Introducing Pharmacology最新文献

{"title":"Infection and antimicrobial drugs","authors":"R. McFadden","doi":"10.4324/9781351001403-8","DOIUrl":"https://doi.org/10.4324/9781351001403-8","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116374101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer and anti-cancer drugs","authors":"R. McFadden","doi":"10.4324/9781351001403-12","DOIUrl":"https://doi.org/10.4324/9781351001403-12","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123243276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A drug’s journey through the body","authors":"R. McFadden","doi":"10.4324/9781351001403-3","DOIUrl":"https://doi.org/10.4324/9781351001403-3","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131557886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cardiovascular system (2): hypertension and antihypertensive drugs","authors":"R. McFadden","doi":"10.4324/9781351001403-5","DOIUrl":"https://doi.org/10.4324/9781351001403-5","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114524127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drugs for mental health and neurological disorders","authors":"R. McFadden","doi":"10.4324/9781351001403-11","DOIUrl":"https://doi.org/10.4324/9781351001403-11","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134474082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cardiovascular system (1): drugs used in the management of cardiovascular disease","authors":"R. McFadden","doi":"10.4324/9781351001403-4","DOIUrl":"https://doi.org/10.4324/9781351001403-4","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"112 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132334775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteins as targets for drugs","authors":"R. McFadden","doi":"10.4324/9781351001403-2","DOIUrl":"https://doi.org/10.4324/9781351001403-2","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122909882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorders and drugs of the endocrine system","authors":"R. McFadden","doi":"10.4324/9781351001403-10","DOIUrl":"https://doi.org/10.4324/9781351001403-10","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130439841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and its management","authors":"Roger McFadden","doi":"10.4324/9781315832883-16","DOIUrl":"https://doi.org/10.4324/9781315832883-16","url":null,"abstract":"The eighth annual day conference in the series 'Growing points in the treatment of rheumatic diseases', which was held at Harrogate on 7 May 1987, was devoted to 'Pain and its management'. An audience of 90 was made up of rheumatologists, anaesthetists with responsibility for pain clinics, representatives from industry, and representatives of the paramedical professions that have an interest in the control of pain. The enthusiasm of anaesthetists for this topic contrasted strongly with the low number of abstracts submitted by rheumatologists. The morning session opened with a review of the neurophysiology of pain by Dr A Harvey (Leeds). Anatomy was well defined in terms of histological tracts of myelinated and unmyelinated fibres. This basic anatomy could be modified in dynamic fashion both by the concept of neuroplasticity (alteration in the connection of the fibres concerned after unmyelinated C fibre activation) and by local humoral control, which was particularly pronounced in the dorsal horn of the spinal cord. The nervous system was biologically well adapted to the handling of acute pain but less so to the handling of chronic pain. Different levels of the nervous system at which intervention might be directed were defined. Dr J Dixon (Harrogate) reviewed the various descriptive scales available for the measurement of subjective pain. Novel semiobjective methods included videotaped recording of attitude, and conventional rheumatological assessments such as grip strength and joint tenderness also reflected an element of pain. The measurement of pain threshold produced a more finite end point, but this was not necessarily the same as pain perceived by the subject. In discussion it was agreed that daily diary card systems provided advantages in circumventing the atypical event of a special visit to clinic, and a plea was made for research on short pain questionnaires that were adapted to rheumatological problems and to modified articular indices that might reflect tenderness as well as synovial proliferation. It was not clear whether the problems inherent in visual analogue scales applied to rheumatology were also experienced when these scales were used for other symptoms such as breathlessness. Three short papers offered insight into different pharmacological approaches to the control of pain. Dr A Jones (St Bartholomew's Hospital) described work performed with the Hammersmith cyclotron in the investigation of opioid physiology in man. The investigation of an Indian fakir who lanced himself with needles showed that when he was not in a trance he had a normal response to pain. The induction of a state of intense concentration produced increased theta activity on EEG (of the sort that occurs during sleep), allowing him to lose awareness of his normal physiological response. Naturally occurring opioids were implicated and these might be manipulated pharmacologically. A technique had been devised using diphenorphine as a marker to identify those a","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129906294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let’s start at basics: cells and how they work","authors":"R. McFadden","doi":"10.4324/9781315832883-10","DOIUrl":"https://doi.org/10.4324/9781315832883-10","url":null,"abstract":"","PeriodicalId":439409,"journal":{"name":"Introducing Pharmacology","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123584176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}