Journal of Advanced Oral Research最新文献_第3页

Effects of Ultrasonic Instrumentation on the Shear Bond Strength of Ceramic Brackets: An In Vitro Study 超声仪器对陶瓷支架剪切结合强度的影响:体外研究

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-04-17 DOI: 10.1177/23202068231166507

Preethi Rajamanickam, N. Ramasamy

{"title":"Effects of Ultrasonic Instrumentation on the Shear Bond Strength of Ceramic Brackets: An In Vitro Study","authors":"Preethi Rajamanickam, N. Ramasamy","doi":"10.1177/23202068231166507","DOIUrl":"https://doi.org/10.1177/23202068231166507","url":null,"abstract":"Aim: Accumulation of plaque during orthodontic treatment makes oral prophylaxis a regular necessity. The use of esthetic brackets has gained popularity, it becomes necessary to assess the consequences of ultrasonic instrumentation during oral prophylaxis on ceramic bracket’s shear bond strength (SBS). Materials and Methods: Fifty-four premolar teeth which were extracted due to therapeutic reasons were divided into six groups with each group containing nine teeth each. Ceramic brackets were bonded onto the labial surfaces using two different adhesive systems (Ormco Enlight and Transbond) and were subjected to ultrasonic scaling at different scaler tip angulations. The samples were then rendered a debonding force in a Universal testing machine and the bond strengths were assessed. Results: In terms of angulation of ultrasonic instrumentation, among the groups bonded with the Ormco Enlight, the 45° angulation group had statistically significant higher bond strength values compared to the 0° angulation group. Among the transbond groups, there was no statistically significant difference in the bond strengths even though the 45° angulation group had slightly higher bond strength value than the 0° angulation group. Conclusion: Supragingival scaling around the bracket base at 0° around the ceramic brackets for 1 min resulted in the reduction of SBS. Therefore, the clinicians should be cautious during plaque removal, avoid performing extended ultrasonic instrumentation at the bracket base, especially at 0° angulation.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"9 1","pages":"81 - 87"},"PeriodicalIF":0.7,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74414181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study 纳米胶束姜黄素和布洛芬对弓丝置入后疼痛减轻效果的比较:一项双盲随机临床试验研究

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-04-12 DOI: 10.1177/23202068231166500

H. Shafaee, M. Ghiasi, Hamidreza Rahimi, Abdolrasoul Rangrazi

{"title":"Comparison of the Effects of Nano Micelles Curcumin and Ibuprofen on Pain Reduction After Initial Arch Wire Placement: A Double-Blind Randomized Clinical Trial Study","authors":"H. Shafaee, M. Ghiasi, Hamidreza Rahimi, Abdolrasoul Rangrazi","doi":"10.1177/23202068231166500","DOIUrl":"https://doi.org/10.1177/23202068231166500","url":null,"abstract":"Aim: To compare the effect of nano micelles curcumin and ibuprofen on pain reduction after primary arch wire placement in orthodontic patients. Materials and Methods: In this double-blind randomized clinical trial study, 60 female patients between the ages of 14 and 30 years who had moderate tooth crowding and were candidates for fixed orthodontic treatment were examined. The subjects were divided into four groups (n = 15) of nano micelles curcumin (SinaCurcumin), ibuprofen, placebo of SinaCurcumin, and placebo of ibuprofen. Each patient received a questionnaire and a rectangular, flexible cube of silicone to record the severity of their pain under each of the three situations (biting posterior teeth together, fitting anterior teeth together, and without fitting the teeth together) at the designated time points (2 h, 6 h, bedtime, the second, third, and seventh days after archwire placement). The obtained outcomes were statistically verified and analyzed by the employment of SPSS Statistics Version 22. Results: despite the lack of any significant differences among the four groups in terms of pain severity upon biting by the anterior teeth 2 h after the intervention, there was a considerable difference in the cases of 6 h, bedtime, and the second, third, and seventh days subsequent of the placement of archwire. Our data indicated a lower rate of pain severity for SinaCurcumin group than the placebo of SinaCurcumin and ibuprofen groups at 6 h after the archwire placement. However, the pain severity of SinaCurcumin group at bedtime was significantly lower than ibuprofen group, which also resulted in a notably lower rate than the other groups at the second, third, and seventh days after the placement of archwire. Conclusion: These findings support the effectiveness of curcumin in reducing the pain severity of orthodontic patients. Nevertheless, it is a necessity to conduct further confirmation trials on this latter.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"3 1","pages":"88 - 95"},"PeriodicalIF":0.7,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89027248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Platelet-Rich Fibrin and Microneedling—A Non-Surgical Approach for Gingival Augmentation: A Randomized Controlled Clinical Trial 注射富血小板纤维蛋白和微针-一种非手术方法牙龈增大:一项随机对照临床试验

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-03-25 DOI: 10.1177/23202068231157997

S. Soundarajan, Sankari Malaippan

{"title":"Injectable Platelet-Rich Fibrin and Microneedling—A Non-Surgical Approach for Gingival Augmentation: A Randomized Controlled Clinical Trial","authors":"S. Soundarajan, Sankari Malaippan","doi":"10.1177/23202068231157997","DOIUrl":"https://doi.org/10.1177/23202068231157997","url":null,"abstract":"Aim: The present study aimed to assess the efficacy of combining microneedling (MN) and injectable platelet-rich fibrin (i-PRF) administration with i-PRF alone in augmenting the thickness of gingiva to manage thin periodontal phenotype. Methodology: The clinical trial involved 36 patients who were diagnosed with thin periodontal phenotype. They were randomized under two groups: MN + i-PRF versus i-PRF alone, carried out as a split-mouth trial. One quadrant was treated only with i-PRF delivery through the gingival sulcus, while the contralateral side was treated with MN and i-PRF in 3 sessions at 10-day intervals. The primary parameter measured was the thickness of the gingiva, at baseline and 3 months following therapy. Statistical analysis was performed using the Mann-Whitney U test. Wilcoxon’s signed ranking test for inter-group and intra-group analysis, respectively. Results: The study results showed a significantly greater increase in gingival thickness (GT) in sites where both MN and i-PRF injection was done, compared to i-PRF alone, with a p value of .04. Conclusion: Both treatment modalities showed improvement in GT, being a minimally invasive alternative for mucogingival surgery. Adjunctive MN was found to be more beneficial than i-PRF alone. However, further research should be carried out to address the drawbacks of the study and for a better understanding of this novel approach.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"62 1","pages":"29 - 35"},"PeriodicalIF":0.7,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79585285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Health Conditions and Tooth Loss in the Population of Brazil: National Health Survey (2013 and 2019) 巴西人口的健康状况和牙齿脱落:全国健康调查(2013年和2019年)

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-03-21 DOI: 10.1177/23202068231163013

Erica Nobre Lima, L. Araújo, C. M. G. D. Florêncio

{"title":"Health Conditions and Tooth Loss in the Population of Brazil: National Health Survey (2013 and 2019)","authors":"Erica Nobre Lima, L. Araújo, C. M. G. D. Florêncio","doi":"10.1177/23202068231163013","DOIUrl":"https://doi.org/10.1177/23202068231163013","url":null,"abstract":"Aim: Certain systemic risk factors associated with tooth loss are much more common. However, population-based studies that have investigated the impact of these diseases on tooth loss and age groups are not found. The study aimed to evaluate the relationship and change in effect by age in systemic diseases with the loss of 13 or more teeth in adults and elderly people in Brazil, comparing two periods, 2013 and 2019. Materials and Methods: A total of 49,553 participants aged 18 years or older from the National Health Survey in 2013 and 77,862 in 2019 were used. Data was sorted out into five different age groups. Using a Poisson Regression model, the magnitudes of associations were analysed with sequential adjustment (95% CI). Results: All diseases (Arterial hypertension, Rheumatoid Arthritis, Diabetes, Depression and Hypercholesterolemia) were associated with tooth loss (statistically significant magnitudes of associations) in the total population in 2013 and 2019. The magnitudes of associations were decreasing in older age groups and it was only statistically significant with cardiovascular diseases and tooth loss in ≥ 65-year age group (1.10 (95% CI:1.05–1.15)). Conclusion: More than 13 teeth loss were associated with Arthritis/rheumatism, Depression, Diabetes Mellitus, Hypercholesterolemia, Systemic Arterial Hypertension and cardiovascular diseases, especially among younger age groups, which suggests a focus on the prevention and control of such systemic diseases and primary dental care.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"11 1","pages":"67 - 80"},"PeriodicalIF":0.7,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74030952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Dental Infection and Increased Incidence of Complications in Sickle Cell Disease Children: A Cross-sectional Study in Jeddah City 镰状细胞病儿童牙齿感染与并发症发生率增加之间的关系:吉达市的一项横断面研究

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-03-21 DOI: 10.1177/23202068231162177

O. Felemban, Lama Alhalees, L. Alattas, K. Baghlaf, M. Aldajani

{"title":"Association Between Dental Infection and Increased Incidence of Complications in Sickle Cell Disease Children: A Cross-sectional Study in Jeddah City","authors":"O. Felemban, Lama Alhalees, L. Alattas, K. Baghlaf, M. Aldajani","doi":"10.1177/23202068231162177","DOIUrl":"https://doi.org/10.1177/23202068231162177","url":null,"abstract":"Aim: Children with sickle cell disease (SCD) are prone to many complications. However, little is known about oral infectious. This study aimed to assess the oral health status of pediatric patients with SCD and explore the associations between oral health conditions and clinical complications of SCD. Materials and Methods: A cross-sectional study was conducted in children with SCD admitted to the pediatric wards of two government hospitals in Jeddah city. The children were examined for dental caries, gingival diseases, oral lesions, and dental infections. Oral findings were compared between children who were hospitalized for vaso-occlusive crisis (VOC) or had a history of VOC in the last 6 or 12 months and those who were admitted for other reasons such as blood transfusion or other complications or had no history of VOC in the last 6 or 12 months. Results: A total of 107 children with SCD were included, with a mean age of 9.82 ± 3.82 years, of which 51 (47.7%) were females. Of the total, 58 (54.2%) were admitted because of VOC. There was a significant relationship between VOC and dental attrition (P = 0.038), osteomyelitis, and dental abscesses (P = 0.004). A significant association was found between the presence of dental abscesses and a history of osteomyelitis or avascular necrosis of long bones in the previous 12 months (P = 0.001 and P = 0.041, respectively). Conclusion: Dental abscesses and non-carious lesions are likely to be associated with VOC; however, further prospective cohort studies are warranted to confirm this association and establish a causal relationship.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"238 1","pages":"54 - 60"},"PeriodicalIF":0.7,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77014648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superabsorbent Polymer Sponge for Saliva Absorption Pad 高吸水性聚合物海绵，用于唾液吸收垫

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-03-16 DOI: 10.1177/23202068231158000

Paila Ravi Sankar, Sreejith Sasidharan Lathikumari, M. Saraswathy

{"title":"Superabsorbent Polymer Sponge for Saliva Absorption Pad","authors":"Paila Ravi Sankar, Sreejith Sasidharan Lathikumari, M. Saraswathy","doi":"10.1177/23202068231158000","DOIUrl":"https://doi.org/10.1177/23202068231158000","url":null,"abstract":"Aim: Saliva is a significant hindrance to most dental procedures (e.g., root canal treatment) as the flow of saliva increases in patients undergoing dental treatment due to anxiety. Saliva absorption pads based on superabsorbent polymers can provide a dry oral environment to ease the dental treatment procedure and reduce the swallowing reflexes common during cotton use. This study focused on developing an indigenous saliva absorption pad using biodegradable superabsorbent polymer (BSAP) sponges. Materials and Methods: BSAP sponges were synthesized using carboxymethyl cellulose (CMC) as the base matrix. Different crosslinking mechanisms were implemented to prepare BSAP sponges, such as ionic crosslinking using aluminum ammonium sulfate (AlAS) and chemical crosslinking using methylene bisacrylamide. Three different BSAP sponges (Sap-2, SAP-PAA-1, and SAP-PAA-2) were characterized for their free swell capacity and thermal degradation kinetics along with other characterization techniques to optimize the composition for saliva absorption pad. One-way ANOVA was used for statistical evaluation. Results: SAP-2, synthesized using 10 wt.% AlAS showed the highest free swell capacity in water and saline (83.21 ± 3.8 g/g and 40.7 ± 3.4 g/g, respectively). However, the moisture content of the particular BSAP sponge was higher (~13%) compared to the standard limit (ISO 17190-4:2001(E)). It was observed that as the crosslinking density increases free swell capacity increases to a threshold point and decreases thereafter. As reported earlier, percentage swelling was controlled by multiple factors including crosslinking that opposes swelling and polymer/water interaction and Donnan pressure that promotes swelling. Conclusion: BSAP sponge based on crosslinked CMC matrix is highly advantageous in developing saliva absorption pad. Hydrophobic surface modification is recommended to reduce the moisture content to improve the storage stability of BSAP sponges.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"31 1","pages":"36 - 43"},"PeriodicalIF":0.7,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78806941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Different Dentin Deproteinizing Agents on Bond Strength and Microleakage of Universal Adhesive to Dentin 不同牙本质脱蛋白剂对牙本质粘接强度及微渗漏的影响

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-02-25 DOI: 10.1177/23202068231157998

Fatih Bedir, G. Y. Telatar

{"title":"Comparison of Different Dentin Deproteinizing Agents on Bond Strength and Microleakage of Universal Adhesive to Dentin","authors":"Fatih Bedir, G. Y. Telatar","doi":"10.1177/23202068231157998","DOIUrl":"https://doi.org/10.1177/23202068231157998","url":null,"abstract":"Aim: To evaluate the effects of papain (Brix 3000), bromelain, sodium hypochlorite (NaOCl), and chlorine dioxide (ClO2) application to the deep dentin surface on shear bond strength (SBS), microleakage, and dentin surface properties. Materials and Methods: Deep dentin surface (n = 100) for evaluating SBS, class V preparation at the buccal surface for testing microleakage (n = 100), and deep dentin slices (n = 20) for evaluating surface properties were conducted on the 220 molar teeth. Four different deproteinizing agents (Brix 3000, 40% bromelain, 5.25% NaOCl (Chloraxid), and 0.12% ClO2) were applied to the dentin, and then the universal adhesive was used in self-etch (SE) and etch&rinse (E&R). Deproteinizing agents were not applied to the control group. All of the samples were subjected to 5000 cycles of thermal aging at 5ºC–55ºC. SBS (MPa) was tested by a universal testing machine. The microleakage of resin composite bonded with different adhesive modes was evaluated under a stereomicroscope. The changes in the surface morphology were examined with scanning electron microscopy (SEM) and attenuated total reflection – fourier transform infrared spectroscopy (ATR-FTIR). Results: ClO2 exhibited the highest bond strength among deproteinizing agents. Compared to the SE mode, E&R mode significantly showed higher bond strength (p < .05). In gingival margin, bromelain SE exhibited the highest marginal leakage, while Brix 3000 SE had the lowest mean microleakage score. Conclusion: Deproteinizing with ClO2 was effective in improving the SBS of universal adhesive in the E&R mode to deep dentin. Deproteinization with bromelain before universal adhesive in SE mode showed more microleakage on both the occlusal and gingival surfaces.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"50 1","pages":"44 - 53"},"PeriodicalIF":0.7,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91205173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of Action of Clove and Ginger Herbal Formulation-Mediated TiO2 Nanoparticles Against Lactobacillus Species: An In Vitro Study 丁香姜中药配方介导TiO2纳米颗粒抗乳杆菌作用机制的体外研究

IF 0.7

Journal of Advanced Oral Research Pub Date : 2023-01-23 DOI: 10.1177/23202068221142440

Rieshy V., J. J. Chokkattu, Rajeshkumar S, S. Neeharika

{"title":"Mechanism of Action of Clove and Ginger Herbal Formulation-Mediated TiO2 Nanoparticles Against Lactobacillus Species: An In Vitro Study","authors":"Rieshy V., J. J. Chokkattu, Rajeshkumar S, S. Neeharika","doi":"10.1177/23202068221142440","DOIUrl":"https://doi.org/10.1177/23202068221142440","url":null,"abstract":"Introduction: With its numerous practical applications, the usage of nanotechnology in the medical profession has been a godsend in our modern technological era. Titanium dioxide (TiO2) is a semiconducting metal oxide with superior inherent qualities which can be utilized in various applications across various fields. Taking into account all of the above information, the current study focused on the mechanism of action of TiO2 nanoparticles mediated by clove and ginger herbal formulations against Lactobacillus species. Materials and Methods: Extract of clove and ginger herbal formulation-mediated TiO2 nanoparticles was obtained with acetone in the ratio of 10:1, yielding 9 mg/mL. After overnight incubation and further serial dilutions, the solution was introduced into microplate wells with cultured Lactobacillus species for 4 hours. A 5% of test solution was added into Kimble tubes containing Muller-Hinton broth along with the plant extract, followed by recording of minimum inhibitory concentrations at certain time intervals. The number of samples used for each concentration was 4 using the convenience method. The grouping sample was 3, i.e. test group, antibiotic and positive control group. The results were statistically analysed following one-way analysis of variances using SPSS software version 22. Result: Optical density determines the degree of scattering of light that is produced by a bacterium within a culture plate. The more the bacteria, the more the light is scattered. The results (P < .005) show that as the concentration increases, the value of optical density decreases which proves that there occurs a bactericidal process that results in the reduced bacterial count. Conclusion: The results of this study suggest that TiO2 nanoparticles enhanced with clove and ginger might be used as an antibacterial agent against Lactobacillus species.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"41 1","pages":"61 - 66"},"PeriodicalIF":0.7,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81328502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of Cytotoxic Effect of Graphene Oxide Added to Mineral Trioxide Aggregate 三氧化二矿骨料中氧化石墨烯的细胞毒性评价

IF 0.7

Journal of Advanced Oral Research Pub Date : 2022-12-21 DOI: 10.1177/23202068221142422

B. Dayı, Elif Nihan Küçükyildiz, A. Taghizadehghalehjoughi

{"title":"Evaluation of Cytotoxic Effect of Graphene Oxide Added to Mineral Trioxide Aggregate","authors":"B. Dayı, Elif Nihan Küçükyildiz, A. Taghizadehghalehjoughi","doi":"10.1177/23202068221142422","DOIUrl":"https://doi.org/10.1177/23202068221142422","url":null,"abstract":"Aim: Recently, although studies have shown that biomaterials containing graphene oxide (GO) in biomedicine stand out for their positive effects, the effect of GO on dental tissues when used with dental materials is not well known. The aim of this study was an evaluation of the cytotoxic effects of GO on gingival fibroblasts when it is combined in two different ratios with Mineral Trioxide Aggregate (MTA). Materials and Methods: In this in-vitro study, a homogenous mixture of adding +0.1 weight (wt)% and +0.3 wt% GO to Angelus MTA was created (two experimental groups) and compared with pure Angelus MTA and negative control groups. The materials were mixed according to the manufacturer’s instructions, and Teflon molds were used to form 24 disc-shaped samples for each group. The samples were divided into groups according to the simple random sampling method. The cytotoxic effect of samples was determined on gingival fibroblast cells by using the MTT test, and total oxidant status (TOS) and total antioxidant capacity (TAC) kits in 24 and 72 hours. The data were statistically analyzed using one-way ANOVA and Tukey tests. Results: A significant difference was found between the material-applied groups and the control group at the TAC 24 and 72 hours and between the groups containing GO and the control group at the MTT 72 hours and TAC and TOS 24 and 72 hours (p < .05). Conclusion: The addition of GO to MTA increased the dose and time-based toxicity and oxidant amount, and decreased antioxidant capacity.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"53 1","pages":"21 - 28"},"PeriodicalIF":0.7,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83319336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary Aspartate Aminotransferase, Alanine Aminotransferase and IgA as biomarkers for Type I Diabetes Mellitus: A Systematic Review 唾液天冬氨酸转氨酶、丙氨酸转氨酶和IgA作为I型糖尿病的生物标志物:系统综述

IF 0.7

Journal of Advanced Oral Research Pub Date : 2022-12-04 DOI: 10.1177/23202068221135433

R. Mohandas, P. Ramani, Subhashree Mohapatra

{"title":"Salivary Aspartate Aminotransferase, Alanine Aminotransferase and IgA as biomarkers for Type I Diabetes Mellitus: A Systematic Review","authors":"R. Mohandas, P. Ramani, Subhashree Mohapatra","doi":"10.1177/23202068221135433","DOIUrl":"https://doi.org/10.1177/23202068221135433","url":null,"abstract":"Introduction: Type I diabetes mellitus (T1DM) is an autoimmune disorder characterized by absolute insulin deficiency, which is caused by progressive destruction of the β-islet cells of the pancreas. Aminotransferases participate in the interconversion of amino acids and oxalic acids by transfer of amino groups. Organ damage leads to leakage of transaminases into the blood. IgA is the only immunoglobulin that is found in saliva and forms the first line of defense. Alteration in the levels of secretory IgA often indicates a local or systemic disease. The aim of this systematic review is to evaluate the role of salivary aspartate aminotransferase (AST), alanine aminotransferase (ALT), and IgA as biomarkers for T1DM patients. Materials and Methods: An electronic literature search was conducted by two independent reviewers using PubMed, Medline and Google scholar without any date filter. The inclusion criteria included case control and cross-sectional studies. Publications in languages other than English, review articles, letters to the editor, and studies done on animal models were excluded from the review. The difference in the levels of salivary AST, ALT, or IgA in T1DM patients and in healthy individuals were compared. Risk of bias assessment was done using the ROBINS-I tool. Results: A total of eight relevant articles were assessed, out of which three studies showed elevated salivary AST and ALT levels and five studies showed elevated salivary IgA levels in patients with T1DM. Conclusion: Our review reflected that salivary AST, ALT, and IgA were elevated in T1DM patients, and they can be used for monitoring these patients. Further studies are needed to establish the diagnostic accuracy of these parameters for clinical application.","PeriodicalId":43017,"journal":{"name":"Journal of Advanced Oral Research","volume":"30 1","pages":"5 - 10"},"PeriodicalIF":0.7,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73198327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0