Capsaicin and its Human Therapeutic Development最新文献

CAP and Metabolic Diseases: A Mini Review on Preclinical Mechanisms and Clinical Efficacy CAP与代谢性疾病:临床前机制和临床疗效综述

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.78353

B. Thyagarajan, V. Krishnan, P. Baskaran

{"title":"CAP and Metabolic Diseases: A Mini Review on Preclinical Mechanisms and Clinical Efficacy","authors":"B. Thyagarajan, V. Krishnan, P. Baskaran","doi":"10.5772/INTECHOPEN.78353","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78353","url":null,"abstract":"Capsaicin (CAP) is the chief active ingredient of natural chili peppers. It has culinary and medicinal benefits. CAP activates its receptor, transient receptor potential vanilloid subfamily 1 (TRPV1), which is expressed in the sensory and motor neurons, adipocytes, liver, vascular smooth muscle cells, neuromuscular junction, skeletal muscle, heart and brain. The specificity of CAP to activate TRPV1 is the fundamental mechanism for its medicinal benefits to treat pain, obesity, hypertension, and other diseases. Preclinical data from rodent model of high fat diet-induced obesity collectively suggest that CAP exerts its effects by activating TRPV1 signaling pathway, which stimulates thermogenic mechanisms in the white and brown adipose tissues to induce browning of white adipose tissues and brown adipose tissue thermogenesis. This leads to enhancement of metabolic activity and thermogenesis to counter obesity. Although CAP and its pungent and nonpungent analogs are used in human clinical studies, their effects on satiety and energy expenditure have been the highlights of such studies. The precise mechanism of action of CAP has not been evaluated in humans. This article summarizes these data and suggests that long-term safety and tolerance studies are important for advancing CAP to treat human obesity.","PeriodicalId":435706,"journal":{"name":"Capsaicin and its Human Therapeutic Development","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131395412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Capsaicinoids and Vitamins in Hot Pepper and Their Role in Disease Therapy 辣椒中的辣椒素和维生素及其在疾病治疗中的作用

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.78243

G. Antonious

{"title":"Capsaicinoids and Vitamins in Hot Pepper and Their Role in Disease Therapy","authors":"G. Antonious","doi":"10.5772/INTECHOPEN.78243","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78243","url":null,"abstract":"Members of the genus Capsicum (Family: Solanaceae), which belongs to a dicotyledonous group of flowering plants, show fluctuating degrees of spiciness that mirror the relative concentrations of capsaicin, dihydrocapsaicin, and other analogs (nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin) collectively known as capsaicinoids pres ent in the fruit placenta. Pungent Chili varieties are grown for their food value, health- promoting properties and as a source of capsaicinoids that have a variety of medicinal uses. Accessions of the cultivated species ( Capsicum annuum , C. baccatum , C. chinense , C. frutescens , and C. pubescens ) have not all been analyzed for their capsaicinoids content. Identifying Capsicum species and accessions (genotypes) within species with high levels of antioxidants and bioactive compounds (capsaicin, dihydrocapsaicin, vitamin C, vita min E, phenols, and β-carotene) that contribute to human disease therapy is the focus of this investigation. The main objectives of this chapter are to compile an overview of most recent achievements of the pharmacological properties of hot pepper compounds and provide a rationale for their use as analgesics and to present an evidence that supports the use of capsaicinoids in the treatment of neuropathic pain and other top leading death of worldwide human diseases.","PeriodicalId":435706,"journal":{"name":"Capsaicin and its Human Therapeutic Development","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114150515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

A Matter of Taste: Capsaicinoid Diversity in Chile Peppers and the Importance to Human Food Preference 味觉问题:辣椒中的辣椒素多样性及其对人类食物偏好的重要性

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.77317

Ivette Guzmán, P. Bosland

引用次数: 4

Emerging Technologies to Improve Capsaicin Delivery and its Therapeutic Efficacy 改善辣椒素输送及其治疗效果的新兴技术

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.77080

V. C. S. R. Chittepu, Poonam Kalhotra, Guillermo Osorio Revilla, Tzayhrí Guadalupe Gallardo Velázquez

引用次数: 4

Predictors of Treatment Response to Capsaicin Patch 辣椒素贴剂治疗反应的预测因素

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.76789

A. Afonso

{"title":"Predictors of Treatment Response to Capsaicin Patch","authors":"A. Afonso","doi":"10.5772/INTECHOPEN.76789","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76789","url":null,"abstract":"Neuropathic pain is a very difficult to treat chronic condition. One of the most promising treatments developed in recent years is the capsaicin 8% patch. But given the high cost of treatment, the patch should be applied only to those most likely to benefit from improve- ment. There have been several studies that have tried to look for predictors of treatment response. Three of them found correlation with pain and response to treatment. The pre- dictors found were: baseline pain scores, variability of pain prior to treatment, pain response for lidocaine pretreatment, and time with preexisting pain. Four studies found that sensory abnormalities used for prediction of response to treatment seems to be useful as well. Though the correct sensory sensations are not clear there seems to be a tendency for the burning or heat-pain sensations and the pressure-pain sensations to be taken into account. From this findings, it seems that patients with exclusively peripheral damage and with no central plastic changes are the most suitable for treatment. There must be some more research to be done, where a combination of the predictors already found could give a very high predictability of treatment response, lowering de NNT to almost 1.","PeriodicalId":435706,"journal":{"name":"Capsaicin and its Human Therapeutic Development","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114888464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introductory Chapter: The General Problems of Human Clinical Nutritional and Pharmacological Observations of Capsaicin in Human Beings and Patients 导论:人类临床营养的一般问题和辣椒素在人类和患者中的药理观察

Capsaicin and its Human Therapeutic Development Pub Date : 2018-08-01 DOI: 10.5772/INTECHOPEN.79122

G. Mózsik

引用次数: 1