The Oxford Handbook of Neuronal Ion Channels最新文献

Gating of Ion Channels 离子通道的门控

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2021-08-11 DOI: 10.1093/oxfordhb/9780190669164.013.19

Rene Barro-Soria

引用次数: 1

TRPC Channels—Insight from the Drosophila Light Sensitive Channels TRPC通道——来自果蝇光敏通道的洞察

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.5

Ben Katz, W. Pak, B. Minke

引用次数: 0

The Voltage-Dependent K+ Channel Family 电压依赖性K+通道族

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.1

H. B. Rasmussen, J. Trimmer

引用次数: 8

N-Methyl-D-Aspartate Receptors n -甲基- d受体

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190669164.013.16

G. Iacobucci, G. Popescu

{"title":"N-Methyl-D-Aspartate Receptors","authors":"G. Iacobucci, G. Popescu","doi":"10.1093/oxfordhb/9780190669164.013.16","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190669164.013.16","url":null,"abstract":"Discovered more than 70 years ago due to advances in electrophysiology and cell culture techniques, N-methyl-D-aspartate (NMDA) receptors remain the target of assiduous basic and clinical research. This interest flows from their intimate engagement with fundamental processes in the mammalian central nervous system and the resulting natural desire to understand how this receptor’s genetically encoded structural properties generate their distinctive functional features and how in turn these unique functional attributes play into the larger opus of physiological and pathological processes. From the overwhelming literature on the subject, the authors briefly outline contemporary understanding of the receptor’s evolutionary origins, molecular diversity, and expression patterns; sketch hypothesized correlations between structural dynamics, signal kinetics, and pathophysiological consequences; and highlight the breadth of processes in which NMDA receptors are implicated, many of which remain poorly understood. Continued developments in cryo-electron microscopy, whole-genome sequencing and editing, imaging, and other emerging technologies will likely confirm some of the current hypotheses and challenge others to produce a more accurate reflection of these receptors’ complex operation and myriad roles in health and disease.","PeriodicalId":439826,"journal":{"name":"The Oxford Handbook of Neuronal Ion Channels","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121577599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 超极化活化环核苷酸门控通道

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.23

A. Masi, M. Romanelli, G. Mannaioni, E. Cerbai

引用次数: 4

Acid-Sensing Ion Channels 酸感离子通道

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190669164.013.12

S. Gründer

引用次数: 1

Tandem Pore Domain Potassium Channels 串联孔域钾通道

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.4

D. Bayliss

{"title":"Tandem Pore Domain Potassium Channels","authors":"D. Bayliss","doi":"10.1093/OXFORDHB/9780190669164.013.4","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190669164.013.4","url":null,"abstract":"The KCNK gene family encodes two-pore-domain potassium (K2P) channels, which generate the background (“leak”) K+ currents that establish a negative resting membrane potential in cells of the nervous system. A pseudotetrameric K+-selective pore is formed by pairing channel subunits, each with two pore-domains, in homo- or heterodimeric conformations. Unique features apparent from high-resolution K2P channel structures include a domain-swapped extracellular cap domain, a lateral hydrophobic-lined fenestration connecting the lipid bilayer to the channel vestibule, and an antiparallel proximal C-terminal region that links the paired subunits and provides a site for polymodal channel modulation. Individual channels transition between open and closed states, with the channel gate located at the selectivity filter. In general, K2P channels display relatively modest voltage- and time-dependent gating, together with distinct single-channel rectification properties, that conspire to yield characteristic weakly rectifying macroscopic currents over a broad range of membrane potentials (i.e., background K+ currents). Of particular note, K2P channel activity can be regulated by a wide range of physicochemical factors, neuromodulators, and clinically useful drugs; a distinct repertoire of activators and inhibitors for different K2P channel subtypes endows each with unique modulatory potential. Thus, by mediating background currents and serving as targets for multiple modulators, K2P channels are able to dynamically regulate key determinants of cell-intrinsic electroresponsive properties. The roles of specific K2P channels in various physiological processes and pathological conditions are now beginning to come into focus, and this may portend utility for these channels as potential therapeutic targets.","PeriodicalId":439826,"journal":{"name":"The Oxford Handbook of Neuronal Ion Channels","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129844578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

AMPA and Kainate Receptors AMPA和盐酸盐受体

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190669164.013.8

G. B. Dawe, P. Brown, D. Bowie

{"title":"AMPA and Kainate Receptors","authors":"G. B. Dawe, P. Brown, D. Bowie","doi":"10.1093/oxfordhb/9780190669164.013.8","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190669164.013.8","url":null,"abstract":"α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate-type glutamate receptors (AMPARs and KARs) are dynamic ion channel proteins that govern neuronal excitation and signal transduction in the mammalian brain. The four AMPAR and five KAR subunits can heteromerize with other subfamily members to create several combinations of tetrameric channels with unique physiological and pharmacological properties. While both receptor classes are noted for their rapid, millisecond-scale channel gating in response to agonist binding, the intricate structural rearrangements underlying their function have only recently been elucidated. This chapter begins with a review of AMPAR and KAR nomenclature, topology, and rules of assembly. Subsequently, receptor gating properties are outlined for both single-channel and synaptic contexts. The structural biology of AMPAR and KAR proteins is also discussed at length, with particular focus on the ligand-binding domain, where allosteric regulation and alternative splicing work together to dictate gating behavior. Toward the end of the chapter there is an overview of several classes of auxiliary subunits, notably transmembrane AMPAR regulatory proteins and Neto proteins, which enhance native AMPAR and KAR expression and channel gating, respectively. Whether bringing an ion channel novice up to speed with glutamate receptor theory and terminology or providing a refresher for more seasoned biophysicists, there is much to appreciate in this summation of work from the glutamate receptor field.","PeriodicalId":439826,"journal":{"name":"The Oxford Handbook of Neuronal Ion Channels","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134382093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM16 Ca2+ Activated Cl– Channels and CLC Chloride Channels and Transporters TMEM16 Ca2+激活的Cl -通道和CLC氯离子通道和转运体

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.17

A. Boccaccio, M. Pusch

引用次数: 3

Ion Channel Permeation and Selectivity 离子通道渗透和选择性

The Oxford Handbook of Neuronal Ion Channels Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190669164.013.22

J. Nogueira, B. Corry

引用次数: 8