus 2019 (COVID-19), the disease caused by the SARS-CoV2 virus, were enrolled in a prospective, case-control, multi-center study. Genetic alterations and messenger RNA (m-RNA) expression levels of the TLR7, TLR8, ACE2, CD40L, CXCR3, and TASL genes were determined using DNA sequencing analysis, and gene expression was determined using quantitative reverse transcriptase polymerase chain reaction testing. PolyPhen-2 (Polymorphism Phenotyping v2;Adzhubei et al., 2010) and SNAP2 (Rostlab, Munich, Germany) genetic analysis tools were used to define the pathogenic effects of detected mutations by sequencing the selected genes in hotspot regions. Result(s): The study group consisted of 80 patients diagnosed with COVID-19 and was divided into groups based on sex and MAS status. Twenty-nine mutations were detected in 6 genes. Among the alterations, 15 were identified in this study for the first time and 9 were pathogenic. Pathogenic missense mutations in the TLR7, TLR8, ACE2, and TASL genes were detected in the MAS (+) group. In males, decreased TLR7, TLR8, and CXCR3 expression was statistically significant in the MAS (+) group (p<0.050). CXCR3 expression was lower in the female and male MAS (+) groups compared with the MAS (-) groups (p<0.050). Conclusion(s): In the absence of major risk factors for COVID-19, the TLR7/8, ACE2, and CXCR3 variants and decreased m-RNA expression levels associated with genetic susceptibility may be independent prognostic risk factors for COVID-19. Copyright © 2022 by Erciyes University Faculty of Medicine.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77395709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Determinants of Frailty and Gait Speed in People Over 65 Years of Age 65岁以上人群虚弱和步态速度的决定因素

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.33396

Mehmet Arslan

引用次数: 1

Imaging in Pediatric Spinal Infections 儿童脊柱感染的影像学研究

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.49465

Merve Yazol

引用次数: 0

Comparison of the Exosome Profile in Ankylosing Spondylitis and Healthy Controls 强直性脊柱炎与健康对照外显体的比较

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.54614

E. Karakaya

引用次数: 0

Evaluation of metacarpophalangeal joint cartilage thickness in patients with rheumatoid arthritis: a clinical and ultrasonographic study 类风湿关节炎患者掌指关节软骨厚度的评价:临床和超声研究

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.35714

H. Harman

引用次数: 0

Evaluation of Stereopsis in Children with Corrected Anisometropia according to the Type, Severity and, Presence of Amblyopia 根据弱视的类型、严重程度和存在程度评价矫正后屈光参差儿童的立体视

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.07742

F. Dikkaya

引用次数: 0

Methods of Pain Self-Care Used by Patients with Chronic Musculoskeletal Pain During the COVID-19 Pandemic in Turkey 2019冠状病毒病大流行期间土耳其慢性肌肉骨骼疼痛患者的疼痛自我护理方法

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Erciyes Medical Journal Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.54889

Şule Şimşek

{"title":"Methods of Pain Self-Care Used by Patients with Chronic Musculoskeletal Pain During the COVID-19 Pandemic in Turkey","authors":"Şule Şimşek","doi":"10.14744/etd.2022.54889","DOIUrl":"https://doi.org/10.14744/etd.2022.54889","url":null,"abstract":"Objective: The aim of this study was to determine the methods of pain self-care used by patients in Türkiye with chronic musculoskeletal pain who could not access a healthcare provider during the coronavirus 2019 (COVID-19) pandemic. Materials and Methods: A total of 255 participants (mean age 40.8±13.2 years) diagnosed with chronic musculoskeletal pain were included in the study. The Nordic Musculoskeletal Questionnaire and a form created by the researchers were used to assess the prevalence of musculoskeletal symptoms and methods of pain management. Results: The primary site of symptoms during the previous 12-month period was the low back, neck, and upper back regions (69%, 64.7%, and 60% respectively). The detailed assessment revealed that in the prior 7 days, patients experienced symptoms most often in the lower back (56.9%), upper back (45.1%), and neck (43.9%). The most frequently used methods of pain self-care were massage (71%), pain relief medication (68.2%), and topical analgesics (55.3%). Conclusion: Patients most often reported symptoms in the spinal area, and the most used means of self-care for pain management were massaging the painful area, pain medication, and topical analgesics. Self-care initiatives can be very valuable, however, at least some initial guidance from health professionals is advisable. Additional exploration of technological means of intervention and awareness of appropriate self-care could be of substantial benefit individuals and society.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74196236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an Active Distraction Method for Pediatric Venipuncture Related Pain and Anxiety 主动牵张法治疗小儿静脉穿刺相关疼痛和焦虑的效果

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Erciyes Medical Journal Pub Date : 2021-07-26 DOI: 10.21203/rs.3.rs-715971/v1

E. Isiyel, Melehat Yurttas, Ezgi Perktas, E. Ozmert, O. Teksam

引用次数: 0

Ventricular Repolarization Parameters In Hospitalized Patients With COVID-19 COVID-19住院患者心室复极参数的研究

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Erciyes Medical Journal Pub Date : 2021-01-01 DOI: 10.14744/ETD.2021.93902

Serkan Sivri

{"title":"Ventricular Repolarization Parameters In Hospitalized Patients With COVID-19","authors":"Serkan Sivri","doi":"10.14744/ETD.2021.93902","DOIUrl":"https://doi.org/10.14744/ETD.2021.93902","url":null,"abstract":"Objective: Coronavirus disease-2019 (COVID-19) may cause atrial and/or ventricular arrhythmias and sudden cardiac deaths, especially in severe cases. In this study, we aimed to investigate whether COVID-19 affects the ventricular repolarization parameters. Materials and Methods: In this study, 152 hospitalized patients with COVID-19 were included retrospectively. Age and sex-matched 151 healthy subjects were assigned as the control group. QT, QTc, Tpe, Tpe/QT, and Tpe/QTc values of all participants were determined and compared between both groups. The relationship between high sensitive-troponin I (hsTnI) and the parameters mentioned was analyzed using the Spearman correlation test. Results: Mean age, male gender and comorbidity rates were similar in both groups (p>0.05 for each). Heart rate, QTc, Tpe, Tpe/QT, and Tpe/QTc values were higher in the study group (p<0.001 for each). However, QT and QRS values were comparable in both groups (p>0.05 for each). There were positive correlations between hsTnI and QT (rho=0.218, p=0.008), QTc (rho=0.308, p<0.001), Tpe (rho=0.646, p<0.001), Tpe/QT (rho=0.571, p<0.001), and Tpe/QTc (rho=0.608, p<0.001). Conclusion: In patients with COVID-19, QTc, Tpe, Tpe/QT, and Tpe/QTc values are higher than the control group and these parameters correlate positively with hsTnI. Therefore, ECG follow-up may be beneficial in preventing arrhythmic events, especially in patients with acute cardiac injuries. [ FROM AUTHOR] Copyright of Erciyes Medical Journal / Erciyes Tip Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.)","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73194499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0