Akhil Chawla, Gheath Alatrash, Yun Wu, Elizabeth A Mittendorf
{"title":"Immune aspects of the breast tumor microenvironment.","authors":"Akhil Chawla, Gheath Alatrash, Yun Wu, Elizabeth A Mittendorf","doi":"10.2217/bmt.13.15","DOIUrl":"https://doi.org/10.2217/bmt.13.15","url":null,"abstract":"<p><p>The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other. Technological advances have allowed investigators to better identify the specific immune cells present and immune-related gene signatures overexpressed in the tumor microenvironment. Increased knowledge of tumor immunology has allowed us to better understand how these cells and the developing tumor interact. Together, these advances have prompted the conduct of numerous studies investigating the prognostic and predictive significance of immune infiltrates.</p>","PeriodicalId":43086,"journal":{"name":"Breast Cancer Management","volume":"2 3","pages":"231-244"},"PeriodicalIF":0.7,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bmt.13.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32106365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of radiotherapy-resistant stem cells in breast cancer recurrence.","authors":"Cheikh Menaa, Jian Jian Li","doi":"10.2217/bmt.13.5","DOIUrl":"https://doi.org/10.2217/bmt.13.5","url":null,"abstract":"","PeriodicalId":43086,"journal":{"name":"Breast Cancer Management","volume":"2 2","pages":"89-92"},"PeriodicalIF":0.7,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bmt.13.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32983382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G van Londen, Eb Beckjord, Ma Dew, P Cuijpers, S Tadic, A Brufsky
{"title":"Breast cancer survivorship symptom management: current perspective and future development.","authors":"G van Londen, Eb Beckjord, Ma Dew, P Cuijpers, S Tadic, A Brufsky","doi":"10.2217/bmt.12.63","DOIUrl":"10.2217/bmt.12.63","url":null,"abstract":"<p><p>Increasing numbers and longevity of cancer survivors has furthered our insight into the factors affecting their health outcomes, suggesting that multiple factors play a role (e.g., effects of cancer treatments and health behaviors). Emotional and physical symptoms may not always receive sufficient attention. In this short narrative review highlighting recent literature, we describe the most common physical and emotional symptoms of breast cancer survivors aged 50 years and older and outline a multidisciplinary symptom management approach, regardless of symptom etiology.</p>","PeriodicalId":43086,"journal":{"name":"Breast Cancer Management","volume":"2 1","pages":"71-81"},"PeriodicalIF":0.7,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693468/pdf/nihms437205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31545712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using large-scale molecular data sets to improve breast cancer treatment.","authors":"Chad J Creighton","doi":"10.2217/BMT.12.14","DOIUrl":"https://doi.org/10.2217/BMT.12.14","url":null,"abstract":"<p><p>The treatment of breast cancer patients could potentially be advanced by having a more complete understanding of breast cancer biology, including a catalog of recurrently altered genes. Over the last decade, thousands of human breast tumors have been profiled for gene expression and DNA copy number alterations, and ongoing efforts in DNA sequencing are establishing the set of somatically mutated genes. Much of the molecular data being generated resides in the public domain, available as a resource for further research. The challenge then becomes how to best utilize all these data, to mine them for candidate biomarkers and targets, which is the subject of this review. Some examples of integrative analysis and combining results from diverse data sets are also presented.</p>","PeriodicalId":43086,"journal":{"name":"Breast Cancer Management","volume":"1 1","pages":"57-64"},"PeriodicalIF":0.7,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BMT.12.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31592864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}