Intelligent Protein-Coated Bismuth Sulfide and Manganese Oxide Nanocomposites by Biomineralization for Multimodal Imaging-Guided Enhanced Tumor Therapy

Abstract

Radiotherapy (RT) has been used clinically to overcome cancer in recent decades. However, the abnormal tumor microenvironment (TME) featured with hypoxia, acidosis, and dense extracellular matrix is found to be related with the resistance of tumors to RT. Herein, intelligent bovine serum albumin (BSA)-coated Bi2S3 and MnO₂ (Bi₂S₃-MnO₂) nanocomposites synthesized by biomineralization are capable of modulating hypoxic TME effectively to enhance the efficacy of RT. After intravenous injection, the BSA-Bi₂S₃-MnO₂ nanocomposites show efficient accumulation in tumor where endogenous H₂O₂ could be reacted with MnO₂ to generate oxygen in-situ, leading to increased tumor oxygenation to overcome the hypoxia-associated resistance for RT. Moreover, the photothermal effect induced by BSA-Bi₂S₃-MnO₂ nanocomposites further relieves the hypoxia in TME and finally synergistically improves RT effect. In this work, we present a simple strategy to fabricate intelligent therapeutic nanoparticles for improving therapeutic efficiency in cervical cancer.