PharmSciRN: Pharmaceutical Nanotechnology (Topic)最新文献

筛选

英文中文

Intelligent Protein-Coated Bismuth Sulfide and Manganese Oxide Nanocomposites by Biomineralization for Multimodal Imaging-Guided Enhanced Tumor Therapy 生物矿化智能蛋白包被硫化铋和氧化锰纳米复合材料用于多模态成像引导增强肿瘤治疗

PharmSciRN: Pharmaceutical Nanotechnology (Topic) Pub Date : 2019-02-22 DOI: 10.2139/ssrn.3339834

Lin Zhang, Qian Chen, Xinwei Zou, Jiawen Chen, Lvzhong Hu, Z. Dong, Jinhua Zhou, Youguo Chen, Zhuang Liu, Liang Cheng

{"title":"Intelligent Protein-Coated Bismuth Sulfide and Manganese Oxide Nanocomposites by Biomineralization for Multimodal Imaging-Guided Enhanced Tumor Therapy","authors":"Lin Zhang, Qian Chen, Xinwei Zou, Jiawen Chen, Lvzhong Hu, Z. Dong, Jinhua Zhou, Youguo Chen, Zhuang Liu, Liang Cheng","doi":"10.2139/ssrn.3339834","DOIUrl":"https://doi.org/10.2139/ssrn.3339834","url":null,"abstract":"Radiotherapy (RT) has been used clinically to overcome cancer in recent decades. However, the abnormal tumor microenvironment (TME) featured with hypoxia, acidosis, and dense extracellular matrix is found to be related with the resistance of tumors to RT. Herein, intelligent bovine serum albumin (BSA)-coated Bi2S3 and MnO2 (Bi2S3-MnO2) nanocomposites synthesized by biomineralization are capable of modulating hypoxic TME effectively to enhance the efficacy of RT. After intravenous injection, the BSA-Bi2S3-MnO2 nanocomposites show efficient accumulation in tumor where endogenous H2O2 could be reacted with MnO2 to generate oxygen in-situ, leading to increased tumor oxygenation to overcome the hypoxia-associated resistance for RT. Moreover, the photothermal effect induced by BSA-Bi2S3-MnO2 nanocomposites further relieves the hypoxia in TME and finally synergistically improves RT effect. In this work, we present a simple strategy to fabricate intelligent therapeutic nanoparticles for improving therapeutic efficiency in cervical cancer.","PeriodicalId":431131,"journal":{"name":"PharmSciRN: Pharmaceutical Nanotechnology (Topic)","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126696633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0