Muscle Cells - Recent Advances and Future Perspectives最新文献

Noncoding RNAs in the Cardiovascular System: Exercise Training Effects 非编码rna在心血管系统:运动训练的影响

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2020-01-22 DOI: 10.5772/intechopen.86054

N. P. Pereira, C. Gatto, E. Oliveira, T. Fernandes

引用次数: 0

Current Approaches in Immunoassay Methods Focus on Skeletal Muscle Proteins 目前的免疫分析方法主要集中在骨骼肌蛋白上

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2019-12-19 DOI: 10.5772/intechopen.90629

G. Gaina

引用次数: 0

Orexin System and Avian Muscle Mitochondria 食欲素系统与禽类肌肉线粒体

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2019-04-11 DOI: 10.5772/INTECHOPEN.85177

K. Lassiter, S. Dridi

引用次数: 3

Excitability of Vascular Smooth Muscle 血管平滑肌的兴奋性

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2019-03-09 DOI: 10.5772/INTECHOPEN.85053

A. V. Ulyanova

引用次数: 0

Leucine and Its Importance for Cell Signalling Pathways in Cancer Cachexia-Induced Muscle Wasting 亮氨酸及其在癌症恶病质诱导的肌肉萎缩细胞信号通路中的重要性

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78990

André Gustavo Oliveira, B. Cruz, Sarah Christine Pereira de Oliveira, L. Viana, Natália Angelo da Silva Miyaguti, L. Ramos, Rafael R Valentim, M. Gomes-Marcondes

{"title":"Leucine and Its Importance for Cell Signalling Pathways in Cancer Cachexia-Induced Muscle Wasting","authors":"André Gustavo Oliveira, B. Cruz, Sarah Christine Pereira de Oliveira, L. Viana, Natália Angelo da Silva Miyaguti, L. Ramos, Rafael R Valentim, M. Gomes-Marcondes","doi":"10.5772/INTECHOPEN.78990","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78990","url":null,"abstract":"The anabolic effects of a supplemented diet with branched-chain amino acids, especially leucine, on skeletal muscle wasting and as a co-adjuvant in cancer treatment have been well-studied. Leucine is a precursor of protein synthesis and acts as a nutritional signal, affecting multiple metabolic processes (e.g., satiety, thermo-genesis, energy efficiency, and body composition). Previous studies related to nutritional therapy have mainly focused on myopenia, which is the loss of skeletal muscle mass in some pathologies, including cancer. Leucine plays a role in the maintenance and even increase of lean body mass in healthy individuals as well as the prevention of disease states that culminate in myopenia. Herein, we review the available data addressing the mechanisms by which leucine acts as a cellular signal, thereby stimulating muscle protein synthesis, leading to the inhibition of muscle catabolism, especially in an experimental model of cancer cachexia. We also show differences found in the metabolomic and proteomic analyses, including the use of leucine in maternal diets as a preventative for muscle wasting as supported by our experimental data.","PeriodicalId":432485,"journal":{"name":"Muscle Cells - Recent Advances and Future Perspectives","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126658766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose Tissue Remodeling during Cancer Cachexia 癌症恶病质期间脂肪组织重塑

Muscle Cells - Recent Advances and Future Perspectives Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79979

Miguel Luiz Batista Júnior, Felipe Henriques

{"title":"Adipose Tissue Remodeling during Cancer Cachexia","authors":"Miguel Luiz Batista Júnior, Felipe Henriques","doi":"10.5772/INTECHOPEN.79979","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79979","url":null,"abstract":"Cancer-induced cachexia (CC), characterized by systemic inflammation, body weight loss, adipose tissue (AT) remodeling, and muscle wasting, is a malignant metabolic syndrome with an undefined etiology. There is a consensus that multiple factors contribute to cancer-induced AT remodeling, and longitudinal studies show that patients lose AT before they start losing muscle mass. In CC, AT remodeling occurs predominantly through adipocyte atrophy, impairment of fatty acid turnover, inflammation, rearrangement of extracellular matrix (ECM), and browning of AT. More recently, some studies have shown that AT is affected early in the course of cachexia. Additionally, studies using experimental models have consistently indicated that the alterations in adipocyte metabolism begin quite early, followed by the downregulation of adipogenic and thermogenic genes. These sets of changes, in addition to metabolites derived from this process, maybe the initial (sterile) trigger of the sequence of events that result in the remodeling and dysfunction of AT in cachexia. Therefore, the present chapter aims to describe state of the art related to the subject of interest by analyzing the primary studies that have addressed the possible interface between inflammation and morphofunctional alterations of AT, in addition to the possible repercussions of this process during the development of CC.","PeriodicalId":432485,"journal":{"name":"Muscle Cells - Recent Advances and Future Perspectives","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128174659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3